LOCUS       NM_027081               4716 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus DENN domain containing 6B (Dennd6b), mRNA.
ACCESSION   NM_027081
VERSION     NM_027081.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4716)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY252285.1, BB658928.1, BQ444357.1, AK006427.1 and BC058958.1.
            
            On Apr 28, 2006 this sequence version replaced NM_027081.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139003.1, SRR17784648.1209994.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BY252285.1         2-22
            22-615              BB658928.1         15-608
            616-864             BQ444357.1         174-422
            865-2001            AK006427.1         2-1138
            2002-4716           BC058958.1         1509-4223
FEATURES             Location/Qualifiers
     source          1..4716
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.7 cM"
     gene            1..4716
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /note="DENN domain containing 6B"
                     /db_xref="GeneID:69440"
                     /db_xref="MGI:MGI:1916690"
     exon            1..256
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1837
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /note="protein FAM116B; family with sequence similarity
                     116, member B; DENN domain-containing protein 6B;
                     DENN/MADD domain containing 6B"
                     /codon_start=1
                     /product="protein DENND6B"
                     /protein_id="NP_081357.2"
                     /db_xref="CCDS:CCDS57000.1"
                     /db_xref="GeneID:69440"
                     /db_xref="MGI:MGI:1916690"
                     /translation="MEVPVGPGPRQAGGGLGATRSSSSGRAARTAEMPWARFSAWLEC
                     VCVVTFDLELGQALELVYPSDFRLTDKEKSSICYLAFPDSHSGCLGDTQFSFRMRQCG
                     GQRSLWQVDDRSYNNKAPLALQREPAHYLGYVYFRQVKDSSVKRGYFQKSLVLVSRLP
                     FVRLFQSLLSLIAPEYFEKLAPCLEAVCNEIDQWPAPVPGQTLNLPIMGVVIQVRIPS
                     RVDKLESSPPKQCDQENLLPAPVVLTSVHELDLFRCFRPVLTHVQTLWELMLLGEPLV
                     VLAPSPDVSSELVLALTSCLQPLKFCCDFRPYFTIHDSEFKELTTRTQAPPNVVLGVT
                     NPFFIKTLQHWPHVLRIGEPKMSGDLPKQVKLKKPSRLKTLDTKPGLYTSYTAHLHRD
                     KALLKRLLKGVQKKRPWDVQSALLRRHLLELTQSFIIPLEHYMASLMPLQKNITPWKS
                     PPQICPFRQDDFLRSLEHAGPQLTCILKGDWLGLYRRFFKSPHFDGWYRQRHKEMAQK
                     LEALHLEAICEANIEAWMKDKSEVEVVDLVLKLREKLVRAQGHQLPVKEVTLQRAQLY
                     IDTVIGSLPKDLQAVLCPP"
     exon            257..295
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            296..338
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            339..451
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            452..532
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            533..638
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            639..718
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            719..781
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            782..837
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            838..960
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1056
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1151
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1217
