LOCUS       NM_001356483            5593 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus DENN domain containing 4B (Dennd4b), transcript
            variant 2, mRNA.
ACCESSION   NM_001356483 XM_006501356
VERSION     NM_001356483.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5593)
  AUTHORS   Marat,A.L., Dokainish,H. and McPherson,P.S.
  TITLE     DENN domain proteins: regulators of Rab GTPases
  JOURNAL   J Biol Chem 286 (16), 13791-13800 (2011)
   PUBMED   21330364
  REMARK    Review article
REFERENCE   2  (bases 1 to 5593)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119825.11.
            
            On Oct 5, 2017 this sequence version replaced XM_006501356.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.185979.1,
                                           SRR10223969.3819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               AC119825.11        160678-161004
            328-667             AC119825.11        162856-163195
            668-920             AC119825.11        163686-163938
            921-990             AC119825.11        164191-164260
            991-1160            AC119825.11        164431-164600
            1161-1405           AC119825.11        164677-164921
            1406-1472           AC119825.11        165498-165564
            1473-1531           AC119825.11        165656-165714
            1532-1676           AC119825.11        165890-166034
            1677-1852           AC119825.11        166272-166447
            1853-1953           AC119825.11        166577-166677
            1954-2169           AC119825.11        167010-167225
            2170-2315           AC119825.11        167699-167844
            2316-2455           AC119825.11        168158-168297
            2456-2582           AC119825.11        168380-168506
            2583-2789           AC119825.11        169247-169453
            2790-2918           AC119825.11        169732-169860
            2919-3117           AC119825.11        170889-171087
            3118-3285           AC119825.11        171666-171833
            3286-3674           AC119825.11        172323-172711
            3675-3797           AC119825.11        172864-172986
            3798-3967           AC119825.11        173178-173347
            3968-4109           AC119825.11        173431-173572
            4110-4346           AC119825.11        173754-173990
            4347-4473           AC119825.11        174603-174729
            4474-4639           AC119825.11        174821-174986
            4640-4704           AC119825.11        175063-175127
            4705-5593           AC119825.11        175220-176108
FEATURES             Location/Qualifiers
     source          1..5593
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.21 cM"
     gene            1..5593
                     /gene="Dennd4b"
                     /note="DENN domain containing 4B"
                     /db_xref="GeneID:229541"
                     /db_xref="MGI:MGI:2446201"
     exon            1..327
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            328..667
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..4850
                     /gene="Dennd4b"
                     /note="isoform 2 is encoded by transcript variant 2; DENN
                     domain-containing protein 4B; brain specific protein 4;
                     brain-specific gene 4 protein; DENN/MADD domain containing
                     4B"
                     /codon_start=1
                     /product="DENN domain-containing protein 4B isoform 2"
                     /protein_id="NP_001343412.1"
                     /db_xref="CCDS:CCDS89660.1"
                     /db_xref="GeneID:229541"
