LOCUS       NM_001417688            2127 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus density-regulated protein (Denr), transcript variant
            2, mRNA.
ACCESSION   NM_001417688
VERSION     NM_001417688.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2127)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2127)
  AUTHORS   Castelo-Szekely,V., De Matos,M., Tusup,M., Pascolo,S., Ule,J. and
            Gatfield,D.
  TITLE     Charting DENR-dependent translation reinitiation uncovers
            predictive uORF features and links to circadian timekeeping via
            Clock
  JOURNAL   Nucleic Acids Res 47 (10), 5193-5209 (2019)
   PUBMED   30982898
  REMARK    GeneRIF: Clock is a DENR target in mouse circadian timekeeping
REFERENCE   3  (bases 1 to 2127)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2127)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   5  (bases 1 to 2127)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2127)
  AUTHORS   Korobova,F., Ramabhadran,V. and Higgs,H.N.
  TITLE     An actin-dependent step in mitochondrial fission mediated by the
            ER-associated formin INF2
  JOURNAL   Science 339 (6118), 464-467 (2013)
   PUBMED   23349293
REFERENCE   7  (bases 1 to 2127)
  AUTHORS   Jerome-Majewska,L.A., Achkar,T., Luo,L., Lupu,F. and Lacy,E.
  TITLE     The trafficking protein Tmed2/p24beta(1) is required for
            morphogenesis of the mouse embryo and placenta
  JOURNAL   Dev Biol 341 (1), 154-166 (2010)
   PUBMED   20178780
REFERENCE   8  (bases 1 to 2127)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (bases 1 to 2127)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2127)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122753.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3835354.280620.1,
                                           SRR7345562.4580290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC122753.11        55439-55611
            174-288             AC122753.11        56009-56123
            289-308             AC122753.11        63100-63119
            309-393             AC122753.11        65109-65193
            394-477             AC122753.11        70089-70172
            478-594             AC122753.11        72640-72756
            595-734             AC122753.11        74907-75046
            735-2127            AC122753.11        75159-76551
FEATURES             Location/Qualifiers
     source          1..2127
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.26 cM"
     gene            1..2127
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /note="density-regulated protein"
                     /db_xref="GeneID:68184"
                     /db_xref="MGI:MGI:1915434"
     exon            1..173
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            174..288
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..779
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /note="isoform a is encoded by transcript variant 2; DRP"
                     /codon_start=1
                     /product="density-regulated protein isoform a"
                     /protein_id="NP_001404617.1"
                     /db_xref="GeneID:68184"
                     /db_xref="MGI:MGI:1915434"
                     /translation="MATDISESSGADCKGDTKNSAKLDADYPLRVLYCGVCSLPTEYC
                     EYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQETGITEGQGPVGEEEEKKKQKRGGRG
                     QIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTG
                     EDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK"
     exon            289..308
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            309..393
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            394..477
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            478..594
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            595..734
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            735..2127
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1053..1058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1077
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /note="major polyA site"
     regulatory      1812..1817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1833
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
     regulatory      2089..2094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /note="hexamer: AATAAA"
     regulatory      2101..2106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2114
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
     polyA_site      2127
                     /gene="Denr"
                     /gene_synonym="1500003K04Rik"
ORIGIN      
        1 agcccagcct tccagcgggc tacctgtcct tttccccagg cctggcccga tttcccctcc
       61 ccaggctgtg gcattgccgt ccttgtccct ggcttggtct cttttcggga ttttgctgtc
      121 gccgcacctt gcattctggg cacctcgagt gacttcgtcc ctgtcgtgcc aaggtttgtg
      181 agatggctac tgacatttct gaatccagcg gggcggattg caaaggcgat acgaagaaca
      241 gtgccaagtt agatgcggat taccctcttc gagtccttta ttgtggagtc tgttcattac
      301 caacagagta ctgtgaatac atgccggatg ttgctaaatg tagacaatgg ctagagaaga
      361 actttccaaa tgaatttgca aaacttactg tagaaaattc acccaaacaa gaaactggaa
      421 ttactgaagg ccaaggacca gtaggggaag aggaggagaa gaaaaaacaa aaaagaggtg
      481 gaagaggtca aataaaacag aagaagaaga cagtaccaca gaaggtcacg atagccaaaa
      541 ttcccagagc aaagaagaaa tacgtgacga gagtgtgtgg ccttgcaact tttgaaattg
      601 atctcaaaga agcacaaaga ttttttgctc aaaaattctc gtgcggtgcc tcagtgacag
      661 gggaggacga gatcatcatt cagggagact tcacagatga catcattgac gtcattcagg
      721 aaaagtggcc agaggtggat gacgacagca ttgaagacct tggagaagtg aagaagtgat
      781 cctgaagtca tgtgtttcta actgtgacct gagagctgac acggccagca gaggagaggc
      841 ctttcagaat atatacatat gtacatttgt gtgtatatat accctacagt aaagctgtcg
      901 actcctcgtc ctcggcgtcc tcactgttcc gtacaaggct gcttgcttgc ttggttggtt
      961 ggtttggttt gttttttttt aaattgccaa agtctgaaaa gtgagagaga gagagagact
     1021 gtcatgctta tgcatgactc tgaatttagt caaataaaac attttggtca tttggtactg
     1081 attttttttt ttctcttttt taacttttca tttttagaaa aacactctag attgtccctc
     1141 cactcagtgc tgtcagtgaa cccagggcct cgtgcatgct gggcaagcac tggcacttct
     1201 ctgtgggaag tttctgttgg ttagcttacg ggtagagagc tgagcaaact tcacagaaga
     1261 atttgtcttt catttcctta ctataagtgt gtctccttgg ttggtgagac tctaatggac
     1321 ttttagttgg attagttcct tcattagcaa aagtccactt tgtcacaggg tgggtaggtt
     1381 tgctcaagct gtttggagat tacttggtac agtgtgttaa acgccttaga accctgtgca
     1441 ctgtttgacc cagtaaacca cttcaacact atcataagct aagggcaagt cctgatacaa
     1501 ctcatggatg agggtgccag gcaatgttac aatgttggag cttataaata gtacagactg
     1561 ggtacagaaa tggtgcagcc tgtggtagga tactatatat ttgaaaatgc cttttccaag
     1621 aatattagga acctgtttgg tgatgttgac taagactgca aatttgtttt agacatttat
     1681 tcttcctgtt gggagtgaca gatgctcagc agagccagga actcttactc tgcctattta
     1741 ccgtggggta aaattctaac cagttaaaaa cagcttctat ctgttttcag tctatagttt
     1801 gggaaatagc aattaaacta tcatactgag aaactagtca ttttaatgaa tcgggtgaac
     1861 ttaagttttg aaaatcaggt gttaacatgt gaaagtcttt tatcttttaa atgccttaag
     1921 tgtgggaata tatgtagctg ggcagaagtg cttacctacc atgcttgtag cgtcacaaac
     1981 acaagttgtt aaagattcct tcaagaatgt agagtccacg aaatcattat gtgaaaacat
     2041 ccttccttga atgaaaggat gctttttttg tttgctttaa agtcttagaa taaaatgtgt
     2101 aataaagatg tgaagttaag ggctaca
//
