LOCUS       NM_024440               1336 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus Der1-like domain family, member 3 (Derl3), transcript
            variant 1, mRNA.
ACCESSION   NM_024440
VERSION     NM_024440.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1336)
  AUTHORS   Eura,Y., Miyata,T. and Kokame,K.
  TITLE     Derlin-3 Is Required for Changes in ERAD Complex Formation under ER
            Stress
  JOURNAL   Int J Mol Sci 21 (17), 6146 (2020)
   PUBMED   32858914
  REMARK    GeneRIF: Derlin-3 Is Required for Changes in ERAD Complex Formation
            under ER Stress.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1336)
  AUTHORS   Filipova,D., Henry,M., Rotshteyn,T., Brunn,A., Carstov,M.,
            Deckert,M., Hescheler,J., Sachinidis,A., Pfitzer,G. and
            Papadopoulos,S.
  TITLE     Distinct transcriptomic changes in E14.5 mouse skeletal muscle
            lacking RYR1 or Cav1.1 converge at E18.5
  JOURNAL   PLoS One 13 (3), e0194428 (2018)
   PUBMED   29543863
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1336)
  AUTHORS   Cameron,T.L., Gresshoff,I.L., Bell,K.M., Pirog,K.A., Sampurno,L.,
            Hartley,C.L., Sanford,E.M., Wilson,R., Ermann,J.,
            Boot-Handford,R.P., Glimcher,L.H., Briggs,M.D. and Bateman,J.F.
  TITLE     Cartilage-specific ablation of XBP1 signaling in mouse results in a
            chondrodysplasia characterized by reduced chondrocyte proliferation
            and delayed cartilage maturation and mineralization
  JOURNAL   Osteoarthritis Cartilage 23 (4), 661-670 (2015)
   PUBMED   25600960
REFERENCE   4  (bases 1 to 1336)
  AUTHORS   Eura,Y., Yanamoto,H., Arai,Y., Okuda,T., Miyata,T. and Kokame,K.
  TITLE     Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency
            appears normal, and Herp deficiency is intolerant to glucose load
            and ischemia in mice
  JOURNAL   PLoS One 7 (3), e34298 (2012)
   PUBMED   22479592
  REMARK    GeneRIF: Derlin-1 deficiency is embryonic lethal, Derlin-3
            deficiency appears normal, and Herp deficiency is intolerant to
            glucose load and ischemia in mice
REFERENCE   5  (bases 1 to 1336)
  AUTHORS   Endoh-Yamagami,S., Karkar,K.M., May,S.R., Cobos,I., Thwin,M.T.,
            Long,J.E., Ashique,A.M., Zarbalis,K., Rubenstein,J.L. and
            Peterson,A.S.
  TITLE     A mutation in the pericentrin gene causes abnormal interneuron
            migration to the olfactory bulb in mice
  JOURNAL   Dev Biol 340 (1), 41-53 (2010)
   PUBMED   20096683
REFERENCE   6  (bases 1 to 1336)
  AUTHORS   Belmont,P.J., Chen,W.J., San Pedro,M.N., Thuerauf,D.J., Gellings
            Lowe,N., Gude,N., Hilton,B., Wolkowicz,R., Sussman,M.A. and
            Glembotski,C.C.
  TITLE     Roles for endoplasmic reticulum-associated degradation and the
            novel endoplasmic reticulum stress response gene Derlin-3 in the
            ischemic heart
  JOURNAL   Circ Res 106 (2), 307-316 (2010)
   PUBMED   19940266
  REMARK    GeneRIF: Study describes a potentially protective role for Derl3 in
            the heart.
REFERENCE   7  (bases 1 to 1336)
  AUTHORS   Schaheen,B., Dang,H. and Fares,H.
  TITLE     Derlin-dependent accumulation of integral membrane proteins at cell
            surfaces
  JOURNAL   J Cell Sci 122 (Pt 13), 2228-2239 (2009)
   PUBMED   19509052
REFERENCE   8  (bases 1 to 1336)
  AUTHORS   Tsukahara,M., Ji,Z.S., Noguchi,S. and Tsunoo,H.
  TITLE     A novel putative transmembrane protein, IZP6, is expressed in
            neural cells during embryogenesis
  JOURNAL   Dev Growth Differ 43 (3), 285-293 (2001)
   PUBMED   11422294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142499.9.
