LOCUS       NM_001404336            8222 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus DEP domain containing 5 (Depdc5), transcript variant
            17, mRNA.
ACCESSION   NM_001404336 XM_030254552
VERSION     NM_001404336.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8222)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8222)
  AUTHORS   Nguyen,L.H., Xu,Y., Nair,M. and Bordey,A.
  TITLE     The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have
            convergent and divergent impacts on cortical neuron development and
            function
  JOURNAL   Elife 12, 91010 (2024)
   PUBMED   38411613
  REMARK    GeneRIF: The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1
            have convergent and divergent impacts on cortical neuron
            development and function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8222)
  AUTHORS   Tao,L., Song,P., Shao,L., Gao,H., Ji,K., Ren,Y., Wang,F. and
            Wang,M.
  TITLE     miR-129-2-3p inhibits colon cancer cell proliferation by
            down-regulating the expression of BZW1
  JOURNAL   Arab J Gastroenterol 25 (1), 42-50 (2024)
   PUBMED   38220481
  REMARK    GeneRIF: miR-129-2-3p inhibits colon cancer cell proliferation by
            down-regulating the expression of BZW1.
REFERENCE   4  (bases 1 to 8222)
  AUTHORS   Kao,H.Y., Yao,Y., Yang,T., Ziobro,J., Zylinski,M., Mir,M.Y., Hu,S.,
            Cao,R., Borna,N.N., Banerjee,R., Parent,J.M., Wang,S.,
            Leventhal,D.K., Li,P. and Wang,Y.
  TITLE     Sudden Unexpected Death in Epilepsy and Respiratory Defects in a
            Mouse Model of DEPDC5-Related Epilepsy
  JOURNAL   Ann Neurol 94 (5), 812-824 (2023)
   PUBMED   37606181
  REMARK    GeneRIF: Sudden Unexpected Death in Epilepsy and Respiratory
            Defects in a Mouse Model of DEPDC5-Related Epilepsy.
REFERENCE   5  (bases 1 to 8222)
  AUTHORS   Zhang,X., Li,S., Malik,I., Do,M.H., Ji,L., Chou,C., Shi,W.,
            Capistrano,K.J., Zhang,J., Hsu,T.W., Nixon,B.G., Xu,K., Wang,X.,
            Ballabio,A., Schmidt,L.S., Linehan,W.M. and Li,M.O.
  TITLE     Reprogramming tumour-associated macrophages to outcompete cancer
            cells
  JOURNAL   Nature 619 (7970), 616-623 (2023)
   PUBMED   37380769
REFERENCE   6  (bases 1 to 8222)
  AUTHORS   Dibbens,L.M., de Vries,B., Donatello,S., Heron,S.E., Hodgson,B.L.,
            Chintawar,S., Crompton,D.E., Hughes,J.N., Bellows,S.T., Klein,K.M.,
            Callenbach,P.M., Corbett,M.A., Gardner,A.E., Kivity,S., Iona,X.,
            Regan,B.M., Weller,C.M., Crimmins,D., O'Brien,T.J.,
            Guerrero-Lopez,R., Mulley,J.C., Dubeau,F., Licchetta,L.,
            Bisulli,F., Cossette,P., Thomas,P.Q., Gecz,J., Serratosa,J.,
            Brouwer,O.F., Andermann,F., Andermann,E., van den Maagdenberg,A.M.,
            Pandolfo,M., Berkovic,S.F. and Scheffer,I.E.
  TITLE     Mutations in DEPDC5 cause familial focal epilepsy with variable
            foci
  JOURNAL   Nat Genet 45 (5), 546-551 (2013)
   PUBMED   23542697
REFERENCE   7  (bases 1 to 8222)
  AUTHORS   Licatalosi,D.D., Yano,M., Fak,J.J., Mele,A., Grabinski,S.E.,
            Zhang,C. and Darnell,R.B.
  TITLE     Ptbp2 represses adult-specific splicing to regulate the generation
            of neuronal precursors in the embryonic brain
  JOURNAL   Genes Dev 26 (14), 1626-1642 (2012)
   PUBMED   22802532
REFERENCE   8  (bases 1 to 8222)
  AUTHORS   Revil,T., Gaffney,D., Dias,C., Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Alternative splicing is frequent during early embryonic development
            in mouse
  JOURNAL   BMC Genomics 11, 399 (2010)
   PUBMED   20573213
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8222)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   10 (bases 1 to 8222)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108773.9 and AC122203.4.
