LOCUS       NM_145980               1317 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus DEPP1 autophagy regulator (Depp1), transcript variant
            1, mRNA.
ACCESSION   NM_145980
VERSION     NM_145980.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1317)
  AUTHORS   Guo,F., Zhu,Y., Han,Y., Feng,X., Pan,Z., He,Y., Li,Y. and Jin,L.
  TITLE     DEPP Deficiency Contributes to Browning of White Adipose Tissue
  JOURNAL   Int J Mol Sci 23 (12), 6563 (2022)
   PUBMED   35743009
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1317)
  AUTHORS   Li,W., Ji,M., Lin,Y., Miao,Y., Chen,S. and Li,H.
  TITLE     DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism
            partly via ROS-induced FGF21
  JOURNAL   FASEB J 32 (10), 5459-5469 (2018)
   PUBMED   29702025
  REMARK    GeneRIF: Hepatic overexpression of DEPP in mice promotes fatty acid
            oxidation and ketogenesis and suppresses lipogenesis and
            gluconeogenesis, which is partly mediated by FGF21 induced by
            elevated cellular ROS levels.
REFERENCE   3  (bases 1 to 1317)
  AUTHORS   Wang,Y., Wu,B., Lu,P., Zhang,D., Wu,B., Varshney,S., Del
            Monte-Nieto,G., Zhuang,Z., Charafeddine,R., Kramer,A.H.,
            Sibinga,N.E., Frangogiannis,N.G., Kitsis,R.N., Adams,R.H.,
            Alitalo,K., Sharp,D.J., Harvey,R.P., Stanley,P. and Zhou,B.
  TITLE     Uncontrolled angiogenic precursor expansion causes coronary artery
            anomalies in mice lacking Pofut1
  JOURNAL   Nat Commun 8 (1), 578 (2017)
   PUBMED   28924218
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1317)
  AUTHORS   Zhang,Z. and Zhou,B.
  TITLE     Accelerated coronary angiogenesis by vegfr1-knockout endocardial
            cells
  JOURNAL   PLoS One 8 (7), e70570 (2013)
   PUBMED   23894673
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1317)
  AUTHORS   Red-Horse,K., Ueno,H., Weissman,I.L. and Krasnow,M.A.
  TITLE     Coronary arteries form by developmental reprogramming of venous
            cells
  JOURNAL   Nature 464 (7288), 549-553 (2010)
   PUBMED   20336138
REFERENCE   6  (bases 1 to 1317)
  AUTHORS   Kuroda,Y., Kuriyama,H., Kihara,S., Kishida,K., Maeda,N., Hibuse,T.,
            Nishizawa,H., Matsuda,M., Funahashi,T. and Shimomura,I.
  TITLE     Insulin-mediated regulation of decidual protein induced by
            progesterone (DEPP) in adipose tissue and liver
  JOURNAL   Horm Metab Res 42 (3), 173-177 (2010)
   PUBMED   19937567
  REMARK    GeneRIF: DEPP is a novel insulin-regulatory molecule expressed
            abundantly in insulin-sensitive tissues including white adipose
            tissue and liver.
REFERENCE   7  (bases 1 to 1317)
  AUTHORS   Shin,D. and Anderson,D.J.
  TITLE     Isolation of arterial-specific genes by subtractive hybridization
            reveals molecular heterogeneity among arterial endothelial cells
  JOURNAL   Dev Dyn 233 (4), 1589-1604 (2005)
   PUBMED   15977181
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078806.1, AK087284.1 and BB683812.1.
