LOCUS       NM_001405424            7853 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus DENN domain containing 4C (Dennd4c), transcript
            variant 2, mRNA.
ACCESSION   NM_001405424 XM_006538022
VERSION     NM_001405424.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7853)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7853)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7853)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   4  (bases 1 to 7853)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 7853)
  AUTHORS   Borner,G.H., Antrobus,R., Hirst,J., Bhumbra,G.S., Kozik,P.,
            Jackson,L.P., Sahlender,D.A. and Robinson,M.S.
  TITLE     Multivariate proteomic profiling identifies novel accessory
            proteins of coated vesicles
  JOURNAL   J Cell Biol 197 (1), 141-160 (2012)
   PUBMED   22472443
REFERENCE   6  (bases 1 to 7853)
  AUTHORS   Sano,H., Peck,G.R., Kettenbach,A.N., Gerber,S.A. and Lienhard,G.E.
  TITLE     Insulin-stimulated GLUT4 protein translocation in adipocytes
            requires the Rab10 guanine nucleotide exchange factor Dennd4C
  JOURNAL   J Biol Chem 286 (19), 16541-16545 (2011)
   PUBMED   21454697
  REMARK    GeneRIF: Insulin-stimulated GLUT4 protein translocation in
            adipocytes requires the Rab10 guanine nucleotide exchange factor
            Dennd4C
REFERENCE   7  (bases 1 to 7853)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772228.5 and BX005084.16.
            
            On Apr 22, 2022 this sequence version replaced XM_006538022.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.6446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AL772228.5         74851-75120
            271-592             AL772228.5         100446-100767
            593-845             AL772228.5         103921-104173
            846-915             AL772228.5         106043-106112
            916-1085            AL772228.5         107750-107919
            1086-1324           AL772228.5         112256-112494
            1325-1391           AL772228.5         115033-115099
            1392-1450           AL772228.5         116112-116170
            1451-1595           AL772228.5         117535-117679
            1596-1771           AL772228.5         121330-121505
            1772-1872           AL772228.5         124252-124352
            1873-2091           AL772228.5         125561-125779
            2092-2237           AL772228.5         129115-129260
            2238-2273           AL772228.5         131578-131613
            2274-2404           AL772228.5         131703-131833
            2405-2537           AL772228.5         133636-133768
            2538-2744           AL772228.5         137621-137827
            2745-2873           AL772228.5         138533-138661
            2874-3018           AL772228.5         139601-139745
            3019-3165           AL772228.5         139990-140136
            3166-3285           AL772228.5         146070-146189
            3286-3429           AL772228.5         147535-147678
            3430-4592           AL772228.5         151126-152288
            4593-4773           AL772228.5         154176-154356
            4774-4883           AL772228.5         155128-155237
