LOCUS       NM_029585               2241 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus DET1 partner of COP1 E3 ubiquitin ligase (Det1),
            transcript variant 1, mRNA.
ACCESSION   NM_029585 XM_910840
VERSION     NM_029585.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2241)
  AUTHORS   Rizzini,L., Levine,D.C., Perelis,M., Bass,J., Peek,C.B. and
            Pagano,M.
  TITLE     Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly
            Defines an Evolutionary Conserved Signaling Mechanism
  JOURNAL   Curr Biol 29 (12), 1954-1962 (2019)
   PUBMED   31155351
  REMARK    GeneRIF: Mechanistically, cryptochromes inactivate Cop1 by
            interacting with Det1, a subunit of the mammalian CRL4(Cop1)
            complex that is not present in other CRL4s. Through this
            interaction, the ability of Cop1 to join the CRL4 complex is
            inhibited; therefore, its substrates accumulate. Thus, the
            interaction between cryptochromes and Det1 in mammals mirrors the
            interaction between cryptochromes and Cop1 in planta.
REFERENCE   2  (bases 1 to 2241)
  AUTHORS   Newton,K., Dugger,D.L., Sengupta-Ghosh,A., Ferrando,R.E., Chu,F.,
            Tao,J., Lam,W., Haller,S., Chan,S., Sa,S., Dunlap,D.,
            Eastham-Anderson,J., Ngu,H., Hung,J., French,D.M., Webster,J.D.,
            Bolon,B., Liu,J., Reja,R., Kummerfeld,S., Chen,Y.J., Modrusan,Z.,
            Lewcock,J.W. and Dixit,V.M.
  TITLE     Ubiquitin ligase COP1 coordinates transcriptional programs that
            control cell type specification in the developing mouse brain
  JOURNAL   Proc Natl Acad Sci U S A 115 (44), 11244-11249 (2018)
   PUBMED   30322923
REFERENCE   3  (bases 1 to 2241)
  AUTHORS   Fernando,V.C.D., Al Khateeb,W., Belmonte,M.F. and Schroeder,D.F.
  TITLE     Role of Arabidopsis ABF1/3/4 during det1 germination in salt and
            osmotic stress conditions
  JOURNAL   Plant Mol Biol 97 (1-2), 149-163 (2018)
   PUBMED   29680877
  REMARK    GeneRIF: the role of ABF1/3/4 in det1 germination phenotypes
REFERENCE   4  (bases 1 to 2241)
  AUTHORS   Zhang,Z., Newton,K., Kummerfeld,S.K., Webster,J., Kirkpatrick,D.S.,
            Phu,L., Eastham-Anderson,J., Liu,J., Lee,W.P., Wu,J., Li,H.,
            Junttila,M.R. and Dixit,V.M.
  TITLE     Transcription factor Etv5 is essential for the maintenance of
            alveolar type II cells
  JOURNAL   Proc Natl Acad Sci U S A 114 (15), 3903-3908 (2017)
   PUBMED   28351980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138376.11 and AC156556.8.
            
            On Mar 27, 2023 this sequence version replaced NM_029585.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031930.1, AK011666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC138376.11        179980-180105
            127-1219            AC138376.11        182948-184040
            1220-1407           AC138376.11        187020-187207
            1408-1599           AC138376.11        192910-193101
            1600-2241           AC156556.8         247783-248424       c
FEATURES             Location/Qualifiers
     source          1..2241
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 44.81 cM"
     gene            1..2241
                     /gene="Det1"
                     /gene_synonym="2610034H20Rik"
                     /note="DET1 partner of COP1 E3 ubiquitin ligase"
                     /db_xref="GeneID:76375"
                     /db_xref="MGI:MGI:1923625"
     exon            1..126
                     /gene="Det1"
                     /gene_synonym="2610034H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            127..1219
                     /gene="Det1"
                     /gene_synonym="2610034H20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1789
                     /gene="Det1"
                     /gene_synonym="2610034H20Rik"
                     /note="isoform 1 is encoded by transcript variant 1; DET1
                     homolog; de-etiolated-1 homolog; de-etiolated homolog 1"
                     /codon_start=1
                     /product="DET1 homolog isoform 1"
                     /protein_id="NP_083861.1"
                     /db_xref="CCDS:CCDS21375.1"
                     /db_xref="GeneID:76375"
                     /db_xref="MGI:MGI:1923625"
                     /translation="MDHHVSTIKPRRIQNQNVIHRLERRRISSGKAGTHWHQVRVFHQ
                     NVFPNFTVVNVEKPPCFLRKFSPDGRYFIAFSSDQTSLEIYEYQGCQAAEDLLQGYEG