                     /db_xref="MGI:MGI:2446201"
                     /translation="MAEERPPRLVDYFVVAGLAGNGAPIPEEKWVPEPTGPLRPPRPA
                     EPITDVAVIARALGEEVPQGYTCIQTSAGGHPLELSAGLLGGTQPVICYRRGRDKPPL
                     VELGVLYEGKERPKLGFQVLDTTPYSHSANLAPPGPGHPRTYLMYRRAAEGAGLHALG
                     ITDLCLVLPSKGEGTPHTYCRLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGR
                     YPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAAL
                     QFYEAFPRARLSERQARALGLMSAVERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFL
                     TFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYDNLLLCQPVSSPLP
                     LSGASFLQLLQNLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQ
                     CPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPADVICVDLDTNTLFQKEEKKPL
                     SARTLPRRPYKLLLATLTSLYQQLDQTYTGPEEEASLEFLLTDYEAVCGRRTRLEREV
                     QGAFLRFMACLLKGYRNFLRPLTQAPSEGSRDVDNLFYLQGFLKSRERSSHKLYSQLL
                     HTQMFSQFIEECSFGSARHAALEFFDSCVDKVHPEQEKPEPTPLVELEELSGSELTVF
                     ITPPEEPPVLEGSESTPQYCYDGFPELKAELFESPQEQQGALPVPGPSRSAPSSPAPR
                     RTKQEMKVAQRMAQKSATVPELWARCLLGHCYGLWFLCLPAYVRSVPSRVRALHTAYH
                     VLREMENRKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRRAGIVPNTITYGYYNK
                     AVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLKDRRQQQQQQQQQQQQKQQVAEQ
                     QKSGSSQTEPYLERPSPTRPLQRQTTWAGRSLREPSSPMGRLVKSGSLGSARGTQPTV
                     EAGVAHMIEALGVLEPRGSPVPWQDGSLSDLSLTGEEMAPGGSPGGSGSALSAQSTEA
                     LEGISGRGSKTSGCQEEVGTPRKGLGARLQQLLTPSRRASASRIPPPELPSDLPPAAR
                     RSPMDSLLWPRERPGSTASESSASLGSEWDISESSLSSLSLRRSSERLSDTPGAFQPP
                     SLEILMSSCSLCHACDSLVYDEEIMAGWAPDDSNLNTTCPFCACHFVPLLSVQTLDSR
                     PSAPSPKSSLAGASGCKDAPAPGGPGPVLSDRRFCLALDQPQLCNGHMGSASRRVENG
                     AWAYLSPLVLRKELESLVENEGSEVLALPELPAAHPIIFWNLLWYFQRLRLPSVLPGL
                     VLASCNGPPPSQLSQGPSPWLTPDPASVHVHLLWDVLTPDPNSCPPLYVLWRVHSQIP
                     QRVVWPGPVPSCLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREI
                     LFLTMAALGKDHVDIVAFDKKYKSAFNKLASSMGKEELRQRRAQMPTPKAIDCRKCFG
                     APLEC"
     exon            668..920
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            921..990
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1160
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1405
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1472
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1531
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1676
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1852
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1953
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2169
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2315
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2455
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2582
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2789
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2918
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3117
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3285
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3674
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3797
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3798..3967
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3968..4109
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4110..4346
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4347..4473
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4474..4639
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4640..4704
