LOCUS       NM_001166597            4090 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus diacylglycerol kinase zeta (Dgkz), transcript variant
            1, mRNA.
ACCESSION   NM_001166597
VERSION     NM_001166597.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4090)
  AUTHORS   Okumura,M., Yokoyama,Y., Yoshida,T., Okada,Y., Takizawa,M.,
            Ikeda,O. and Kambayashi,T.
  TITLE     The diacylglycerol kinase zeta inhibitor ASP1570 augments natural
            killer cell function
  JOURNAL   Int Immunopharmacol 125 (Pt A), 111145 (2023)
   PUBMED   37935092
REFERENCE   2  (bases 1 to 4090)
  AUTHORS   Singh,B.K., Yokoyama,Y., Tanaka,Y., Laczko,D., Deshpande,D.A. and
            Kambayashi,T.
  TITLE     Diacylglycerol kinase zeta deficiency attenuates papain-induced
            type 2 airway inflammation
  JOURNAL   Cell Immunol 393-394, 104780 (2023)
   PUBMED   37918056
  REMARK    GeneRIF: Diacylglycerol kinase zeta deficiency attenuates
            papain-induced type 2 airway inflammation.
REFERENCE   3  (bases 1 to 4090)
  AUTHORS   Harabuchi,S., Khan,O., Bassiri,H., Yoshida,T., Okada,Y.,
            Takizawa,M., Ikeda,O., Katada,A. and Kambayashi,T.
  TITLE     Manipulation of diacylglycerol and ERK-mediated signaling
            differentially controls CD8+ T cell responses during chronic viral
            infection
  JOURNAL   Front Immunol 13, 1032113 (2022)
   PUBMED   36846018
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4090)
  AUTHORS   Hernandez-Lara,M.A., Yadav,S.K., Shah,S.D., Okumura,M.,
            Yokoyama,Y., Penn,R.B., Kambayashi,T. and Deshpande,D.A.
  TITLE     Regulation of Airway Smooth Muscle Cell Proliferation by
            Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma
  JOURNAL   Int J Mol Sci 23 (19), 11868 (2022)
   PUBMED   36233170
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4090)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4090)
  AUTHORS   Yakubchyk,Y., Abramovici,H., Maillet,J.C., Daher,E., Obagi,C.,
            Parks,R.J., Topham,M.K. and Gee,S.H.
  TITLE     Regulation of neurite outgrowth in N1E-115 cells through
            PDZ-mediated recruitment of diacylglycerol kinase zeta
  JOURNAL   Mol Cell Biol 25 (16), 7289-7302 (2005)
   PUBMED   16055737
  REMARK    GeneRIF: DGK-zeta, syntrophin, and Rac1 form a regulated signaling
            complex that controls polarized outgrowth in neuronal cells
REFERENCE   7  (bases 1 to 4090)
  AUTHORS   Regier,D.S., Higbee,J., Lund,K.M., Sakane,F., Prescott,S.M. and
            Topham,M.K.
  TITLE     Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3
            and inhibits Rap1 signaling
  JOURNAL   Proc Natl Acad Sci U S A 102 (21), 7595-7600 (2005)
   PUBMED   15894621
REFERENCE   8  (bases 1 to 4090)
  AUTHORS   Zhong,X.P., Hainey,E.A., Olenchock,B.A., Jordan,M.S.,
            Maltzman,J.S., Nichols,K.E., Shen,H. and Koretzky,G.A.
  TITLE     Enhanced T cell responses due to diacylglycerol kinase zeta
            deficiency
  JOURNAL   Nat Immunol 4 (9), 882-890 (2003)
   PUBMED   12883552
  REMARK    GeneRIF: Diacylglycerol kinase zeta functions as a physiological
            negative regulator of tcr signaling and t-cell activation
REFERENCE   9  (bases 1 to 4090)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 4090)
  AUTHORS   Ding,L., McIntyre,T.M., Zimmerman,G.A. and Prescott,S.M.
