LOCUS       NM_033324               4226 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus DGCR8, microprocessor complex subunit (Dgcr8), mRNA.
ACCESSION   NM_033324
VERSION     NM_033324.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4226)
  AUTHORS   Eom,T.Y., Schmitt,J.E., Li,Y., Davenport,C.M., Steinberg,J.,
            Bonnan,A., Alam,S., Ryu,Y.S., Paul,L., Hansen,B.S., Khairy,K.,
            Pelletier,S., Pruett-Miller,S.M., Roalf,D.R., Gur,R.E.,
            Emanuel,B.S., McDonald-McGinn,D.M., Smith,J.N., Li,C.,
            Christie,J.M., Northcott,P.A. and Zakharenko,S.S.
  TITLE     Tbx1 haploinsufficiency leads to local skull deformity,
            paraflocculus and flocculus dysplasia, and motor-learning deficit
            in 22q11.2 deletion syndrome
  JOURNAL   Nat Commun 15 (1), 10510 (2024)
   PUBMED   39638997
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4226)
  AUTHORS   Trigg,N.A. and Conine,C.C.
  TITLE     Epididymal acquired sperm microRNAs modify post-fertilization
            embryonic gene expression
  JOURNAL   Cell Rep 43 (9), 114698 (2024)
   PUBMED   39226174
REFERENCE   3  (bases 1 to 4226)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
  REMARK    GeneRIF: Dgcr8 functions in the secondary heart field for outflow
            tract and right ventricle development in mammals.
REFERENCE   4  (bases 1 to 4226)
  AUTHORS   Tao,S., Xie,S.J., Diao,L.T., Lv,G., Hou,Y.R., Hu,Y.X., Xu,W.Y.,
            Du,B. and Xiao,Z.D.
  TITLE     RNA-binding protein CCDC137 activates AKT signaling and promotes
            hepatocellular carcinoma through a novel non-canonical role of
            DGCR8 in mRNA localization
  JOURNAL   J Exp Clin Cancer Res 42 (1), 194 (2023)
   PUBMED   37542342
  REMARK    GeneRIF: RNA-binding protein CCDC137 activates AKT signaling and
            promotes hepatocellular carcinoma through a novel non-canonical
            role of DGCR8 in mRNA localization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4226)
  AUTHORS   Ralston,B.A., Khan,L., DeVore,S.B., Bronnenberg,T.A., Flock,J.W.,
            Sequoia,A.O., Thompson,P.R., Navratil,A.M. and Cherrington,B.D.
  TITLE     Peptidylarginine deiminase 2 regulates expression of DGCR8
            affecting miRNA biogenesis in gonadotrope cells
  JOURNAL   Reproduction 166 (2), 125-134 (2023)
   PUBMED   37310889
  REMARK    GeneRIF: Peptidylarginine deiminase 2 regulates expression of DGCR8
            affecting miRNA biogenesis in gonadotrope cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4226)
  AUTHORS   Lund,J., Chen,F., Hua,A., Roe,B., Budarf,M., Emanuel,B.S. and
            Reeves,R.H.
  TITLE     Comparative sequence analysis of 634 kb of the mouse chromosome 16
            region of conserved synteny with the human velocardiofacial
            syndrome region on chromosome 22q11.2
  JOURNAL   Genomics 63 (3), 374-383 (2000)
   PUBMED   10704284
REFERENCE   7  (bases 1 to 4226)
  AUTHORS   Lund,J., Roe,B., Chen,F., Budarf,M., Galili,N., Riblet,R.,
            Miller,R.D., Emanuel,B.S. and Reeves,R.H.
  TITLE     Sequence-ready physical map of the mouse chromosome 16 region with
            conserved synteny to the human velocardiofacial syndrome region on
            22q11.2
  JOURNAL   Mamm Genome 10 (5), 438-443 (1999)
   PUBMED   10337614
REFERENCE   8  (bases 1 to 4226)
  AUTHORS   Puech,A., Saint-Jore,B., Funke,B., Gilbert,D.J., Sirotkin,H.,
            Copeland,N.G., Jenkins,N.A., Kucherlapati,R., Morrow,B. and
            Skoultchi,A.I.