            
            On Oct 29, 2009 this sequence version replaced NM_145980.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078806.1, BC031533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AK078806.1         2-70
            70-162              AK087284.1         71-163
            163-1258            AK078806.1         165-1260
            1259-1317           BB683812.1         382-440
FEATURES             Location/Qualifiers
     source          1..1317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.83 cM"
     gene            1..1317
                     /gene="Depp1"
                     /gene_synonym="8430408G22Rik; Depp; Fseg"
                     /note="DEPP1 autophagy regulator"
                     /db_xref="GeneID:213393"
                     /db_xref="MGI:MGI:1918730"
     exon            1..162
                     /gene="Depp1"
                     /gene_synonym="8430408G22Rik; Depp; Fseg"
                     /inference="alignment:Splign:2.1.0"
     exon            163..1317
                     /gene="Depp1"
                     /gene_synonym="8430408G22Rik; Depp; Fseg"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..785
                     /gene="Depp1"
                     /gene_synonym="8430408G22Rik; Depp; Fseg"
                     /note="fat-specific expressed; protein DEPP; decidual
                     protein induced by progesterone; fat-specific-expressed
                     gene protein"
                     /codon_start=1
                     /product="protein DEPP1"
                     /protein_id="NP_666092.1"
                     /db_xref="CCDS:CCDS51882.1"
                     /db_xref="GeneID:213393"
                     /db_xref="MGI:MGI:1918730"
                     /translation="MRSRLLLPVPHLPTIREMSEELSHGAAGQEPPASPSLDDYVRCI
                     CQLAQPTSVLDKVTAQSRPNRPSRPAWTREKRRQAESPGDSSLCVSSLQPTLPSPGTD
                     NPLDWLFGKSQGEQADGRGRPNRTGSSDPWDVPRQMGKDTGRLCEARVPEHSLGRKPG
                     PRHQTSDLKSWTSRKSCRALASVSSSRPSSILGTLYLHLPVIHEL"
     regulatory      1238..1243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Depp1"
                     /gene_synonym="8430408G22Rik; Depp; Fseg"
                     /note="hexamer: CATAAA"
     polyA_site      1264
                     /gene="Depp1"
                     /gene_synonym="8430408G22Rik; Depp; Fseg"
                     /note="major polyA site"
ORIGIN      
        1 agaccgcaca ggggaagaaa ccacagcaca tcgtcctgac tgtcctcttc ccagggacca
       61 agagctagag acccggctgt gactgcccgc ctctggggct tcctttagag gagacagtct
      121 ttacccatct agactcctgc caccctgact gctgacttac agcagctatg aggtcccggc
      181 ttctgctgcc cgtgccccat ttgccaacga ttcgggaaat gtcagaagag ctgtcacatg
      241 gggcagctgg gcaggaaccc ccagcgtccc ccagcctgga tgactacgtc aggtgtatct
      301 gtcagctggc acagcccacc tcagtgctgg acaaggtcac agcccagagc cgtcccaaca
      361 gaccctcccg gccagcctgg actcgagaga agaggcgcca ggccgagtct ccaggagaca
      421 gctctctttg cgtcagcagc ctgcagccca cactgccctc tcccggcact gacaaccctc
      481 tggactggct ctttgggaag tcacagggag agcaggcaga tgggagaggt cgacccaaca
      541 ggactggttc ttcagatccc tgggatgtgc ccagacagat gggcaaggac acggggagac
      601 tctgtgaggc cagggtacct gagcactctc tgggaagaaa accagggccc aggcaccaga
      661 cctccgacct gaaaagctgg acttctagaa agtcctgccg ggccttagcg tccgtctcca
      721 gctctcgccc cagcagtatc ctaggtactc tctatttgca cctcccagtg atccatgaac
      781 tctaactcct accccaggaa aaacccataa aggatatggt gggcccctgt gctctctcta
      841 gctttcctct cctgtggtgg acacttcctg gcaggtctgc agggactggg caattcctag
      901 tgagacccat cctctaaaga gcgatgacag tctagctccc acaatgcgac tttgactggt
      961 accttttgtg tctggctggc ccgtgacttt gaagcgactc agtgtcctct atgtcttggt
     1021 tttatcatga ctaaagtgag tgtaggtgga gtgaccacct cccagattgc tctaatgagg
     1081 agatgcgggc tgtactctgg gtggctgcca cagtctcatg agaaaccaag ggcaaaggac
     1141 caaggaaaag ggtctcaggc ccctaaagca gtggctttca accatcctaa tgttgtgacc
     1201 ttttaataca gttcctcatg ttgtgtgacc ccccaaccat aaaatgattt ttgtttctac
     1261 ttcataactg caattttgtt actgttacga atcatggtgt aaatctttga gctttcc
//