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1282
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1372
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1426
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1536
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1639
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1714
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..4611
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1989..1994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /note="hexamer: AGTAAA"
     polyA_site      2012
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /note="major polyA site"
     regulatory      4585..4590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
                     /note="hexamer: ATTAAA"
     polyA_site      4611
                     /gene="Dennd6b"
                     /gene_synonym="1700027J05Rik; Fam116b"
ORIGIN      
        1 agctcgactg ctccgaggcg gcccaggtga acccctgcgt ttctccgcaa cgtgcccggg
       61 taccgctgga gctgctacca tggaggtgcc ggtgggtccc gggccccggc aagctggcgg
      121 aggactaggc gcgacaagat cctcgtcctc cggccgcgcg gcgcggaccg cggagatgcc
      181 ctgggcgcgc ttctctgcct ggctggagtg tgtgtgcgtg gtcaccttcg atctggagct
      241 gggccaggcg ctagagctag tctacccaag tgacttccgg ctcacagaca aggagaaaag
      301 cagcatctgc tacctggcct tcccagactc gcactcaggg tgcctgggag acactcagtt
      361 cagtttccgt atgcgtcagt gtgggggaca aaggagcctc tggcaggtgg atgatcggtc
      421 gtataacaac aaggccccct tggcattgca gagggagcca gcacactatc tgggctatgt
      481 gtacttcaga caggtgaagg acagctctgt gaagaggggt tacttccaga agtctttagt
      541 gctggtgtcc cgcctgccat tcgtccggct gtttcagtca ctcctaagcc tgattgcccc
      601 tgaatacttt gagaagttgg caccctgcct ggaagcagtt tgtaatgaga ttgaccaatg
      661 gccagcgccg gtgcctgggc agaccctgaa cctacccatc atgggagtcg tcattcaggt
      721 gcgcatccca tccagggtgg acaagctgga atccagtcct ccaaagcagt gtgatcaaga
      781 gaacctgctg ccagctccag ttgtcctcac tagtgtccat gaactggatc tgtttaggtg
      841 cttccggcca gtgctcaccc acgtgcagac cctgtgggaa ctcatgcttc ttggggagcc
      901 cctcgtggtg ctggcaccct cacccgacgt gtcttcagag ctggtgctag ccctaaccag
      961 ctgcctccag cccctgaagt tctgctgtga cttccgcccc tacttcacca ttcatgacag
     1021 tgagttcaag gagcttacaa ctcgaaccca ggctccacca aacgtggtcc tgggagtcac
     1081 aaaccctttc tttatcaaaa cactccagca ctggcctcat gtcctccgaa ttggggagcc
     1141 caagatgtca ggggaccttc caaagcaggt caagcttaaa aaaccctcac ggctgaagac
     1201 ccttgacacc aagccaggcc tctacacctc ctatactgcc cacctccacc gggacaaagc
     1261 gctgcttaaa cgactgctca agggcgtaca gaagaagcgg ccatgggatg tgcagagtgc
     1321 cctgctgagg cggcaccttc tagagctcac acagagtttc atcattcctc tggagcacta
     1381 catggccagc ctcatgccgc tacagaagaa catcacaccc tggaagagcc ccccgcagat
     1441 ctgccccttc cgccaggacg atttcctgcg aagcctggag catgcgggac cccagctcac
     1501 ctgcatcctc aagggtgact ggctgggcct ctacaggcgg tttttcaagt ccccccattt
     1561 tgatggctgg tatcggcaac gacacaaaga gatggcccag aagctggaag ctctgcacct
     1621 ggaagctatt tgtgaggcga acattgaggc ttggatgaag gacaagtccg aggtggaagt
     1681 ggtcgacctg gtcctgaaac ttcgggagaa gctggtacgg gcacagggcc accaactccc
     1741 cgtgaaggag gtgacactgc agcgggctca gctgtacatt gatacagtta ttggctccct
     1801 tcccaaggac ctgcaagcag tcctgtgccc tccctaggac aaggccaacc tgtgtggtcc
     1861 tgggggggta gggaggctaa gcctgccaag ttccctctcc cttgaaaggc aggcctccaa
     1921 gctggggctc tcagccttag gctcctacct cagcttcagc cccctcccag aaccaccctt