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4705..5593
                     /gene="Dennd4b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5567..5572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd4b"
                     /note="hexamer: AGTAAA"
     polyA_site      5593
                     /gene="Dennd4b"
                     /note="major polyA site"
ORIGIN      
        1 atgagtggag aaagcagggc gcgttgaaga gcttggggtc cccagcaacg tgggagccgg
       61 gaggaccgcg cggctggaac tagcggtgtg gtgtggcagc agtccccgcg tggcgcagcg
      121 cgcggggacg ctgggaccgc ccagatcttc ttccaccgtg cccggcgccc tcggctgctg
      181 cttcttcctt cagcccgggc gcgagcggct cctaagtcga gtgcgccatg tccggggctg
      241 gatagcagcc cagccgcccg ccggcccgcc agcccgccct cagagccacc cgccagcggg
      301 ccggctgggg agtcccaggg caggcagatg cagtgagtga agcagaggcc atggcagagg
      361 agcggcctcc ccggttggtg gattactttg tggtggctgg gcttgcagga aatggagcgc
      421 ctatacctga ggagaagtgg gttcccgagc ctaccgggcc cctgcgccct ccccggccag
      481 ctgaacctat tacagatgtg gcagtcatcg ctagggcact gggcgaggag gtgccccagg
      541 gctatacatg cattcagact tctgcgggtg gccacccctt ggagctcagt gctgggctcc
      601 tgggtggaac tcaaccagtc atctgctacc gcagggggcg tgacaagccc cccctcgttg
      661 agctgggggt gttatatgaa gggaaggaac gacccaagct tgggttccaa gtgcttgaca
      721 cgacaccgta tagccactca gccaatctgg cccctccagg ccccgggcac ccccgcacct
      781 acctcatgta tcggcgggca gcagaagggg cagggctgca tgccctgggc atcactgacc
      841 tctgcctggt tctgcccagc aagggtgagg gtactcctca tacttactgc cggctacccc
      901 gcaacctcaa ccctggcatg tggggcccag cagtgtacct gtgctacaag gtaggcctgg
      961 ccaaggccaa cacactggtg tatgaggcag agctgctggg ccgctaccca gaggaagaca
     1021 atgaggcgtt tccgctgccc gagtcagtcc ctgtcttctg tctgcccatg ggggccacta
     1081 ttgagtgctg gcctgcccag accaagtacc cagtacctgt cttctccacc tttgtgctca
     1141 caggcgctgc tggtgataag gtgtatggtg ctgctttgca gttctatgaa gcgttcccga
     1201 gggccaggct gtcagagagg caggcacggg cactgggcct gatgagtgcc gtggaacggg
     1261 gccgggcgct gggaggccga gctgtgcgca gccgacgagc catagctgtg ctgtcccgct
     1321 ggcctgcctt cccagccttc cgagccttcc tcaccttcct ttaccgatac tccgtctcag
     1381 gcccccatcg tctgcccttg gaagcgcaca tctcccactt cattcacaac gtcccattcc
     1441 catccccaca gagaccacgc atcctagtgc agatgtctcc ctatgacaac ctgctcctct
     1501 gtcaacctgt ctcctcaccc ctgcccctca gtggtgctag ctttttgcag ctgctgcaga
     1561 acctgggccc agaactggct attacattgc tgctggctgt gctcacagag cacaaactgc
     1621 tggtccactc gctgcggcca gatctgctca ccagcgtgtg cgaggccctt gtctcaatga
     1681 tcttccctct gcattggcag tgtccctaca tcccattgtg cccgctagtg ctggcggatg
     1741 tgctgagtgc ccccgtgccc ttcattgtgg gtatccactc cagttatttc gatctgcatg
     1801 acccacctgc tgacgtcatc tgtgttgatc ttgataccaa cacgctcttc caaaaggagg
     1861 aaaagaagcc cctctccgct aggaccctgc cccgaagacc atacaagctt ttattggcca
     1921 ccctgacaag tctgtaccag cagctggacc agacttacac tggaccagag gaagaggcct
     1981 ccctggaatt cctgctgaca gactatgagg ctgtgtgtgg ccgcaggact cgcctggaac
     2041 gggaagtcca gggagccttc ctgcgcttca tggcctgtct gctcaaaggt taccggaact
     2101 tcctccgtcc tctcacgcag gccccctctg aggggtctcg agatgttgac aacctttttt
     2161 accttcaggg tttcctcaag tcccgggaac gctcaagcca caagctgtac tctcagctgc
     2221 tgcacacaca gatgttctca cagttcatcg aggaatgctc ttttggctcc gcccggcacg
     2281 cagccctgga attctttgac tcttgtgttg acaaggttca cccagagcag gagaagcccg
     2341 aaccaacacc cttagtggag ctggaggaac tatcaggaag tgagctcact gtctttatca
     2401 cacccccaga ggaaccacca gtactggaag gcagtgagtc tactcctcag tactgttatg
     2461 atgggtttcc agagctaaag gctgagctat ttgagtctcc tcaggaacaa cagggggccc
     2521 tccctgtgcc aggcccatcc cggagtgctc ccagcagtcc tgcacctcgc cgaaccaaac
     2581 aggagatgaa ggttgcacag cgaatggcac agaagtcagc cactgtgcct gagctgtggg
