LOCUS       NM_033562               3668 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Der1-like domain family, member 2 (Derl2), transcript
            variant 1, mRNA.
ACCESSION   NM_033562
VERSION     NM_033562.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3668)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3668)
  AUTHORS   Sugiyama,T., Murao,N., Kadowaki,H., Takao,K., Miyakawa,T.,
            Matsushita,Y., Katagiri,T., Futatsugi,A., Shinmyo,Y., Kawasaki,H.,
            Sakai,J., Shiomi,K., Nakazato,M., Takeda,K., Mikoshiba,K.,
            Ploegh,H.L., Ichijo,H. and Nishitoh,H.
  TITLE     ERAD components Derlin-1 and Derlin-2 are essential for postnatal
            brain development and motor function
  JOURNAL   iScience 24 (7), 102758 (2021)
   PUBMED   34355142
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3668)
  AUTHORS   Eura,Y., Miyata,T. and Kokame,K.
  TITLE     Derlin-3 Is Required for Changes in ERAD Complex Formation under ER
            Stress
  JOURNAL   Int J Mol Sci 21 (17), 6146 (2020)
   PUBMED   32858914
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3668)
  AUTHORS   Volpi,V.G., Ferri,C., Fregno,I., Del Carro,U., Bianchi,F.,
            Scapin,C., Pettinato,E., Solda,T., Feltri,M.L., Molinari,M.,
            Wrabetz,L. and D'Antonio,M.
  TITLE     Schwann cells ER-associated degradation contributes to myelin
            maintenance in adult nerves and limits demyelination in CMT1B mice
  JOURNAL   PLoS Genet 15 (4), e1008069 (2019)
   PUBMED   30995221
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3668)
  AUTHORS   Ren,G., Tardi,N.J., Matsuda,F., Koh,K.H., Ruiz,P., Wei,C.,
            Altintas,M.M., Ploegh,H. and Reiser,J.
  TITLE     Podocytes exhibit a specialized protein quality control employing
            derlin-2 in kidney disease
  JOURNAL   Am J Physiol Renal Physiol 314 (3), F471-F482 (2018)
   PUBMED   29167172
  REMARK    GeneRIF: Derlin-2 is part of a protein quality control mechanism
            that can rescue glomerular injury attributable to impaired protein
            folding pathways in the endoplasmic reticulum.
REFERENCE   6  (bases 1 to 3668)
  AUTHORS   Lilley,B.N. and Ploegh,H.L.
  TITLE     Multiprotein complexes that link dislocation, ubiquitination, and
            extraction of misfolded proteins from the endoplasmic reticulum
            membrane
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14296-14301 (2005)
   PUBMED   16186509
REFERENCE   7  (bases 1 to 3668)
  AUTHORS   Kaput,J., Klein,K.G., Reyes,E.J., Kibbe,W.A., Cooney,C.A.,
            Jovanovic,B., Visek,W.J. and Wolff,G.L.
  TITLE     Identification of genes contributing to the obese yellow Avy
            phenotype: caloric restriction, genotype, diet x genotype
            interactions
  JOURNAL   Physiol Genomics 18 (3), 316-324 (2004)
   PUBMED   15306695
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3668)
  AUTHORS   Lilley,B.N. and Ploegh,H.L.
  TITLE     A membrane protein required for dislocation of misfolded proteins
            from the ER
  JOURNAL   Nature 429 (6994), 834-840 (2004)
   PUBMED   15215855
REFERENCE   9  (bases 1 to 3668)
  AUTHORS   Ying,H., Yu,Y. and Xu,Y.
  TITLE     Cloning and characterization of F-LANa, upregulated in human liver
            cancer
  JOURNAL   Biochem Biophys Res Commun 286 (2), 394-400 (2001)
   PUBMED   11500051
REFERENCE   10 (bases 1 to 3668)
  AUTHORS   Watters,J.W. and Dietrich,W.F.
  TITLE     Genetic, physical, and transcript map of the Ltxs1 region of mouse
            chromosome 11
  JOURNAL   Genomics 73 (2), 223-231 (2001)
   PUBMED   11318612
  REMARK    Erratum:[Genomics 2002 Mar;79(3):462]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596136.5, AK082564.1, BC037503.1 and CB526064.1.
