LOCUS       NM_199011               4673 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus diacylglycerol kinase, theta (Dgkq), transcript
            variant 1, mRNA.
ACCESSION   NM_199011 XM_132245
VERSION     NM_199011.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4673)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4673)
  AUTHORS   Barber,C.N. and Raben,D.M.
  TITLE     Roles of DGKs in neurons: Postsynaptic functions?
  JOURNAL   Adv Biol Regul 75, 100688 (2020)
   PUBMED   31836314
  REMARK    GeneRIF: Roles of DGKs in neurons: Postsynaptic functions?
            Review article
            Erratum:[Adv Biol Regul. 2021 Dec;82:100846. doi:
            10.1016/j.jbior.2021.100846.. PMID: 34862141]
REFERENCE   3  (bases 1 to 4673)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 4673)
  AUTHORS   Goldschmidt,H.L., Tu-Sekine,B., Volk,L., Anggono,V., Huganir,R.L.
            and Raben,D.M.
  TITLE     DGKtheta; Catalytic Activity Is Required for Efficient Recycling of
            Presynaptic Vesicles at Excitatory Synapses
  JOURNAL   Cell Rep 14 (2), 200-207 (2016)
   PUBMED   26748701
REFERENCE   5  (bases 1 to 4673)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 4673)
  AUTHORS   Wergedal,J.E., Ackert-Bicknell,C.L., Beamer,W.G., Mohan,S.,
            Baylink,D.J. and Srivastava,A.K.
  TITLE     Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J
            intercross and a combined intercross involving NZB/B1NJ, RF/J,
            MRL/MpJ, and SJL/J mouse strains
  JOURNAL   J Lipid Res 48 (8), 1724-1734 (2007)
   PUBMED   17496333
REFERENCE   7  (bases 1 to 4673)
  AUTHORS   Crotty,T., Cai,J., Sakane,F., Taketomi,A., Prescott,S.M. and
            Topham,M.K.
  TITLE     Diacylglycerol kinase delta regulates protein kinase C and
            epidermal growth factor receptor signaling
  JOURNAL   Proc Natl Acad Sci U S A 103 (42), 15485-15490 (2006)
   PUBMED   17021016
REFERENCE   8  (bases 1 to 4673)
  AUTHORS   Schneider,H., Patil,S.P., Canisius,S., Gladmon,E.A., Schwartz,A.R.,
            O'Donnell,C.P., Smith,P.L. and Tankersley,C.G.
  TITLE     Hypercapnic duty cycle is an intermediate physiological phenotype
            linked to mouse chromosome 5
  JOURNAL   J Appl Physiol (1985) 95 (1), 11-19 (2003)
   PUBMED   12794091
REFERENCE   9  (bases 1 to 4673)
  AUTHORS   Topham,M.K. and Prescott,S.M.
  TITLE     Mammalian diacylglycerol kinases, a family of lipid kinases with
            signaling functions
  JOURNAL   J Biol Chem 274 (17), 11447-11450 (1999)
   PUBMED   10206945
  REMARK    Review article
REFERENCE   10 (bases 1 to 4673)
  AUTHORS   Pilz,A., Schaap,D., Hunt,D. and Fitzgibbon,J.
  TITLE     Chromosomal localization of three mouse diacylglycerol kinase
            (DAGK) genes: genes sharing sequence homology to the Drosophila
            retinal degeneration A (rdgA) gene
  JOURNAL   Genomics 26 (3), 599-601 (1995)
   PUBMED   7607687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161813.2 and BC062929.1.