            
            On Apr 9, 2022 this sequence version replaced XM_030254552.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR9219380.81050.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849381, SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC108773.9         139988-140102
            116-418             AC108773.9         140291-140593
            419-541             AC108773.9         140858-140980
            542-629             AC108773.9         144255-144342
            630-676             AC108773.9         145102-145148
            677-762             AC108773.9         151563-151648
            763-846             AC108773.9         153351-153434
            847-896             AC108773.9         154909-154958
            897-975             AC108773.9         169656-169734
            976-1037            AC108773.9         172161-172222
            1038-1107           AC108773.9         174160-174229
            1108-1180           AC108773.9         175273-175345
            1181-1284           AC108773.9         177737-177840
            1285-1359           AC108773.9         178111-178185
            1360-1494           AC108773.9         180058-180192
            1495-1556           AC108773.9         180556-180617
            1557-1630           AC108773.9         180740-180813
            1631-1700           AC108773.9         186738-186807
            1701-1737           AC108773.9         188490-188526
            1738-1858           AC108773.9         189381-189501
            1859-2079           AC108773.9         194206-194426
            2080-2283           AC108773.9         200443-200646
            2284-2419           AC108773.9         203171-203306
            2420-2514           AC108773.9         204126-204220
            2515-2580           AC108773.9         210231-210296
            2581-2764           AC108773.9         213802-213985
            2765-2925           AC108773.9         214426-214586
            2926-3043           AC108773.9         219513-219630
            3044-3211           AC108773.9         220252-220419
            3212-3431           AC108773.9         221204-221423
            3432-3565           AC122203.4         89746-89879
            3566-3671           AC122203.4         98965-99070
            3672-3737           AC122203.4         102393-102458
            3738-3889           AC122203.4         107744-107895
            3890-3967           AC122203.4         110843-110920
            3968-4100           AC122203.4         111751-111883
            4101-4209           AC122203.4         116929-117037
            4210-4437           AC122203.4         118429-118656
            4438-4607           AC122203.4         122497-122666
            4608-4779           AC122203.4         126971-127142
            4780-4840           AC122203.4         130048-130108
            4841-4923           AC122203.4         133854-133936
            4924-8222           AC122203.4         134051-137349
FEATURES             Location/Qualifiers
     source          1..8222
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.35 cM"
     gene            1..8222
                     /gene="Depdc5"
                     /note="DEP domain containing 5"
                     /db_xref="GeneID:277854"
                     /db_xref="MGI:MGI:2141101"
     exon            1..115
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            116..418
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            419..541
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            542..629
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            630..676
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            677..762
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            763..846
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            847..896
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            897..975
