LOCUS       NM_001134465            6666 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DENN domain containing 6A (Dennd6a), transcript
            variant 1, mRNA.
ACCESSION   NM_001134465
VERSION     NM_001134465.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6666)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6666)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   3  (bases 1 to 6666)
  AUTHORS   Alvarez-Dominguez,J.R., Hu,W., Yuan,B., Shi,J., Park,S.S.,
            Gromatzky,A.A., van Oudenaarden,A. and Lodish,H.F.
  TITLE     Global discovery of erythroid long noncoding RNAs reveals novel
            regulators of red cell maturation
  JOURNAL   Blood 123 (4), 570-581 (2014)
   PUBMED   24200680
REFERENCE   4  (bases 1 to 6666)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054295.1, AK131163.1 and AC121919.3.
            
            On Oct 22, 2013 this sequence version replaced NM_001134465.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131163.1, AK054295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AK054295.1         2-29
            29-5746             AK131163.1         1-5718
            5747-6666           AC121919.3         109449-110368       c
FEATURES             Location/Qualifiers
     source          1..6666
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 16.09 cM"
     gene            1..6666
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /note="DENN domain containing 6A"
                     /db_xref="GeneID:211922"
                     /db_xref="MGI:MGI:2442980"
     exon            1..313
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1903
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /note="isoform a is encoded by transcript variant 1;
                     protein FAM116A; family with sequence similarity 116,
                     member A; protein DENND6A; DENN domain-containing protein
                     6A; DENN/MADD domain containing 6A"
                     /codon_start=1
                     /product="protein DENND6A isoform a"
                     /protein_id="NP_001127937.1"
                     /db_xref="CCDS:CCDS49430.1"
                     /db_xref="GeneID:211922"
                     /db_xref="MGI:MGI:2442980"
                     /translation="MALPGPAVFGPGSRGSLDEAGAEGREAAALAAAGVALEDEEEDD
                     GRRGLLRWDGFSAWLHCVCVVGFDLELGQAVEVIYPQHSKLTDKEKTNICYLSFPDSN
                     SGCLGDTQFCFRFRQSSGRRVSLHCLLDEFDKDLPVYLKKDPAYFYGYVYFRQVRDKT
                     LKRGYFQKSLVLISKLPYIHFFHTVLKQIAPEYFEKNEPYLEAACNDVDRWPAPVPGK
                     TLHLPIMGLVMKVRIPTCHDKPGTTQMVQLTQQADTHTSIILPTVHEVDLFRCFCPVF
                     LHSQMLWELVLLGEPLVVMAPSPSESSETVLALVNCISPLKYFSDFRPYFTIHDSEFK
                     EYTTRTQAPPSVILGVTNPFFAKTLQHWPHIIRIGDLKPAGEIPKQVKVKKLKNLKTL
                     DSKPGVYTSYKPYLNRDEEIIKQLQKGIQQKRPSEAQSVILRRYFLELTQSFIIPLER
                     YVASLMPLQKSISPWKSPPQLRQFLPEEFMKTLEKTGPQLTSGIKGDWIGLYRQFLKS
                     PNFDGWFKTRRKEMTQKLEALHLEALCEEDLLLWIQKHTEVETVDLVLKLKNKLLQAG
                     RESLPVKPDTVEKLRTHIDAIILALPDDLQGILLKTGMT"
     exon            314..352
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            353..395
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            396..508
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            509..589
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            590..695
