LOCUS       NM_021494               4972 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus DENN domain containing 5A (Dennd5a), transcript
            variant 1, mRNA.
ACCESSION   NM_021494 XM_133852
VERSION     NM_021494.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4972)
  AUTHORS   Iwaki,A., Moriwaki,K., Sobajima,T., Taniguchi,M., Yoshimura,S.I.,
            Kunii,M., Kanda,S., Kamada,Y., Miyoshi,E. and Harada,A.
  TITLE     Loss of Rab6a in the small intestine causes lipid accumulation and
            epithelial cell death from lactation
  JOURNAL   FASEB J 34 (7), 9450-9465 (2020)
   PUBMED   32496646
REFERENCE   2  (bases 1 to 4972)
  AUTHORS   Fernandes,H., Franklin,E. and Khan,A.R.
  TITLE     Crystallization of an engineered RUN domain of Rab6-interacting
            protein 1/DENND5
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 5), 556-560
            (2011)
   PUBMED   21543860
  REMARK    GeneRIF: In contrast to wild-type R6IP1-Rab6 crystals, which took
            several weeks to grow to full size, the engineered R6IP1
            (RPdel)-Rab6 crystals could be grown in a matter of days
REFERENCE   3  (bases 1 to 4972)
  AUTHORS   Recacha,R., Boulet,A., Jollivet,F., Monier,S., Houdusse,A., Goud,B.
            and Khan,A.R.
  TITLE     Structural basis for recruitment of Rab6-interacting protein 1 to
            Golgi via a RUN domain
  JOURNAL   Structure 17 (1), 21-30 (2009)
   PUBMED   19141279
REFERENCE   4  (bases 1 to 4972)
  AUTHORS   Miserey-Lenkei,S., Waharte,F., Boulet,A., Cuif,M.H., Tenza,D., El
            Marjou,A., Raposo,G., Salamero,J., Heliot,L., Goud,B. and Monier,S.
  TITLE     Rab6-interacting protein 1 links Rab6 and Rab11 function
  JOURNAL   Traffic 8 (10), 1385-1403 (2007)
   PUBMED   17725553
  REMARK    GeneRIF: May couple Rab6 and Rab11 function throughout the cell
            cycle; R6IP1 overexpression alters the distribution of peripheral
            recycling endosomes.
REFERENCE   5  (bases 1 to 4972)
  AUTHORS   Ghosh,U., Das,N. and Bhattacharyya,N.P.
  TITLE     Inhibition of telomerase activity by reduction of
            poly(ADP-ribosyl)ation of TERT and TEP1/TP1 expression in HeLa
            cells with knocked down poly(ADP-ribose) polymerase-1 (PARP-1) gene
  JOURNAL   Mutat Res 615 (1-2), 66-74 (2007)
   PUBMED   17141279
REFERENCE   6  (bases 1 to 4972)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   7  (bases 1 to 4972)
  AUTHORS   Callebaut,I., de Gunzburg,J., Goud,B. and Mornon,J.P.
  TITLE     RUN domains: a new family of domains involved in Ras-like GTPase
            signaling
  JOURNAL   Trends Biochem Sci 26 (2), 79-83 (2001)
   PUBMED   11166556
REFERENCE   8  (bases 1 to 4972)
  AUTHORS   Janoueix-Lerosey,I., Jollivet,F., Camonis,J., Marche,P.N. and
            Goud,B.
  TITLE     Two-hybrid system screen with the small GTP-binding protein Rab6.
            Identification of a novel mouse GDP dissociation inhibitor isoform
            and two other potential partners of Rab6
  JOURNAL   J Biol Chem 270 (24), 14801-14808 (1995)
   PUBMED   7782346
REFERENCE   9  (bases 1 to 4972)
  AUTHORS   Landsman,D. and Wolffe,A.P.
  TITLE     Common sequence and structural features in the heat-shock factor
            and Ets families of DNA-binding domains
  JOURNAL   Trends Biochem Sci 20 (6), 225-226 (1995)
   PUBMED   7631419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060230.1.
