LOCUS       NM_001404315            7956 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus DEP domain containing 5 (Depdc5), transcript variant
            7, mRNA.
ACCESSION   NM_001404315
VERSION     NM_001404315.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7956)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7956)
  AUTHORS   Nguyen,L.H., Xu,Y., Nair,M. and Bordey,A.
  TITLE     The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have
            convergent and divergent impacts on cortical neuron development and
            function
  JOURNAL   Elife 12, 91010 (2024)
   PUBMED   38411613
  REMARK    GeneRIF: The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1
            have convergent and divergent impacts on cortical neuron
            development and function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7956)
  AUTHORS   Tao,L., Song,P., Shao,L., Gao,H., Ji,K., Ren,Y., Wang,F. and
            Wang,M.
  TITLE     miR-129-2-3p inhibits colon cancer cell proliferation by
            down-regulating the expression of BZW1
  JOURNAL   Arab J Gastroenterol 25 (1), 42-50 (2024)
   PUBMED   38220481
  REMARK    GeneRIF: miR-129-2-3p inhibits colon cancer cell proliferation by
            down-regulating the expression of BZW1.
REFERENCE   4  (bases 1 to 7956)
  AUTHORS   Kao,H.Y., Yao,Y., Yang,T., Ziobro,J., Zylinski,M., Mir,M.Y., Hu,S.,
            Cao,R., Borna,N.N., Banerjee,R., Parent,J.M., Wang,S.,
            Leventhal,D.K., Li,P. and Wang,Y.
  TITLE     Sudden Unexpected Death in Epilepsy and Respiratory Defects in a
            Mouse Model of DEPDC5-Related Epilepsy
  JOURNAL   Ann Neurol 94 (5), 812-824 (2023)
   PUBMED   37606181
  REMARK    GeneRIF: Sudden Unexpected Death in Epilepsy and Respiratory
            Defects in a Mouse Model of DEPDC5-Related Epilepsy.
REFERENCE   5  (bases 1 to 7956)
  AUTHORS   Zhang,X., Li,S., Malik,I., Do,M.H., Ji,L., Chou,C., Shi,W.,
            Capistrano,K.J., Zhang,J., Hsu,T.W., Nixon,B.G., Xu,K., Wang,X.,
            Ballabio,A., Schmidt,L.S., Linehan,W.M. and Li,M.O.
  TITLE     Reprogramming tumour-associated macrophages to outcompete cancer
            cells
  JOURNAL   Nature 619 (7970), 616-623 (2023)
   PUBMED   37380769
REFERENCE   6  (bases 1 to 7956)
  AUTHORS   Dibbens,L.M., de Vries,B., Donatello,S., Heron,S.E., Hodgson,B.L.,
            Chintawar,S., Crompton,D.E., Hughes,J.N., Bellows,S.T., Klein,K.M.,
            Callenbach,P.M., Corbett,M.A., Gardner,A.E., Kivity,S., Iona,X.,
            Regan,B.M., Weller,C.M., Crimmins,D., O'Brien,T.J.,
            Guerrero-Lopez,R., Mulley,J.C., Dubeau,F., Licchetta,L.,
            Bisulli,F., Cossette,P., Thomas,P.Q., Gecz,J., Serratosa,J.,
            Brouwer,O.F., Andermann,F., Andermann,E., van den Maagdenberg,A.M.,
            Pandolfo,M., Berkovic,S.F. and Scheffer,I.E.
  TITLE     Mutations in DEPDC5 cause familial focal epilepsy with variable
            foci
  JOURNAL   Nat Genet 45 (5), 546-551 (2013)
   PUBMED   23542697
REFERENCE   7  (bases 1 to 7956)
  AUTHORS   Licatalosi,D.D., Yano,M., Fak,J.J., Mele,A., Grabinski,S.E.,
            Zhang,C. and Darnell,R.B.
