LOCUS       NM_024282               4214 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Mus musculus desumoylating isopeptidase 2 (Desi2), mRNA.
ACCESSION   NM_024282
VERSION     NM_024282.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4214)
  AUTHORS   He,Y., Wang,J., Gou,L., Shen,C., Chen,L., Yi,C., Wei,X. and Yang,J.
  TITLE     Comprehensive analysis of expression profile reveals the ubiquitous
            distribution of PPPDE peptidase domain 1, a Golgi apparatus
            component, and its implications in clinical cancer
  JOURNAL   Biochimie 95 (7), 1466-1475 (2013)
   PUBMED   23567336
  REMARK    GeneRIF: expression regulation and biological functions of PPPDE1
            in development and carcinogenesis.
REFERENCE   2  (bases 1 to 4214)
  AUTHORS   Shin,E.J., Shin,H.M., Nam,E., Kim,W.S., Kim,J.H., Oh,B.H. and
            Yun,Y.
  TITLE     DeSUMOylating isopeptidase: a second class of SUMO protease
  JOURNAL   EMBO Rep 13 (4), 339-346 (2012)
   PUBMED   22370726
REFERENCE   3  (bases 1 to 4214)
  AUTHORS   Cai,P., Xia,X., Li,F., Cui,Y., Yang,Q. and Chen,M.
  TITLE     PNAS4 knockout does not induce obviously neurocytes apoptosis and
            abnormal development in mice brain
  JOURNAL   Mol Biol Rep 39 (1), 621-628 (2012)
   PUBMED   21553223
  REMARK    GeneRIF: PNAS4 was not involved in mice brain development and
            apoptosis.
REFERENCE   4  (bases 1 to 4214)
  AUTHORS   Yan,F., Gou,L., Yang,J., Chen,L., Tong,A., Tang,M., Yuan,Z.,
            Yao,S., Zhang,P. and Wei,Y.
  TITLE     A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549
            human lung adenocarcinoma cells and inhibits tumor growth in mice
  JOURNAL   Biochimie 91 (4), 502-507 (2009)
   PUBMED   19133312
  REMARK    GeneRIF: overexpression of mouse PNAS4 significantly suppressed
            Lewis lung carcinoma growth and prolonged survival time through
            induction of tumor cell apoptosis
REFERENCE   5  (bases 1 to 4214)
  AUTHORS   Lee,Y.J., Park,C.W., Hahn,Y., Park,J., Lee,J., Yun,J.H., Hyun,B.
            and Chung,J.H.
  TITLE     Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely
            linked to Peg1/Mest(1)
  JOURNAL   FEBS Lett 472 (2-3), 230-234 (2000)
   PUBMED   10788617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029574.1, AK049579.1 and AC119928.8.
            
            On Dec 19, 2006 this sequence version replaced NM_024282.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146492.1, SRR1660821.28181.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               AK029574.1         1-366
            367-1713            AK049579.1         136-1482
            1714-4214           AC119928.8         35307-37807         c
FEATURES             Location/Qualifiers
     source          1..4214
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 82.93 cM"
     gene            1..4214
                     /gene="Desi2"
                     /gene_synonym="5830417C01Rik; DeSI-2; Fam152a; Pppde1"
                     /note="desumoylating isopeptidase 2"
                     /db_xref="GeneID:78825"
                     /db_xref="MGI:MGI:1926075"
     exon            1..541
                     /gene="Desi2"
                     /gene_synonym="5830417C01Rik; DeSI-2; Fam152a; Pppde1"
                     /inference="alignment:Splign:2.1.0"
     CDS             500..1084
                     /gene="Desi2"
                     /gene_synonym="5830417C01Rik; DeSI-2; Fam152a; Pppde1"
                     /EC_number="3.1.2.22"
                     /EC_number="3.4.19.12"