  TITLE     The cloning and developmental regulation of murine diacylglycerol
            kinase zeta
  JOURNAL   FEBS Lett 429 (1), 109-114 (1998)
   PUBMED   9657393
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087503.1, CD564532.1, BE862117.1 and BY545365.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087503.1, SRR13422601.401820.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2169              AK087503.1         2-2170
            2170-2737           CD564532.1         51-618
            2738-2891           AK087503.1         2740-2893
            2892-3341           BE862117.1         20-469
            3342-3661           AK087503.1         3344-3663
            3662-3807           BY545365.1         18-163
            3808-4090           AK087503.1         3811-4093
FEATURES             Location/Qualifiers
     source          1..4090
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.63 cM"
     gene            1..4090
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /note="diacylglycerol kinase zeta"
                     /db_xref="GeneID:104418"
                     /db_xref="MGI:MGI:1278339"
     exon            1..128
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            129..879
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..3508
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /EC_number="2.7.1.107"
                     /EC_number="2.7.1.93"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DGK-zeta; DAG kinase zeta; diglyceride kinase zeta"
                     /codon_start=1
                     /product="diacylglycerol kinase zeta isoform 1"
                     /protein_id="NP_001160069.1"
                     /db_xref="CCDS:CCDS50643.1"
                     /db_xref="GeneID:104418"
                     /db_xref="MGI:MGI:1278339"
                     /translation="METFFRKHFQRKARGPGERQRRSSGVGLPTGKARRRSPAGQASS
                     SLAQRRRSSAQLQGCFPSCGVGTRGASRRRSSTAPPTCNPRFMVDVVPTLQPVTVGAQ
                     LLGAPLLLAGLTSMKEEEEEEGVQEGNETAEATSDARPGTRTTPFSHQGTWPLLPMPR
                     CLRRASSHLLPADVECGHTLWGLHGHYRRLSQRWPSGQHPGLGGRSPRASGAAACPMI
                     PARVRPLSRRRQVALRRKSAGPQPWSTLLMKAITKSGLQHLAPPPPTPGAPCGESEEQ
                     IQSTVDWSESAVYGEHIWFETNVSGDFCYVGEQHCVAKMLPKSAPRKKCAACKIVVHT
                     QCIKQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTF
                     HSKEIVAISCSWCKQAYHSKVSCFMMQQIEEPCSLGVHAAVVIPPTWILRARRPQNTL
                     KASKKKKRASFKRRSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKII
                     QSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKP
                     PPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLRAEPNPEA
                     GPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGT
                     AFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRYCAGTMPWGHPGE
                     HHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIPVQVDGEP
                     CKLSASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVPEQLRIQVSRVSMHDYEALHY
                     DKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQREPDGAGAKSPMCHQLSSKWCFLD
                     ATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPASPCSP
                     TPGSMQGDTALPQGEELIEAAKRNDCCKLQELHRAGGDLMHRDQKSRTLLHHAVSTGS
                     KEVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDLQGDT
                     PRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV"
     exon            880..988
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1084
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1162
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1219
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1288
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1360
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1477
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1549
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1645
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1728
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1789
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1903
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2044
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2123
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2179
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2242
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2316
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2428
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2628
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2729
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2809
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2879
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..2920
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3060
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3092
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3136
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3257
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3291
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3391
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..4090
                     /gene="Dgkz"
