LOCUS       NM_026384               2251 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus diacylglycerol O-acyltransferase 2 (Dgat2), mRNA.
ACCESSION   NM_026384
VERSION     NM_026384.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2251)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   2  (bases 1 to 2251)
  AUTHORS   Rong,S., Xia,M., Vale,G., Wang,S., Kim,C.W., Li,S., McDonald,J.G.,
            Radhakrishnan,A. and Horton,J.D.
  TITLE     DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic
            steatosis by increasing phosphatidylethanolamine in the ER
  JOURNAL   Cell Metab 36 (3), 617-629 (2024)
   PUBMED   38340721
  REMARK    GeneRIF: DGAT2 inhibition blocks SREBP-1 cleavage and improves
            hepatic steatosis by increasing phosphatidylethanolamine in the ER.
REFERENCE   3  (bases 1 to 2251)
  AUTHORS   Bu,S.Y.
  TITLE     Role of Dgat2 in Glucose Uptake and Fatty Acid Metabolism in C2C12
            Skeletal Myotubes
  JOURNAL   J Microbiol Biotechnol 33 (12), 1563-1575 (2023)
   PUBMED   37644753
  REMARK    GeneRIF: Role of Dgat2 in Glucose Uptake and Fatty Acid Metabolism
            in C2C12 Skeletal Myotubes.
REFERENCE   4  (bases 1 to 2251)
  AUTHORS   Chitraju,C., Fischer,A.W., Ambaw,Y.A., Wang,K., Yuan,B., Hui,S.,
            Walther,T.C. and Farese,R.V. Jr.
  TITLE     Mice lacking triglyceride synthesis enzymes in adipose tissue are
            resistant to diet-induced obesity
  JOURNAL   Elife 12, 88049 (2023)
   PUBMED   37782317
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2251)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w.. PMID: 37322272]
REFERENCE   6  (bases 1 to 2251)
  AUTHORS   Wakimoto,K., Chiba,H., Michibata,H., Seishima,M., Kawasaki,S.,
            Okubo,K., Mitsui,H., Torii,H. and Imai,Y.
  TITLE     A novel diacylglycerol acyltransferase (DGAT2) is decreased in
            human psoriatic skin and increased in diabetic mice
  JOURNAL   Biochem Biophys Res Commun 310 (2), 296-302 (2003)
   PUBMED   14521909
  REMARK    GeneRIF: DGAT2 expression is increased in diabetic mice.
REFERENCE   7  (bases 1 to 2251)
  AUTHORS   Meegalla,R.L., Billheimer,J.T. and Cheng,D.
  TITLE     Concerted elevation of acyl-coenzyme A:diacylglycerol
            acyltransferase (DGAT) activity through independent stimulation of
            mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin
  JOURNAL   Biochem Biophys Res Commun 298 (3), 317-323 (2002)
   PUBMED   12413942
  REMARK    GeneRIF: role in assembly of de novo synthesized fatty acids into
            VLDL particles in the liver
REFERENCE   8  (bases 1 to 2251)
  AUTHORS   Yen,C.L., Stone,S.J., Cases,S., Zhou,P. and Farese,R.V. Jr.
  TITLE     Identification of a gene encoding MGAT1, a monoacylglycerol
            acyltransferase
  JOURNAL   Proc Natl Acad Sci U S A 99 (13), 8512-8517 (2002)
   PUBMED   12077311
REFERENCE   9  (bases 1 to 2251)
  AUTHORS   Waterman,I.J. and Zammit,V.A.
  TITLE     Activities of overt and latent diacylglycerol acyltransferases
            (DGATs I and II) in liver microsomes of ob/ob mice
  JOURNAL   Int J Obes Relat Metab Disord 26 (5), 742-743 (2002)
   PUBMED   12032764
  REMARK    GeneRIF: the increased rate of hepatic TAG secretion and
            intracellular accumulation in ob/ob mice is accompanied by parallel
            increases in the activities of both DGAT I and DGAT II
REFERENCE   10 (bases 1 to 2251)
  AUTHORS   Cases,S., Stone,S.J., Zhou,P., Yen,E., Tow,B., Lardizabal,K.D.,
            Voelker,T. and Farese,R.V. Jr.