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             921..5216
                     /gene="Depdc5"
                     /note="isoform 11 is encoded by transcript variant 17; DEP
                     domain-containing protein 5; GATOR complex protein DEPDC5;
                     GATOR1 complex protein DEPDC5"
                     /codon_start=1
                     /product="GATOR1 complex protein DEPDC5 isoform 11"
                     /protein_id="NP_001391265.1"
                     /db_xref="GeneID:277854"
                     /db_xref="MGI:MGI:2141101"
                     /translation="MVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCS
                     HEVTVVLFSRTFYDAKSIDEFPEINRASIQEDHKGRFYEDFYKVVVQNERREEWTSLL
                     VTIKKLFIQYPVLVRLEQAGGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRT
                     GQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSV
                     PRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKSASEKTKNGRDTSLGT
                     PKESENTLPIQVDYDAYDAQVFRLPGPSRAQRLATCRSVREQENHSRKSASSCDVSSS
                     PSLPSRALPTEEVRSQASDDSSLGKSTNILMIPNPHLHQYEVSSSLGYTSTRDVLENM
                     IEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMH
                     TFPVGPSGEAIQIHHQTRQNMAELQGSRQRDPTHSSAELLELAYHEAAGRHSTSRQPG
                     DSMSLNFSGTEELSVSLLSNSSTGVNPRTQNKDSLEDSVSTSPDPILTLSAPPVVPGF
                     CCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADMDRRDEEGVQMT
                     AQQVFEEFICQRLMQGYQIIVQPKTQKPNTTVPPPLSSSPLYSRGLVSRNRPEEEGQY
                     WLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVDFCH
                     ERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEVHCDI
                     YGDKPRADEDEWQLLDGFIRFVEGLNRIRRRHRSDRMIRKGTAMKGLQMTGPISAHSL
                     EAAGPPVGKKGTSALSALLEMEASQKSLGEQQTTVHGKSSTQPAENSSVAMTPTYVDS
                     PRKDGAFFMEFVRSPRTASSAFYPQASVDQTAPLVLDSTSLGVSTGQPMDRGNNQTFG
                     NSQNIEQAFPSANSGDYSSQQHVASSLTSSSTLVEILEAMKHPSTGVQLLSEQKGLSP
                     CCFISAEVVHWLMNNVEGVQTQAMGIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKI
                     VMDKEPERVAMQQPSAPWYTAGADDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPS
                     RPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHG
                     NFSLNAAFEIKLHWMAVTATVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDP
                     LRAQLFIPLNLSCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSVSAF
                     NFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAY
                     NTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFWTNCLEKMHASAP"
     exon            976..1037
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1107
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1180
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1284
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1359
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1494
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1556
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1630
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1700
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1737
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1858
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2079
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2283
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2419
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2514
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2580
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2764
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2925
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3043
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3211
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3431
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3565