            4884-5059           AL772228.5         155699-155874
            5060-5242           AL772228.5         162588-162770
            5243-5438           AL772228.5         163589-163784
            5439-5684           AL772228.5         165840-166085
            5685-5802           AL772228.5         167193-167310
            5803-5953           BX005084.16        5480-5630
            5954-6018           BX005084.16        8611-8675
            6019-7853           BX005084.16        9423-11257
FEATURES             Location/Qualifiers
     source          1..7853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 40.69 cM"
     gene            1..7853
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /note="DENN domain containing 4C"
                     /db_xref="GeneID:329877"
                     /db_xref="MGI:MGI:1914769"
     exon            1..270
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            271..592
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..6155
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     likely ortholog of H. sapiens chromosome 9 open reading
                     frame 55 (C9orf55); DENN domain-containing protein 4C;
                     DENN/MADD domain containing 4C"
                     /codon_start=1
                     /product="DENN domain-containing protein 4C isoform 2"
                     /protein_id="NP_001392353.1"
                     /db_xref="GeneID:329877"
                     /db_xref="MGI:MGI:1914769"
                     /translation="MIEDKGPRVTDYFVVAGLTDTSTLLDQEINRTDTNSIGPKAPIT
                     DIAVIIKSAGETVPEGYTCVEATPSALQANLNYGSLKSPELFLCYRRGRDKPPLTDIG
                     VLYEGKERLMPGCEVIQATPYGRCANVNNSSTTSQRIFITYRRAPPVRSQNSLAVTDI
                     CVIITSKGETPPHTFCKVDKNLNCGMWGSNVFLCYKKSVPASNAIAYKAGLIFRYPEE
                     DYESFPLSPSVPLFCLPMGATIECWDPQIKYPLPVFSTFVLTGSSAEKVYGAAIQFYE
                     PYSQERLTEKQLTQLGLLTLVEKRVVSKPINSNKCICLLSHWPFFEAFKNFLMFIYKV
                     SVSGPHPLPIEKHISHFMQNIPFPSPQRPRILIQLSVHDAFILSQPVSTPLPLSGANF
                     SSLLMNLGPENCATLLLLVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPL
                     CPLSLAGVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNTLYVADERKNINWKQLP
                     KRPCKSLLGTLRRLYQQLCSVHRKPQESSAIEMTPIEADYSWQKKMTQLEMEIQETFL
                     RFMASILKGYRSYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYTKFYTLLSKTQIF
                     IRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGVERTEKVDLDSAEDTRLIELDDSQRS
                     EHTVFIMPPEPPPDDGNNLSPQYSYTYFPRLDLKLFDSPQKLKLCFNRHPPGSSITNS
                     PALMAKRTKQEIKTAHKLAKRCYTNPPQWAKYLFSHCYSLWFICLPAYVRVSHPKVRA
                     LQQAHDVLVKMRKTDVDPLDEVCYRVVMQLCGLWVNPVLAVRVLFEMKTARIKPNAIT
                     YGYYNKVVLESPWPSSTRSGIFLWTKVRNVVHGLAQFRQPLKKTGQKSQVFSISAPQN
                     AACGSDGDTVSHGSVDSSNDANNGEHTVFVRDLISLDSIDNHSSTGGQSDQGYGSKDE
                     LVKEGADGHAPEEHTPPELTTTELHIEEECDISAIVSKHLQPTPEPQSPTEPPAWGSS
                     IVKVPSGLFDTNNRTSTGSTSTVLFSTQAPVEDAVFSEVTNFKKNGDRGEKKQKHFPE
                     RSCSFSSESRAGMLLKKSSLDLNSSEMAIMMGADAKILTAALTCPKTSPPHVTRTHSF
                     ENVNCHLADSRTRMSEGTRDSEHRSSPVLEMLEESQELLEPVVGDNVAETAAEMTCNS
