LOCUS       NM_024207               3145 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus Der1-like domain family, member 1 (Derl1), mRNA.
ACCESSION   NM_024207
VERSION     NM_024207.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3145)
  AUTHORS   Murao,N., Matsuda,T., Kadowaki,H., Matsushita,Y., Tanimoto,K.,
            Katagiri,T., Nakashima,K. and Nishitoh,H.
  TITLE     The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal
            neurogenesis
  JOURNAL   EMBO Rep 25 (8), 3678-3706 (2024)
   PUBMED   39080439
  REMARK    GeneRIF: The Derlin-1-Stat5b axis maintains homeostasis of adult
            hippocampal neurogenesis.
REFERENCE   2  (bases 1 to 3145)
  AUTHORS   Wang,T., Wang,D., Kuang,G., Gong,X., Zhang,L., Wan,J. and Li,K.
  TITLE     Derlin-1 promotes diet-induced non-alcoholic fatty liver disease
            via increasing RIPK3-mediated necroptosis
  JOURNAL   Free Radic Biol Med 217, 29-47 (2024)
   PUBMED   38522486
  REMARK    GeneRIF: Derlin-1 promotes diet-induced non-alcoholic fatty liver
            disease via increasing RIPK3-mediated necroptosis.
REFERENCE   3  (bases 1 to 3145)
  AUTHORS   You,H., Wen,X., Wang,X., Zhu,C., Chen,H., Bu,L., Zhang,J. and Qu,S.
  TITLE     Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting
            ubiquitylation and degradation of FABP1
  JOURNAL   Free Radic Biol Med 207, 260-271 (2023)
   PUBMED   37499886
  REMARK    GeneRIF: Derlin-1 ameliorates nonalcoholic hepatic steatosis by
            promoting ubiquitylation and degradation of FABP1.
REFERENCE   4  (bases 1 to 3145)
  AUTHORS   Sugiyama,T., Murao,N., Kadowaki,H. and Nishitoh,H.
  TITLE     Chemical chaperones ameliorate neurodegenerative disorders in
            Derlin-1-deficient mice via improvement of cholesterol biosynthesis
  JOURNAL   Sci Rep 12 (1), 21840 (2022)
   PUBMED   36528738
  REMARK    GeneRIF: Chemical chaperones ameliorate neurodegenerative disorders
            in Derlin-1-deficient mice via improvement of cholesterol
            biosynthesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3145)
  AUTHORS   Sugiyama,T., Murao,N., Kadowaki,H., Takao,K., Miyakawa,T.,
            Matsushita,Y., Katagiri,T., Futatsugi,A., Shinmyo,Y., Kawasaki,H.,
            Sakai,J., Shiomi,K., Nakazato,M., Takeda,K., Mikoshiba,K.,
            Ploegh,H.L., Ichijo,H. and Nishitoh,H.
  TITLE     ERAD components Derlin-1 and Derlin-2 are essential for postnatal
            brain development and motor function
  JOURNAL   iScience 24 (7), 102758 (2021)
   PUBMED   34355142
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3145)
  AUTHORS   Oda,Y., Okada,T., Yoshida,H., Kaufman,R.J., Nagata,K. and Mori,K.
  TITLE     Derlin-2 and Derlin-3 are regulated by the mammalian unfolded
            protein response and are required for ER-associated degradation
  JOURNAL   J Cell Biol 172 (3), 383-393 (2006)
   PUBMED   16449189
REFERENCE   7  (bases 1 to 3145)
  AUTHORS   Lilley,B.N. and Ploegh,H.L.
  TITLE     Multiprotein complexes that link dislocation, ubiquitination, and
            extraction of misfolded proteins from the endoplasmic reticulum
            membrane
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14296-14301 (2005)
   PUBMED   16186509
REFERENCE   8  (bases 1 to 3145)
  AUTHORS   Katiyar,S., Joshi,S. and Lennarz,W.J.