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3671
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3672..3737
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..3889
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3890..3967
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3968..4100
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4101..4209
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4437
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4438..4607
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4608..4779
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4780..4840
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4841..4923
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4924..8222
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5634..5639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Depdc5"
                     /note="hexamer: AATAAA"
     polyA_site      5655
                     /gene="Depdc5"
                     /note="major polyA site"
     regulatory      7975..7980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Depdc5"
                     /note="hexamer: AATAAA"
     polyA_site      8003
                     /gene="Depdc5"
     regulatory      8191..8196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Depdc5"
                     /note="hexamer: AATAAA"
     polyA_site      8222
                     /gene="Depdc5"
                     /note="major polyA site"
ORIGIN      
        1 gactcggggc ggagcctcgg gagcggcgcg ggctcaggtg agcgctcttc ggtggtgctg
       61 tctgtctggt tcctagagcc ctggtgcgga agctgcgcga actgtggggg ctcagttccc
      121 cgtgtgacct tggaccagtc tttctctcac caagcttccc ggaccgcagc ggtgaaatgg
      181 aggcaggacg gtccgctgag agttggtacc agtagagggg tcggcaagga aaccgcagcc
      241 ttcctcagtt ctcttttccc caggacattg ttagtggacc gcgagtcatg ggagtgcata
      301 acagttcgag tgaccttggg cgaatccctt gttttgacgt tcctctactt atgtgatgga
      361 ctaacctctt cgaatatccc tgtactattt tggtgttcct gatgcagaca aaaacaagta
      421 gcaggaaagc aagatgactt ccctgctcca agattggaac agctgaagaa atcacaagac
      481 aaaatgagaa ccacaaaggt ctacaaactt gtcatccaca agaagggctt tgggggcagt
      541 gatgatgagc tagtcgtgaa ccctaaagta tttcctcaca tcaaacttgg agacattgtg
      601 gagattgctc accccaatga tgagtacagt cctttgcttt tgcaagtcaa gtcgcttaag
      661 gaagatttac agaaagaaac tatcagtgtg gaccagactg tgactcaagt attccggcta
      721 agaccttatc aagatgtcta tgtgaatgtt gtagacccca aggatgtgac tcttgacctg
      781 gtggaattga cttttaagga tcagtatatt ggccgtgggg atatgtggcg actaaagaaa
      841 agtttggtga gcacctgtgc ctatatcact caaaaagtgg aatttgctgg catcaggtgg
      901 tgttccgttc tacgtcggct atggtttaca tatttattca gatgagctgt gaaatgtggg
      961 attttgatat ttatggggat ctgtactttg agaaagctgt gaacggtttc ctcgccgacc
     1021 tgtttactaa atggaaggag aagaactgta gtcatgaagt gactgtggtc ctgttttcca
     1081 gaactttcta tgatgcaaaa tctattgatg aatttcctga aataaaccga gcttcaattc
     1141 aagaggatca caaagggaga ttctatgagg acttttacaa agtggtggtg cagaatgaga
     1201 gaagggaaga gtggacttca ctcctcgtga ccattaaaaa actcttcatc cagtatccag
     1261 tgttggtgcg actggaacag gcagggggct ttcctcaagg agacaattct acctcagcac
     1321 aaggaaacta cctagaggcc atcaacttgt cattcaatgt gtttgacaag cactacatca
     1381 accgaaactt tgaccgaact gggcagatgt ctgtggtgat cacgccgggg gtgggtgtct
     1441 ttgaagtgga ccgcctactc atgatcttga ccaagcagcg gatgattgat aatggaattg
     1501 gtgtggactt agtgtgcatg ggagagcagc cactacatgc tgtgccatta ttcaagctac
     1561 ataaccggag tgttccgagg gattctcgac tgggtgatga ttataatatt cctcactgga
     1621 taaaccatag tttctacaca tccaaaagcc agctcttttg taacagtttc actccacgga
     1681 taaaactagc aggaaagaag tctgcctctg agaaaaccaa aaatggtcgt gatacatctc
     1741 tcgggactcc aaaggaatct gaaaacaccc ttcccatcca agtagattat gatgcctacg
     1801 atgctcaagt gttcaggctg cctggcccat cccgggctca gcgcctcgcc acctgcaggt
     1861 ctgtgagaga acaggagaat cacagtcgca aaagtgcaag ctcctgtgat gtctcatcca
     1921 gcccttccct gccaagccgt gcactgccca ctgaggaagt gaggagccag gcttctgatg