            
            On Dec 18, 2003 this sequence version replaced XM_133852.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060230.1, SRR13422597.247100.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..4972
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.62 cM"
     gene            1..4972
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /note="DENN domain containing 5A"
                     /db_xref="GeneID:19347"
                     /db_xref="MGI:MGI:1201681"
     exon            1..349
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..4104
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /note="isoform 1 is encoded by transcript variant 1; DENN
                     domain-containing protein 5A; rab6-interacting protein 1;
                     Rab6 interacting protein 1; DENN/MADD domain containing
                     5A"
                     /codon_start=1
                     /product="DENN domain-containing protein 5A isoform 1"
                     /protein_id="NP_067469.1"
                     /db_xref="CCDS:CCDS21741.1"
                     /db_xref="GeneID:19347"
                     /db_xref="MGI:MGI:1201681"
                     /translation="MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQA
                     SKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPK
                     GLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAE
                     YDVLHAPLADGGDQSGMEDGEGIPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKA
                     CRSVLQQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPST
                     NELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFP
                     FQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDVDNHFI
                     ELPEDLPQFPNKLEFVQEVSEILMAFGVPPEGNLHCSESASKLKRIRASELVSDKRNG
                     NIAGSPLHSYELLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDFKVQCDEEELR
                     IYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPE
                     PYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTS
                     MYQKCTTVDEAEKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLCTGP
                     ASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSP
                     SVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCD
                     LLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGILLDSERRKSDASAV
                     MSPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKL
                     YKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFT
                     ANPWICISGELGETQILQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVECVM
                     VRNEVTGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSLPEVDERPCRTPPLQQSPSV
                     IRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSA
                     LEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNDVVPEENWHTRARNFCRFVTA
                     VNNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNS
                     LIRVLQTLQEFNITLDTSLVKGIDI"
     exon            350..421
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..531
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..1189
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1377
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1695
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1911
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2146
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2297
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2391
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2523
