LOCUS       NM_001081066            5256 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus DENN domain containing 3 (Dennd3), transcript variant
            1, mRNA.
ACCESSION   NM_001081066 XM_128129
VERSION     NM_001081066.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5256)
  AUTHORS   Li,Y., Xu,A., Ouyang,Q., Zhang,W., Zhang,C., Chen,Z., Zhou,D.,
            Zhang,B., Duan,W., Zhao,X., Wang,X., You,H., Ou,X., Jia,J. and
            Huang,J.
  TITLE     DENND3 p.L708V activating variant is involved in the pathogenesis
            of hereditary hemochromatosis via the RAB12/TFR2 signaling pathway
  JOURNAL   Hepatol Int 17 (3), 648-661 (2023)
   PUBMED   36729283
  REMARK    GeneRIF: DENND3 p.L708V activating variant is involved in the
            pathogenesis of hereditary hemochromatosis via the RAB12/TFR2
            signaling pathway.
REFERENCE   2  (bases 1 to 5256)
  AUTHORS   Matsui,T., Noguchi,K. and Fukuda,M.
  TITLE     Dennd3 functions as a guanine nucleotide exchange factor for small
            GTPase Rab12 in mouse embryonic fibroblasts
  JOURNAL   J Biol Chem 289 (20), 13986-13995 (2014)
   PUBMED   24719330
  REMARK    GeneRIF: Dennd3 not only functions as a Rab12-GEF but also
            modulates Akt signaling in mouse embryonic fibroblast cells
REFERENCE   3  (bases 1 to 5256)
  AUTHORS   Matsui,T., Itoh,T. and Fukuda,M.
  TITLE     Small GTPase Rab12 regulates constitutive degradation of
            transferrin receptor
  JOURNAL   Traffic 12 (10), 1432-1443 (2011)
   PUBMED   21718402
REFERENCE   4  (bases 1 to 5256)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132863.8 and AC119914.10.
            
            On Jan 25, 2023 this sequence version replaced NM_001081066.1.
            
            Transcript Variant: This variant (1) represents the protein coding
            transcript.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173046.1, BC137791.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               AC132863.8         205371-205629
            260-536             AC119914.10        200435-200711       c
            537-652             AC119914.10        199387-199502       c
            653-786             AC119914.10        198669-198802       c
            787-898             AC119914.10        194914-195025       c
            899-1018            AC119914.10        190003-190122       c
            1019-1237           AC119914.10        189462-189680       c
            1238-1359           AC119914.10        185530-185651       c
            1360-1515           AC119914.10        182093-182248       c
            1516-1612           AC119914.10        180125-180221       c
            1613-1716           AC119914.10        178480-178583       c
            1717-1916           AC119914.10        177796-177995       c
            1917-2438           AC119914.10        175299-175820       c
            2439-2698           AC119914.10        167625-167884       c
            2699-2869           AC119914.10        166423-166593       c
            2870-2999           AC119914.10        165230-165359       c
            3000-3107           AC119914.10        160509-160616       c
            3108-3247           AC119914.10        158305-158444       c
            3248-3405           AC119914.10        157768-157925       c
            3406-3539           AC119914.10        155775-155908       c
            3540-3643           AC119914.10        154416-154519       c
            3644-3781           AC119914.10        154196-154333       c
            3782-5256           AC119914.10        150713-152187       c