                     LQSNSHSDQSRDTQAGAQDPVNKRSSSYATRKAIEREDVETGLDPLSLLATECVEKTS
                     DSEDKLFSPVISRNLADEIESYMNLKSPLGSKSCSMELHGEGNQEPGSPAVFAHPLER
                     SSSLPSDRGPPARDSTETEKSSPAVSSSKTLTGRFKPQSPYRAYKDRSTSLSALVRSS
                     PNSSLGSVVNSLSGLKLDNILSGPKIDVLKSSMKQAATVASKMWVAVASAYSYSDDEE
                     ETNKDYSFPAGLEDHHIVGETLSPNTSVSGLVPSELTQSNTSLGSSSSSGDVGKLQCP
                     AGEVPFSRNIKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEE
                     IMAGWTADDSNLNTTCPFCKSNFLPLLNVEFKDLRGSASFFLKPSTSGDSLQSGSIPS
                     ASEPSEHKPTSSSAEPDLISFMDFSKHSETITEEASYTVESSDEIKKTNGDVQSVKMS
                     SVPNSLSKRNVSLTRSHSVGGPLQNIDFSQRPFHGVSTVSLPSSLQEDVDHLGKRPSP
                     PPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNL
                     PGLILTSEHCNGGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPGEPLYVSWRNLNSEK
                     KPSLLSEQQQAASALVETIRQSIQQNDVLKPINLLSQQMKPGTKRQRSLYREILFLSL
                     VSLGRENIDIEAFDNEYGLAYRSLPSESLERLQRIDAPPSISVEWCRKCFGAPLI"
     exon            593..845
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            846..915
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1085
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1324
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1391
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1450
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1595
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1771
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1872
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2091
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2237
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2273
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2404
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2537
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2744
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2873
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3018
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3165
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3285
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3429
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..4592
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4593..4773
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4774..4883
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4884..5059
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5060..5242
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5243..5438
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5439..5684
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5685..5802
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5803..5953
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5954..6018
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6019..7853
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7832..7837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7853
                     /gene="Dennd4c"
                     /gene_synonym="1700065A05Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaaacatgg cggtctgtgg tccggacagt ctcgccccgg gcagtgccta gacgtcggtc
       61 ctcccgcagc gcccgcggcc cgcgagccct tcggtcggca gttgccctcg ctgcaggctg