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            696..775
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            776..838
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            839..894
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1017
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1113
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1208
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1274
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1339
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1429
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1483
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1593
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1696
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1771
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..6666
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3457..3462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /note="hexamer: AATATA"
     polyA_site      3475
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
     regulatory      4051..4056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /note="hexamer: ATTAAA"
     polyA_site      4079
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /note="major polyA site"
     regulatory      4426..4431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /note="hexamer: AATGAA"
     polyA_site      4444
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
     regulatory      6649..6654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
                     /note="hexamer: ATTAAA"
     polyA_site      6666
                     /gene="Dennd6a"
                     /gene_synonym="Fam116a"
ORIGIN      
        1 agcactcggt gcgcgtgcgc ggaggcctgc gcgctctgcg gcgcggtccg cagcggaggc
       61 ggctcaagcg cctagggggt ggcggatggc tctgccgggc ccggcggtct ttgggcccgg
      121 ttcccgcggg tcgttggacg aggccggggc tgaggggcgc gaggcggcgg cccttgcggc
      181 ggcgggagtc gcgctggagg acgaggagga ggacgatggc cgccggggcc tgctgcgctg
      241 ggacggcttc tcggcctggc tacactgcgt gtgtgtggtg ggcttcgacc tggagctggg
      301 ccaggcggtg gaggtgatat atcctcagca ttccaaactt actgataaag aaaaaaccaa
      361 tatttgctac ttgtcttttc cagactcaaa ttcaggttgt cttggagata cccagttttg
      421 ttttagattc cgacagtctt ctgggagaag ggtgtcacta cactgtcttc ttgatgaatt
      481 tgacaaagat ttaccagttt acttaaagaa agatcctgca tatttttatg gatatgtgta
      541 ttttcgacaa gttcgagata aaactcttaa aagaggctac tttcaaaagt cattggtttt
      601 gatcagcaaa ctaccttata ttcatttttt tcacaccgta ctcaaacaga tagcaccaga
      661 gtattttgaa aaaaatgaac cttacttgga agcagcttgt aatgatgttg accgatggcc
      721 tgccccagtg ccagggaaaa cgctgcacct gcctatcatg ggactagtaa tgaaggttcg
      781 gattcccacg tgtcatgaca agcctgggac cacgcagatg gtgcagttaa ctcagcaggc
      841 agatacacac acatctatta ttttgcctac tgttcacgag gtggatcttt tcaggtgttt
      901 ctgcccagtt tttcttcaca gtcagatgct ctgggagttg gtgctcttgg gagagcccct
      961 ggtggtcatg gcgccatcgc cgtcagaatc ttcagaaact gtactggctc ttgttaactg
     1021 tatctctcca ttaaagtact ttagtgattt tcggccttac ttcacgattc atgatagtga
     1081 attcaaagaa tatactaccc gtactcaagc tccgccctca gtcatcttag gagtaaccaa
     1141 cccctttttt gctaaaacac tacagcactg gccacacatt attcgaatag gagatcttaa
     1201 acctgcaggt gaaattccta agcaagttaa agtgaaaaag ctgaagaacc taaaaactct
     1261 ggattctaaa cctggagttt atacttctta caagccatat ctaaacagag atgaggagat