  TITLE     Cloning of DGAT2, a second mammalian diacylglycerol
            acyltransferase, and related family members
  JOURNAL   J Biol Chem 276 (42), 38870-38876 (2001)
   PUBMED   11481335
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC115850.11.
            
            On Nov 17, 2006 this sequence version replaced NM_026384.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043447.1, AK002443.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               AC115850.11        19892-20213
            323-451             AC115850.11        32779-32907
            452-559             AC115850.11        37416-37523
            560-630             AC115850.11        37900-37970
            631-835             AC115850.11        43568-43772
            836-1010            AC115850.11        44278-44452
            1011-1213           AC115850.11        45426-45628
            1214-2251           AC115850.11        47905-48942
FEATURES             Location/Qualifiers
     source          1..2251
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.01 cM"
     gene            1..2251
                     /gene="Dgat2"
                     /gene_synonym="0610010B06Rik; ARAT; DGAT-2"
                     /note="diacylglycerol O-acyltransferase 2"
                     /db_xref="GeneID:67800"
                     /db_xref="MGI:MGI:1915050"
     exon            1..322
                     /gene="Dgat2"
                     /gene_synonym="0610010B06Rik; ARAT; DGAT-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1368
                     /gene="Dgat2"
                     /gene_synonym="0610010B06Rik; ARAT; DGAT-2"
                     /EC_number="2.3.1.20"
                     /EC_number="2.3.1.76"
                     /note="diacylglycerol acyltransferase 2; diglyceride
                     acyltransferase 2; retinol O-fatty-acyltransferase;
                     acyl-CoA retinol O-fatty-acyltransferase"
                     /codon_start=1
                     /product="diacylglycerol O-acyltransferase 2"
                     /protein_id="NP_080660.1"
                     /db_xref="CCDS:CCDS21477.1"
                     /db_xref="GeneID:67800"
                     /db_xref="MGI:MGI:1915050"
                     /translation="MKTLIAAYSGVLRGERRAEAARSENKNKGSALSREGSGRWGTGS
                     SILSALQDIFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSVILMYTFCTDCWLI
                     AVLYFTWLAFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGY
                     HPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNR
                     DTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLKNRKGFVKLALRHGADLVPT
                     YSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPI
                     TTVVGEPITVPKLEHPTQKDIDLYHAMYMEALVKLFDNHKTKFGLPETEVLEVN"
     exon            323..451
                     /gene="Dgat2"
                     /gene_synonym="0610010B06Rik; ARAT; DGAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            452..559
                     /gene="Dgat2"
                     /gene_synonym="0610010B06Rik; ARAT; DGAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            560..630
                     /gene="Dgat2"
                     /gene_synonym="0610010B06Rik; ARAT; DGAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..835
                     /gene="Dgat2"
