LOCUS       NM_134095               2934 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Mus musculus desumoylating isopeptidase 1 (Desi1), transcript
            variant 1, mRNA.
ACCESSION   NM_134095
VERSION     NM_134095.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2934)
  AUTHORS   Shin,E.J., Shin,H.M., Nam,E., Kim,W.S., Kim,J.H., Oh,B.H. and
            Yun,Y.
  TITLE     DeSUMOylating isopeptidase: a second class of SUMO protease
  JOURNAL   EMBO Rep 13 (4), 339-346 (2012)
   PUBMED   22370726
  REMARK    GeneRIF: A new deSUMOylase named DeSI-1 (DeSumoylating Isopeptidase
            1), was identified.
REFERENCE   2  (bases 1 to 2934)
  AUTHORS   Kaput,J., Klein,K.G., Reyes,E.J., Kibbe,W.A., Cooney,C.A.,
            Jovanovic,B., Visek,W.J. and Wolff,G.L.
  TITLE     Identification of genes contributing to the obese yellow Avy
            phenotype: caloric restriction, genotype, diet x genotype
            interactions
  JOURNAL   Physiol Genomics 18 (3), 316-324 (2004)
   PUBMED   15306695
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2934)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102176.8.
            
            On Sep 8, 2022 this sequence version replaced NM_134095.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056972.1, AK146155.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AC102176.8         46361-46646         c
            287-308             AC102176.8         34241-34262         c
            309-378             AC102176.8         33024-33093         c
            379-488             AC102176.8         29988-30097         c
            489-611             AC102176.8         28593-28715         c
            612-2934            AC102176.8         23006-25328         c
FEATURES             Location/Qualifiers
     source          1..2934
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.34 cM"
     gene            1..2934
                     /gene="Desi1"
                     /gene_synonym="D15Wsu75e; DeSI-1; Fam152b; Pppde2"
                     /note="desumoylating isopeptidase 1"
                     /db_xref="GeneID:28075"
                     /db_xref="MGI:MGI:106313"
     exon            1..286
                     /gene="Desi1"
                     /gene_synonym="D15Wsu75e; DeSI-1; Fam152b; Pppde2"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..705
                     /gene="Desi1"
                     /gene_synonym="D15Wsu75e; DeSI-1; Fam152b; Pppde2"
                     /EC_number="3.1.2.22"
                     /note="isoform 1 is encoded by transcript variant 1; PPPDE
                     peptidase domain-containing protein 2; family with
                     sequence similarity 152, member B; PPPDE peptidase domain
                     containing 2; S-depalmitoylase DESI1; palmitoyl protein
                     thioesterase DESI1"
                     /codon_start=1
                     /product="desumoylating isopeptidase 1 isoform 1"
                     /protein_id="NP_598856.1"
                     /db_xref="CCDS:CCDS27681.1"
                     /db_xref="GeneID:28075"
                     /db_xref="MGI:MGI:106313"
                     /translation="MEPPNLYPVKLYVYDLSKGLARRLSPIMLGKQLEGIWHTSIVVH
                     KDEFFFGSSGISSCTPGGTLLGPPDSVVDVGNTEVTEEIFLEYLSSLGESLFRGEAYN
                     LFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALRPFLDSIQIQPPGGNS
                     VGRPNGQS"
     exon            287..308
                     /gene="Desi1"
                     /gene_synonym="D15Wsu75e; DeSI-1; Fam152b; Pppde2"
                     /inference="alignment:Splign:2.1.0"
     exon            309..378
                     /gene="Desi1"
                     /gene_synonym="D15Wsu75e; DeSI-1; Fam152b; Pppde2"
                     /inference="alignment:Splign:2.1.0"
     exon            379..488
                     /gene="Desi1"
                     /gene_synonym="D15Wsu75e; DeSI-1; Fam152b; Pppde2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..611
                     /gene="Desi1"
                     /gene_synonym="D15Wsu75e; DeSI-1; Fam152b; Pppde2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..2934
                     /gene="Desi1"
                     /gene_synonym="D15Wsu75e; DeSI-1; Fam152b; Pppde2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1424..1429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Desi1"