  TITLE     Comparative mapping of the human 22q11 chromosomal region and the
            orthologous region in mice reveals complex changes in gene
            organization
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14608-14613 (1997)
   PUBMED   9405660
REFERENCE   9  (bases 1 to 4226)
  AUTHORS   Reeves,R.H., Rue,E.E., Citron,M.P. and Cabin,D.E.
  TITLE     High-resolution recombinational map of mouse chromosome 16
  JOURNAL   Genomics 43 (2), 202-208 (1997)
   PUBMED   9244437
REFERENCE   10 (bases 1 to 4226)
  AUTHORS   Galili,N., Baldwin,H.S., Lund,J., Reeves,R., Gong,W., Wang,Z.,
            Roe,B.A., Emanuel,B.S., Nayak,S., Mickanin,C., Budarf,M.L. and
            Buck,C.A.
  TITLE     A region of mouse chromosome 16 is syntenic to the DiGeorge,
            velocardiofacial syndrome minimal critical region
  JOURNAL   Genome Res 7 (1), 17-26 (1997)
   PUBMED   9037598
  REMARK    Erratum:[Genome Res. 1997 Apr;7(4):399. PMID: 9110179]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB086857.1.
            
            On Jan 23, 2004 this sequence version replaced NM_033324.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB086857.1, BC062919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4226
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.31 cM"
     gene            1..4226
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /note="DGCR8, microprocessor complex subunit"
                     /db_xref="GeneID:94223"
                     /db_xref="MGI:MGI:2151114"
     exon            1..66
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     exon            67..1066
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..2668
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /note="diGeorge syndrome critical region 8 homolog;
                     DiGeorge syndrome critical region gene 8"
                     /codon_start=1
                     /product="microprocessor complex subunit DGCR8"
                     /protein_id="NP_201581.2"
                     /db_xref="CCDS:CCDS28018.1"
                     /db_xref="GeneID:94223"
                     /db_xref="MGI:MGI:2151114"
                     /translation="METYESPSPLPREPAGEAMMENRACPFQVLPHEQSPPPPLQTSS
                     DAEVMDVGSGGDGQSEPPADDPFNFYGASLLSKGSFSKGRLLIDPNCSGHSPRTARHA
                     PAVRKFSPDLKLLKDVKISVSFTESCRSKDRKVLYTGVERSTRPECGQLLSPVSGDVH
                     ACPFGGSVGNGVGLGGESADKKDEENELDQEKRVEYAVLDELEDFTDNLELDEEGTGG
                     FTAKAIVQRDRVDEEALNFSYEDDFDNDVDALLEEGLCAPKKRRMEEKYGGDSDHPSD
                     GETSVQPMMTKIKTVLKSRGRPPTEPLPDGWIMTFHNSGVPVYLHRESRVVTWSRPYF
                     LGTGSIRKHDPPLSSIPCLHYKKMKDNEEREQNCDLAPSGEVSPVKPLGRSAELDFPL
                     EEPDSMGGDSGSMDEKDPLGAEAAAGALGQVKAKVEVCKDESVDLEEFRNYLEKRFDF
                     EQVTVKKFRTWAERRQFNREMKRKQAESERPILPANQKLITLSVQDAPTKKEFVINPN
                     GKSEVCILHEYMQRVLKVRPVYNFFECENPSEPFGASVTIDGVTYGSGTASSKKLAKN
                     KAARATLEILIPDFVKQTSEEKPKDSEELEYFNHISIEDSRVYELTSKAGLLSPYQIL
                     HECLKRNHGMGDTSIKFEVVPGKNQKSEYVMACGKHTVRGWCKNKRVGKQLASQKILQ
                     LLHPHVKNWGSLLRMYGRESSKMVKQETSDKSVIELQQYAKKNRPNLHILSKLQEEMK