     1321 cataaaacaa cttcagaagg gtatacagca gaagcgtcct tctgaggccc aaagtgttat
     1381 tctccggcgc tattttttgg aactaacaca aagtttcatc attccattag aaagatatgt
     1441 ggcaagcttg atgcctttgc agaaaagtat ttctccttgg aagagtccac cccagttacg
     1501 gcagttcctt ccagaagaat ttatgaaaac acttgaaaaa acagggcctc agctcacctc
     1561 tggaataaag ggcgactgga ttggacttta ccggcagttt ctaaagtctc caaattttga
     1621 tggctggttc aagacccggc ggaaagaaat gactcaaaaa ttggaggcac ttcatctaga
     1681 agctctttgt gaagaggacc tccttctctg gatccagaaa cacacagaag tagaaacagt
     1741 ggaccttgtg ttgaagctga aaaataagtt gttgcaggct ggccgagaga gcttacctgt
     1801 gaagcctgac actgtggaga agttacggac acatatagat gcaattatcc tggccttacc
     1861 agacgacctg caaggcatac tgctcaagac cggcatgaca taacacttgt caggttttcc
     1921 agccagaaag gactgtgaag caggaagcat actgacattc atctagacgc acactgagca
     1981 agctcagggg cacagcacgg aaataagcag caattgctag atacagctgg aaaggctgag
     2041 cggacacaca gacatttgta gtgcgttctg tggtggttcc acaatgctga aataccgaaa
     2101 gacatttcca tatttttaat cacgttctaa agtgctctta tgagagacct atggggccat
     2161 cagtgtaagt gactccaaac tgcagtgccg gcattgcaga tattttttta aattggtgct
     2221 gctttgccca atcatgttga actcagggga atagaagaat aatgttcaca ctggctgtct
     2281 tcttaagaag gaaaaactga actttccaac tatagttaga tataactgag gcttatgtag
     2341 tgccttccat tgtcctatat gtttcacagg gtccagctgc taattgtaag gctttttctt
     2401 ttttaattat gatacataat ttcaaaggca ttatgtcaag taatcacttg cccaaaagta
     2461 tttcttgttg cccctcatgt ttattgcctg ttgttttaaa ttatcatgta ggttttcatg
     2521 tcacaactct ctaccatttt cacaacttag gtgtgtctcc gaggaaggag gcacatgcag
     2581 ttctggctat ggaagagctg atttctcctc tctcttttac tcactggcct gcatacacta
     2641 ggtagcttga atgtcttttg aagacattct cacaatgaac atcatagttg ttttttaaaa
     2701 gaatattttt atgtcaaaga taagccattc atgtaataat tatttgagag ttttacattt
     2761 accttttaac gttatttgtt gggtgacact atttccccta gtggatgatt tttagaagac
     2821 ttttcctgtt gttgtttgac atgggacctt ttgtgtaaat cagcattaca cttttgtttg
     2881 tttgttttca ttttgtttgt actaccttgc caaaagtaga atgagatagt ttggtttcag
     2941 atgggagtgt tgcagaagcc actgttcaga taggcacaca caaagcagca catgtgtaaa
     3001 tagctgtgac ttaagtacct gcccttctga gcagccacac ggtggcttca gaagccatct
     3061 cttattcttt tgctgttatt ttcaagggca ttcctgatcc aagaaggttt ctctgtgtgt
     3121 gtgactgtgg tctcatatct agggtgcccc ttccttactc atggatacag tctcttgaag
     3181 cataccactg tcctaggaag aatatggcat ttgaatgaaa tcatttgtct ggattgattg
     3241 attgaaaatt tattttgtga aacaatactg acctttcaga aaaggggcaa ctacttttat
     3301 atgctaaagt acttcataac tttctgggaa actttattta ggtagaaatg gtcatcttat
     3361 tatttttcaa aaaaatgtat tttaataatt tcacaattta tatacagttt gtgacatgaa
     3421 tatgaaagtc attagtatta tatcaaggat ttttgaaata tacttctaca ggatatatca
     3481 tttgaagttt attttgcaca cctaaagaaa aacatgaaat atcaattagc atgataatgc
     3541 tgtctttatg tttaccacat ataacagaaa ctcaacacat ggtgaaaacc aaatcatatt
     3601 cacctacttt atctcttaat ttcaaattat gcattggaaa cccaaggaag actgaatggt
     3661 taacttaaat ttttatgtca gttttagaat ttcagaattg tctctttcat tgtttttgtt
     3721 ttttgttttt tttttttttc gagacagggt ttctctgtgt agccctggct gtcctgcaac
     3781 tcactctgta gaccaggctg gcctccaact cagaaatcca cctgcctctg cctcccgagt
     3841 gctgggatta aaggcgtgtg ctaccaccgc taggctcttt cattgttttt aaggagttta
     3901 gtattcaaac cctgcggttt gtttaatgtg ttatctccac cagcattaga aggaatcagt