  TITLE     Ptbp2 represses adult-specific splicing to regulate the generation
            of neuronal precursors in the embryonic brain
  JOURNAL   Genes Dev 26 (14), 1626-1642 (2012)
   PUBMED   22802532
REFERENCE   8  (bases 1 to 7956)
  AUTHORS   Revil,T., Gaffney,D., Dias,C., Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Alternative splicing is frequent during early embryonic development
            in mouse
  JOURNAL   BMC Genomics 11, 399 (2010)
   PUBMED   20573213
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 7956)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   10 (bases 1 to 7956)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108773.9 and AC122203.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.295683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC108773.9         139988-140024
            38-160              AC108773.9         140858-140980
            161-248             AC108773.9         144255-144342
            249-295             AC108773.9         145102-145148
            296-381             AC108773.9         151563-151648
            382-465             AC108773.9         153351-153434
            466-515             AC108773.9         154909-154958
            516-585             AC108773.9         163260-163329
            586-664             AC108773.9         169656-169734
            665-726             AC108773.9         172161-172222
            727-796             AC108773.9         174160-174229
            797-869             AC108773.9         175273-175345
            870-973             AC108773.9         177737-177840
            974-1048            AC108773.9         178111-178185
            1049-1183           AC108773.9         180058-180192
            1184-1245           AC108773.9         180556-180617
            1246-1319           AC108773.9         180740-180813
            1320-1389           AC108773.9         186738-186807
            1390-1426           AC108773.9         188490-188526
            1427-1547           AC108773.9         189381-189501
            1548-1768           AC108773.9         194206-194426
            1769-1972           AC108773.9         200443-200646
            1973-2108           AC108773.9         203171-203306
            2109-2203           AC108773.9         204126-204220
            2204-2269           AC108773.9         210231-210296
            2270-2453           AC108773.9         213802-213985
            2454-2614           AC108773.9         214426-214586
            2615-2732           AC108773.9         219513-219630
            2733-2900           AC108773.9         220252-220419
            2901-3120           AC108773.9         221204-221423
            3121-3254           AC122203.4         89746-89879
            3255-3360           AC122203.4         98965-99070
            3361-3426           AC122203.4         102393-102458
            3427-3471           AC122203.4         107569-107613
            3472-3623           AC122203.4         107744-107895
            3624-3701           AC122203.4         110843-110920
            3702-3834           AC122203.4         111751-111883
            3835-3943           AC122203.4         116929-117037
            3944-4171           AC122203.4         118429-118656
            4172-4341           AC122203.4         122497-122666
            4342-4513           AC122203.4         126971-127142
            4514-4574           AC122203.4         130048-130108
            4575-4657           AC122203.4         133854-133936
            4658-7956           AC122203.4         134051-137349
FEATURES             Location/Qualifiers
     source          1..7956
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.35 cM"
     gene            1..7956
                     /gene="Depdc5"
                     /note="DEP domain containing 5"
                     /db_xref="GeneID:277854"
                     /db_xref="MGI:MGI:2141101"
     exon            1..37
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            38..160