                     RLAAEREETRKKPKMSIVASAQPGGEPLCTVDV"
     exon            1067..1226
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1369
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1652
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1850
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1952
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2051
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2134
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2235
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2342
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2470
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2584
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..4226
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3233..3238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
                     /note="hexamer: AACAAA"
     polyA_site      3254
                     /gene="Dgcr8"
                     /gene_synonym="D16H22S1742E; D16H22S788E; D16Wis2; Gy1;
                     mir-1306; N41; Vo59c07"
ORIGIN      
        1 ggtcggtgag ggtcgaccgg ctgtggtcgg gctgcgggcg gctcgggcag gtcgcgggcg
       61 ccacaggtgg aagaagaaag gtgccacttt ggcatgaaga tagactcact tagacgtcaa
      121 tcttttaagc tgagtgcatt gtgatttcca ataattgagg cagtggttct aaaagctgtc
      181 tacattaatg aaaagagcaa tgtggccagc ttgactaagc cgccagtgtg tacagcgcgg
      241 gcaggacgac accgggtctc gacggacttg tgcatgttag cagtatagat ttatgtaagg
      301 tggtttaaaa ctctggtctt ttaaagtagt cttaactgct cataatatgg agacatatga
      361 gagtccctct cctctcccgc gtgagcccgc aggagaagcg atgatggaga accgagcttg
      421 ccccttccaa gtgctgcccc atgaacagtc tccaccacct cccctgcaaa cgtccagtga
      481 tgcagaggta atggacgttg gctctggtgg tgatggacag tccgaacctc ctgccgacga
      541 cccattcaac ttctacggag cttctcttct ctccaaagga tccttctcta agggccgcct
      601 cctcatagac ccgaactgta gtggccacag cccgcgcact gcccggcacg cacctgcggt
      661 ccggaagttc tcccctgacc ttaagttgct taaggatgta aagattagcg tgagctttac
      721 tgagagctgc aggagtaagg acaggaaggt gctgtacaca ggagtagaac gcagcactcg
      781 gcctgagtgt ggccagctcc ttagtcctgt cagtggggac gtgcatgctt gtccctttgg
      841 cgggagtgtt ggtaatgggg taggcctagg gggtgagagt gcagataaga aggatgagga
      901 aaatgagctg gatcaggaaa agagagtgga gtatgcagtg ctcgatgagt tagaagattt
      961 tactgacaat ttggagctag atgaagaagg aacaggcggg ttcacggcta aagcaatcgt
     1021 tcaaagagac agagtggatg aagaggcctt gaatttctcc tatgaggatg actttgacaa
     1081 tgatgtggac gctttactag aagaaggtct ctgtgctccc aagaagaggc gaatggagga
     1141 aaaatatggc ggagacagtg atcatccatc tgatggagag acaagtgtac agccaatgat
     1201 gaccaagatt aaaacagtgc tcaaaagtcg tggccgtcca cctacagagc cattgcctga
     1261 tggatggatc atgacttttc ataattctgg agtccctgta tacctgcaca gagagtctcg
     1321 agtggtcact tggtccagac cctacttctt gggaacagga agcatacgga aacatgatcc
     1381 tcctctaagc agtatcccct gcctacatta taagaaaatg aaggacaatg aggaacgaga
     1441 acaaaactgt gatcttgccc ccagtggaga ggtgtcacct gtcaagccct tgggtcggtc
     1501 tgcagagttg gatttccctc tggaagagcc tgactccatg ggtggagact cagggtccat
     1561 ggatgagaag gacccattgg gggctgaggc agccgctgga gccctgggac aagtgaaggc
     1621 taaagttgag gtgtgcaaag atgaatcagt tgatctggag gaatttcgta attaccttga