     3961 gcttagggtg ttctgtaatg cctagtgcct tctctttaca gtggaaaaga gggtttgtgg
     4021 aggcatttat ggtcattacc caaagcttga attaaaggcc ttggatttta aaaaacttag
     4081 gtagcttgtg ttatgtgtct tcttttttgg ttggttttgt tttggagaca agctttcgtg
     4141 tatcctggac tggcttcaca ctccatgtgt agccatggat gatcttgaac gtctgctttt
     4201 cctgcttcta ccgcctcagc gtggagattg ctggcctgtt ccaccatgcc tagttcagtg
     4261 ctgaggcctg agcccaagga tccatgcatc taggctagca ctctgccaac tgagctacgt
     4321 gcccagccct aacttggatt tcttatattt gcaatacttg gagaaacata cataatgaaa
     4381 cttgtacatt attaaaatat tttatttcta gatagttttt ttccaaatga aatgaaaatc
     4441 caaacctttt tgtgtgtatt ttattataaa caggtgaaat gatgagatcc tagccagacg
     4501 ccggtggtgt acacctttaa tcccagtgct cagaaggcag agacagtgaa gtgaaatgaa
     4561 gtgtactgag gtttaaagcg gtttagatgt ggtactcatt atgggtattt gtgtttgagt
     4621 ttacttgttt ttgaggcagg gtgtctttat gtagctctca acattctgaa actcactaat
     4681 gtctggactg gttttgagct cacagagatt ccatgtctct cccttcctag tgctgtgatt
     4741 aaaggcaagt gtcaccatgc ccagcataat ggatggatgg gcacttgtat gggtgcacaa
     4801 aaaatcaact ttgagtgctg ttcctcagga accatacttt ggtgttttgg tttgtttttt
     4861 tgagacagag tttctcactg acctggctag ctaaagactc taaaaattcc acactgatgc
     4921 ctacaggaga aaaggtaggt gggtaagact cttcactgag gcagagatac ttttctacta
     4981 ctgaggataa gtaatgttca gaagatgtag cttttcagaa gatgagtaat gaagtaacgt
     5041 aagaaaatga gattagtgat acagtttaca aagccaaagg gaaagcaagg gcaaaaattc
     5101 cactgtttgt acagcaatta gtagaccatg tcgcctgtag tctctgaaca gtgagtgata
     5161 tatgttacat tgagattaag ttttatttat ttgcaatact tgaatttgat cagagagcct
     5221 catgcacagt aggcaagtta ccactaggca aagtaagagg attcaatgga atactgtatg
     5281 ttcagtgcaa tgtctgtctt tgtaatcctt cataaccact tatcactgct agatattagt
     5341 actatagaat atatcctctc aaatgtttga atgttaagaa atatgcagtt cccttttggt
     5401 ttttgctaag tagccaagtg tagtcttgaa ctcacaatcc tcctatccca gactccagag
     5461 tagtacaact tcagacatgt accactgtcc ccagttattt tttaaatgag cttgaagtgt
     5521 agaaatacct acagcattaa acccaaaagg actatatata caacatttgt aagcaaaggg
     5581 atgtcattaa gaatgattgg ttagccgggc gtggtgtcgc atgcctttaa tcctagcact
     5641 cgggaagcag aggcaggcgg atttctgagt tggaggccag cctggtctac aaagtgagtt
     5701 ccaggacagc cagggctata cagagaaacc ctgtctcgaa aaaaccaaaa aaaaaaaaaa
     5761 aagaaggatt ggttagagat aggtgtgtaa tccagcaact gagaagctga agcaagagga
     5821 acttgagttc aagctctggg ctataaagtt agatgctatt agaaagagcc aggtgctgga
     5881 gagagaattc agtgggtgag aggacttgct gtacaatcac tggggcccac gttggttcct
     5941 agcatccttg taagaattta aagttacatg cacctgtaac cctagaactg tcggaacggg
     6001 caagagaacg actggggcgt tctggggtac caacgtagct tcagttttag tgagagaccc
     6061 tttctcaggg gagtaatggg aagaatgaca ggatacctga tgtctttttc tggcctttaa
     6121 atgtgtatga tgcacatggc atataaacca caaacataca gcacatacat aagcttacat
     6181 atatgcaggt aaacatacaa gacatacata agcttacata tatgcaggta aaaagtaggg
     6241 ggaggggaga tgggcgtgag gaatgaactg gtgtgttgag aatttggaca atgttaccat
     6301 gtctacctca agttgttagg atgaatgaga tataggaaat gaagtataga attggcctgg
     6361 ataaacagta gcaatccccc ccccccaggg ttcagtttcc ttacttctca agtaacaagt
     6421 cattgtgcat agtggctaca taatatttat catcagaaga aataggttac tatcctaatt
     6481 ccatttccct tacaacttga gctacgtgtg tggttcaatc tctctgatcc tgaataacct
     6541 tatctgtata atacattcca gcaggctaga tgtaacctgt ggccgctggc agctacagtt
     6601 actattgttt tgtgatcagt tgcctacttg atatatagca tattcttaat taaaagtcta
     6661 aaaata
//