            
            On Oct 17, 2017 this sequence version replaced NM_199011.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062929.1, SRR1660817.252817.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC161813.2         25650-25710
            62-4673             BC062929.1         1-4612
FEATURES             Location/Qualifiers
     source          1..4673
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.24 cM"
     gene            1..4673
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /note="diacylglycerol kinase, theta"
                     /db_xref="GeneID:110524"
                     /db_xref="MGI:MGI:102918"
     exon            1..388
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..2940
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /EC_number="2.7.1.107"
                     /EC_number="2.7.1.93"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DGK-theta; DAG kinase theta; diglyceride kinase theta;
                     diacylglycerol kinase, delta (110 kDa); Dgk theta"
                     /codon_start=1
                     /product="diacylglycerol kinase theta isoform 1"
                     /protein_id="NP_950176.1"
                     /db_xref="CCDS:CCDS19515.1"
                     /db_xref="GeneID:110524"
                     /db_xref="MGI:MGI:102918"
                     /translation="MAAAAEPGARTWPGSGSPRLGSPAGSPVLGISGRTRPGSGPERT
                     SRAIGSAAPGHSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKQVKTPC
                     TSIAPSLVRVPVAHCFGSLGLYKRKFCVVCRKSLEVPAFRCEVCELHVHPDCVPFACS
                     DCRQCHQDGQQDYDTYHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHS
                     VCSTALAPECTFGRLRSMVLPPSCVRLLSRNFSKMHCFRIPETMVLELGDGDDGVDGS
                     AAIGTGREVLTATESTKQTLKIFDGNDSMRKNQFRLVTVSRLARNEEVMEAALRAYYI
                     SEDPKDFQLQALPLSGNAQALGKAGTTEEEASKGSCPRDSVPEAWVIRSLPRTQEILK
                     IYPGWLKVGVAYVSIRVNSQSTARSVVQEVLPLFGQQVEDKERFQLIEVLMSSRQVQR
                     TVLADEEPLLDRLWDIRQTSVRQVSQTRFYVAETRATAPRVSLFVGGLPPGLSPQDYS
                     NLLHEAMATKAAVVSVSHVYSLQGAVILDVTCFAEAERLYMLARDTAVHGRPLTALVL
                     PDVLHTKLPPDCCPLLVFVNPKSGGLKGRELLCSFRKLLNPHQVFELTNGGPLPGFHL
                     FSQVPSFRVLVCGGDGTVGWVLAALEETRRHLACPEPSVAILPLGTGNDLGRVLRWGA
                     GYSGEDPFSVLVSVDEADAVLMDRWTILLDAHEIDSTENNVVETEPPKIVQMNNYCGI
                     GIDAELSLDFHQAREEEPGKFTSRFHNKGVYVRVGLQKISHSRSLHKEIRLQVEQQEV
                     ELPSIEGLIFINIPSWGSGADLWGSDNDSRFEKPRIDDGLLEVVGVTGVVHMGQVQGG
                     LRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGHMIISATAPKVHMLRKAKQKPRK
                     AGANRDTRVDTLPAPEGNPL"
     exon            389..468
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            469..568
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            569..654
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            655..780
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            781..934
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1009
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1110
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1331
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1422
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1477
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1539
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1690
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1729