  TITLE     The retrotranslocation protein Derlin-1 binds peptide:N-glycanase
            to the endoplasmic reticulum
  JOURNAL   Mol Biol Cell 16 (10), 4584-4594 (2005)
   PUBMED   16055502
REFERENCE   9  (bases 1 to 3145)
  AUTHORS   Ye,Y., Shibata,Y., Yun,C., Ron,D. and Rapoport,T.A.
  TITLE     A membrane protein complex mediates retro-translocation from the ER
            lumen into the cytosol
  JOURNAL   Nature 429 (6994), 841-847 (2004)
   PUBMED   15215856
REFERENCE   10 (bases 1 to 3145)
  AUTHORS   Lilley,B.N. and Ploegh,H.L.
  TITLE     A membrane protein required for dislocation of misfolded proteins
            from the ER
  JOURNAL   Nature 429 (6994), 834-840 (2004)
   PUBMED   15215855
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC154874.9.
            
            On Apr 29, 2007 this sequence version replaced NM_024207.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043420.1, BC085490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN02415138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               AC154874.9         115541-115816       c
            277-388             AC154874.9         106833-106944       c
            389-453             AC154874.9         103398-103462       c
            454-480             AC154874.9         102447-102473       c
            481-576             AC154874.9         101883-101978       c
            577-629             AC154874.9         100816-100868       c
            630-740             AC154874.9         98895-99005         c
            741-3145            AC154874.9         92900-95304         c
FEATURES             Location/Qualifiers
     source          1..3145
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 24.06 cM"
     gene            1..3145
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
                     /note="Der1-like domain family, member 1"
                     /db_xref="GeneID:67819"
                     /db_xref="MGI:MGI:1915069"
     exon            1..276
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..388
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..453
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..480
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..576
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..629
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..740
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            741..3145
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2091..2096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
                     /note="hexamer: AATAAA"
     polyA_site      2111
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
     regulatory      2857..2862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2876
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
                     /note="major polyA site"
ORIGIN      
        1 gtcggtctcc gcctcctgca cagcggctgc gcctccactt tccctggcca agccggccgc
       61 ggagcgcggg gtgggcacgg gaggacgcgc ggcgctgcgc agccggtcac ctgacgggcg
      121 accatgtcgg acatcgggga ctggttcagg agcatcccgg ccatcacgcg ctactggttt
      181 gctgccaccg ttgctgtccc cttgatcggc aagctcggca tcatcagccc ggcctacttc
      241 ttcctctggc ccgaagcctt cctctatcgc ttccagatat ggaggccgtt cactgccacc
      301 ttttacttcc ccgtgggccc agggactgga tttctgtatt tggtcaattt atatttctta
      361 tatcagtatt ctactcggct tgaagcagga gcttttgacg ggaggccagc agactattta
