LOCUS       NM_178683               2493 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus DEP domain containing 1B (Depdc1b), transcript variant
            1, mRNA.
ACCESSION   NM_178683
VERSION     NM_178683.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2493)
  AUTHORS   Li,W. and Wu,W.
  TITLE     Circ_0005276 Promotes Prostate Cancer Progression Through the
            Crosstalk of miR-128-3p/DEPDC1B Axis
  JOURNAL   Biochem Genet 61 (5), 1987-2003 (2023)
   PUBMED   36913076
  REMARK    GeneRIF: Circ_0005276 Promotes Prostate Cancer Progression Through
            the Crosstalk of miR-128-3p/DEPDC1B Axis.
REFERENCE   2  (bases 1 to 2493)
  AUTHORS   Figeac,N., Pruller,J., Hofer,I., Fortier,M., Ortuste Quiroga,H.P.,
            Banerji,C.R.S. and Zammit,P.S.
  TITLE     DEPDC1B is a key regulator of myoblast proliferation in mouse and
            man
  JOURNAL   Cell Prolif 53 (1), e12717 (2020)
   PUBMED   31825138
  REMARK    GeneRIF: DEPDC1B plays a central role in myoblasts by driving
            proliferation and preventing precocious myogenic differentiation
            during skeletal myogenesis in both mouse and human.
REFERENCE   3  (bases 1 to 2493)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   4  (bases 1 to 2493)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 2493)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161252.2 and CT030256.13.
            
            On Mar 24, 2023 this sequence version replaced NM_178683.4.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036550.1, AK077676.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC161252.2         111033-111123
            92-357              AC161252.2         118560-118825
            358-493             AC161252.2         152048-152183
            494-621             AC161252.2         156889-157016
            622-752             AC161252.2         158187-158317
            753-800             CT030256.13        177767-177814       c
            801-941             CT030256.13        172774-172914       c
            942-1108            CT030256.13        163705-163871       c
            1109-1285           CT030256.13        161725-161901       c
            1286-1471           CT030256.13        159607-159792       c
            1472-2493           CT030256.13        157065-158086       c
FEATURES             Location/Qualifiers
     source          1..2493
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 59.69 cM"
     gene            1..2493
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /note="DEP domain containing 1B"
                     /db_xref="GeneID:218581"
                     /db_xref="MGI:MGI:2145425"
     exon            1..91
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1633
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /note="isoform 1 is encoded by transcript variant 1; DEP
                     domain-containing protein 1B"
                     /codon_start=1
                     /product="DEP domain-containing protein 1B isoform 1"
                     /protein_id="NP_848798.1"
                     /db_xref="CCDS:CCDS26762.1"
                     /db_xref="GeneID:218581"
                     /db_xref="MGI:MGI:2145425"
                     /translation="MEHRVVGPGPYRATRLWNETVELFRARMPLRRHRCRFKSYEHCF
                     TASEAVDWLHELLRNSQNFGPEVTRKQTVQLLGKFLKNHVIEDIKGKWGQEDFEDNRH
                     LYRFPPSSPLKPYPKKPLYQRDVIKFPEWNDPPPGTSQENIPVRPIVMNSEMWFKRHS
                     IAIGEVPACRLVHRRQLTEANVEEIWKSTTLSYLQKILGLDSLEEVLNTKLVSSKFII
                     HNVYSVSKQGVVILDDKSKELPHWVLSAMKCLANWPNCTDWKQPMYLGFEKDVFKTIA
                     DYYGHLKEPLLTFHLFDAFVSVLGLLPKEKTAIEAFQLCCLLLPPENRRKLQLLMRMM
                     ARICLNKEMPPLSDGFGTRTLMVQTFSRCILCSKDEVDLDELLAARLVTFLMDNYQEI
                     LKVPLALQTSIEERVAHLRRVQIKYPGADMDITLSAPSFCRQISPEEFEYQRAYGSQE
                     PLAALLEEVIADDKLSSKEKKKKLKQFQKSYPEVYQERFPTPESEALLFPEKPKAKPQ
                     LFMWALRKPFQPFQRTRSFRM"
     exon            92..357
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..493
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..621