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2676
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2761
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2846
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2975
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3097
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3243
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3362
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3544
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..3627
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3751
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3752..3920
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3921..4956
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4937..4942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /note="hexamer: AATAAA"
     polyA_site      4956
                     /gene="Dennd5a"
                     /gene_synonym="1500012B19Rik; mKIAA1091; ORF37; Rab6ip1"
                     /note="major polyA site"
ORIGIN      
        1 ccgcccttcc tcaggcttgc tcaggccgcg gtgcagagga cagcgtccag gatgcggcgc
       61 ggggtggccc ggcgcccccc tgccccggca cggcagcggc ggccgctagg acccggcgag
      121 gcccgggggc ggcggccgga gcctcggtag cggcggcgga gggagcggcg gctgagggcg
      181 ggcgggcggc cgggggcggg ggctcggctc cgcgcggctt gccccgctcg gcccggagcc
      241 atgagcggcg gcggcggcgg agggggctcg gcgcccagtc gcttcgccga ctattttgtc
      301 atctgcgggc tggacaccga gaccgggctg gagccggacg agctgtcggc attatgccag
      361 tacattcagg cttctaaagc cagggatggt gccagccctt tcatttcaag tacgactgaa
      421 ggagaaaatt ttgagcagac gccattgaga cgaacattca agtctaaggt ccttgcccga
      481 taccctgaga atgtagactg gaatcccttt gatcaggatg cagtaggaat gctgtgcatg
      541 cccaaagggc tggcattcaa gacccaggct gatcccaggg agccacagtt ccatgccttt
      601 attatcacaa gggaggatgg ttctcggaca tttgggtttg ctcttacctt ttatgaagaa
      661 gtgaccagca agcaaatctg cagtgcaatg cagaccctct accacatgca caatgctgag
      721 tatgatgtcc ttcatgctcc acttgctgat ggtggagacc agagtggcat ggaagatggt
      781 gaaggcattc ctgggaccaa gctgcagcgc ttcaactcct atgatattag cagggacaca
      841 ctctatgtct ctaaatgcat ctgtctcatt acacccatgt ctttcatgaa ggcatgtcgg
      901 agtgtgctgc agcagctcca ccaggcagtc acatcgcctc agccccctcc tctgcccctt
      961 gagagctaca tatacaacgt actctatgag gtgccacttc cacctcctgg ccgctcccta
     1021 aagttttctg gggtctatgg gccaataatc tgccagagac caagtaccaa tgagcttcct
     1081 ctattcgatt ttcccgtcaa agaggtcttt gaactgcttg gggtggagaa tgtgtttcag
     1141 ctttttactt gtgcccttct ggagtttcaa atactgctct actcacagca ttaccagaga
     1201 ctgatgactg tggcggagac aattacagct ctgatgtttc ctttccagtg gcagcatgtc
     1261 tatgtcccca tcctcccagc ttctctcctg catttcttag atgctcctgt accatacctg
     1321 atgggcttgc attccaacgg cctggatgac cgctccaagt tggagctgcc tcaggaggct
     1381 aacctctgct ttgtggatgt tgacaaccac ttcattgagt tgccagagga cttgcctcaa
     1441 tttcccaaca aactggagtt tgtccaggag gtctctgaga tcctcatggc ctttggcgtt
     1501 ccccctgaag ggaacctcca ttgcagcgaa agcgcctcaa agctgaagag gatccgagct
     1561 tctgagcttg tgtctgacaa gaggaacggg aacattgcgg gctccccttt gcactcctat
     1621 gagctcctca aggaaaatga aactattgct cggttgcaag ctttggtcaa gaggactgga
     1681 gtgagtttgg aaaaactgga agttcgtgaa gatcccagta gcaataaaga tttcaaagtt
     1741 caatgtgatg aagaagagct caggatttac cagctaaaca ttcaaatccg ggaagtcttt
     1801 gccaatcgct ttactcagat gtttgccgat tatgaagtgt ttgtcatcca gcccagccag
     1861 gataaggagt cctggttcac caacagggaa cagatgcaga actttgataa agcatccttc
     1921 ctgtcagatc agcctgagcc ctacctgccc ttcctctcaa gattcctaga gacccagatg
     1981 tttgcatctt ttattgataa caagatcatg tgtcatgatg atgatgataa agaccctgtc
     2041 ctccgggtct ttgactcaag ggtagacaag atcagactgt tgaatgttcg aacacctact
