LOCUS       NM_010048               4099 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus DiGeorge syndrome critical region gene 2 (Dgcr2),
            transcript variant 1, mRNA.
ACCESSION   NM_010048
VERSION     NM_010048.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4099)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4099)
  AUTHORS   Ren,D., Luo,B., Chen,P., Yu,L., Xiong,M., Fu,Z., Zhou,T., Chen,W.B.
            and Fei,E.
  TITLE     DiGeorge syndrome critical region gene 2 (DGCR2), a schizophrenia
            risk gene, regulates dendritic spine development through cell
            adhesion
  JOURNAL   Cell Biosci 13 (1), 134 (2023)
   PUBMED   37480133
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4099)
  AUTHORS   Molinard-Chenu,A., Godel,M., Rey,A., Musardo,S., Bodogan,T.,
            Vutskits,L., Bellone,C. and Dayer,A.
  TITLE     Downregulation of the schizophrenia risk-gene Dgcr2 alters early
            microcircuit development in the mouse medial prefrontal cortex
  JOURNAL   Int J Dev Neurosci 82 (3), 277-285 (2022)
   PUBMED   35212007
  REMARK    GeneRIF: Downregulation of the schizophrenia risk-gene Dgcr2 alters
            early microcircuit development in the mouse medial prefrontal
            cortex.
REFERENCE   4  (bases 1 to 4099)
  AUTHORS   Molinard-Chenu,A. and Dayer,A.
  TITLE     The Candidate Schizophrenia Risk Gene DGCR2 Regulates Early Steps
            of Corticogenesis
  JOURNAL   Biol Psychiatry 83 (8), 692-706 (2018)
   PUBMED   29305086
  REMARK    GeneRIF: SZ-risk gene DGCR2 regulates critical steps of early
            corticogenesis possibly through a Reelin-dependent mechanism.
REFERENCE   5  (bases 1 to 4099)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 4099)
  AUTHORS   Sirotkin,H., Morrow,B., Saint-Jore,B., Puech,A., Das Gupta,R.,
            Patanjali,S.R., Skoultchi,A., Weissman,S.M. and Kucherlapati,R.
  TITLE     Identification, characterization, and precise mapping of a human
            gene encoding a novel membrane-spanning protein from the 22q11
            region deleted in velo-cardio-facial syndrome
  JOURNAL   Genomics 42 (2), 245-251 (1997)
   PUBMED   9192844
REFERENCE   7  (bases 1 to 4099)
  AUTHORS   Taylor,C., Wadey,R., O'Donnell,H., Roberts,C., Mattei,M.G.,
            Kimber,W.L., Wynshaw-Boris,A. and Scambler,P.J.
  TITLE     Cloning and mapping of murine Dgcr2 and its homology to the Sez-12
            seizure-related protein
  JOURNAL   Mamm Genome 8 (5), 371-375 (1997)
   PUBMED   9107688
REFERENCE   8  (bases 1 to 4099)
  AUTHORS   Galili,N., Baldwin,H.S., Lund,J., Reeves,R., Gong,W., Wang,Z.,
            Roe,B.A., Emanuel,B.S., Nayak,S., Mickanin,C., Budarf,M.L. and
            Buck,C.A.
  TITLE     A region of mouse chromosome 16 is syntenic to the DiGeorge,
            velocardiofacial syndrome minimal critical region
  JOURNAL   Genome Res 7 (1), 17-26 (1997)
   PUBMED   9037598
  REMARK    Erratum:[Genome Res. 1997 Apr;7(4):399.. PMID: 9110179]
REFERENCE   9  (bases 1 to 4099)
  AUTHORS   Kajiwara,K., Nagasawa,H., Shimizu-Nishikawa,K., Ookura,T.,
            Kimura,M. and Sugaya,E.
  TITLE     Cloning of SEZ-12 encoding seizure-related and membrane-bound
            adhesion protein
  JOURNAL   Biochem Biophys Res Commun 222 (1), 144-148 (1996)
   PUBMED   8630060
REFERENCE   10 (bases 1 to 4099)
  AUTHORS   Kajiwara,K., Nagawawa,H., Shimizu-Nishikawa,S., Ookuri,T.,
            Kimura,M. and Sugaya,E.
  TITLE     Molecular characterization of seizure-related genes isolated by
            differential screening
  JOURNAL   Biochem Biophys Res Commun 219 (3), 795-799 (1996)
   PUBMED   8645260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY123353.1 and BC060636.1.