      121 tcccctggag acccggccgc gcggaggcgc aggcgcagag gggccccgga gtcccggccc
      181 tgccagcgga gggtgcccag gccgcgtagc cggcgctttc tcaccccagg aagctccggt
      241 gtcggacagt cgccgactgg gccggcgcag gaagtagaac agccatcatg atagaagaca
      301 aaggacctag agtgacagac tacttcgttg tggcaggtct cactgataca tccactcttt
      361 tggatcaaga aataaatcgt acagatacta actcgattgg tcctaaagct ccaatcacag
      421 acattgctgt tattatcaaa tcagctgggg aaactgtacc tgaaggctac acctgtgtgg
      481 aagccactcc atcagcactc caagcaaact tgaattatgg aagtctgaag agcccagagc
      541 ttttcctgtg ctacaggaga gggagagata agccgcccct tacagatatt ggcgtgctat
      601 atgaagggaa agaaaggctt atgccaggat gtgaagtgat ccaagccacg ccgtacggcc
      661 gctgtgccaa tgtcaacaat agttcaacta cttctcaaag aatctttatc acctatcgaa
      721 gggctccccc agtgcggtcc cagaattcct tggccgtcac tgatatctgt gttattataa
      781 ccagtaaagg agaaacccct ccgcatactt tctgcaaagt ggataaaaat ttaaactgtg
      841 gcatgtgggg ttccaacgtg tttctgtgtt acaagaagtc tgtgcctgct tcaaatgcaa
      901 tagcatataa ggctggtttg atttttcgat atccggaaga agactatgag tcttttccgc
      961 tctcaccatc tgtgcctctc ttctgccttc ctatgggagc cactattgaa tgctgggatc
     1021 ctcaaatcaa atacccactt cctgttttct caacatttgt cctgacaggg tcttcagctg
     1081 aaaaggtata tggagctgcc atccagtttt atgaacctta ctctcaagaa cgtctaacag
     1141 agaaacaact tacacagctg ggcctattga ccctcgtgga gaaaagagtg gtctccaaac
     1201 ccatcaattc aaacaagtgc atttgtttgc tttcacactg gccttttttt gaagctttta
     1261 agaattttct tatgtttatc tacaaagttt ctgtgtctgg accacatcct cttcccattg
     1321 aaaagcacat ttcacatttt atgcaaaata tcccttttcc ttcaccacaa agaccaagaa
     1381 tcctcatcca gctatcagtc catgatgcat ttatattatc acagccagtg tccacacctt
     1441 taccattaag tggcgccaac tttagctcct tgctgatgaa tctgggtcct gagaactgcg
     1501 cgacattgct gctgctggtt ttgctcgaga gtaagattct gctgcactct ctgaggccag
     1561 cggtactaac tggggtagcc gaagctgtcg ttgctatgat ctttccattt cagtggcagt
     1621 gcccatatat ccccctctgt cctctttcat tggctggagt gcttagtgcg cctttaccat
     1681 ttatagttgg agtggactca aggtactttg atcttcatga cccaccacaa gatgttgtct
     1741 gcattgactt ggatacgaac acattatatg tagctgatga aagaaagaac ataaactgga
     1801 agcagcttcc caaaaggccg tgcaagagtc tgcttggcac cctgaggagg ctgtatcagc
     1861 agctctgctc agttcaccga aaacctcaag aaagttcagc aattgagatg actccaattg
     1921 aagcagatta ctcttggcaa aaaaagatga cacaattgga gatggaaatt caggagacat
     1981 ttttgcgatt tatggcgtct attttaaaag ggtacaggtc atatctcaga ccaatcacag
     2041 aagctccttc taataaagcc acagctgcgg attcattgtt tgatcgacag ggttttttga
     2101 aaagtcggga tcgtgcctat acaaaattct atactctttt atccaaaaca cagattttta
     2161 ttcgtttcat tgaagaatgc agttttgtaa gtgataaaga tactggattg gcattttttg
     2221 atgattgcat cgagaagttg tttccagata aaggtgtaga gagaacagaa aaggttgact
     2281 tggattcagc agaagacacc agattgatag agctagatga ttcacagaga agtgaacaca
     2341 ctgtatttat aatgccacct gagccgcctc ctgatgatgg aaataactta tcacctcagt
     2401 acagttacac atactttcca agattggatc ttaagctttt tgacagccca cagaagctga
     2461 aactgtgctt caatagacat cctcctggga gtagcattac aaacagccct gccctcatgg
     2521 ctaaaaggac taaacaggag ataaaaacag ctcataagtt ggcgaagaga tgttatacga
     2581 atccaccaca atgggccaag tatctattca gccactgtta cagtctgtgg tttatttgtc
     2641 tcccagccta tgttagagtt tctcacccta aggtccgagc actccagcag gcacatgatg