     2101 cttaggacat ctatgtacca gaagtgtacc actgtggatg aagcagaaaa agcaattgaa
     2161 ctacgtctgg caaaaattga ccatactgca gttcacccac atcttcttga catgaaaatt
     2221 ggacaaggaa aatatgaacc tggctttttc cctaagctgc agtctgatgt gctttgcacc
     2281 gggccagcca gcaacaagtg gacaaaaagg aatgcccctg cacagtggag gcggaaagac
     2341 cggcagaagc agcacacaga acacttgcgc ttagacaatg accagagaga gaagtacatc
     2401 caggaagcca ggaatatggg cagtaccatc cgtcagccca aactgtccaa cctctctcca
     2461 tcagtcattg cccagaccaa ctggaagttt gtagaaggcc tgctgaagga atgtcgaaac
     2521 aagaccaaga ggatgctggt agagaagatg ggtcgagagg ccgtggagct ggggcatggg
     2581 gaggtgaaca tcaccggtgt ggaagagaac actttgattg ccagcctctg tgaccttctg
     2641 gagaggatct ggagccatgg gctacaagtg aagcagggga aatcagcttt gtggtcccat
     2701 ctgttacatt atcaggaaaa ccggcagaga aaactcacat caggaagcct tagtacctca
     2761 ggaatacttc ttgattcaga acggagaaag tctgatgcca gtgccgtcat gtctcccctg
     2821 aggatttccc taattcagga tatgaggcac atccagaata ttggggaaat caagactgat
     2881 gtgggaaaag ccagagcatg ggtgcgactg tccatggaga agaaattact gtccagacac
     2941 ctgaagcagc ttctttcaga ccatgagctc accaagaagc tgtacaagcg ttacgccttc
     3001 ctgcgctgtg atgacgagaa ggagcagttc ctctatcacc tgctctcctt caacgcagtg
     3061 gactacttct gcttcaccaa cgtctttaca accatcctga ttccatacca cattttgatt
     3121 gtaccaagca agaagctggg cggctccatg ttcaccgcca acccgtggat ctgtatatca
     3181 ggagagctgg gtgagaccca gatcctgcag atccccagga atgtgctaga gatgacgttt
     3241 gagtgccaga acctggggaa gctcaccact gtccagattg gccatgataa ttctgggctg
     3301 tatgccaagt ggcttgtgga atgtgtgatg gtcaggaatg aggtcacagg acacacctac
     3361 aagtttccgt gtggccgatg gctggggaag ggtatggacg acggaagctt ggagcgcgtg
     3421 cttgttgggg agctgctcac ttccctacct gaggtggatg agaggccttg tcgcactccg
     3481 ccactacagc agtcccccag tgtcatccgg agacttgtga ccatctcgcc caacaataag
     3541 cccaagctga acactgggca gatccaggag tccattgggg aggcagtcaa tggcattgtg
     3601 aagcacttcc ataaacctga gaaagagcgt ggcagcctga cactgttgct ctgtggagag
     3661 tgtggtctcg tttcagcact ggaacaagct tttcagcatg gatttaaatc accccggctc
     3721 ttcaaaaatg tcttcatttg ggatttcctg gagaaagcac aaacctatta tgagacgtta
     3781 gagcagaatg acgtagttcc agaagaaaac tggcacacac gggcccgcaa tttctgccgc
     3841 tttgtcactg cagtcaacaa cacgccccgg aacattggca aggacggcaa atttcagatg
     3901 ctggtgtgcc tgggagccag agatcacctc ctgcaccact ggatagcctt gctggccgac
     3961 tgccccatca ctgcgcacat gtatgaggac gtggcgctga tcaaggacca cacactcgtc
     4021 aattccttga tccgagtgct gcagaccctg caagaattca acatcacact ggacacttcc
     4081 ctcgttaagg gcattgacat ctgacctctg agcaccagcc agcagcagga cccagaaaga
     4141 ctccctgcag ctctgcctct tcatcccaaa gggacctaag caagttgtgg gggacagaga
     4201 ggatatgtat acttactgta aaaagaaaac tagaggattt ttggaaaaaa aataatctat
     4261 tttagagttt atttgctgac ctgcttttta cacactttca tgtgaaagag acagagaggg
     4321 gcaaggttgg cgctgcttgt tttgaagctg gtgcctccct tgcatggccg cacgctggga
     4381 gcctgtggcc tcccagactg agcctgcaac aagtgtgggg ctgttccaca tgccgccccg
     4441 tcacggcggt gaggccattc cacatcgttt ttaaactaat gttttctata ttaacattat
     4501 tctggctatc tggctttcac gggccacgca caggtgtgcg agtgggacat cccatgctcc
     4561 aatcaaaggg atttttagca gtgcctctga tcaagcactg ccaagtcagc tccacatccg
     4621 tttcccccct tccccttttt tgtcagtatt atttgggaag gagacatgcc aggacaatgt
     4681 cattgtgcta catgcagaaa atcatgtttc ctgttggcac aaagttgcac aggagtaaac
     4741 atgagcatgt ttaacaggtt tgtcttttct tcacctatct tatttattta acctgccatt
     4801 gtgtgtttta agtatttgtt tttcttttct ttttttcttt aagagaagga aagcttgtca
     4861 gtctaactgg ctatgttatt actgttcaat ttatgttgtt ttgcaactta gaaaccagct
     4921 acagtatggc ccacttaata aaacacctga aacaaaaaaa aaaaaaaaaa aa
//