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..4950
                     /gene="Depdc5"
                     /note="isoform 5 is encoded by transcript variant 7; DEP
                     domain-containing protein 5; GATOR complex protein DEPDC5;
                     GATOR1 complex protein DEPDC5"
                     /codon_start=1
                     /product="GATOR1 complex protein DEPDC5 isoform 5"
                     /protein_id="NP_001391244.1"
                     /db_xref="GeneID:277854"
                     /db_xref="MGI:MGI:2141101"
                     /translation="MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHP
                     NDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVEL
                     TFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEET
                     RVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTV
                     VLFSRTFYDAKSIDEFPEINRASIQEDHKGRFYEDFYKVVVQNERREEWTSLLVTIKK
                     LFIQYPVLVRLEQAGGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSV
                     VITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSVPRDSR
                     LGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKSASEKTKNGRDTSLGTPKESE
                     NTLPIQVDYDAYDAQVFRLPGPSRAQRLATCRSVREQENHSRKSASSCDVSSSPSLPS
                     RALPTEEVRSQASDDSSLGKSTNILMIPNPHLHQYEVSSSLGYTSTRDVLENMIEPPQ
                     RDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVG
                     PSGEAIQIHHQTRQNMAELQGSRQRDPTHSSAELLELAYHEAAGRHSTSRQPGDSMSL
                     NFSGTEELSVSLLSNSSTGVNPRTQNKDSLEDSVSTSPDPILTLSAPPVVPGFCCTVG
                     VDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADMDRRDEEGVQMTAQQVF
                     EEFICQRLMQGYQIIVQPKTQKPNTTVPPPLSSSPLYSRGLVSRNRPEEEGQYWLSMG
                     RTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVDFCHERLEE
                     YKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEVHCDIYGDKP
                     RADEDEWQLLDGFIRFVEGLNRIRRRHRSDRMIRKGTAMKGLQMTGPISAHSLEAAGP
                     PVGKKGTSALSALLEMEASQKSLGEQQTTVHGKSSTQPAENSSVAMTPTYVDSPRKDG
                     AFFMEFVRSPRTASSAFYPQGPVGTEDGRNGKTLCASVDQTAPLVLDSTSLGVSTGQP
                     MDRGNNQTFGNSQNIEQAFPSANSGDYSSQQHVASSLTSSSTLVEILEAMKHPSTGVQ
                     LLSEQKGLSPCCFISAEVVHWLMNNVEGVQTQAMGIDIMQKMLEEQLITHASGEAWRT
                     FIYGFYFYKIVMDKEPERVAMQQPSAPWYTAGADDFASFQRKWFEVAFVAEELVHSEI
                     PAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDR
                     LEWCSCYYHGNFSLNAAFEIKLHWMAVTATVLFEMVQGWHRKATSCGFLLVPVLEGPF
                     ALPSYLYGDPLRAQLFIPLNLSCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGF
                     VQDKYSVSAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFC
                     EERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFWTNCLEKM
                     HASAP"
     exon            161..248
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            249..295
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            296..381
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            382..465
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            466..515
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            516..585
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            586..664
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            665..726
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            727..796
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            797..869
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            870..973
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1048
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1183
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1245
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1319
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1389
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1426
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1547