                     /gene_synonym="D15Wsu75e; DeSI-1; Fam152b; Pppde2"
                     /note="hexamer: AATAAA"
     polyA_site      1457
                     /gene="Desi1"
                     /gene_synonym="D15Wsu75e; DeSI-1; Fam152b; Pppde2"
                     /note="major polyA site"
     regulatory      2914..2919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Desi1"
                     /gene_synonym="D15Wsu75e; DeSI-1; Fam152b; Pppde2"
                     /note="hexamer: AATAAA"
     polyA_site      2934
                     /gene="Desi1"
                     /gene_synonym="D15Wsu75e; DeSI-1; Fam152b; Pppde2"
                     /note="major polyA site"
ORIGIN      
        1 ctctctgtca cctcacagta gtcgttgccg gtcgcgggtg tccgggcgcg agcagcgcag
       61 ggccgcctct cccccgccct caggccgggc cccggctcgg tcccccgctc cctcttctcc
      121 ccaccccggt cgggtaccgg aaggtccaag ccgctgccgg gtgcccgagg gccatcgtgg
      181 ccgccgccac gggtcctgat ggagccgcca aatctctatc cggtgaagct ctacgtgtac
      241 gacctgtcca agggcctggc ccgccggctc agccccatca tgctggggaa acaactggaa
      301 ggcatctggc acacctctat agttgtacac aaggatgagt tcttcttcgg cagcagcggt
      361 atttccagct gtaccccggg agggacattg cttgggcccc cagactctgt ggttgatgtg
      421 ggaaacacag aagtcacaga agaaatcttt ctggaatacc tgtcctccct gggggagtct
      481 ctgttccgag gagaagccta caacctcttt gaacacaact gtaacacctt tagcaatgaa
      541 gtggcgcagt tcctgactgg gcgaaagatc ccttcttaca tcaccgacct gccctcagaa
      601 gttctttcca cgccctttgg acaagcactt cggcccttcc tggactccat tcagatccag
      661 cctccaggag ggaactctgt gggcagaccc aatggccaaa gctaacagga ctgcacggga
      721 ccacccacct cgccagggct tttccttttt aaacaaaaca aaccctacca gatttctatt
      781 ttataatttt acatcagagc taacagggac ggctttttaa atttcccagg gaaggagttc
      841 ttcaggctgc atgtaggaca atgctcctga gaaagatcga atgccatccc ttctaatagt
      901 attatactaa tttattaagg ctgtcttgtc tgtgagttca cttttgacgc tgttgcctaa
      961 gcgtcctcca cactggagag agagggtgct tgtttaaaga gaaagcaaga gtcacagtct
     1021 gggagaaccc catctcggac cctctttcca gagaacaccc acattccacc caggttgcca
     1081 ccctgtggga cccaggtgag ttttatactg tccattcccc tggagcagtc accttctagc
     1141 agtaactgaa gcaaaggact tggagtacat ggggcagctg gaggctcctc actcaagcta
     1201 agtgacctct ttaaccacaa gtttaccctc ctcccgagac aaggccactc atcacagccc
     1261 agccggagca gccgcagcgt caggatcaaa ggagactggc agcaggtgtg aggccagaga
     1321 aaacaggaga aagccattcc tcctcctcct cctatctgag tgccaaccct cgatgcccac
     1381 ccctaagctg ctcttcctca gcgtagcttg acctgtcacc tttaataaag gtctaggctg
     1441 cagcagcaga gacacaggcc ttctgtctga gaattagtta tttatagtca atagagccag
     1501 ccactcacac ccttatgggt ttgtcagcta gggactaggg ggacatgatt gttctcccaa
     1561 aacaagtctc tgatgtagaa aataccataa tgatgtagat tcatggtggg aagaaaattt
     1621 ggagttgtct ccagtaggga ctttcacatt atccttaata cgtctccatt gtcattctga
     1681 ccttatgggg tgtggttggg gtgtgagtgg gcgttttctt aatgatatgc tgctaggatt
     1741 tcatgggcag caatagccta gaagtctatg atctagactc cagattccag agggacctta
     1801 aggttccctt ctgtggtgtc agtcttctac tagctaatat gggaaactgg atatggagaa
     1861 gggagctcag agcaggcacc tgagactcag ctccacaccc atggggagcc ccccaccgtg
     1921 gcttcctgcc acttctgaaa cttgagccca cttgttcctt ttggggtagg cctttcctcc
     1981 ctgaaaagcc cctattggct cccttgcccc taccctgcag gctttgccac tagccatagc
     2041 agtggcatca tggagatctc tgcctcagag ctgacctgtt gtctgaccag agagagctat
     2101 gtccacctag ggtgtcgagt ggtgtttggg aacttgaagg tcacagtcag aaaggtctca
     2161 ggactcaaca gtgtacaggt gtatgtggct gtcacaacgt agagtggaaa ccaacagaga
     2221 ctgtttagtg ttggtctctt tggcagaata gggcttagaa ggttcagtgt ttaaagcttg
     2281 gtatctggga aggcagaggt tgctggaagc catcactttt tcctttgcct ggccccagct
     2341 ggtagcatct ctgcccagag ctctgtcctt agggtgctct cacatggcca ttctctgttt
     2401 ttctcctcag cagtaaccat ggtattctga gacatttgcc tgaggatttt agtcacttaa
     2461 ttgcttgaat tatctcctgt catgtctagc agccatccat gccaacgtct gtggccatgg
     2521 ctagcagaga gatgggaaga ctggacagtc tctctggtct cctttcccta tgcaagttcc
     2581 gttgtcacca gaatcccagg ccaggaaccc cacatcccac ctttacattt ctctgtccca
     2641 gtacctcagg agcatactgt tcatgagcag gtgactcccc ctgggcatgt acaagcaagc
     2701 tgagaggaaa aggagtcacg tggttcatgc cacatagtgg acagccctgt ccattggtca
     2761 gttggtcaag ggacaaggga ggtggaggca tgagaccctt gtccgctcct agactgaagg
     2821 gtttctttga gattccttca tgacttcctt gaagtcaaac taatgtctaa tacggaggtg
     2881 tttgctgctt ttcattggtg ttttttctaa tgcaataaac tcatgtctgc ctgc
//