     1981 gtcccagcag taaaatgaca tttggaatga cagtctggtc cctgactatt gggggattct
     2041 gtgctggcac tgcctcactt cttcctgggc cacacctgtc ctccacagct ggaggtggga
     2101 gtggcctagt agcccttact gatgtaggtg ccttcaccac ctgctgcctc ctggctccat
     2161 ctgcccacac tccaggatgc cttgtgttgg gggtccttta gcccagcagg cttccccgct
     2221 cagagaagag ggaggcagct gccagggcca gcccctttcc tttacacccc actcgttctg
     2281 cagagggatg aagggatgga cagagggtgg gaaggggtac tttgcctagg cagctacttg
     2341 agagggcaga agctctttgt cctgagagga tctaattctc cttcctgctg tgattggcca
     2401 gcatgagaga atgagggatg gtgtgggggc ctggcacccc acttgcaaaa gcaagctcag
     2461 gctgttcttg gaggtcctcg ccacagtcct tattcccttt cttggaacac cccctgaaca
     2521 cctgctccat gcatttcacc catgctgcca agggctactc cagcttttcc ccctgtgtct
     2581 gcccctcctc ctgcagcttg cttgagaggc gttgggctgt agcctgatgc tatattctct
     2641 gctgtcttgg ccttagggta caattgaacc cgtaggcaga ggtatctctt ggaggtgctg
     2701 ttctgtgctc ttcctaaagg gctaaaatgg ctctggggac ctaagtctgc caagcttccc
     2761 tttcccttca aggctctagc ttgtcttcag acctcccctc cccccaaaga agcacttttg
     2821 tcctagcagt aagaatggga cgtggaacac agcctggtcc ctgaatgttg gaggattctg
     2881 tgttagttta gccctgtctc acccattcct ggattgatgc tattgtgcag tactgctaat
     2941 cctgggtaca gcgcgttaca atgttacaac ctagcatcac aacctggccc ttggggtggt
     3001 ccagactgaa gtgaggacct ggagcagcag ccaaccctca gctgagtatc agaaacctgt
     3061 aggtgggtct cctgaccact taagactgct cctctgaggg actgggccat gtgggttcac
     3121 tgggcagtgt cagtgtcagg cagtatcagg gaaaaggggc attctgagag gatgggccgt
     3181 acatcctgtg atgctttaaa gggccactag caaagtaagt tggtttagag ctgcatggtg
     3241 agcgtttgtt ttcttagaga gctgctgagt agcatggcca tgacctgttc tgggttcttt
     3301 ggactcttta atcaaacctc aagtatgtac tgcctcgccc ttccccactg atcctggcta
     3361 agccagacac agcgaaggta tcccagtggt aacaggtgtc agcactgtgc ctagatcttt
     3421 gcatgtgctc agttgtttac ccctgacctt agcccatgac agcttgtcac actgcccact
     3481 ctacaggtga gcagacagat gagatagatg ggtgaattta cacagtgatc taggtcagtc
     3541 taatgcagta tccaaggagg tgacctgtta gaaaattgag caaaggcagg ttgagatgga
     3601 gaccttgtcc ttaggaagaa tggcattagc atctcctgga acagtggtgc cagcctcacc
     3661 actaagagcc tggtctctaa gggatcttca gaaccatggc accatcctct gtgacagctg
     3721 gagctccccg gctgtgggga ctagccattt ggagtctgca gaactgtgcc ttccatgtgc
     3781 cagcctccta tccgagtgac aggtctaagc ctcctccgtc ttaatggctc caccgtaaaa
     3841 tgcacatctc aaatatcact gcagtgtgtt tctcgtgcta gttttcactt gactttcaca
     3901 cagtaggctt cagggtgccc caccccacac caccccaagg acctcagcca ccatcagcct
     3961 aggactcttc atgggaatca gcagacagat ttagaggagg ggctggtggg gaggtagaag
     4021 gctatagaca caacagtgct gcttagggca caaacccaag gctgacacac aggaatgagc
     4081 aaagttccag tttcttcgag gggcttgtcc tggttactgg tagagtatac cgcctgcctg
     4141 ctggcttcct accagctaca tcctctccga ctctctctct cccaggatgg gatcagctga
     4201 gttagtggag cttctgtcca aagtaggctc aagcccatct ctttccatcc atgccaaggg
     4261 cagagcctgg agggatgtcg agacagatgg ctccaaagag gtgctcccct ccccccagcc
     4321 cagaggtccc ttacagttta gatgcctgga gagtgagaag ctaatcctgg agattgtgat
     4381 tcccagagct cccttgtgtg gccagttggg agagcgcagt gagccagcat tcaggggatc
     4441 taagagggtt gggtggaggt catgaggcag ccagccccag ggacagaccg gaaggacagg
     4501 aggactcttt taccctccag cttcctgcct tttctatttt gagccctact cagttcagaa
     4561 tactggcctt cccacaactt tgttattaaa atatcttttt ttgttataca aaaaaaaaaa
     4621 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4681 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