            
            On Mar 27, 2014 this sequence version replaced NM_033562.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082564.1, SRR1660811.147148.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AL596136.5         178481-178520       c
            41-528              AK082564.1         1-488
            529-1176            BC037503.1         111-758
            1177-1258           AK082564.1         1137-1218
            1259-1259           CB526064.1         282-282
            1260-3663           AK082564.1         1220-3623
            3664-3668           AL596136.5         166657-166661       c
FEATURES             Location/Qualifiers
     source          1..3668
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.21 cM"
     gene            1..3668
                     /gene="Derl2"
                     /gene_synonym="CGI-101; Derlin-2; F-lana; Flana"
                     /note="Der1-like domain family, member 2"
                     /db_xref="GeneID:116891"
                     /db_xref="MGI:MGI:2151483"
     exon            1..160
                     /gene="Derl2"
                     /gene_synonym="CGI-101; Derlin-2; F-lana; Flana"
                     /inference="alignment:Splign:2.1.0"
     exon            161..226
                     /gene="Derl2"
                     /gene_synonym="CGI-101; Derlin-2; F-lana; Flana"
                     /inference="alignment:Splign:2.1.0"
     exon            227..300
                     /gene="Derl2"
                     /gene_synonym="CGI-101; Derlin-2; F-lana; Flana"
                     /inference="alignment:Splign:2.1.0"
     exon            301..394
                     /gene="Derl2"
                     /gene_synonym="CGI-101; Derlin-2; F-lana; Flana"
                     /inference="alignment:Splign:2.1.0"
     exon            395..590
                     /gene="Derl2"
                     /gene_synonym="CGI-101; Derlin-2; F-lana; Flana"
                     /inference="alignment:Splign:2.1.0"
     exon            591..681
                     /gene="Derl2"
                     /gene_synonym="CGI-101; Derlin-2; F-lana; Flana"
                     /inference="alignment:Splign:2.1.0"
     exon            682..3668
                     /gene="Derl2"
                     /gene_synonym="CGI-101; Derlin-2; F-lana; Flana"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1151..1156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Derl2"
                     /gene_synonym="CGI-101; Derlin-2; F-lana; Flana"
                     /note="hexamer: AATAAA"
     polyA_site      1183
                     /gene="Derl2"
                     /gene_synonym="CGI-101; Derlin-2; F-lana; Flana"
                     /note="major polyA site"
     regulatory      3638..3643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Derl2"
                     /gene_synonym="CGI-101; Derlin-2; F-lana; Flana"
                     /note="hexamer: AATAAA"
     polyA_site      3666
                     /gene="Derl2"
                     /gene_synonym="CGI-101; Derlin-2; F-lana; Flana"
                     /note="major polyA site"
ORIGIN      
        1 gctttgagtc cgccccgccg cctggcatac tggcggaagg ggaagggggg caggcgcggt
       61 gggaaagatg gcgtaccaga gcctccggct ggagtacctg cagatcccgc cggtcagccg
      121 cgcctatact accgcctgcg tcctcaccac cgcggccgtg cagttggaat tgatcacacc
      181 ttttcagtta tacttcaatc ctgaattaat ttttaaacat tttcaaatct ggaggctaat
      241 caccaatttc ttattttttg gtccagttgg attcaatttt ttgtttaaca tgatttttct
      301 ataccgttat tgtcgaatgc tagaagaagg ctctttccga ggtcggacag cagactttgt
      361 atttatgttc ctttttggtg gatttttaat gactctcttt ggtttgtttg tgagcttagt
      421 ttttttaggc caggccttta caataatgct ggtctacgtg tggagccgaa ggaacccgta
      481 tgtccgcatg aacttctttg gtcttctaaa cttccaggcc cccttcctgc cctgggtgct
      541 catggggttt tccctgttgc tggggaactc aattatagtg gaccttttgg gtattgcagt
