LOCUS       NM_028110               4048 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DENN domain containing 2D (Dennd2d), transcript
            variant 1, mRNA.
ACCESSION   NM_028110 XM_131083
VERSION     NM_028110.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4048)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4048)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140380.3.
            
            On Jun 2, 2012 this sequence version replaced NM_028110.1.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008266.1, SRR13422601.1025964.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               AC140380.3         22450-22730         c
            282-457             AC140380.3         21722-21897         c
            458-570             AC140380.3         20807-20919         c
            571-640             AC140380.3         20129-20198         c
            641-718             AC140380.3         18358-18435         c
            719-859             AC140380.3         17404-17544         c
            860-1008            AC140380.3         16193-16341         c
            1009-1186           AC140380.3         13762-13939         c
            1187-1228           AC140380.3         9911-9952           c
            1229-1313           AC140380.3         9465-9549           c
            1314-1553           AC140380.3         8776-9015           c
            1554-4048           AC140380.3         5740-8234           c
FEATURES             Location/Qualifiers
     source          1..4048
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.49 cM"
     gene            1..4048
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /note="DENN domain containing 2D"
                     /db_xref="GeneID:72121"
                     /db_xref="MGI:MGI:2181193"
     exon            1..281
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1624
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /note="isoform 1 is encoded by transcript variant 1; DENN
                     domain-containing protein 2D; DENN/MADD domain containing
                     2D"
                     /codon_start=1
                     /product="DENN domain-containing protein 2D isoform 1"
                     /protein_id="NP_082386.2"
                     /db_xref="CCDS:CCDS17722.2"
                     /db_xref="GeneID:72121"
                     /db_xref="MGI:MGI:2181193"
                     /translation="MPPKLRMMEGQGVGRTLRLLRNRLPRLRAGQSQNNPGEAVTEPE
                     RIQEHSPSSFAGGQHFFEYLLVVSLKKKRLGDDYEPTITYQFPKRENLLRGQQEEEDR
                     LLSAIPLFCFPDGNEWAPLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPQLPKV
                     YCIISCIGCFGLFSKILDEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPD
                     SGTEFISLTRPLDSHLEHVDFSVLLHCLHLEQIIQIFASAVLERKIIFLAEGLSTLSQ
                     CIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFLQEVMDSPMEEVLL
                     VNLCEGTFLLSVGDEKDILPPKLQDDILDSLGQGINELKTSEQINEHVSGPFVQFFVK
                     TVGHYASYIKREASGQGHFQERSFCKAVTSKTKRRFVKKFVKTQLFSLFIQEAEKSRN
                     PPAGYFQKKILEYEEQKKQKKSRERL"
     exon            282..457
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            458..570
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            571..640
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            641..718
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            719..859
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1008
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1186
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1228
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1313
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1553
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..4048
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2043..2048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2072
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /note="major polyA site"
     regulatory      3470..3475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3493
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
     regulatory      3978..3983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3995