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1768
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1972
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2108
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2203
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2269
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2453
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2614
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2732
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2900
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3120
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3254
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3360
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3426
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..3471
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3472..3623
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3701
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3834
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..3943
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            3944..4171
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4172..4341
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4342..4513
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4514..4574
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4575..4657
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     exon            4658..7956
                     /gene="Depdc5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5368..5373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Depdc5"
                     /note="hexamer: AATAAA"
     polyA_site      5389
                     /gene="Depdc5"
                     /note="major polyA site"
     regulatory      7709..7714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Depdc5"
                     /note="hexamer: AATAAA"
     polyA_site      7737
                     /gene="Depdc5"
     regulatory      7925..7930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Depdc5"
                     /note="hexamer: AATAAA"
     polyA_site      7956
                     /gene="Depdc5"
                     /note="major polyA site"
ORIGIN      
        1 gactcggggc ggagcctcgg gagcggcgcg ggctcagtag caggaaagca agatgacttc
       61 cctgctccaa gattggaaca gctgaagaaa tcacaagaca aaatgagaac cacaaaggtc
      121 tacaaacttg tcatccacaa gaagggcttt gggggcagtg atgatgagct agtcgtgaac
      181 cctaaagtat ttcctcacat caaacttgga gacattgtgg agattgctca ccccaatgat
      241 gagtacagtc ctttgctttt gcaagtcaag tcgcttaagg aagatttaca gaaagaaact
      301 atcagtgtgg accagactgt gactcaagta ttccggctaa gaccttatca agatgtctat
      361 gtgaatgttg tagaccccaa ggatgtgact cttgacctgg tggaattgac ttttaaggat
      421 cagtatattg gccgtgggga tatgtggcga ctaaagaaaa gtttggtgag cacctgtgcc
      481 tatatcactc aaaaagtgga atttgctggc atcagggcac aggctggtga gctgtgggtc
      541 aagaatgaga aggtcatgtg tggttacatt agtgaagaga ccagggtggt gttccgttct
      601 acgtcggcta tggtttacat atttattcag atgagctgtg aaatgtggga ttttgatatt
      661 tatggggatc tgtactttga gaaagctgtg aacggtttcc tcgccgacct gtttactaaa
      721 tggaaggaga agaactgtag tcatgaagtg actgtggtcc tgttttccag aactttctat
      781 gatgcaaaat ctattgatga atttcctgaa ataaaccgag cttcaattca agaggatcac
      841 aaagggagat tctatgagga cttttacaaa gtggtggtgc agaatgagag aagggaagag
      901 tggacttcac tcctcgtgac cattaaaaaa ctcttcatcc agtatccagt gttggtgcga
      961 ctggaacagg cagggggctt tcctcaagga gacaattcta cctcagcaca aggaaactac
     1021 ctagaggcca tcaacttgtc attcaatgtg tttgacaagc actacatcaa ccgaaacttt
     1081 gaccgaactg ggcagatgtc tgtggtgatc acgccggggg tgggtgtctt tgaagtggac
     1141 cgcctactca tgatcttgac caagcagcgg atgattgata atggaattgg tgtggactta
     1201 gtgtgcatgg gagagcagcc actacatgct gtgccattat tcaagctaca taaccggagt
     1261 gttccgaggg attctcgact gggtgatgat tataatattc ctcactggat aaaccatagt
     1321 ttctacacat ccaaaagcca gctcttttgt aacagtttca ctccacggat aaaactagca
     1381 ggaaagaagt ctgcctctga gaaaaccaaa aatggtcgtg atacatctct cgggactcca
     1441 aaggaatctg aaaacaccct tcccatccaa gtagattatg atgcctacga tgctcaagtg