     2701 tgcttgttaa gatgcggaag acagacgtgg atccactaga tgaggtgtgc tatcgagtag
     2761 tcatgcagct ttgtggactt tgggttaatc ctgttttagc agtgagagtc ttattcgaga
     2821 tgaaaactgc tagaataaaa ccaaatgcta tcacttatgg ctattacaat aaggtagttt
     2881 tggagagccc atggcccagc agtactcgca gtggtatttt cttgtggacg aaagtacgga
     2941 atgttgtaca tggtttggcc cagtttaggc aaccacttaa aaagactggg caaaaatcac
     3001 aggtcttttc aatatcagct cctcagaatg ctgcatgtgg aagtgatggg gacacagtga
     3061 gccatggtag tgtggatagt tctaacgatg ctaacaatgg ggagcacaca gtcttcgtca
     3121 gagacttaat cagccttgat tccattgata atcactctag cacaggcggt cagtctgacc
     3181 agggctacgg gtctaaggat gagctggtaa aggagggtgc agatggtcac gcccctgaag
     3241 agcacacgcc accagagctg acgaccacag agctgcacat cgaagaggag tgtgatatat
     3301 ctgccattgt ctcaaaacac ctgcagccta ctcctgaacc tcagagtcct acggagcctc
     3361 ctgcatgggg cagcagtatt gtgaaagttc catctgggtt atttgatacc aacaatagga
     3421 caagtactgg tagtacttca actgtgctat tttctactca agctccagtc gaggatgcag
     3481 tcttcagtga ggttactaat ttcaagaaga atggtgatag aggagagaaa aaacagaagc
     3541 atttccctga gaggagctgt agctttagtt ctgaaagtcg agcggggatg ctgcttaaga
     3601 agagcagttt ggacctgaat tcaagcgaaa tggccatcat gatgggagca gatgccaaga
     3661 tcctcacagc agcactgaca tgtcctaaga cttccccgcc tcatgtcaca agaactcaca
     3721 gctttgagaa tgttaactgt catctagctg acagtaggac tcgcatgtca gaaggcaccc
     3781 gggattctga gcacagatca tctcctgtgc tagagatgct ggaggaaagc caggagctcc
     3841 tggagcctgt ggttggtgat aatgtggcag agactgcggc agagatgacg tgtaacagtc
     3901 tacaaagtaa cagtcacagt gaccagtcca gagacacaca agctggagcc caagatccag
     3961 tgaacaagag gagcagttca tatgctacta ggaaagccat tgagagggag gatgtggaga
     4021 cgggactaga tccgttgtct cttttagcca ctgaatgtgt agaaaaaacg tctgattctg
     4081 aagataagtt attttctcca gtaatttcac gtaatctggc tgatgaaatt gaaagttaca
     4141 tgaacctaaa aagcccacta ggcagtaaat cttgtagtat ggaattgcat ggagagggga
     4201 accaggagcc tggctctcct gctgtgtttg ctcacccttt agaaaggagc tcgagtctgc
     4261 cttcagaccg tggcccgcca gcacgagaca gcaccgagac tgagaagagc tcccctgctg
     4321 tgtccagctc taaaactctg actgggcgtt tcaagccaca gagtccttac cgcgcttaca
     4381 aagaccggtc cacttcctta tcagcattag tacgttcttc accaaacagc tctctgggtt
     4441 ctgtagtcaa ttctctatcg gggctaaagt tggacaatat actctcaggg cccaagatag
     4501 atgtcctaaa atctagtatg aaacaagcag caacggtggc cagtaagatg tgggtggctg
     4561 tagcatctgc ctatagctac tcagatgacg aggaggaaac taataaagat tacagtttcc
     4621 cagctggcct agaagaccat catatagtgg gagagactct gtcgcctaac acaagtgtct
     4681 cagggttggt tcccagtgaa ctgacccaga gcaacacaag cctcggcagt agtagcagca
     4741 gtggagacgt tggaaaactg cagtgtccag caggtgaagt tccattttca agaaatatca
     4801 aagggcagga ctttgaaaag tcagaccatg gttcttctca gaataccagt atgtctagca
     4861 tctatcaaaa ttgtgcgatg gaggttttga tgtcgagttg ctcacagtgc agagcttgtg
     4921 gcgctctggt ttatgatgag gaaatcatgg ctggatggac agcagatgac tcaaatttga
     4981 atacaacctg cccgttctgt aaaagcaact tcttgcctct tctcaatgta gaatttaaag
     5041 acctgcgagg ctctgccagc tttttcttga aaccaagcac gtctggtgac agtttacaaa
     5101 gcggcagcat tccatcagcc agtgagccct ctgaacacaa acccacgtcc agttcagcag
     5161 aacctgacct gatcagcttt atggatttct caaaacacag tgagaccata acagaagaag
     5221 caagttatac agtcgaatca agtgatgaaa taaagaaaac caatggtgat gtccagagtg