                     EILSNGNDQRSVSIRGRLFERFFVLLHITNVAANGEHLNRECSLFTDDCRCVIVGSAA
                     YLPDEPHPPFYEVYRNSESVTPNPRSPLEDYSLHIIDLHTGRLCDTRTFKCDKVVLSH
                     NQGLYLYKNILAILSVQQQTIHVFQVTPEGTFIDVRTIGRFCYEDDLLTVSAVFPEVQ
                     RDSQTGMANPFRDPFINSLKHRLLVYLWRRAEQDGSAMAKRRFFQYFDQLRQLRMWKM
                     QLLDENHLFIKYTSEDVVTLRVTDPSQASFFVVYNMVTTEVIAVFENTSDELLELFEN
                     FCDLFRNATLHSEVQFPCSASSNNFARQIQRRFKDTIINAKYGGHTEAVRRLLGQLPI
                     SAQSYSGSPYLDLSLFSYDDKWVSVMERPKTCGDHPIRFYARDSGLLKFEIQAGLLGR
                     PINHTVRRLVAFTFHPFEPFAISVQRTNAEYVVNFHMRHCCT"
     exon            1220..1407
                     /gene="Det1"
                     /gene_synonym="2610034H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1599
                     /gene="Det1"
                     /gene_synonym="2610034H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..2241
                     /gene="Det1"
                     /gene_synonym="2610034H20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2019..2024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Det1"
                     /gene_synonym="2610034H20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2042
                     /gene="Det1"
                     /gene_synonym="2610034H20Rik"
                     /note="major polyA site"
     regulatory      2216..2221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Det1"
                     /gene_synonym="2610034H20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2241
                     /gene="Det1"
                     /gene_synonym="2610034H20Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggaaacccgg gctggtggct gccgacgccg gggtcccgag gcatggtggg ggcggggccg
       61 ggggaggtgt gcgcggagca ggctagggcg acccttgccc tggccccatg agccaggact
      121 cgacagagat gttataatgg atcatcatgt ttccacaatt aaacctcgaa gaatccaaaa
      181 tcaaaatgtc attcaccgcc tcgaacgccg gcgcatcagt tcaggcaagg cgggcaccca
      241 ctggcatcag gtccgagtgt tccaccagaa cgtcttcccc aacttcacgg ttgtcaacgt
      301 cgaaaagcct ccttgtttct tacggaaatt ctcgcctgac gggcgctact ttattgcctt
      361 ttcatctgac cagacatctc ttgaaatcta tgagtaccag ggctgtcagg cagcagagga
      421 cctcttgcag ggatacgaag gggagatctt gtccaatggc aatgaccaga ggtcggtcag
      481 catccgaggt cggctctttg agcgtttttt tgttctgctg cacattacca acgtggcggc
      541 caatggcgag cacttgaacc gggagtgtag cctcttcaca gatgactgcc gctgcgtcat
      601 cgtgggctct gctgcctacc tcccagacga gcctcaccct ccattctatg aggtgtatcg
      661 gaacagtgag tcggtgaccc ccaatccacg gtccccactt gaggactatt ccctccacat
      721 cattgacctt cacactggcc gtttgtgtga cacacgcaca ttcaagtgtg acaaagtggt
      781 cttgtcgcac aatcaagggc tctacttgta taaaaacatc ctggccatat tgtctgtgca
      841 gcagcagacg attcatgtct tccaggtgac ccctgaaggc acctttatcg acgttcgaac
      901 catcggccgc ttctgctatg aggatgacct gctcactgtg tctgccgttt tccctgaggt
      961 gcagcgggac agccagacag gcatggccaa ccctttcagg gaccctttca tcaactcctt
     1021 gaagcaccgc ttgctggttt acctctggcg ccgggcagag caggatggca gtgccatggc
     1081 gaagaggcgg ttcttccagt actttgacca gctgcgccag ctgcgcatgt ggaagatgca
     1141 gctcctggac gagaaccatc tgttcatcaa gtacaccagc gaggacgtag tgacgctgcg
     1201 ggtcacagac ccgtctcagg cctccttctt tgtggtatac aacatggtga caacagaggt
     1261 gattgccgtg tttgagaaca catccgatga gcttctggaa ctcttcgaga acttctgtga
     1321 cctcttccgc aacgccaccc tgcacagtga agtccaattc ccttgctcag cttctagcaa
     1381 caactttgca aggcagatcc agcgccggtt caaagacacg attataaatg ccaagtatgg
     1441 agggcacacg gaggctgtgc gccgactgct aggccagctc cccatcagtg cccagtctta
     1501 cagtgggagc ccatacctgg atttgtctct cttcagctac gatgacaagt gggtgtcagt
     1561 catggagcga cccaagactt gtggagatca cccgatcagg ttctatgccc gggactctgg
     1621 cttgctgaag tttgagatcc aggcgggctt gctgggccgc cccatcaacc acacagtgcg
     1681 acgcctcgtg gccttcacct ttcacccctt tgagccattt gccatttctg tgcagaggac
     1741 taacgcagag tatgttgtca acttccacat gcgacactgc tgcacctagt cacctcatta
     1801 caatcgtgct gtccaggact ttgcccctgc ttcgctcagt gggcaataaa gcaaaagctc
     1861 tgagctgcca gctttcgtcg gtattccaga ctgctgtgcc tcccctacca cagagcctga
     1921 gagaaaggat ggggggcaac ctggtgggac tctgttttcc tcttacccgg atgatcagtt
     1981 ttcatgtcct ctcgcttttc cctgtgggaa cacctagcat taaatccatt ttattttgtt
     2041 tacttagcat tttatgtctg tggagataga agcatttaca cctttcccgc ctttccgcct
     2101 tgatgtcgct cttcgcatta tggtgtgaag ctggcagcag gtaaatcatg tttactctgg
     2161 aaactatgta ctcctttcca ttcccacaac aggcagggct ggctttatac gagaaaataa
     2221 agccttggta ttttcgtagg a
//