            
            On Oct 5, 2007 this sequence version replaced NM_010048.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060636.1, SRR1660813.195741.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BY123353.1         2-60
            60-4099             BC060636.1         1-4040
FEATURES             Location/Qualifiers
     source          1..4099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.05 cM"
     gene            1..4099
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /note="DiGeorge syndrome critical region gene 2"
                     /db_xref="GeneID:13356"
                     /db_xref="MGI:MGI:892866"
     exon            1..343
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1914
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; DiGeorge syndrome protein C; integral membrane
                     protein DGCR2/IDD; seizure-related membrane-bound adhesion
                     protein; DiGeorge syndrome gene c"
                     /codon_start=1
                     /product="integral membrane protein DGCR2/IDD isoform 1
                     precursor"
                     /protein_id="NP_034178.2"
                     /db_xref="CCDS:CCDS37276.1"
                     /db_xref="GeneID:13356"
                     /db_xref="MGI:MGI:892866"
                     /translation="MVPKADSGAFLLLFLLVLTVTEPLRPELRCNPGQFACHGGTIQC
                     IPLPWQCDGWPTCEDKSDEADCPEVTGEARPYGKETVDLRQGRARGGDPTHFHTVNVA
                     QPVRFSSFLGKCPSGWHHYEGTASCYRVYLSGENYWDAAQTCQRVNGSLATFSTDQEL
                     RFVLAQEWDQPERSFGWKDQRKLWVGYQYVITGRNHSLEGRWEVAFKGSPEVFLPPDP
                     IFASAMSENDNVFCAQLQCFHFPTLRHHDLHSWHAESCSEKSSFLCKRSQTCVDIKDN
                     VVDEGFYFTPKGDDPCLSCTCHRGEPEMCVAALCERPQGCQQYRKDPKECCKFMCLDP
                     DGSSLFDSMASGMRLVVSCISSFLILSLLLFMVHRLRQRRRERIESLIGANLHHFNLG
                     RRIPGFDYGPDGFGTGLTPLHLSDDGEGGTFHFHDPPPPYTAYKYPDMDQPDDPPPPY
                     EASINPDSVFYDPADDDAFEPVEASLPAPRDGGIEGALPRHLDQPLPPAETSLADLED
                     STDSSSALLVPPDPAQSGSTPATEAPPGGGRLPRASLNTVV"
     exon            344..466
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /inference="alignment:Splign:2.1.0"
     exon            467..589
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /inference="alignment:Splign:2.1.0"
     exon            590..809
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /inference="alignment:Splign:2.1.0"
     exon            810..886
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1063
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1267
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1420
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1657
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..4080
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4058..4063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /note="hexamer: AATAAA"
     polyA_site      4080
                     /gene="Dgcr2"
                     /gene_synonym="9930034O06Rik; DGS-C; Dgsc; Idd; Lan;
                     mKIAA0163; Sez12"
                     /note="major polyA site"
ORIGIN      
        1 tcattggtta gtgcgggccg gaggcggggt ggcgcgggcc ggagcaggac ggccgccatc
       61 ttgcgcgagc cggaatctca tcccgctcct gcggcctaga gtgcgcgcga gtcggtggcg
      121 ttctcttgcc gcggcccagc tggatccctc gcctgccgcc cctcagcccc aggtcggagt
      181 ccggccttca cccactcctc tcggccaggt ccggcctccc cgcggggtca cgcggctgcc
      241 ccggggacga tgaacggagg ataaatggtg cccaaggcag acagcggtgc cttcctgctg
      301 ctcttcctgc tggttctcac tgtcaccgag ccgctgcggc cagagcttcg gtgcaaccct
      361 gggcagtttg catgtcacgg tggtaccatc cagtgcatac ccctcccctg gcagtgtgat
      421 ggctggccaa cgtgtgagga taagagtgat gaagccgact gtccagaagt gactggagag
      481 gcccgtcctt atgggaagga aactgtggat ctgcggcagg ggcgagccag aggaggtgac
      541 cccacacact tccacacagt gaacgtggct cagcctgtac gcttcagcag cttcctaggg
      601 aaatgcccaa gtgggtggca ccactatgaa ggcacagcca gctgctaccg ggtctacctc
      661 agtggagaga actactggga tgctgcacag acctgtcagc gtgtgaatgg ctcacttgct
      721 accttctcca ctgaccagga gctgcgcttc gtcctagccc aggaatggga ccagccagag
      781 cggagcttcg gctggaaaga ccagcgcaag ctctgggttg gttatcagta tgtcattact