      601 tgggcacata tattttttct tggaagatat atttcccaat cagcctggtg gaataagaat
      661 tctgaaaaca ccatctattt tgaggactat ttttgatacg ccagatgagg atcccaatta
      721 caacccacta cctgaagagc ggccgggagg cttcgcctgg ggtgagggcc agcgccttgg
      781 tgggtaaagc agcggtgcca attacgagac ccatctgaga aagactcagt gacatgtcca
      841 tgggggtctt ttatcccttg ttgcaaaagc gtggacagtt ttgacagctt gacagatttt
      901 taactccaga agcactttac gggatggtac actgactaac atagaagaca tttccaggag
      961 tttgccaggg gttcctcact atgctggtac taaaagtata acctcttgga gccaaaaact
     1021 ggagacccag gcaccctgcc tgtgccgtga gcaagtccat gggtacttga gctcagtggc
     1081 acaggcgggt gctcctcctc ctctttgata gacaaggccg tggtgtaaat ggaagttacg
     1141 gagaggacaa aataaaactg aattccatct ctctcacact gtatttaagc tttcgtgtga
     1201 tcttttaaat catggtagtg tgttctagct ctcctgcgta tgtttgaaca cagcagtttc
     1261 cgtgcctgcc ctcatgtctc cacggctttc aactggattt catttcaaga ttggaaatac
     1321 acagctgcta tgtacatctg actaattcta gttcagagtc ttagcctctg gagagggaag
     1381 attggtttct gccattcaga tagttctcca tctgaatacc atgaagcttc aagtttagac
     1441 cacaggagga gggagaaggg agggtaattt cttgtagcca aggaatctga ctgtagagaa
     1501 gccagctata aaccaaaagc aactgtgata tctctttgag ttggagttcc tctactaaga
     1561 aatacccaga ttagtaatgg ccacccgttg tcaaagcaca ggaataagaa tgggcagcat
     1621 tgggcatgtg ttcctcttgt cattcatttc aagaaaagct caagaccctt ccagggccaa
     1681 gggcctggtt caccttccca gtcgggcaga aatcagggtc tttggaagca gccacactga
     1741 tggttcagag tacttatcaa agatggcaca tcttgtctga ctcaacagtt ttccattcat
     1801 gctgctttat cagagctcag aaagatggcc tcagacagtt ttcataaatg tcaaagaggc
     1861 acaggacttc ccaggctggg tcatcctgtt taggctgagt tgcttttcag atgagatttt
     1921 ctcagaggtt agcataggct taagtaagct ctagtaaaca ttctaggtgg aaagtttcag
     1981 atacatttga ggtagaaagt attttaatga ctaagtggaa ctcgataagg aatggaatga
     2041 gtacggtact agtaaatcac tgaagaccat tgtaactcta tgggacgtgg gccaatggga
     2101 ctgcttttgt cttgtttaaa aatttttaac gtttaatgac aatcttagat tgtatgatcc
     2161 ttatgggatt cttaagtttg ataattgttt ttgttcaaga aggccttgtc agtaactttt
     2221 aggaatttat ttttattatt attgcttgct tttaagccag aaatgggttt ctttaaggtt
     2281 ttatttattt tccctaagtt aattttagat ttagctagtt catggagtta ttgtgaccga
     2341 tctttaattc taaaatctct ccaccagcta ttttcatttt aaacagtgaa tacctataca
     2401 tattagtgac tgaaaacaga aaatatattt tggattattg ttagggtgtg aattcctagt
     2461 ggtagaacac catgctgtgt gacacactgt ctcctggcag tgctgatttc agtcacttgg
     2521 cctcttagta gtttggcagg tccctggccc tgtgttgttt ggcaagatcc ctgtgctcac
     2581 tgggacacaa gggaaagtcc tcacttcccc agccaacctc tcaattccaa ttcttccaaa
     2641 acacacttcc tttttgcgat atgagtcagc agaaaagtga gattgcatta tgggattctg
     2701 tgaccgctta aacttacatg aatacagttt gagccatttc ctggattgat tgtatcagaa
     2761 atatccgaaa agcacaccta aagcataggg cattttgttt cgttgttaca ggaatacagt
     2821 atatgttcat ttaaaaatga atggacatgc caattgcatc tccataggag atagatttta
     2881 tatactttgg tgtgtttttt tcactatgaa tttttacttg tttcttccac ttctttttct
     2941 gtccctctgt gtcctcctgt cttttatatt tcttttgtac ttgcgtgagg caaagcgtcc
     3001 acatcctgga tcttgaaatg gaaccataac actgtctcta gagtcctctg ggaggaatta
     3061 ggaaacattg gagctattgg catgttggca taacatgctt cctagaattg tcatgccttc
     3121 ggccactgtt tattttgtgg ctataatttc ctttctcggg tgagttctat ctgtgttagc
     3181 taagatcctg cccttccatc ctctcgggat gactaaacta cttactgttt tgagtttgat
     3241 tcaagttctt gaaccttgct tgtctcgttc agccgctctg ttccgaagtc tgcaatcacg
     3301 tcttagccct tatcaaatgc atattttgtg tcttttctct gaaccttgct cctacttctc
     3361 ccttgcagga acgtcgattt aagtttcttc aagaccttga cactaaactc ttaaaactaa
     3421 ggcctatttc actgtcttct ttaaatcctt atgaagcttc aaatctgtgc taaaattcct
     3481 ataccaaatc atatattgtc ttgtactgtt cttagctgct acatgtatgt tagttttgtt
     3541 cccctcatga gaatgtaagc tccttaaggg cagggactat gtcttaattt ttgtatccac
     3601 cacagtgcct agcactgtgc ttggcacatg ggtgctgaat aaatactttg tttattgatc
     3661 agcaaact
//