                     /gene_synonym="E130307B02Rik; F730209L11Rik; mDGK[z]"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcggagcca ctgcagctag ctgtccaaac taggacttgc tctgcagagg ccggcaatcc
       61 cagcaaactg gagcaagagc agaggcgcct gggaccccag tccccacctg cttgtccttc
      121 cagatcagcc cctggcatgg agaccttctt taggaagcat ttccaacgaa aggcacgagg
      181 tcccggagag aggcagcggc ggtccagtgg cgtggggctg cccacaggca aggctcgacg
      241 ccgctcccct gcagggcagg cgtcctcttc actggcccag aggcgccgct ccagtgcaca
      301 gctccagggc tgttttccca gctgcggggt gggcacgaga ggtgccagcc gcaggcgatc
      361 cagcactgca ccccctacct gcaatccccg cttcatggtg gatgtggtgc ctaccctaca
      421 gcctgtcaca gttggggccc agcttctggg tgcacccctg ctgttggctg ggctcacaag
      481 catgaaggag gaagaggagg aggaaggggt ccaggaggga aatgagacag ctgaggcgac
      541 aagtgatgct aggccaggta cccggacaac gcccttctca caccagggca cctggccact
      601 gcttcccatg ccccgctgcc tgcgtcgagc ctcctcccac ctgctccctg ctgatgtgga
      661 gtgtggccat accctttggg gcctgcatgg tcactatcga cgcctcagcc agcggtggcc
      721 ctcaggccag caccctggtc ttgggggccg aagcccaaga gcctcgggcg ctgcagcatg
      781 ccccatgata ccggcccgtg tgcgcccact gtctcgcaga cgccaggtag ctctaaggcg
      841 gaagtcagct ggaccccagc cctggagcac cctgcttatg aaagccatca ccaagtcggg
      901 cctccagcac ctggcacccc ctcctcccac gcccggggcc ccgtgcggtg aatctgagga
      961 gcagatccag agcactgtgg actggagtga gtcagcagtg tatggggagc acatctggtt
     1021 tgagaccaac gtgtccggtg acttctgcta tgtcggggag cagcactgtg tagctaagat
     1081 gctgccgaag tcagcgccca gaaaaaagtg tgcagcctgt aagatcgtgg tgcataccca
     1141 atgcattaag cagctggaaa agatcaattt ccgctgtaag ccgtccttcc gcgaatcagg
     1201 ctccaggaat gtccgtgagc caaccttcgt aagacaccac tgggtccaca gacgacgcca
     1261 ggatggcaag tgtcggcact gtgggaaggg cttccagcag aagttcacct tccacagcaa
     1321 ggagatcgta gccatcagct gctcctggtg caaacaggca taccacagca aggtgtcgtg
     1381 cttcatgatg caacagattg aggaaccctg ctccctaggg gtgcatgcag ccgtggtcat
     1441 cccacccacc tggatcctgc gggcccggag gccccagaac accctcaagg ccagcaagaa
     1501 gaaaaagaga gcgtccttca agaggaggtc cagcaagaaa ggacctgagg aaggccgctg
     1561 gagacccttc atcatcagac ccaccccatc ccccctcatg aaacccctgc tggtgtttgt
     1621 gaaccccaag agtgggggca accagggtgc caagatcatc cagtcttttt tgtggtatct
     1681 gaatccccga caagtctttg atctgagcca gggaggaccc agggaagcgc tggaaatgta
     1741 ccgcaaagta cataatttga ggattctggc ttgcgggggt gatggcacgg ttggctggat
     1801 tctctccacc ctggaccagc tgcgcttaaa accaccgcct cctgtagcca tcctgcctct
     1861 gggcactggc aatgacctgg cccgaaccct caactggggt gggggttaca cagatgagcc
     1921 tgtgtcaaag atcctttccc atgttgagga ggggaatgtg gtacagctgg accgttggga
     1981 cctccgagca gagcccaacc ctgaggcggg gcctgaggag cgagatgatg gagccactga
     2041 ccggctgccc ctggatgtct ttaacaacta cttcagcctg ggcttcgatg cccacgtcac
     2101 cctggaattt catgagtctc gagaagccaa cccagagaag ttcaacagcc gctttcggaa
     2161 taagatgttc tatgctggga cggccttctc tgacttcctg atgggcagct ccaaggactt
     2221 agccaagcac atccgagtag tgtgtgacgg aatggaccta acccccaaga ttcaggacct
     2281 gaaaccgcag tgcatcgtct ttctgaatat ccccaggtac tgtgcaggca ccatgccctg
     2341 gggccacccc ggggagcacc atgacttcga gccccagagg catgatgatg gctacctgga
     2401 ggtcatcggc ttcaccatga catccttggc agcactgcag gtgggtgggc acggcgagcg
     2461 attgacgcag tgccgagaag tgctgctcac cactgccaag gccatccctg tgcaggtgga
     2521 cggtgagccc tgcaagcttt cagcatcacg gattcgaatt gccctgcgca accaggccac
     2581 tatggtgcag aaggccaagc gccggagtac tgccccactg cacagcgacc agcagccagt
     2641 tcctgagcag ctgaggatcc aggtgagcag ggtcagtatg cacgactacg aggctctaca
     2701 ttatgacaag gagcagctca aggaagcctc tgtgcctctg ggcactgtgg tggtccccgg
     2761 agacagtgac ctggagctct gccgcgccca cattgagaga ctgcagcggg agcccgatgg
     2821 ggctggagcc aagtccccga tgtgccacca actctcctcc aagtggtgtt tcctggatgc
     2881 caccactgcc agccgcttct acaggatcga cagagcccag gagcacctca actatgtgac
     2941 ggagattgcc caggacgaga tttacatcct agacccagag cttctgggag catcagcccg
     3001 gcctgacctc cccaccccta cctccccact ccctgcttcc ccctgctccc ctacacccgg
     3061 gtcaatgcag ggggacactg cactgcccca aggtgaagaa ctgattgaag cagccaagag
     3121 gaatgactgc tgcaagctcc aggagctaca ccgagcagga ggtgacctca tgcaccgtga
     3181 ccagaagagc cgcacgctct tgcaccacgc ggtcagcact ggcagtaagg aagtggtccg
     3241 ctatctgctg gatcatgcac ctccagagat ccttgatgct gtggaggaga atggggagac
     3301 ctgtctacac caggcagccg ccctgggtca gcgcaccatc tgccactaca ttgtggaagc
     3361 cggggcctcc ctcatgaaga cagatctgca gggcgacact ccccggcagc gcgctgagaa
     3421 ggctcaagac acagagctcg ctgcctacct ggagaacaga cagcattacc agatgatcca
     3481 gcgtgaggac caggagacag ctgtgtagtt aaggggacca tggatcaaca agggacacta
     3541 ccagaggact ctccttgccc atctcactgc cacattcctg tcagatggct atggggggac
     3601 cctgccacag ggaaggagcc ccgtgccacc ccctgagaag ctgttcagat ctagggctgg
     3661 actctaagga gctggactct cacctgtccc tggtttcatg gggaacagga aacaggctgg
     3721 gctggctggt tccctccctt cagggcagcc tccagctcac cacagcagat ggaagggctg
     3781 gacagagctc agcatcgatg tcagggaggc ctgcactcag caggactttc aaaagccacc
     3841 tgatcctttg ggctctctgg agggttctgg gtacctaacc ctcctctctg atccacccac
     3901 cctgggcatc ccagaaactc aagagcctgc tgtattcact tgcccgctgc cctgcttggc
     3961 acctaccctg gtcttcctcc tcatgtatcc agccatttca tttcggactg tatggcctgg
     4021 ggtggggggt ggggctccca cggtgacttg tttacagctg ggtgtgactc agtaaagtga
     4081 attttttttc
//