FEATURES             Location/Qualifiers
     source          1..5256
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.01 cM"
     gene            1..5256
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /note="DENN domain containing 3"
                     /db_xref="GeneID:105841"
                     /db_xref="MGI:MGI:2146009"
     exon            1..259
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..3982
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /note="DENN/MADD domain containing 3"
                     /codon_start=1
                     /product="DENN domain-containing protein 3"
                     /protein_id="NP_001074535.1"
                     /db_xref="CCDS:CCDS37100.1"
                     /db_xref="GeneID:105841"
                     /db_xref="MGI:MGI:2146009"
                     /translation="MAEPAARHLSLPSGLLELCALLGASQDSLRGLEQIAQKRGVKSA
                     SSLVPEVLSVFVPPFTTKEDGQVPGASCALGKGRRRSFRKKREKPRMEPWKSHPGDSK
                     GPDSEDVTIPGGVDLLALPQLCFPGCVCVASEPKEDYIHFLVLTDVCGNRTYGVVAQY
                     YRPLHDEYCFYNGKSHWEPSVISARCFVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLC
                     KDFEVDNHIKDFAARLSLIPSPPPGPLHLIFNMKPLQVVFPSRADPESPIVDLDLHLP
                     LLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSG
                     QMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDIDHGSVTCSKSSDDNIDIPDVPL
                     LLAQTFIQRVQSLQLHPDLHLAHLSASTDLNEGRARRRAWQQTLNCKIQHITLQLLVG
                     IFREVKNHLNYEHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLNGRMDAFA
                     RMDLDTQSEEDRIDRMLISPRRPTVEKMASRKASPLHITHRRMVVSMPNLQDISLPEL
                     PPRNSSLRIMDTSNCRSSSPVLKVTPKSTYMFKIPDIHFPLESQCVQAYYTDFVTLLS
                     KAMALLGPGDSLLLARYFYLRGLLHLMQGQLLSALLDFQNLYKTDIGIFPADLVKRTV
                     ESMSASERAQAERTPELRRLITEVFDKHGEAPKADDAVKNFELPKKHMQLNDFVKRVQ
                     ESGIVKDAVIIHRLFDALTFGHEKQIDPETFRDFYTCWKETEAEAQEVSLPALLMEHL
                     DKNECVYKLSSSVKTNRGVGKIAMTQKRLFLLTEGRPGYVEIATFRNIEEVKNSTVAF
                     LLLRIPTLKIKTVAKKEVFEANLKSECDLWHLMVKEMWAGKQLADDHKDPQYVQQALT
                     NVLLMDAVVGTLQSPSAIHAASKLAYFDNMKKKSPMAVPKTTSETLKHKINPSAGETA
                     PQAIEVLLYTPGRLDPAEKVEDAHPKLWCALNEGKVVVFDASSWTVHQHCFKVGSSKV
                     NCMVMAEHNQVWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVHNGKKPSEIYSC
                     SLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHNDRIWCCTVHKILVVTPQGFVRQEL
                     KHPKDASFLAFQLLPEEQQLWAASTGVSELYMWSLKDLDQPPQKTYLQDCSEVTCMIR
                     VKRQIWVGGRGLSQGKTRGKIYVMDVEKVTVEKELVAHLDTVRTLCSAEDRYVLSGAG
                     QEEGKIAIWKVE"
     exon            260..536
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            537..652
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            653..786
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            787..898
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1018
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1237
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1359
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1515
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1612
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1716
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1916
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2438
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2698
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2869
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..2999
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3107