                     /gene_synonym="0610010B06Rik; ARAT; DGAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1010
                     /gene="Dgat2"
                     /gene_synonym="0610010B06Rik; ARAT; DGAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1213
                     /gene="Dgat2"
                     /gene_synonym="0610010B06Rik; ARAT; DGAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..2251
                     /gene="Dgat2"
                     /gene_synonym="0610010B06Rik; ARAT; DGAT-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgcttcg ctggctttct gctcatctag ggtggcagcg gctacctacc tcagctctcg
       61 ccctgctgcc gccacggcct gggcgctgtc cctcagctcc cggagctcag cgcgaagccc
      121 tggccccggc ggccggggca tgggtcaggg gcgcggcgtg aggcggcttt ctgcacggcc
      181 gtgacgtgca ttggcttcag catgaagacc ctcatcgccg cctactccgg ggtcctgcgg
      241 ggtgagcgtc gggcggaagc tgcccgcagc gaaaacaaga ataaaggatc tgccctgtca
      301 cgcgaggggt ctgggcgatg gggcactggc tccagcatcc tctcagccct ccaagacatc
      361 ttctctgtca cctggctcaa cagatctaag gtggaaaaac agctgcaggt catctcagta
      421 ctacaatggg tcctatcctt cctggtgcta ggagtggcct gcagtgtcat cctcatgtac
      481 accttctgca cagactgctg gctgatagct gtgctctact tcacctggct ggcatttgac
      541 tggaacacgc ccaagaaagg tggcaggaga tcgcagtggg tgcgaaactg ggccgtgtgg
      601 cgctacttcc gagactactt tcccatccag ctggtgaaga cacacaacct gctgaccacc
      661 aggaactata tctttggata ccacccccat ggcatcatgg gcctgggtgc cttctgtaac
      721 ttcagcacag aggctactga agtcagcaag aagtttcctg gcataaggcc ctatttggct
      781 acgttggctg gtaacttccg gatgcctgtg cttcgcgagt acctgatgtc tggaggcatc
      841 tgccctgtca accgagacac catagactac ttgctctcca agaatgggag tggcaatgct
      901 atcatcatcg tggtgggagg tgcagctgag tccctgagct ccatgcctgg caagaacgca
      961 gtcaccctga agaaccgcaa aggctttgtg aagctggccc tgcgccatgg agctgatctg
     1021 gttcccactt attcctttgg agagaatgag gtatacaagc aggtgatctt tgaggagggt
     1081 tcctggggcc gatgggtcca gaagaagttc cagaagtata ttggtttcgc cccctgcatc
     1141 ttccatggcc gaggcctctt ctcctctgac acctgggggc tggtgcccta ctccaagccc
     1201 atcaccaccg tcgtggggga gcccatcact gtccccaagc tggagcaccc gacccagaaa
     1261 gacatcgacc tgtaccatgc catgtacatg gaggccctgg tgaagctctt tgacaatcac
     1321 aagaccaaat ttggccttcc agagactgag gtgctggagg tgaactgacc cagccctcgc
     1381 gtgccagctc ctgggaggga cgactgcaga tccttttcta ccgagttctt gagtgcattt
     1441 tgttctgtaa atttggaagc gtcatgggtg tctgtgggtt atttaaaaga aattataatt
     1501 tgttaaacca ttgcaatgtt agatgttttt taagaaggga agagtcagta ttttaagctc
     1561 acttctagtg tgtcctgctc aaggtggagg ctgatattta tgggccttgg tggtttctta
     1621 cccacccctt ctagcgttcc ccagacgaca gacacttggc cctggctagc tgggcaaggg
     1681 cagtccttag tgactccagg gattcttgag aggcagaggc catgtcccac ccgtggctgc
     1741 aggtcgggtt cctcgtacca aggggaggct gagggcacag ctggccccac ttggggaggg
     1801 tagataacat ctggactgcc cggcttgggt ctctgctcct caccctagcc ctcttctcca
     1861 atctgagcct accctggcct cctgtctcct ggctagggac acggctgtcc cacaggtgcc
     1921 gtcttgggtt atctcgctgc tgttggctgg tttcactctg gaggttggca ccatggacac
     1981 agctcagcgt tgctctggcg catatcctcc tgagccacac cccaagtctg gtgtgaggaa
     2041 gggcttctct tctcttcaca gaggtgcctg gcttcctgtg cagcacactg ggtccaggac
     2101 aggaggcccc ccccccaaac caagcctcac gtgtgtgcct ttatgaggcg ttgggagaaa
     2161 gctaccctcc tgtgtattct gttttctcca tgagattgtt gtgccatgtc acacttttgt
     2221 atattcctag actaataaat ggaaacaaga a
//