                     /note="PPPDE peptidase domain-containing protein 1; family
                     with sequence similarity 152, member A; PPPDE peptidase
                     domain containing 1; S-depalmitoylase DESI2; palmitoyl
                     protein thioesterase DESI2"
                     /codon_start=1
                     /product="deubiquitinase DESI2"
                     /protein_id="NP_077244.1"
                     /db_xref="CCDS:CCDS35803.1"
                     /db_xref="GeneID:78825"
                     /db_xref="MGI:MGI:1926075"
                     /translation="MGANQLVVLNVYDMYWMNEYTSSIGIGVFHSGIEVYGREFAYGG
                     HPYPFSGIFEISPGNASELGETFKFKEAVVLGSTDFLEDDIEKIVEELGKEYKGNAYH
                     LMHKNCNHFSSALSEILCGKEIPRWINRLAYFSSCIPFLQSCLPKEWLTPAALQSSVS
                     QELQDELEEAEDAAASSAMASAAAGARTGRHTKL"
     exon            542..614
                     /gene="Desi2"
                     /gene_synonym="5830417C01Rik; DeSI-2; Fam152a; Pppde1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..708
                     /gene="Desi2"
                     /gene_synonym="5830417C01Rik; DeSI-2; Fam152a; Pppde1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..850
                     /gene="Desi2"
                     /gene_synonym="5830417C01Rik; DeSI-2; Fam152a; Pppde1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..4214
                     /gene="Desi2"
                     /gene_synonym="5830417C01Rik; DeSI-2; Fam152a; Pppde1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4191..4196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Desi2"
                     /gene_synonym="5830417C01Rik; DeSI-2; Fam152a; Pppde1"
                     /note="hexamer: ATTAAA"
     polyA_site      4214
                     /gene="Desi2"
                     /gene_synonym="5830417C01Rik; DeSI-2; Fam152a; Pppde1"
                     /note="major polyA site"
ORIGIN      
        1 agtcagactg cttacacgcc caataggaat cgcgggttct ccctctgctt tctgggaacg
       61 gtagtctttc tgcgacctcg agccaccagg gtgaagaggc atccggcctg tcgccatttt
      121 aggtctccag ctgcagagcc tgagagcctc aacgcgcagg cgggctcatc cctggatcct
      181 ggccggcccc gcctccaggg tgcctaaagc ccgcccctcg cccaggcccc gccttccccc
      241 acgtgtctgc ggccgagggg aggcgcctga gctggagctg cctctccacc tgtctggccg
      301 ggtcctcgta caggtttctg acagcgtctc ccgggagcgg tcccggctgc cggatgcttc
      361 cgccccggct gcggtgggcc gggctggacg cttagtgccc ggctcgagcc ctgcctgagg
      421 cgcccgcggg ggtggcagcg gcctccgccc cgcggagacc gagcggctgg aggacgaggc
      481 ggcggccgtg gggagaagga tgggggctaa ccagttagtg gtgctcaacg tctacgacat
      541 gtactggatg aatgaataca cctcatctat tggaattgga gtttttcatt ctggaattga
      601 agtatatggc agagagtttg cttatggtgg ccatccatat cctttttctg gaatatttga
      661 aatttcccca ggaaatgctt ctgagctagg agaaacattt aaatttaaag aagctgttgt
      721 tctaggaagt acggactttc tagaagatga tatagagaaa attgtagaag aactggggaa
      781 agagtataag ggcaacgcct accatctgat gcacaaaaac tgcaatcact tttcttcagc
      841 tttatcagag attctctgtg ggaaagagat tcctcgctgg atcaaccggc tggcctactt
      901 cagctcctgt ataccctttc tacagagttg cctgccaaag gagtggctca ctcctgctgc
      961 acttcagtct agtgtcagcc aagaactcca ggatgaacta gaagaagcag aggatgcagc
     1021 cgcatccagt gccatggcaa gtgctgcagc tggtgccaga actgggcgtc acactaaact
     1081 ataagacctc tgaagtcagg ccttcagaac tgtctctggc agttgagtat cactagagaa
     1141 aaagaaaata gagttaaatg tcctttggat attttgtatg caaagatggc tctcccccaa
     1201 atcccagttt ttcagctcag gattatattt gtaatcaaaa acaaaaaaac aaaaaagaag
     1261 aaaaatagct tggcgcagga gggagaactt tgtatgaagc tgccctcttt tcttttcttt
     1321 ttaacccact tgtaaatttg gattcacttc ctctgtttta tacgagctct gttaaattac