     1981 acagctccct gggcaagagc accaacatcc tgatgatccc taacccccac ctgcaccagt
     2041 atgaagtcag cagctcactg ggctacacca gcacccgaga tgtcctggag aacatgatag
     2101 aacccccaca gagggactcc agtgcaccag gaaggttcca tgtgggtagt gcagagtcca
     2161 tgctccatgt ccgacctgga ggatacacgc ctcagagagc gctgattaac cccttcgccc
     2221 cctcgaggat gcccatgaag ctcacctcca acagaaggcg ctggatgcac acttttcctg
     2281 taggcccatc tggagaggcc atccagatcc atcatcagac ccggcaaaac atggcagagc
     2341 tgcagggcag caggcagagg gaccctaccc actcctctgc agagctgttg gagttggcat
     2401 accatgaagc tgccgggagg cacagcactt cccgccagcc tggtgacagc atgtccttga
     2461 acttcagtgg aacggaagag ctttctgtca gcctgcttag caacagcagt acaggtgtga
     2521 atcctaggac ccagaacaag gactccctag aggacagtgt ttctacctct ccagacccaa
     2581 ttctgacact gtctgctccc cctgtagtgc caggcttctg ttgcacagtt ggagtggatt
     2641 ggaagtctct tactactcct gcatgccttc ccctcaccac tgactacttc ccggaccgtc
     2701 agggcctgca gaatgactac acagagggct gctatgatct cctcccagaa gcagacatgg
     2761 acaggaggga tgaggagggt gttcaaatga cagcccagca agtgtttgaa gagttcatct
     2821 gccagcgtct catgcagggt taccaaatca tagtacagcc aaagacccag aaacccaaca
     2881 ccacagtccc acccccattg agcagtagcc cactctatag cagaggcctt gtgtcccgaa
     2941 atcgccctga ggaggaaggc cagtattggt taagtatggg cagaactttc cataaggtga
     3001 cactcaagga caagatgatc acagtaactc gttaccttcc caagtaccct tatgaatctg
     3061 cccagatcca ttacacctac agcctctgcc cttcccactc tgactcggag tttgtctcct
     3121 gttgggtgga tttctgccac gaacggctcg aggaatacaa gtggaattac ttagatcagt
     3181 atatttgttc tgctggctct gaagacttca gcttaatcga gtctctgaag ttctggagaa
     3241 cccgattttt actactgcca gcctgtgtta ctgccaccaa gcgcatcaca gaaggggagg
     3301 tgcactgtga catctatggg gacaaacccc gtgcagatga agatgagtgg cagcttctag
     3361 atggctttat tcgctttgta gagggcttaa atcgcatccg caggcgccac cgctcagacc
     3421 gcatgattcg gaaggggact gccatgaaag gcttgcagat gaccgggccc atctctgcac
     3481 actctctcga ggcagcaggc cctccagtcg gcaagaaagg aacctcagct ctgtctgccc
     3541 tgctggagat ggaagctagt cagaagagcc taggagaaca gcagacgact gtgcacggaa
     3601 aaagctccac tcagccagct gagaacagca gtgttgccat gactcccacc tatgtggaca
     3661 gcccacgcaa ggacggggcc ttctttatgg agtttgtccg cagcccacgc acagcatcat
     3721 ctgccttcta ccctcaggca tctgtggacc aaacagctcc tctggtgtta gacagcacca
     3781 gtttaggggt cagcacaggc cagcccatgg atagaggcaa caaccagacc tttgggaact
     3841 cccagaacat agaacaggcc tttccctctg caaactctgg tgactacagc tctcagcagc
     3901 atgtagcaag ctctctaaca tcgtcttcta ccctggtgga gattctggaa gccatgaagc
     3961 atccctcgac aggagtccag ctgctgtctg aacagaaggg cctttcaccg tgctgcttca
     4021 tcagtgctga ggtcgtacac tggttgatga acaacgtgga gggggtccag acgcaggcga
     4081 tgggcataga catcatgcag aaaatgctgg aagagcagct cataacgcat gcatctggtg
     4141 aagcatggcg gaccttcatc tatggcttct atttctacaa gatagtaatg gacaaagaac
     4201 cggaaagagt ggctatgcag cagccctctg ccccctggta cacagcagga gcggatgact
     4261 ttgccagctt ccaacgcaag tggtttgagg tggcctttgt ggcagaagag cttgtgcact
     4321 ctgagattcc tgccttcctc ctgccctggc tacctagccg gccagcctct tatgcaagca
     4381 gacacagctc ctttagccga agttttggag gacggagcca ggcagctgcg ctgttagctg
     4441 ctactgtccc agagcagagg actgtgaccc tggatgttga tgtgaacaac cgaacggacc
     4501 ggctggaatg gtgcagctgt tactaccatg gaaacttctc tctcaatgcc gcctttgaga
     4561 tcaagctaca ctggatggca gtgactgcca cagtgctgtt tgagatggtc caaggttggc
     4621 atcgaaaagc tacctcctgt ggcttcttgc tggtcccagt tttggagggt ccttttgctc
     4681 tgcccagtta cctgtatggt gatcccctga gggcccagct cttcatcccg ctcaacctca
     4741 gctgcttgct caaggagggc agcgagcacc tgttcgatag ctttgaacca gagacatatt
     4801 gggatcgaat gcatcttttc caggaagcca ttgcacacag gtttggattt gtgcaagata
     4861 aatattctgt ctccgctttt aacttccctg ctgagaataa gccacagtat atccatgtca
     4921 caggaacggt gttccttcag ctgccgtact ccaaacgcaa gttttcaggg cagcagcggc
     4981 ggcgacggaa ctctaccagc tccaccaacc aaaacatgtt ctgtgaggag cgggttggct
     5041 acaactgggc ctacaacacc atgctgacca agacatggcg ctctagtgcc acaggggacg