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3247
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3405
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3539
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3643
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3644..3781
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..5256
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5234..5239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5256
                     /gene="Dennd3"
                     /gene_synonym="E030003N15Rik"
                     /note="major polyA site"
ORIGIN      
        1 gctggctggc aaccagccca agagaggcgg ggaggcttgg gcaggggtgc tccgctgggg
       61 tctgggttgt gggcgccggc gccctctgag tcgcgtcacc ccggcccgac aatcgagggc
      121 tcggagcgca gtgtgctagg cgggtggcgg gaaggtcatg gcggagcccg cggcgcgaca
      181 cctgtcgctg ccctcggggc tgctggagtt gtgcgcgctg ctgggcgcct ctcaagacag
      241 cctccgcggc ctggagcaga ttgcccagaa acgaggagtg aagagcgcct cttcccttgt
      301 ccccgaagtt ctgtctgttt tcgtgcctcc tttcaccaca aaagaggatg gccaggtacc
      361 gggggccagc tgtgctcttg gcaaaggcag gaggcgttcc ttccggaaga agcgagagaa
      421 gcccaggatg gagccctgga agagccaccc tggagactcc aaggggcccg attctgaaga
      481 tgtcaccatc ccaggaggtg tggacctcct tgccctgcct cagctctgct tcccagggtg
      541 tgtgtgtgtg gcttcggaac ccaaagagga ctacatccat ttcctggtgc tcacggatgt
      601 ctgtggaaat agaacctatg gtgtggtcgc ccagtactat cgacccctgc atgatgaata
      661 ttgtttctac aatggcaaga gccactggga gcccagcgtg atctcagcta ggtgctttgt
      721 gccttttgca gtgtgtgtgg tgtcccgatt cccctactat aactccctca aggactgcct
      781 ctcctgttta ttgactcatc tgaagctctg taaagatttt gaagttgaca atcacataaa
      841 ggatttcgct gcacgactgt ccttaatacc tagtccaccg cctgggccgc tccacttgat
      901 atttaacatg aagccgctgc aggtcgtctt tccctctcga gcggaccccg agagccccat
      961 cgtcgacttg gaccttcacc tgcccctgct gtgcttccgg cctgagaaag tgttgcagat
     1021 cctgacctgt atcttgacgg aacagcgcat cgtgttcttc tcctcagact gggccctgct
     1081 gacgctcatg gccgagtgct ttgtggccta cctccacccg ctgcagtggc agcacacgtt
     1141 tgtgcccatc ctgtcgggtc agatgctgga cttcgtcatg gctcccacgt ctttcctcat
     1201 gggctgtcat ctcgaccact ttgaagaagt cagaaaggaa gctgatggtt tggtcctgat
     1261 tgacattgac cacgggagtg tcacctgctc caagtcttct gacgacaaca tagacattcc
     1321 tgatgtcccc cttctgctgg cacagacctt cattcagaga gtccagagtc tccagctgca
     1381 cccggatttg caccttgccc acctgagtgc cagcacagac ttgaacgagg gccgagcccg
     1441 ccgccgagcc tggcagcaga ctctcaactg caagattcag cacatcactc tacagctgct
     1501 cgttggcatc ttcagggaag tgaagaatca cttgaattat gaacaccgcg tcttcaacag
     1561 cgaggagttt ctcaagacaa gagcggcagg ggaccagcag ttttataagc aggttttgga
     1621 cacctacatg ttccactcct ttctgaaggc gcggctcaac ggcaggatgg acgcctttgc
     1681 tcggatggac ctcgacactc agtctgagga ggacaggata gacaggatgc tgataagtcc
     1741 aaggagacct actgtggaga agatggcctc caggaaggcc tcacccctgc acatcaccca
     1801 cagacgcatg gtggtcagca tgcccaacct gcaggacatc tccctgcccg agctgcctcc
     1861 caggaactca tcgcttcgga taatggacac ctcaaactgc agaagcagca gtccagttct
     1921 caaagtgacc cctaagtcaa catatatgtt caagatccct gatatccact tcccactgga
     1981 gagccagtgt gttcaggcat actatacaga cttcgtcact ctcctgagca aggccatggc
     2041 gctgttgggt cctggcgact ctctgctcct agccaggtac ttctacctgc gtggtcttct
     2101 ccatctgatg cagggacaac tgctgagtgc cctcttggat ttccagaacc tgtataagac
     2161 cgacataggg atcttcccgg ctgatctggt caagagaacg gtggaatcca tgtcggcctc
     2221 tgagcgggcc caggccgagc ggacgcctga gctcaggcgg ctcatcacag aggtctttga
     2281 taagcacggc gaggccccca aggcagatga cgccgtgaag aacttcgaac tgcccaagaa
     2341 gcacatgcaa ctcaatgact ttgtgaagcg agtccaggag tcggggatcg tgaaggacgc