     1381 gtttacagta ttttgtacca ctgtttacaa atcttgcatg gacttctgcc accatgaaag
     1441 aagaatatcc tcatcttcaa atattaggca gatgatcttt gtacacttcc tgacagttgc
     1501 cagagctaca gcataggtag taggcacaag gaaaggcttc cacagccgca gtcctcatcg
     1561 ctgcttacaa gctgtcccgg agatctgtat ttgttttgtt accaatgttg gcacccagat
     1621 accggaatcc aaactggcct gacatgaagg agcacacaca cagccagagg gcttgggtcc
     1681 tggtcagttc ctctccacac ccttcttccc attctgagta gcacatttcc caaggtgccc
     1741 gtggagcagc tggtctcacc ccagatatgc ccacctcagc agggtggtac tcttgtatct
     1801 gcctggcttg atgcctctga ttctttaatg aagatactct tataactgat gagtgttttt
     1861 gcacatgtgt taggagaggg gcttcatttt attttaatac attctaactc ctccctgtac
     1921 aggatatttt ggtggggtgg gagtatccta acctagcttc ctgagcagca gtacaagctg
     1981 acactgaact gctttttaaa ctagccaggc taccttttgt actggatatt gaaacctaga
     2041 atctaaaaca caccccaaag gtaattcttt aatagtttgt gtacaccgta tcagaaatgg
     2101 cttattggag tttcttagtt catgatggga gtagccgcac ctcataatag agattctatt
     2161 ttcattgata tcttgttgaa aattatactt ttgtgtgtct taaattcatt tttttatgtt
     2221 ctcaaatgta tctctcttac ataacatact cttgggaatg aggttgtgct acagagaagt
     2281 cttagtgagg aagtcatctg ttagagtcca accccagttg acccttggat gtagaaccaa
     2341 tcattacatg tcacaatcaa tgttctgcct taagagtgag tgtcctgtgt aagtagtgga
     2401 tacaacatag gaacatccaa ggtactgact gcagctttag atacgtgatt agtgtgagag
     2461 tcacattctc tgtgtgaaga tacatgtctt tgagtaaatt tcatctttaa tttttccatg
     2521 agctgatttt gattgatact ttttaacgta agcacaccct ctttataggg aaagtaaacc
     2581 ttgagttatt taacactggc ctgaggaaaa cgaagtcact ttgtactgtt tgactgttct
     2641 gtttccagag aagaaagctg ctgcaagtta ctctacccgt gccgggtggg gcagagcatt
     2701 tgtttcagga acggtgcagc aagacagaat atgtggtctt tatgaagagt caacttagtt
     2761 caggtctgaa aatgagactt aggacaaaac actaatgctc cccaagaggt gtcaccacga
     2821 gagcccaagc cctcagccca gcttggtaag aaagagatgc ttggtacagt tgacttgggt
     2881 ttttgttgtt gttgttgttt tattaatagt gtggatcatg gtgttttcta atccattgag
     2941 atataaatgt tttgacccaa gggagtggcc cctcagttag acacttctgg gtaaatagcc
     3001 aggtacatct ctgtgcttac cctcatttca gcagctcagc acacaagtga cttgctgttc
     3061 tcatgcctga ctgggacatt tgacgtttga agaaatgtaa aagtcttcta ggaaataaac
     3121 agctcatgtg caggtcacct gagagtcagg acacaagatt ccttgcactt tggtgtccct
     3181 gaggttggaa ggaagaaaat ctctttagtg agaccaacct tctccacagt gtagattagc
     3241 aatggattaa ttaactttgc ttttcttgcc ctcagaaggt aacaatgagt tctccacatg
     3301 aactcataag aaaaaccaca agtcagaact ccagtcatga atttacatga gtttacatat
     3361 tttgtagttg taaccaagtg aaactgtttc ttctggtagg tgtttgaaca ataatagcag
     3421 taatagatca gatagttggt ttctggtgct tgttttaaat atgcttgggc tttttaaatc
     3481 ctcattggtg gcattggctt tagaagtgtg acttgtgagg ctgtagaaag tggtgactgt
     3541 cctagagcac ctccaggcct gaactccggc caactattgc tctgcttcac agcaatagca
     3601 tacctaccat caccagcatc ttacagagca gggaattcca gggttagtcc attgatagcc
     3661 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtagatta
     3721 agcactgcag acagctgcag gactctgttt ccatggcttc ttccatcata agtcgggtag
     3781 aaccatgttc actgcttcac agctctaacc catgtgttgt cttatggctc cattatatat
     3841 ttactatagc tttggtgtat gctatgtttt ctttttaaat gactaatgtt aaaagttagt
     3901 ttttcagcag ttagccatcc tctcattaca tcttattctt gccggtatgg tttgagagtg
     3961 tagcttgatt gttagacttt cattgtctgc tcagtctatt cacacacatc tccactgtca
     4021 acaagtggga cagctgtcaa caaatcttca tggatctgaa gagaatttct gtgaagttga
     4081 atgcaagtgt actgtcattc acagtgttta taaaacacca ggaaccttca cttttgctac
     4141 cttgatatag aattggacta tcatgttaca acattgaaat acatcaattt attaaaaact
     4201 acttttataa gaaa
//