     2641 cccggtgcct gctgggtcac tgctacggac tgtggttctt atgcctgccc gcctacgtgc
     2701 gttccgtacc ctcccgggtg cgtgcattac atacggccta ccacgtgtta cgggaaatgg
     2761 agaaccgcaa ggtggtgctc cctgatgagg tgtgttaccg cgtgctgatg cagctctgct
     2821 cacactatgg gcagcccgtt ctgtctgtgc gagtcatgct agagatgcga cgggcaggca
     2881 ttgtgcccaa caccatcact tacggttact acaacaaggc agtgctggaa agcaaatggc
     2941 catctggtac tccgggtgga cgcctacgct gggccaagct ccggaatgtt gtcctggggg
     3001 ctgctcagtt ccgccagccc ttaaaggacc gaaggcagca acagcagcag cagcagcagc
     3061 agcagcagca gaagcaacag gtggccgagc agcaaaagtc gggcagctct cagacagagc
     3121 cctatctgga gcgtccctcc ccaacgcgcc ctcttcagcg ccagactact tgggctgggc
     3181 gaagtctacg ggaaccatct tcacccatgg ggcgcctggt caagagtggt agcctaggca
     3241 gtgcccgtgg gacacagccc acggtggagg ctggtgtggc tcacatgata gaggccttgg
     3301 gggtcctgga accccgcgga tcacctgtgc cttggcagga cggaagcctc tcagacctga
     3361 gtctgacagg ggaagaaatg gcacctggag gcagccctgg gggctcaggc tccgccctga
     3421 gtgcccagtc cactgaggcc ctagaaggga taagtgggcg gggttccaaa actagtggat
     3481 gtcaggagga ggtgggcact cccagaaaag ggctgggtgc ccgcctccaa cagctgctca
     3541 ccccttcccg ccgcgcctct gcttcccgca tccccccacc tgagttgccc tctgacctgc
     3601 ctcctgcggc ccgccgaagt cccatggata gccttctgtg gccccgagaa cgccccggat
     3661 ccactgcttc tgagagctct gcttctctgg gcagtgagtg ggatatctca gagtcttccc
     3721 tcagcagcct gagtctccgc cgttcctcag agcgtctcag tgacacccct ggggctttcc
     3781 agccaccctc tctggaaatt ctgatgtcta gctgttcctt gtgtcatgcc tgtgattccc
     3841 tggtgtacga tgaggaaatc atggctggct gggcaccgga tgactctaac cttaatacaa
     3901 cttgtccctt ctgcgcctgt cactttgtgc ccctgctcag tgtccagact cttgattctc
     3961 gacccagtgc acctagtcca aagtcttccc ttgctggcgc cagtggctgc aaagatgctc
     4021 ctgcccctgg gggccctggc cctgtgctca gtgaccggag gttctgcctt gccctggatc
     4081 agccccagct ctgcaatggg catatgggga gtgcttcccg gcgagttgag aatggggcat
     4141 gggcgtacct gagccctctg gtgctgcgta aggaactgga gtccctggta gagaatgagg
     4201 gcagcgaggt gctggcgtta cctgaactgc ctgctgccca ccctatcatc ttctggaacc
     4261 tcctgtggta tttccaacgg ctacgcctgc ctagtgttct accaggcctg gtgttggcct
     4321 cctgtaatgg gcccccaccc agccagctct cccagggacc atctccatgg ctaacccctg
     4381 atccagcttc tgtgcatgtg catctgctgt gggatgtcct gacccctgat cccaacagct
     4441 gcccacctct ctacgtgctc tggagggtcc acagccagat cccacagcgg gtggtgtggc
     4501 caggcccagt accctcatgt cttagcttgg cattactgga gtcagtgctg cgccacgtcg
     4561 gactcaacga ggttcataaa gctgttgggc ttctgctgga gacgctaggg ccccctccca
     4621 ccggcctgca cctacagagg ggaatctacc gtgagatctt attcctgacc atggctgctc
     4681 tgggcaagga ccacgtggat atagtggcct tcgacaagaa gtacaagtct gcctttaaca
     4741 agctggccag cagcatgggc aaggaggaac tgaggcagcg gcgggcacag atgcccactc
     4801 ccaaggccat cgactgccga aagtgttttg gagcacctct ggaatgctag ggacccttaa
     4861 gctcccctct ccagccttga gtggagaggt gcggaagagt ggattctaga catagcctga
     4921 ctccctgttc ccttcacaga ggaattggga acaggatgtt cagcctaggc tccaagtggg
     4981 aatagtagaa agagggactc actgttaccc aaagtcacaa ttctcctatc tccaccctgc
     5041 cctgtttgtt catgctgatg tgggggagag ctagggaagt tgacacaact ccgtctttct
     5101 ccatcccatt ccagggtctc ctttccaggg tgtcctcaga tccgcagtgc cctggtagac
     5161 ttagaagttt ttgttttaaa aaacaactgg aaaaactcag agctcctgag cctttgccct
     5221 gagtggaagg gaggaatttc attccccacg tctcttccct gacattgcta aaggagccca
     5281 aggcaatctt agtgttgtat tctatttagt tatttattct gaggccacag ctcctatact
     5341 tatgggagtc tcaaggagcg tgagaaagaa gggaattaga tttgtagcac cttgagagcc
     5401 atgctctggg acccagagga gtcccaagct tcccttagga agaactggtg cctcttctag
     5461 tcctgatcct cttgtccact ccaccttggg gaacacctct cccatccatg gccttgacct
     5521 gtgcaataag gattgttctc tgcaaagttt ttttggatgt aaatatagta aaagctgctt
     5581 ctgtcttttt ttt
//