     5101 agaagtttgc tgatcggctg ctgaaggact tcacggattt ctgcatcaac cgtgacaacc
     5161 gactggtcac gttctggaca aactgcctgg agaagatgca tgccagtgct ccatgaagcc
     5221 aggctgcttc tcttaagaga ggctgtgggt atgctggagc tggccttccg gtcaggctct
     5281 gggcagcagg tgtcaggctg ctcctatcag tgagtggggc cactgctgat atttggcctc
     5341 tgcacaagtg tgagtgaaga gaaagattgg aagcagctgc tgccgctacc gccaaccaaa
     5401 tcttgccaat cctgtccctg aagcaggggg aggcacagat tgtccgtggg agtgagtcag
     5461 tgtctgggag tggggtaggc agcttccatt agggtccttt tccttcacca gcagtgggat
     5521 attcggaaca gaacctcctg ctttctgccc aagagtgtgt gtatgaggta aatctgtggc
     5581 ataatgtacc attggctcac accagctgta catatgtgta catagcagaa tctaataaag
     5641 ccctccctcc ctccctccct ccctccctct ctccctcccc cggtgtctgt tcccagcctt
     5701 gttggtagcc aggccagtca ggtcacctca ggtggccaga gggcttcagg acacactggt
     5761 cttgagtctg gctctgagct ggcttgatag gtttcttttt caaagtcctt gggcaagaac
     5821 aaggatcttc tggacaggac aggactactg agcagacagt acagtacagt atagtaagaa
     5881 gctctaggct tgtcatgtca gaaatatgcc tcgttaagtg gatgggccag ctcagggaag
     5941 cagacatcac ggcattccct acacgtccag tgagtgcttt tcgctctaga ctgctcaggg
     6001 aaggcaaaga ccgaagacca tgactactgc ttcctcctat actagagtta atcacacacc
     6061 ccattgatgt accttttttt tttaaagatt ttattcatgt atttggtata tatgataaat
     6121 acactgtagc tatcttcaga caccagaaca gggcatcgga tcccattaca gatggttctg
     6181 agccaccatg tgcttgctgg gatttgaact caggacctct gggagagcag tcagtgctct
     6241 taacctctga gccatctctc cagccccttg atgtacctta ccttctttac ctctcctggg
     6301 ccctatgtac aactccaggt ccagccttcc ttgtttctct tctctccagg aaacctaact
     6361 tgtctctggt tcatcctact gcactctcct gggaaactag ggttttgttg ggtttttgtt
     6421 ttttaaaaaa actactccaa gcaggtacag cagcttcctg taataccagt gtttaggaga
     6481 ctgaggtagg ctggcctcca tagtgtgtac ttagcaaagt tgagctttac aatgagactg
     6541 tctcagaaag tctcactttg gggctggaaa gatgactcag ttaagagcat ttgactgatc
     6601 ttacagagca cctgagttca gtgccagcgt gaggtcactc acagccatcc atacctggag
     6661 ttccagggga ctccacaccc tcttctgacc ttcttttgca tcgggcacac atgtggtaca
     6721 tatacatata tccacatata taatacgtgc aagcaaagca ctcacataaa acaaaaataa
     6781 atcttaaaat caaacagaca gctccactcc atttagactt gccacttaga attctcttga
     6841 ctacctgact ccaaaaacct tcagtatggt gctggagatg cagatcagag ccagcatagc
     6901 aggcaccagg ctctggactc aattcacaac actacaaaag taaaaccaag tattgtcttg
     6961 cctagtgggc tgttctcaca gctgccttgg gagttgtgca ttcccttgaa ccagctcaaa
     7021 tcttctgcgt acactgttcc aagctgcact catcgggaac ttctaatcac agctattaag
     7081 tcctgtatgt aaaggttttt tttttttaaa ggtgtgtgtg tgttgtgtgt gtgtatgggt
     7141 gcatcgttag gtcaaaagag aggacatcag atcccctgga actagagtct agacggtcgt
     7201 gagccaccat ttgggtgctg ggttgggaac ctgggtcctc ccagagctcc aagtgctctt
     7261 actggctgag ccatgtccct agctcctgca tgtgaagctt ttgagagagt aagctgttaa
     7321 cgtgtgaaag tgtgatccat gggaagtaag cctaaaaaaa acttagcttc acacacacac
     7381 atacttttct tcccatgaat attgctcctc cttgatgtca gccttcttgt cagtgggagc
     7441 tgtctggagt aactgggggg ttgaggcagg tacagctgga ctttgtggag tgtacctgta
     7501 accgcagcac ttgagaagac taaaggagag ggaagaaggt tgctgtgatt ttgaggtcac
     7561 tccaggacac acacagtaag acactgtccc aagcaaataa gcacacacaa acaaaaagga
     7621 tgttttcgtt tgaaagagct tagtactgaa aagagagtaa atcaagttct cgttttccca
     7681 gatgggtatg ttcagggttc catgccagcc tcctctgtgg tcacagcagc tgttggccac
     7741 gccagaccgt gtgatctcgt gtggtcctgt tatccatcct atggagccat caattacccc
     7801 ttcacataca gtttttgtca tattccagag gtaacttgga agacatagaa aattacctgg
     7861 caggagttca actgatggaa taccaggtca cttgcctatc agctgtcctg agatgctcct
     7921 ggccttgagc tccagttcct gcagtctcta gcattccaga ttccaagctc aataaataaa
     7981 ggtgtttgcc attggtgatt taagttcagc tccccagacc tatatggtgg aaaggatcaa
     8041 ctccagaaag ttctctgatg gccacacaga tgttgtggta ctcatgtatc cacatatata
     8101 catacatgca taaatttaat tgaaaaattt taaatattaa gatctgttaa agttcactaa
     8161 agtggataga aaacagccgg agagaagcag aataaaggcc aatttattgt tctctacagc
     8221 ca
//