     2401 cgtcattatc caccgtctgt ttgatgcact gaccttcgga cacgagaagc agattgaccc
     2461 ggagaccttc cgagactttt acacctgctg gaaggagact gaggcagagg cacaggaggt
     2521 cagcctgccc gcactgctca tggagcacct ggataagaac gagtgcgtct acaagctgtc
     2581 gagctctgtg aagaccaacc gtggagtggg caagatcgcc atgacccaga agcgcctgtt
     2641 cttgctcacc gaggggcggc ccggctatgt ggagattgcc accttcagga acatagagga
     2701 agtcaaaaat agcaccgtgg catttctcct cctgaggata cccaccttaa agatcaagac
     2761 ggtggccaag aaggaagtct tcgaggccaa cctcaagtcg gagtgtgacc tctggcacct
     2821 catggtgaag gagatgtggg ccggaaagca gctggcagat gaccacaagg acccacagta
     2881 cgtccagcag gcactgacca atgtcctgct catggatgcc gtggttggca cgctgcagtc
     2941 acctagtgcc attcatgctg cctccaagct ggcctacttt gacaacatga agaagaagtc
     3001 acccatggcg gtcccaaaga caacctcgga gaccctaaaa cacaagatta acccttcagc
     3061 cggagagacc gctccccaag ccattgaagt cctgctgtat actccagggc gcctggatcc
     3121 tgcagagaag gtggaagatg cccaccccaa gctgtggtgt gccctgaacg aaggcaaagt
     3181 ggtcgtgttt gatgcctcct cttggaccgt ccaccagcat tgctttaaag tgggttcctc
     3241 gaaagtgaac tgtatggtga tggcggagca caaccaggtg tgggtgggct ccgaggactc
     3301 tgtcatctac atcatcaatg tccacagcat gtcctgcaac aaacagctca cggatcaccg
     3361 ttctccagtc actggcttgg ccgtgcacaa tggaaagaag cccagtgaga tctactcctg
     3421 tagtctggat gggacggtca tcgcgtggaa tgtcagcaca ctgcgagtga tcagccggtt
     3481 ccagctgtca tacggtgacc tcctgtccat cagcctgcac aacgaccgca tatggtgttg
     3541 tacagtccac aagatcttgg tggtgacccc gcagggcttt gttcgtcaag agctgaagca
     3601 tccgaaagat gcctccttcc tggccttcca acttctgcct gaggagcagc agctgtgggc
     3661 ggcctctacg ggggtcagtg agctgtatat gtggagcctg aaggacctgg accagcctcc
     3721 tcagaagact tacttacaag actgctccga ggtcacctgt atgatccggg tgaagaggca
     3781 gatctgggtg ggcggcaggg ggctgtctca gggaaaaacc agagggaaga tctacgtgat
     3841 ggacgtggag aaggtgacgg tggaaaagga gctggtggca cacttggaca ccgtgaggac
     3901 cctgtgttct gctgaggacc gctacgtact gagcggagcg ggccaggagg agggaaagat
     3961 cgccatctgg aaggtggagt gagagctcca tactgaacca atgctgtcct gtgagggccc
     4021 gcctcccgac cctccaaccc tccactgtgt cagtggccag ctaggtgggg cctgtctgct
     4081 ctggcggcct tcacctcctt gggcgagcag ctacagctta ctgctgataa cctccactgt
     4141 aaagttacct catattacct agaaacttcc agaatccata actagaagtc agcacctgag
     4201 ctgccaactc agctgaatca catgtgactt gtggtcctct aggctggcct ctcctcttcg
     4261 tgtttactct taaacacttg ggctcattgc cattggtgta gggcaaaggc tagtgtgtca
     4321 cagtcagcca cagaaacaga gcctttcggg tttccactaa cttcctgatt ccagagagtc
     4381 ttctgagcat tcgaaggtaa tcaccgaccg aactggcttg cactgggcag gtgattcctc
     4441 cttcagggaa agtgaccaag gcctggccca ggaaggggac agtactggcc agatttgtct
     4501 gtgtagaaat tgggcagctg aacggctctg tcttagcatt aaaggtttaa tgaagacacc
     4561 gactactaca ggcaggaagc acatctcaca agcacaagtg agtgactgtg tcactggctt
     4621 gtggcatagc tgcactttgc gtgtctcctg cacgtgtgga cacaacgcct ctattgaact
     4681 gtacatagct atctgcacgg aggcttgtga atgtgtttgc cacactggcc caatttcatt
     4741 ctgcaagtgt tctgcaaggt gtgtttgtat ggatgctgga cacgcagagg aaatggcctg
     4801 tatcctgtgt atcctcctgt gagttctgca tggagccctt gggatcccct gccttgggtc
     4861 ttcaagattc catgtccgcc attggagagg cggtcactaa gaggttacca gtggtccacg
     4921 cccgtctctg agatcaacca gggtccagag gtacttgagc ccatgcctgt gaagacccag
     4981 gcctgaaggg tccatgtcac tgactgctgg ctcacttgag gtgtggctcc cttgaacaca
     5041 gtgcagagga tctcagagcc acacctctcc ctagagtctg tattccctaa gaggtgtccc
     5101 atatgtccag agggacaatg tggccagcgg ccaagggcac aggttcacac tgtctttgta
     5161 aaagtcgacc ataaatgcat tctaagttat ttaatgccag tccatgtatg accaggtgtt
     5221 tacaacttgt gataataaac cctttttgtt aataaa
//