            
            On Mar 21, 2007 this sequence version replaced NM_024440.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004729.1, AK007948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC142499.9         30701-30820         c
            121-186             AC142499.9         30534-30599         c
            187-260             AC142499.9         30375-30448         c
            261-354             AC142499.9         30158-30251         c
            355-550             AC142499.9         29591-29786         c
            551-641             AC142499.9         29089-29179         c
            642-1336            AC142499.9         28277-28971         c
FEATURES             Location/Qualifiers
     source          1..1336
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.61 cM"
     gene            1..1336
                     /gene="Derl3"
                     /gene_synonym="1810006I20Rik; 1810063P04Rik; derlin-3;
                     IZP6"
                     /note="Der1-like domain family, member 3"
                     /db_xref="GeneID:70377"
                     /db_xref="MGI:MGI:1917627"
     exon            1..120
                     /gene="Derl3"
                     /gene_synonym="1810006I20Rik; 1810063P04Rik; derlin-3;
                     IZP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..714
                     /gene="Derl3"
                     /gene_synonym="1810006I20Rik; 1810063P04Rik; derlin-3;
                     IZP6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     der1-like protein 3; degradation in endoplasmic reticulum
                     protein 3"
                     /codon_start=1
                     /product="derlin-3 isoform 1"
                     /protein_id="NP_077760.1"
                     /db_xref="CCDS:CCDS23935.1"
                     /db_xref="GeneID:70377"
                     /db_xref="MGI:MGI:1917627"
                     /translation="MAGQRLAAGFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFN
                     PHLVFRKFQVWRLITTFLFFGPLGFGFFFNMLFVFRYCRMLEEGSFRGRKADFVFMFL
                     FGGVLMTLLGFLGSLFFLGQALMAMLVYVWSRRSPHVRVNFFGLLNFQAPFLPWALMG
                     FSLLLGNSVVTDLLGILVGHIYYFLEDVFPNQPGGKRLLLTPSVLKLLLDDPQEDPDY
                     LPLPEEQPEL"
     exon            121..186
                     /gene="Derl3"
                     /gene_synonym="1810006I20Rik; 1810063P04Rik; derlin-3;
                     IZP6"
                     /inference="alignment:Splign:2.1.0"
     exon            187..260
                     /gene="Derl3"
                     /gene_synonym="1810006I20Rik; 1810063P04Rik; derlin-3;
                     IZP6"
                     /inference="alignment:Splign:2.1.0"
     exon            261..354
                     /gene="Derl3"
                     /gene_synonym="1810006I20Rik; 1810063P04Rik; derlin-3;
                     IZP6"
                     /inference="alignment:Splign:2.1.0"
     exon            355..550
                     /gene="Derl3"
                     /gene_synonym="1810006I20Rik; 1810063P04Rik; derlin-3;
                     IZP6"
                     /inference="alignment:Splign:2.1.0"
     exon            551..641
                     /gene="Derl3"
                     /gene_synonym="1810006I20Rik; 1810063P04Rik; derlin-3;
                     IZP6"
                     /inference="alignment:Splign:2.1.0"
     exon            642..1336
                     /gene="Derl3"
                     /gene_synonym="1810006I20Rik; 1810063P04Rik; derlin-3;
                     IZP6"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1336
                     /gene="Derl3"
                     /gene_synonym="1810006I20Rik; 1810063P04Rik; derlin-3;
                     IZP6"
                     /note="major polyA site"
ORIGIN      
        1 gccagcgcgc gcgctaagga tttttcgatg gctgggcaga ggctggcggc gggcttcctg
       61 caggtgcccg cggtgacacg cgcctacacc gcggcctgcg tcctcaccac ggccgcagtg
      121 cagctggagc tcctcagccc cttccagctc tacttcaacc cgcacctggt gttccggaag
      181 ttccaggtct ggaggctcat caccaccttc ctcttcttcg ggcccctggg attcggcttc
      241 tttttcaaca tgctcttcgt gttccgctac tgccgcatgc tggaggaggg ttctttccgt
      301 ggccgcaagg ctgacttcgt tttcatgttt ctcttcggtg gtgttcttat gactctgctg
      361 ggattcctgg gcagcctgtt tttcctggga caggccctca tggccatgct ggtctatgta
      421 tggagccgtc gcagccctca cgtgagggtc aacttcttcg gcttactcaa cttccaggca
      481 ccattcctgc cctgggccct catgggcttc tcgctgctgc tgggcaactc ggttgtcaca
      541 gacctgttag ggatccttgt gggccacatc tactacttcc tagaagacgt ctttcccaac
      601 cagcccggag gcaagagact gctgctgacc cccagcgtgt tgaagctgct actagatgac
      661 cctcaggaag accccgatta cctgcccctt cccgaagagc agccagagct ctaactgcag
      721 ctcctggagc aggaagccca ctctgacagc actctatcct tccctccacc tcagctccag
      781 ctgagcagcc cacctcggcc agcaacaccc tccacttccc tgtaccatct ctgctcagcg
      841 gtaatgacag gacacagggc ccagagaggt cccggactgc ctgcagatgc tgagcagagt
      901 tctgaactag gtacccacag gcctcacctt cacattgcct atgcctccat ggagacctca
      961 gcccagtcaa caggaatccc accgtggtgc ctctgggctg atgccacccc ctagcctgtc
     1021 ttcatttaaa gcaagcaagt cttcaccttc tccagctggt gacacacagg tcccatggtc
     1081 tcaggtgcag aggacaagcc tgaccctctg ccatgctagt gagcccaggg ccttgagctc
     1141 tatttaagca gcagccgtgt acagtggagg tagatctggg acattccttc catttgcctt
     1201 gtagcggaag gcctgtgcag gccttcctac ctagctttct ttgttgctct acatgtgccc
     1261 cacggggttc actcagtacg ggatttcccc aaatctggcc tgttatttct atggcatcaa
     1321 aaatgttttc tactga
//