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1845
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1997
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2146
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2325
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2426
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2573
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2685
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2838
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..4606
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4381..4386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /note="hexamer: AAGAAA"
     polyA_site      4401
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
     regulatory      4577..4582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /note="hexamer: AATACA"
     polyA_site      4604
                     /gene="Dgkq"
                     /gene_synonym="110kDa; DAGK; Dagk4; DAGK7; Dgkd"
                     /note="major polyA site"
ORIGIN      
        1 agtctggccc cgcccacgtg agcctgcgcg ttaggtagcg cagtcggaag ccgggagcgg
       61 gctctgccga gggccctctc tacaccgcgg acctggcttt atcgtgcgct tggagctggg
      121 gcgctcgggt tgtggatggc ggcggcagcc gagcccggtg cccggacctg gccgggcagt
      181 ggttccccac gtcttggcag cccggccggc agtccagtgc tgggcatctc gggccgcaca
      241 cgcccggggt cagggccgga gcggactagc agagctattg gctccgcagc acctggccac
      301 agctttcgca aggtgacact caccaagcct accttctgcc acctctgctc ggacttcatc
      361 tggggactgg ctggcttcct gtgcgatgtc tgcaacttca tgtcccatga gaagtgcctg
      421 aagcaggtga agaccccgtg cacaagcatt gcaccaagcc tcgtccgggt gcctgtagcc
      481 cactgctttg gttcccttgg tctctacaag cgcaagttct gtgtggtctg ccgcaagagc
      541 ctggaggtac ccgcattccg ctgtgaagtg tgtgagctgc acgttcaccc cgactgtgtg
      601 cccttcgcct gcagcgactg tcgtcagtgc caccaggatg gacagcagga ttatgacacg
      661 tatcaccacc actggaggga ggggaacctg ccttctggtg cacgatgtga ggtctgtagg
      721 aagacttgtg gttcctcaga tgtgctggct ggtgtacgct gcgagtggtg tggtgtacag
      781 gctcactcag tgtgctccac agcacttgcg cctgagtgta catttggacg tctacgctcc
      841 atggtactgc ctccttcgtg tgtgcgcctg ttgtcccgaa acttcagcaa gatgcactgt
      901 ttccgaatcc ctgagaccat ggtcctggag cttggtgatg gggatgatgg cgtagacggg
      961 agtgctgcta taggcacagg cagagaggta ctgacagcta cagagtccac caaacagacc
     1021 ctgaagatct ttgatggcaa cgactccatg aggaaaaatc agtttcgtct ggttacagtt
     1081 tcccgcctgg ctcggaatga ggaagtgatg gaggcagcac ttcgggccta ctatattagc
     1141 gaggacccta aggacttcca gctgcaggca ctgcccctgt ctggcaatgc ccaggctctg
     1201 gggaaggctg ggaccactga ggaggaggct agtaaaggct cttgtccccg ggattccgtg
     1261 cctgaggcct gggtcatcag gtctttgcct cgtacccaag agatcctgaa gatctaccct
     1321 ggctggctca aggtaggtgt ggcctacgtg tccatccgtg tgaactccca gagtacagca
     1381 cggtctgtgg ttcaagaggt tctcccactg tttggacaac aggttgagga taaggagaga
     1441 ttccagctga ttgaggtgct catgagcagc agacaagtcc aacggaccgt gctggcagat
     1501 gaagaacctc tgctagaccg actctgggac atccgacaga cttctgtgcg ccaggtgagc
     1561 cagacgcggt tctacgtggc cgagaccagg gccacggccc cacgtgtctc cctgttcgtg
     1621 ggtggcctgc cacctggctt gtccccccag gattacagca acctgctgca tgaggccatg
     1681 gccaccaaag ctgctgtggt gtctgtgagt cacgtctact ccttacaagg tgcagtaatt
     1741 ctggacgtca cctgcttcgc ggaggctgag cggctataca tgctggccag ggacacagca
     1801 gtgcatggcc ggccactgac tgcattagtg cttccagatg tgctgcacac gaagctgcct
     1861 cctgactgct gccctctcct cgtgtttgtg aaccccaaga gtgggggtct caagggacga