      421 ttcatgcttc tctttaactg gatctgcatc gttattactg gcttagcaat ggatatgcag
      481 ctgctgatga tccctctgat catgtcagtg ctctacgtct gggcccagct gaacagagac
      541 ctgatcgtgt cgttctggtt cggaacgcga tttaaggcct gttacttacc ttgggttatc
      601 cttggattca actatatcat tggaggctcg gtgatcaatg agctcattgg aaaccttgtc
      661 ggccatcttt atttcttcct gatgttcaga tacccaatgg acttgggagg aaggaatttt
      721 ctgtccacac ctcagttttt gtaccgctgg ctacccagta ggagaggagg ggtgtcagga
      781 tttggtgtgc cccctgctag catgaggcga gctgctgatc agaatggcgg aggcgggaga
      841 cacaactggg gccagggctt ccgacttgga gaccagtgag gggcagccct ggcctgctca
      901 ccagccatgc cgagcagatg acagtctcct cccagtgctg ggcatgctta gtggccgagc
      961 tcttgctgcc gctcttggac ctgacccaca ctgaatgtag tctttcagta caagacacat
     1021 ttttaagtcc tcaaggaaaa tacaagtgtt cctcaagttt catgattctc attcaagtcc
     1081 ttactgctat gaagaacaaa tatcagctgt gcagatttca aaactgactc attttctggt
     1141 gtcttctctt cctccccttc catctgaata atgagctggg caggaggggt tggttaacca
     1201 aatccagtca aagaaccctt tcctctcact catgtcccca gagttgcagc tagagttgtc
     1261 cacagaaggg ttttgccttt gacaaacttg ctgacttttg ccaaagcttg gtcacaaaga
     1321 gctgcttcac acatggctct cggccatcac aagcaggact gtaacagtaa ggagaagatg
     1381 gagcagctga ggaagctctt cctctgctgt ggggcctgca tccgcctgtc cgcagtgccg
     1441 ccatttgccg ccttctcaga tattcatacc caaaggcacc actgagtcag tggtggccca
     1501 gactgggagt gatgagggtt aggactcgtt gctaggcact tttctcctct gagccatgtg
     1561 atcagaacca tagtggagtt gctcctgaca caggatgggt ttaaataccg cgatcccctt
     1621 gggtttcttc cgaggggtga actgactgtg tgcccagagc atttgtgctg cgctgtgttg
     1681 tggtaggagg ttccagatca cactggccag acacacgtcc ctggaggcaa gcttcgggac
     1741 actgattccg ttccatcctc gttgcggatg tgtgttcacc gagtcggtgg agaaaagagt
     1801 gtcaggctct aaattttttg ttcattgttt tttgtcccag gccttttctg gtcgagtgtt
     1861 tgtgttaatg gcaagggaag tacaactcct cagatgtgtg tcgatcagtt tttaaggcta
     1921 atagaggcac atctgaatga gtcactcata attagaggtt ccaatagctt taggatcatt
     1981 tgcgtttgga ggtcattatt atcttgagtc atgcatgtat actctttgtg aatcagacct
     2041 gctccctttt cataggtggg cttttgccag cagagctcag cttatcacta aataaagttt
     2101 tctgaaggct acagtgcttt atatagttac tttatgttgt cattctgaaa tcaggctgct
     2161 ggccgcagtg tggtgtagct ggtatgctct gaatgatgtc tgaaggtttt tgctacttgg
     2221 gtttttcctt tgaggcaatg tgctctaaca gtgtgacttg tctttctctg cgcattaaaa
     2281 ctgtgatgta tgttatatta ggaaggggga gtttgaaaaa gagctctccc tttctccata
     2341 tttaatttat gtgattaaac tgtcgggtgg agagaggctg accctgagcc gcctggttct
     2401 cctgccgacc cgaggctgtg ataaaatgtg tttgtctaag atccacaagc cgatctccct
     2461 gtgccggtgc ctgtgcactt ctgtgcaagg aaggtggaga ctcaccttcg gaaaggactg
     2521 ccacttgagc gagcgagaga ttattctaat gtcctggtac ccggctggct tctgggagga
     2581 ctggcttttc gaagggtctg caagaatgca gaacttttct gtacaaggca gatgttcata
     2641 acagtttttc ccctggacct gattaggaag ctgataactt tattatcctt ccaggatagt
     2701 tttaccaaag tgagccggtt ttgagtgttg acttcacaag gtaagaattc atagtgggtt
     2761 ctcttcatga atgtgaaaaa acaaacaaac aaaccttatt ttgtacagac agctttcctt
     2821 tttgtaacta atccttttta ctggtaaata ttgtaaatta aaatgtgcaa cttgaaggct
     2881 gtctgtgtta agtttccgta cctttgcggt ggtgtgttat atgatggaat ctatgtcact
     2941 gccttcaccg ggtcggtttt atgtgatctc cagtagttta tgactagcag gacagcaagc
     3001 ctttttgtat gtgattggtg ctcacgtatt agagaatgtc tgaattcctg gaagaaatca
     3061 gtactgaggt ttcctctgtg tgtgtgcacg cgcctgaacc tgcctgaggg tgtgggtgtt
     3121 ggtgtgggga gagagtgtgt gaggg
//