     5281 tgaaaatgtc atctgtgcct aacagtttat ctaagcgaaa cgtatctttg actcgaagtc
     5341 acagtgttgg aggccctctg cagaatatcg acttctccca gcgaccattt catggcgtct
     5401 caacagtcag tcttccaagc agtctgcagg aagatgtgga ccatctaggc aagcgaccca
     5461 gtcctcctcc tgtgtctgtg ccctatttga gtcctctagt gcttcggaag gaacttgaat
     5521 ctttgctaga aaatgaaggt gatcaggtca tccatacatc ctcattcatc aatcaacacc
     5581 caatcatttt ctggaacctg gtttggtatt tcagacgttt ggaccttcct agcaacttgc
     5641 caggccttat tctcacctct gagcattgta atggaggtgt gcagcttcct ctatcatctt
     5701 tgtcccagga cagcaaactg gtgtatattc aactgctgtg ggataatatc aaccttcatc
     5761 aggaaccagg agaacctctg tatgtctctt ggaggaactt gaattctgag aagaagccgt
     5821 cacttctgtc agagcagcag caggcagcca gcgctttagt ggagacgatc aggcagagca
     5881 tccagcagaa tgacgttctc aagcccatca acctgctttc ccagcaaatg aagccaggca
     5941 cgaaacggca gaggagttta tacagagaaa tccttttctt atcattagtg tctcttggga
     6001 gagaaaacat tgatattgag gcttttgaca atgaatatgg actcgcatac agaagtctgc
     6061 cttcagagag tcttgaaagg ttacagagaa tcgatgcccc acccagtatc agtgtggagt
     6121 ggtgcaggaa gtgttttgga gcgcctctca tttaaacgag attctttcca attttggttg
     6181 agtactgggg aaatggatcc tgtctgaaaa ctttctgtgt tcttccaaaa tcctaacttg
     6241 gtgaaagctg aaatgaagta actctgggga tgaaatacaa atgaactgca attcatacgg
     6301 aatcatctca gaatgtacaa cagcactcag ttcctggagg tttgttgatg gtgaagactc
     6361 ctgacctatt tcccagcctc tgctgaaaat caacacaact atttttgcat ctcacacagt
     6421 aaaagaaata atggaagttt tcatctttct agaaaacttg cttttattga agctgtccag
     6481 ctagggaatg gcagattaaa tttgcctaac caaaagacat gaaatagttg aataataaga
     6541 ctaactgtgt atgattgtat gtatgaggct atgtagtcag tgtgtgtata ggtgtctatt
     6601 tattaacatg ctgaggttgc atgttgcagc agttttctga agtaggcctc attgcccagt
     6661 cagtgactac tatacttgtt tgtagtcagc agttccaaaa acatctaagt ctttcttaac
     6721 aactgccttc cctacaactt aaaatcttat atctttgcct tttaaattat gtaatatctt
     6781 gcttaatagg ttatatctta gatatccagg tgctccttcc gtcttcttcc aatactaagt
     6841 tcatctgcaa tgctttcatt ggaatccagt aggtaaaatg aaattaatct ttgtaaccta
     6901 acaaacttat ccagcacatg cttttaaaat actaatgaat aaatagtctt tgaccccgaa
     6961 atctttattc aggcaggcca cttgttggta ttgattactt ttttataatc ctggtttcat
     7021 gggaggcaga ggcaggagga tctcaagttg gaggcccgcc tgaacaactt ttagtgagcc
     7081 ctgtttcagt aacttgaaag gagatctggg aatgtagttc agtgtagagc acttgcctag
     7141 catacatgag gctctaggtt cagttcctag taccacaaaa taagtaagta aataaataac
     7201 tagatagata gattaaacct gtgggatgga gaatttgcac tgcacataaa agttttattc
     7261 ttgtacaata ttttgattta tatgcttgtg aataaaagtg tgtatttgta aatactggtt
     7321 ttttaggttg aatcaattaa gtctaaaaac tttaaagctt attgagctca ttgccaggtt
     7381 gaagaatcat gacctcatgc cccacccacc ttgacataaa ttgtactttt tgtttaaaat
     7441 gtccatttaa gagcaaattt gccttagctg tctgtgtggt ttagaagccc agtggctatg
     7501 tgtgcactta cagtaatagt gcagatgact aaaccggttg acaaacttac ctcagtgtgg
     7561 tacacactaa tagcatgaat ctcttcaatg tggtgggcat tttttaaaat tatgtaccaa
     7621 catttcaacg ttaaaggttg ttaatctgac tttgcagaat tctagtctga atttgaatgt
     7681 taaaagtttt accagaaatt ttgtaaaggc tttcttacat tcaaattgga tcttttacag
     7741 tttcaaatat atatattttt acagcttata ctttaacatt tattgaccca acagattttg
     7801 aaattatctt acatatataa aattaaagtt gaataaaaag aaaaatctca aat
//