     1921 gaactgctct gcagtttccg gaagctgctg aatccgcacc aggtctttga gctaaccaac
     1981 gggggccctc ttcctgggtt ccaccttttc tcccaggtgc ccagttttcg ggtactggtg
     2041 tgtggtggag atggcaccgt tggctgggtg ctcgctgccc tggaggagac aaggcgccat
     2101 ctggcctgtc cagagccatc tgtggccatc ttgcccctgg gtacagggaa tgaccttggc
     2161 cgggtccttc gttggggggc aggctatagt ggtgaggacc cattttctgt gctggtgtcg
     2221 gtggatgagg ctgatgctgt gctcatggat cgatggacaa tcctgctgga tgctcatgaa
     2281 attgatagta cagagaacaa tgtggtagaa acagagcccc ccaagattgt tcagatgaat
     2341 aactactgtg gcattggtat tgatgcggag ctcagcctgg acttccacca ggcacgtgaa
     2401 gaggagcctg gcaaattcac aagcaggttc cacaacaagg gcgtgtatgt gcgggtcggg
     2461 ctgcagaaga tcagccactc tcgaagccta cacaaggaga tccggctgca ggtggagcag
     2521 caggaggtgg agctacccag cattgagggt ctcatcttca ttaacatccc cagctggggc
     2581 tcaggggccg acttgtgggg ctctgacaac gactcaaggt ttgagaagcc acgcatagac
     2641 gacgggctgt tggaggtggt gggtgtgaca ggtgtcgtgc acatgggcca ggtacaaggt
     2701 gggctacgct ctggaatccg cattgcccag ggctcctact tccgtgtcac actcctcaag
     2761 gctactccag tgcaggtgga tggtgagccc tgggttcagg ccccaggtca catgatcatc
     2821 tctgctactg cacctaaggt tcacatgctg agaaaggcta agcagaagcc caggaaggct
     2881 ggcgccaaca gggatacccg agtggacacc ttgcctgctc ctgagggcaa tcctttatag
     2941 aggagccaag atgagaggtc tcaaccaccc agcctttctt tggttggtca cacactggct
     3001 ggccagcaga tggacttagc tgtagcactg accatagcat cttcatgggt cttgggatgt
     3061 ttccatccca atgtcatgtg caaacttagg agtgggtagg taatggtcat tactcacgct
     3121 gccatacata gtaccaatgt atatgactgg gcatgaggct ctggctagct tgtcttctgc
     3181 acaagactag ttcttacagg aaaaacggag ctggtcctgt tagccacatt ccttcctttg
     3241 aaacctctct tgaaaccctc ttagacccaa tacgtctgga tgcaggccat ccaggtgggt
     3301 cctctgattt catttgttct ttcaaagcag ctaaccatgt tgggccctgg cctaacagat
     3361 ccagaaagct gcctgttctc ctgtactgac tgggtgggtg tggcattctc aagtcccctg
     3421 gacttatcac tagatgtcag tttgggctta acatactagt tacaaggtct catccagctg
     3481 gtgcccatgg actgacaaag ttgtacttag ggatgggaat ctttgtctac ccttaggcta
     3541 agtgagttta gttatcactc acatgtcata gctggaatgt gtgctaggcc cttagtgtcc
     3601 ctcttcaact ccagagtggg cacctagtgc ccagaagggt tcagaacagg gccaggtagt
     3661 acctggttga ggagtgtgta aataacatct gttgtggagt ggcttgaact cccttagact
     3721 caacttatag cactttatat acatggtgtt tgcctgccta cagcccttcc ttgtagctgt
     3781 agagcttcta ctctggcacc tacacaaatg gaagcagctc tgatggccag gtcttgctgg
     3841 aggcaccagg ttcacagaac gagagaaaag cggtctcttc catgcaccca agaattcatt
     3901 gtcacactta agaccctaga aagaatttgt ccaaaaatga gctgcctagc taagcctggt
     3961 acatgcctat aattcatttc tccaggctaa agcataactg ggttatagcg ctaaagcccc
     4021 tctcaaaaag tgaaaacatt aaaaaaaaat gctaaagaca tctaaaggtc tagccccagg
     4081 cctggctcgg ggaagactat gtgggaagtc tcctgtgatg agtacccccc acccccaaaa
     4141 gccagtcagt gcagagcctt ctcctgtgtg tcattacttg gcttgtggac accttcagaa
     4201 gtgtgatacc agggtagtgt gtggaccagg gtgtctccct gcctgacagc ttcatgggac
     4261 cattgtgcca ccccccccta ccccaccccc tgcttctgcc aaaactgcat acaagtgcat
     4321 cagatagcca tgtgtgagct cagtgccgat gatcatgttt acatcatttt caatgttcaa
     4381 aagaaattct ttgtgatgta atttttcatt tttatttcaa tctgtaggaa ttgtttgtaa
     4441 attacggtca gtgtagcatg tcctctgtat ttaagtgaga ctgtctttat gtggagtgtg
     4501 tcctgtgcac tgactggtcc tgtctttgtg tgtaatttat cactacctga atgtgatcta
     4561 agttatatct gggccaaata cacagtgtgg gttttgctgt cccataaaaa aaaaaaaaaa
     4621 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