     1501 ttcaggctgc ctggcccatc ccgggctcag cgcctcgcca cctgcaggtc tgtgagagaa
     1561 caggagaatc acagtcgcaa aagtgcaagc tcctgtgatg tctcatccag cccttccctg
     1621 ccaagccgtg cactgcccac tgaggaagtg aggagccagg cttctgatga cagctccctg
     1681 ggcaagagca ccaacatcct gatgatccct aacccccacc tgcaccagta tgaagtcagc
     1741 agctcactgg gctacaccag cacccgagat gtcctggaga acatgataga acccccacag
     1801 agggactcca gtgcaccagg aaggttccat gtgggtagtg cagagtccat gctccatgtc
     1861 cgacctggag gatacacgcc tcagagagcg ctgattaacc ccttcgcccc ctcgaggatg
     1921 cccatgaagc tcacctccaa cagaaggcgc tggatgcaca cttttcctgt aggcccatct
     1981 ggagaggcca tccagatcca tcatcagacc cggcaaaaca tggcagagct gcagggcagc
     2041 aggcagaggg accctaccca ctcctctgca gagctgttgg agttggcata ccatgaagct
     2101 gccgggaggc acagcacttc ccgccagcct ggtgacagca tgtccttgaa cttcagtgga
     2161 acggaagagc tttctgtcag cctgcttagc aacagcagta caggtgtgaa tcctaggacc
     2221 cagaacaagg actccctaga ggacagtgtt tctacctctc cagacccaat tctgacactg
     2281 tctgctcccc ctgtagtgcc aggcttctgt tgcacagttg gagtggattg gaagtctctt
     2341 actactcctg catgccttcc cctcaccact gactacttcc cggaccgtca gggcctgcag
     2401 aatgactaca cagagggctg ctatgatctc ctcccagaag cagacatgga caggagggat
     2461 gaggagggtg ttcaaatgac agcccagcaa gtgtttgaag agttcatctg ccagcgtctc
     2521 atgcagggtt accaaatcat agtacagcca aagacccaga aacccaacac cacagtccca
     2581 cccccattga gcagtagccc actctatagc agaggccttg tgtcccgaaa tcgccctgag
     2641 gaggaaggcc agtattggtt aagtatgggc agaactttcc ataaggtgac actcaaggac
     2701 aagatgatca cagtaactcg ttaccttccc aagtaccctt atgaatctgc ccagatccat
     2761 tacacctaca gcctctgccc ttcccactct gactcggagt ttgtctcctg ttgggtggat
     2821 ttctgccacg aacggctcga ggaatacaag tggaattact tagatcagta tatttgttct
     2881 gctggctctg aagacttcag cttaatcgag tctctgaagt tctggagaac ccgattttta
     2941 ctactgccag cctgtgttac tgccaccaag cgcatcacag aaggggaggt gcactgtgac
     3001 atctatgggg acaaaccccg tgcagatgaa gatgagtggc agcttctaga tggctttatt
     3061 cgctttgtag agggcttaaa tcgcatccgc aggcgccacc gctcagaccg catgattcgg
     3121 aaggggactg ccatgaaagg cttgcagatg accgggccca tctctgcaca ctctctcgag
     3181 gcagcaggcc ctccagtcgg caagaaagga acctcagctc tgtctgccct gctggagatg
     3241 gaagctagtc agaagagcct aggagaacag cagacgactg tgcacggaaa aagctccact
     3301 cagccagctg agaacagcag tgttgccatg actcccacct atgtggacag cccacgcaag
     3361 gacggggcct tctttatgga gtttgtccgc agcccacgca cagcatcatc tgccttctac
     3421 cctcagggac cagtggggac tgaggatggg aggaatggaa aaaccctatg tgcatctgtg
     3481 gaccaaacag ctcctctggt gttagacagc accagtttag gggtcagcac aggccagccc
     3541 atggatagag gcaacaacca gacctttggg aactcccaga acatagaaca ggcctttccc
     3601 tctgcaaact ctggtgacta cagctctcag cagcatgtag caagctctct aacatcgtct
     3661 tctaccctgg tggagattct ggaagccatg aagcatccct cgacaggagt ccagctgctg
     3721 tctgaacaga agggcctttc accgtgctgc ttcatcagtg ctgaggtcgt acactggttg
     3781 atgaacaacg tggagggggt ccagacgcag gcgatgggca tagacatcat gcagaaaatg
     3841 ctggaagagc agctcataac gcatgcatct ggtgaagcat ggcggacctt catctatggc
     3901 ttctatttct acaagatagt aatggacaaa gaaccggaaa gagtggctat gcagcagccc
     3961 tctgccccct ggtacacagc aggagcggat gactttgcca gcttccaacg caagtggttt
     4021 gaggtggcct ttgtggcaga agagcttgtg cactctgaga ttcctgcctt cctcctgccc
     4081 tggctaccta gccggccagc ctcttatgca agcagacaca gctcctttag ccgaagtttt
     4141 ggaggacgga gccaggcagc tgcgctgtta gctgctactg tcccagagca gaggactgtg
     4201 accctggatg ttgatgtgaa caaccgaacg gaccggctgg aatggtgcag ctgttactac
     4261 catggaaact tctctctcaa tgccgccttt gagatcaagc tacactggat ggcagtgact
     4321 gccacagtgc tgtttgagat ggtccaaggt tggcatcgaa aagctacctc ctgtggcttc
     4381 ttgctggtcc cagttttgga gggtcctttt gctctgccca gttacctgta tggtgatccc
     4441 ctgagggccc agctcttcat cccgctcaac ctcagctgct tgctcaagga gggcagcgag
     4501 cacctgttcg atagctttga accagagaca tattgggatc gaatgcatct tttccaggaa
     4561 gccattgcac acaggtttgg atttgtgcaa gataaatatt ctgtctccgc ttttaacttc
     4621 cctgctgaga ataagccaca gtatatccat gtcacaggaa cggtgttcct tcagctgccg
     4681 tactccaaac gcaagttttc agggcagcag cggcggcgac ggaactctac cagctccacc