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            622..752
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..800
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..941
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1108
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1285
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1471
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..2493
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1783..1788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /note="hexamer: GATAAA"
     polyA_site      1815
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
     regulatory      2466..2471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /note="hexamer: AATAAA"
     polyA_site      2493
                     /gene="Depdc1b"
                     /gene_synonym="9830132O03; XTP1"
                     /note="major polyA site"
ORIGIN      
        1 ggagtccccg ccggcgttgc cccgcgactg ctgcgcgttg gcaatggagc accgcgtagt
       61 gggacccggg ccgtaccggg ccaccaggct gtggaatgaa acagtggagc ttttccgggc
      121 caggatgcct ttacggagac atcgttgccg gttcaagagt tacgagcatt gcttcactgc
      181 atcggaggct gtggactggc tgcacgagct tctgcggaac agtcaaaact ttgggcccga
      241 ggtaactcgc aaacaaacag tccagctgct gggaaaattc ctgaagaatc atgttattga
      301 ggacatcaag gggaagtggg gccaggagga ttttgaagac aaccgtcacc tctacagatt
      361 tcctccctcc tcacccctga agccatatcc aaagaagccc ctgtatcaaa gagatgttat
      421 taagtttcca gaatggaacg atcccccacc gggcacttca caggagaaca ttccagtgag
      481 gccgattgtg atgaattctg agatgtggtt caagcgccac agtattgcta ttggagaggt
      541 gccggcatgc cgcctcgtcc accgcagaca gctgaccgag gccaatgtgg aagagatctg
      601 gaagtctacg acgttgtcat atttacagaa aattcttggc ctggattcct tggaggaagt
      661 tttaaacacc aagctggtca gctccaagtt catcatccat aacgtgtaca gtgtcagcaa
      721 gcagggagtg gtcatcctgg acgacaagtc gaaagaactt cctcactggg tcctgtcagc
      781 tatgaagtgt ttggcaaatt ggcccaactg tacagactgg aagcagccta tgtacttggg
      841 atttgagaag gatgtcttta agactatagc agattactat ggtcacctga aggagccact
      901 gctcacattt catctctttg atgctttcgt cagcgtctta ggtttgctgc cgaaggagaa
      961 aacggccatt gaagcatttc agctttgctg tctcctcctg cctcctgaaa acaggagaaa
     1021 gttacagctg ttgatgagga tgatggcgag gatctgccta aacaaggaga tgcccccact
     1081 gagtgatggc ttcggcaccc gcacactgat ggttcagacc ttttcccggt gcatcctgtg
     1141 ctctaaggat gaagtagact tagatgagtt actagctgct cgattggtga cattcctgat
     1201 ggacaattac caggagattc tgaaagtgcc tctggccctg cagacctcca tagaagagcg
     1261 tgtggctcat ctgcgaagag tccagataaa atacccagga gctgatatgg atatcactct
     1321 gtctgcacct tcgttttgcc gtcaaattag tcccgaggag tttgagtacc aaagggcgta
     1381 tggctcccag gagcccctgg cagccttgtt ggaagaagtc atagccgacg acaaactctc
     1441 cagcaaggag aagaagaaga agctgaagca gtttcagaaa tcttaccctg aggtctacca
     1501 ggaacgattt cctaccccag agagcgaagc acttctcttt cctgaaaaac ccaaggccaa
     1561 gccgcagctg ttcatgtggg cactgaggaa gcccttccag ccgtttcaga gaactagaag
     1621 tttccggatg tgatgcagtg atggagcttg agagacctct gcggcagaga cagtttgagt
     1681 cagcagaggt tctggaaggc tggtgtaaac tactgcaata tggagtctcg gagcatccag
     1741 ccgatcgccc gactcctcgt gctgagccct tgtcagtatt ctgataaatc tcgatgctgt
     1801 ttgtagagat gtaaatgagt gggtgactgt gagtctcgtg ggtaggggtg gtgtgaacag
     1861 gcttgggtag gttacaaaat ctaaaggtaa aacattcgtt cccttccttc tgtttgttgt
     1921 tttccacggt gtgtaaagtc cttgtgtgtg ccccctgctc tcgtgtgcgt ctgtgaaaac
     1981 caagcctagg aatactgtac atacttgaat gagaacaatc ctgtgtgtgc tgttactgtg
     2041 gtagccctga cccagtgcat attctgattt ctcctgtgta agtcccactg gttgttgttt
     2101 gtttgtttgt ttttattttt taatttcttg tttgtttggt tagtgtgaaa agtccaactg
     2161 ttttgcactg tgattgccgt gtcttgtatt gcagatttgc ctgtcgctct ttgattaccc
     2221 gtatgccggg ctgggtctgc gcgtggctgg atgtggaatg gtgtgcatct gcccccgggc
     2281 ccgcaatccg ggtctccgct aaaggcggca ggttgagctg gatgaagtct ttggttccct
     2341 tagacctgca aacctgaatt cagtctgttt tatgaaaagt ataaaggggt tgagtgagat
     2401 gaattacgtc ctttatgaat atattttctc agcttcttca ttgttttgaa agtacatgga
     2461 atgtaaataa atactgagtt gtttatatat ata
//