     1681 gaagcgtttt gactttgaac aagtaactgt gaaaaaattc aggacttggg ctgagcggcg
     1741 tcagttcaac cgtgagatga agcggaagca ggccgagtca gagaggccca tcctgccagc
     1801 caaccagaag ctgatcactc tatctgtaca agatgcaccc acaaagaaag agtttgtcat
     1861 caatcccaat gggaagtctg aggtttgcat cctgcacgaa tacatgcagc gtgtcctcaa
     1921 ggtccgccct gtttataatt tctttgaatg tgagaatcca agtgagcctt ttggtgcctc
     1981 cgtgaccatt gatggtgtga cttacggatc tggaactgca agcagcaaaa aacttgcgaa
     2041 gaataaagct gcccgagcca ccctggaaat tctcatccct gactttgtta aacagacctc
     2101 tgaggagaag cctaaagaca gtgaagaact ggagtatttt aaccacatca gtattgagga
     2161 ttcacgagtc tatgagctga caagcaaggc tgggctgttg tctccatatc agatcctcca
     2221 tgagtgcctt aaaagaaacc atggaatggg tgacacatcc atcaagtttg aagtggttcc
     2281 tgggaaaaac cagaagagtg aatatgttat ggcatgcggc aaacacacag tgcgcgggtg
     2341 gtgtaagaat aaacgagttg ggaaacaatt agcatctcag aaaatccttc agctactgca
     2401 cccacatgtc aagaactggg gttccttact acgcatgtat ggtcgtgaga gcagcaaaat
     2461 ggtcaagcag gagacctctg acaagagtgt gatagagcta cagcagtatg ccaagaagaa
     2521 caggcccaac cttcacatcc tgagcaagct acaagaagag atgaagaggc tggctgcaga
     2581 gcgggaggag actcggaaga aacccaagat gtcaattgta gcatctgccc agcctggtgg
     2641 tgagcccttg tgcacagtcg atgtatgagg taggcagcat gggccaacag tgctacccag
     2701 gagagaccat cagccacaca tcatcactct gcagctccag gcctccaacc taagttcctt
     2761 ccctgtggca gggtctgggc tctggctctg gcacatgggg acagctgtga ctacacagta
     2821 cacatgcaaa gaagcagttc tggacaagct gctctcaatg tgactggata tacttaagga
     2881 tcagtcataa gttaactgca caagtggaag ctgatagaca gctgtagatc ctgcttgtat
     2941 gtatctgctg cggaccgttt ttatgaaggt tttcattaat tttagtacac tatatgcact
     3001 gacaagaagt aatacttcgt tgatagatga gatgaccagg ttttatagct ttggctggcc
     3061 tatgatgcca ggtagcccct ttgctatggt tctttctggt ggagccactg agacttggtc
     3121 agaagatgca ggtatcctgt cctgtagaat tacctgcttt gtgtgttttg cattttcttc
     3181 tgaaaaagtt ataacagaaa ggaatatttc aggctatttt ggcttaaaat aaaacaaaat
     3241 tttagcacca gaaatactct tccgagattg cagtgaagat actgagtgtt agtccgattg
     3301 atcctttttc ttatgaagtc ttaatgtcct aacagccgtc ttctggatac tgaagcttcc
     3361 accttcgata aacttagcaa caatttttta cagagatttt tgcacaacca agcccatctg
     3421 ttcatcaatt tttaaagctt ttatgatgtt ttaaaatttg gaaagaaact tttacagtaa
     3481 gaatgaaaga tgcatttcaa cagatgaata tgcataaata gggaactggc cttcaatgta
     3541 gcccatcact gaccaagagc tgcctggcac attgtacacg ataagtagtt atggtgtttt
     3601 ttgatctcaa ggatagctgc tctgtgcagc caggcctgat tgcaggtttt tgtctaccta
     3661 tgctcattgg atagcccctg taaatgggta ttgagtagag gggtattcag agccctatta
     3721 cctgttcaga ggggctacac tctacatcct cagtgtctct aaccatgtac ctgaagatac
     3781 atgggtgaca tgtgctgtta gaaagataag atggcaactg tgggcctccc aacagcatct
     3841 tcctcctcct taatcatgtg tgtgacagca gttaatgttt atgttaatct tggcaaaaag
     3901 aacccttaat tcaagttggt agacttggac acttgattct tttctgcctc ccattcagtt
     3961 gtgttcagtc ttttgactaa ccattgccct taaaacatac ttaacattga aaaagcatat
     4021 ggtaatggtg gtatctctgc agcctcaccg acccaggcac tgtcaacagg tgctgccaca
     4081 cattcctggt ctccagtgcc ctccctgtct cttacaggtg ggtcttatat gtacagtcat
     4141 gctgcaaggg tggggagcct gtgctgatgt gcttctgtgt gttggccaag gctgtagggt
     4201 gtaccctgat ggtctgaaca cataaa
//