     4741 aaccaaaaca tgttctgtga ggagcgggtt ggctacaact gggcctacaa caccatgctg
     4801 accaagacat ggcgctctag tgccacaggg gacgagaagt ttgctgatcg gctgctgaag
     4861 gacttcacgg atttctgcat caaccgtgac aaccgactgg tcacgttctg gacaaactgc
     4921 ctggagaaga tgcatgccag tgctccatga agccaggctg cttctcttaa gagaggctgt
     4981 gggtatgctg gagctggcct tccggtcagg ctctgggcag caggtgtcag gctgctccta
     5041 tcagtgagtg gggccactgc tgatatttgg cctctgcaca agtgtgagtg aagagaaaga
     5101 ttggaagcag ctgctgccgc taccgccaac caaatcttgc caatcctgtc cctgaagcag
     5161 ggggaggcac agattgtccg tgggagtgag tcagtgtctg ggagtggggt aggcagcttc
     5221 cattagggtc cttttccttc accagcagtg ggatattcgg aacagaacct cctgctttct
     5281 gcccaagagt gtgtgtatga ggtaaatctg tggcataatg taccattggc tcacaccagc
     5341 tgtacatatg tgtacatagc agaatctaat aaagccctcc ctccctccct ccctccctcc
     5401 ctctctccct cccccggtgt ctgttcccag ccttgttggt agccaggcca gtcaggtcac
     5461 ctcaggtggc cagagggctt caggacacac tggtcttgag tctggctctg agctggcttg
     5521 ataggtttct ttttcaaagt ccttgggcaa gaacaaggat cttctggaca ggacaggact
     5581 actgagcaga cagtacagta cagtatagta agaagctcta ggcttgtcat gtcagaaata
     5641 tgcctcgtta agtggatggg ccagctcagg gaagcagaca tcacggcatt ccctacacgt
     5701 ccagtgagtg cttttcgctc tagactgctc agggaaggca aagaccgaag accatgacta
     5761 ctgcttcctc ctatactaga gttaatcaca caccccattg atgtaccttt tttttttaaa
     5821 gattttattc atgtatttgg tatatatgat aaatacactg tagctatctt cagacaccag
     5881 aacagggcat cggatcccat tacagatggt tctgagccac catgtgcttg ctgggatttg
     5941 aactcaggac ctctgggaga gcagtcagtg ctcttaacct ctgagccatc tctccagccc
     6001 cttgatgtac cttaccttct ttacctctcc tgggccctat gtacaactcc aggtccagcc
     6061 ttccttgttt ctcttctctc caggaaacct aacttgtctc tggttcatcc tactgcactc
     6121 tcctgggaaa ctagggtttt gttgggtttt tgttttttaa aaaaactact ccaagcaggt
     6181 acagcagctt cctgtaatac cagtgtttag gagactgagg taggctggcc tccatagtgt
     6241 gtacttagca aagttgagct ttacaatgag actgtctcag aaagtctcac tttggggctg
     6301 gaaagatgac tcagttaaga gcatttgact gatcttacag agcacctgag ttcagtgcca
     6361 gcgtgaggtc actcacagcc atccatacct ggagttccag gggactccac accctcttct
     6421 gaccttcttt tgcatcgggc acacatgtgg tacatataca tatatccaca tatataatac
     6481 gtgcaagcaa agcactcaca taaaacaaaa ataaatctta aaatcaaaca gacagctcca
     6541 ctccatttag acttgccact tagaattctc ttgactacct gactccaaaa accttcagta
     6601 tggtgctgga gatgcagatc agagccagca tagcaggcac caggctctgg actcaattca
     6661 caacactaca aaagtaaaac caagtattgt cttgcctagt gggctgttct cacagctgcc
     6721 ttgggagttg tgcattccct tgaaccagct caaatcttct gcgtacactg ttccaagctg
     6781 cactcatcgg gaacttctaa tcacagctat taagtcctgt atgtaaaggt tttttttttt
     6841 taaaggtgtg tgtgtgttgt gtgtgtgtat gggtgcatcg ttaggtcaaa agagaggaca
     6901 tcagatcccc tggaactaga gtctagacgg tcgtgagcca ccatttgggt gctgggttgg
     6961 gaacctgggt cctcccagag ctccaagtgc tcttactggc tgagccatgt ccctagctcc
     7021 tgcatgtgaa gcttttgaga gagtaagctg ttaacgtgtg aaagtgtgat ccatgggaag
     7081 taagcctaaa aaaaacttag cttcacacac acacatactt ttcttcccat gaatattgct
     7141 cctccttgat gtcagccttc ttgtcagtgg gagctgtctg gagtaactgg ggggttgagg
     7201 caggtacagc tggactttgt ggagtgtacc tgtaaccgca gcacttgaga agactaaagg
     7261 agagggaaga aggttgctgt gattttgagg tcactccagg acacacacag taagacactg
     7321 tcccaagcaa ataagcacac acaaacaaaa aggatgtttt cgtttgaaag agcttagtac
     7381 tgaaaagaga gtaaatcaag ttctcgtttt cccagatggg tatgttcagg gttccatgcc
     7441 agcctcctct gtggtcacag cagctgttgg ccacgccaga ccgtgtgatc tcgtgtggtc
     7501 ctgttatcca tcctatggag ccatcaatta ccccttcaca tacagttttt gtcatattcc
     7561 agaggtaact tggaagacat agaaaattac ctggcaggag ttcaactgat ggaataccag
     7621 gtcacttgcc tatcagctgt cctgagatgc tcctggcctt gagctccagt tcctgcagtc
     7681 tctagcattc cagattccaa gctcaataaa taaaggtgtt tgccattggt gatttaagtt
     7741 cagctcccca gacctatatg gtggaaagga tcaactccag aaagttctct gatggccaca
     7801 cagatgttgt ggtactcatg tatccacata tatacataca tgcataaatt taattgaaaa
     7861 attttaaata ttaagatctg ttaaagttca ctaaagtgga tagaaaacag ccggagagaa
     7921 gcagaataaa ggccaattta ttgttctcta cagcca
//