      841 ggccggaacc attccttaga aggtcgctgg gaagtggcat tcaaaggctc cccagaagtg
      901 ttcctgcccc cagatcccat cttcgcctct gccatgtctg agaatgacaa cgtgttctgc
      961 gcccagctcc agtgtttcca ctttcctacc ctgaggcacc atgacctcca cagctggcac
     1021 gccgagagct gctctgagaa gtcttcgttt ctgtgtaaaa gaagtcagac gtgtgttgat
     1081 atcaaagata atgtggtgga tgaagggttc tacttcactc ccaagggaga tgacccatgc
     1141 ttgagctgta cctgccatcg aggggagcct gagatgtgtg ttgctgccct gtgtgagcgg
     1201 ccccaggggt gtcagcagta ccgcaaggac cctaaggaat gctgcaaatt catgtgtctg
     1261 gacccagatg gcagcagcct gtttgactcc atggctagtg ggatgcgcct ggtcgtcagc
     1321 tgtatctcct ccttcctcat cctctcgctg ctgcttttca tggtccaccg gctacgccag
     1381 cggcgccggg agcgcatcga gtccctgatt ggagcaaact tgcaccattt caaccttggc
     1441 cggaggatcc ctggctttga ctatggtcca gatgggtttg gcacaggcct cacgccacta
     1501 catctttctg acgacgggga aggtgggact ttccatttcc acgaccctcc acctccttat
     1561 acagcttaca agtacccaga catggaccag ccggatgatc caccaccacc ctatgaggcg
     1621 tctatcaacc cagacagtgt gttctacgac cctgcagatg acgatgcctt tgagcctgtg
     1681 gaggccagcc tgccagcccc aagagatggt ggcattgaag gtgcattgcc caggcacttg
     1741 gatcagccgc tgccccctgc agagacatcc ttagcagatc tggaagactc tacagacagt
     1801 agcagtgccc tgctggtgcc tcctgatccc gcccagagtg gaagcacccc agctacagaa
     1861 gcaccgccag ggggtgggcg cctcccccgt gcttccctca acactgtggt ttaggtggct
     1921 cagcttgtgg ccccccgtgg gctaggagtg tatgtttctt gtccagaaga cacctatctc
     1981 agtgggggac ttgaaggggt cctgtcatag cctggaccct actccactgc cacatcccca
     2041 ccagctgcgg gtgtgtacat agaaactgaa atcaggcact cagagaggag caagtgcctg
     2101 taccatcttt acctgggggc tgttagtctc ttctttaaat ggtggaatga cacaggtgtt
     2161 gaaagcacac gtttccaaga agcagaggca gtgggcttca cttataccaa gtacatcttt
     2221 ggatgggctt gcttactgca ttctcaccct taggagccag tcatcagcca gtgtagacac
     2281 agtagagcta gcgctagtgg ctgcttagag gcagcagagc atctgaactg cttctgggga
     2341 aagcattcac agctgctgta ctggctctct gggggcttcc tgtccggggc cagctgcaaa
     2401 tttcaaggtg ccgatcgatc cctgggagga aattgaactt gccacaccat ttctagcttt
     2461 gctttgaggc cagcactgtg gcaggaggcc ctgctcattc ctagcactct tccatggtat
     2521 acctctgcat ggctccccag gagtagactc tagacccttg tggagggttg gggcatgctg
     2581 gcttttctct gccacactct ggatccctgt gctctgcttg ctggtgaatg accactgggt
     2641 ctagccatgc ccgttcatcc tatctgtgcc ataaagggtt gtttgggaag agaatggttc
     2701 aagtggacat cctgagttgt catctgagtc cacttcaccc cgtgaacact gctggagccc
     2761 agtgtctgcc agccacatac atgcctccca gtccctccac agcaaccggg tacctgggga
     2821 tttttcccaa aggactccat tgccagctcc agctccatgc agtggtcttg tctcctgaca
     2881 caggccttta gcatttctaa ggtttggaga ttaagcaagg ttctgtgcaa tttttagcac
     2941 attcgtgtct tttttatgtt ggatgtctgg gtctttatat ctgtgtgtgt gtcctaatgt
     3001 ggccaaatgt ttgcaggtga taatggttca caggagctca ggacagggga caatacccca
     3061 catgagccat ttgcccatgg gccactcttg cacctttgag cttcttctag gctgtggtca
     3121 gtgggcctgt gactcctgtg caggtgagaa caggagtgga ggtgactggt gtctgttctg
     3181 ttgtgcatga tcagacccac acagctctag gtgcagcctt acactacttg gaacctatgt
     3241 ttccccttcc catacggagc atcttcagac caggtcccca gggctgacag gagtatatga
     3301 ttgcttacgg atagtctgcc ccatgtctga gcccacagac catctgctgc agacatccct
     3361 ctgcagaggg cccttgcccc ctctacccat tgctaaggac atcaggaagt tcgtcatgcc
     3421 tccagcaagt cctaagtgct gggcgctggg cagccatgct ccagagcaac aattgggaat
     3481 tgtgttggtg ccaggccacc caaaagagcc ctaaggacca cacagcagtg cctcaggaga
     3541 ctgcacagac tggaacttac gtggggacca aatggctgtt ggggttgaga ttaggaggcc
     3601 cagtggagag ggtgacctaa agtggactgg tgctacagag gtaggcttgt caggcctgtg
     3661 gggtccgtcc cccatgcctt aggggtgcat ggaaggcctc tgttgggggc tgtttagact
     3721 attgctattc cagttccaag cactggagtc tgccagatct cactggtgaa taatcccaaa
     3781 tccaagattt gatgaggttt gtgtgttctt tacccatccc gcaaggcccc agagggacag
     3841 gctcctagga ggcccctttc ccaggactgc cttgccactc ttctgaggcc aggtgccctc
     3901 tgacctgcct tgaagtggaa tttgatactg tacattgtct caatgcctgt ttttacatat
     3961 tcctttcatt aaaggtttta gtttgggtgt atttttttgg tcaggttggc attgatcctt
     4021 tcttaagatg ctgtgagaac catttcatcc aatgccaaat aaacttgtgt tatggaaaaa
     4081 aaaaaaaaaa aaaaaaaaa
//