                     /gene="Dennd2d"
                     /gene_synonym="2010308M01Rik"
ORIGIN      
        1 agtgcccaca ctaagctgcc tcgtgggtcc tttcacatcc ttcttgctca attacggagt
       61 acacaggatg gaaactgctc tctgcctttg ggagacagcg tgtggctcag ctcaataaag
      121 ttgtgattgg agaccaaggc agaaggcact ttctcaggct ttctgtggcc agcctgaagg
      181 agaaagaaca tccatgcccc caaagctcag aatgatggaa ggacaagggg taggccgaac
      241 cctcaggctg ctccgaaatc gcttgccacg acttcgagca ggacaatccc agaacaatcc
      301 tggggaagct gtcacagagc cagaaaggat ccaggagcat tctccatcta gctttgctgg
      361 aggccagcac ttctttgaat accttcttgt tgtttcttta aagaaaaagc gtttagggga
      421 tgactatgag cccacgatca cttaccagtt tcccaagagg gagaacctgc tccgaggtca
      481 gcaggaggag gaggaccggt tgctcagtgc catccctttg ttctgcttcc ctgatggaaa
      541 tgagtgggca ccactcacag agtatcccag ggagaccttc tcatttgtcc tgaccaatgt
      601 ggatgggagc aggaagatcg gatactgcag gcgcctcctg cctgccggtc ctggtcctca
      661 acttcccaaa gtgtactgca tcatcagctg catcggctgc ttcggcttgt tctccaagat
      721 actagatgaa gtagagaaga ggcatcagat ctccatggct gtcatctacc cattcatgca
      781 aggtctccga gaggcagcct ttcctgcacc tggaaagaca gtcaccctta agagcttcat
      841 tcctgactca ggcacagagt tcatctcact gacacggccc ctagactccc accttgaaca
      901 cgtggacttc agtgttctgc tacactgtct ccatttggag cagattattc agatctttgc
      961 ctctgcagtg ctggaaagaa aaatcatctt tttggcagag ggtctcagta ccctgtctca
     1021 gtgtatccat gctgctgcag ctctgcttta cccatttagt tgggcacaca catacatccc
     1081 tgtggtccct gagagccttc tggccactgt ctgctgccct acccccttca tggttggggt
     1141 acagatgcgc ttcctgcagg aggttatgga cagtcccatg gaagaggtcc tgttagtgaa
     1201 tctttgtgaa ggaaccttct tattgtcggt tggtgatgag aaagatattc taccaccaaa
     1261 acttcaggat gacatcttgg actctcttgg tcaagggata aatgagttaa agacttcaga
     1321 acaaatcaat gagcatgttt caggcccttt tgtacagttc tttgtcaaga ctgtgggcca
     1381 ctatgcctcc tatataaaac gggaggccag tggacaaggt catttccaag aacgatcctt
     1441 ctgtaaggct gttacctcca agaccaagcg ccgatttgtg aagaagtttg tgaagacaca
     1501 acttttctcc ctattcatcc aggaagcaga gaagagcagg aaccctcctg caggctactt
     1561 ccaaaagaaa atacttgagt acgaggaaca gaagaaacag aagaaatcaa gagaaagact
     1621 gtgaagtaaa agctgtggtg agcaggagtg tctagagata cagctagaac cacaggccaa
     1681 tctggacttt ggcccttcta gtgggacaga atcagtgagg tcttcggccc tggaatccat
     1741 ggccttcttc caactgataa tgcagtctta cttcaaagtg gtgtgtgaat ctgggagcct
     1801 tggtgtcagg gcttctcaga actttgaaag ctcacatcca aactcagaac tgtactcaaa
     1861 gctgcatttt ttggcagagt ggacatagtg ggagatagta gtacaggtgt atagctgttg
     1921 tgggtgctta attagaagtt gctagcactg ctgtctccta tgaacctctg ttataaaatc
     1981 ctcaatacag aacactggcc caatgaccca tgtacaaaat agtggtctga cgtgaggatg
     2041 agaataaaga tgaaaacctt gttatttgtc aatctaggag gcactgcatg ggagaaaaaa
     2101 ctgaactaga catgaaggat gacctggtca tgataggcta cgtggaatca caaaaccggg
     2161 ggtcagcagc tccacttccc ataagaagag taagagatct tgatcagaat ggcctcagca
     2221 gagagtttgt actatctggt gtgtttccca gaattctgag cagagacagc tccagaaggg
     2281 tggcagctgg ggcctaggac tgtttaatag gagaattcct gatcaacaga agtccttgca
     2341 ggctattact ccaagacttc catcaacagg tcagactgcc cataacctag tcagggccag
     2401 tcctttaact tcagttttgg tcatctcatc aagtgtttat taagacttta gatccattct
     2461 ctagctaaag gtcgaacaat ccctgcactg ccagtttttc cccattatgg tatttagtag
     2521 tttacctagg ctttcttttt tctatacctt tgtttaaacc cttcaagaga tggccaacat
     2581 ctttaaaagc atcttctctt caagaattct tttaaatgtt ttgcctatct tttaatgtgg
     2641 cccttacaag tttcagaatt ccaaagaatg cagatgatat gggggttgga ataaagttac
     2701 aaaagggaag gttacactct gatttggaga tcacaaactc ctactgcagg tgggaaattt
     2761 ccacacgcca tgcccaacta ctacttctgc aacttctagg aatcattaca tctttctaga
     2821 tggtttgtag atgtgagtgc taaacccact taggtcttga aaagtttcag cctgaggacc
     2881 agaatcctgt tagagctgtg aaaataatga ggctccaata taatctacca aattagagac
     2941 tgaacctgaa catgttgtga tggcacagtc tacaatccta gcattcagga ggctaaggca
     3001 ggggaacaga aagttcaagg ccagcctgag ctactgtggg atcctgttca gaccacacca
     3061 cccccgcccc cccccccaaa aaaaaaaggc ctgggaatat gttttgcaaa aatatccaca
     3121 atgttgaatg attctgatac ttcattaagt atgtgaattc aacaaccagg gccagctgtg
     3181 tctttctaca aagaaaccat tggctgatgc ttgtagtatc tttgaccaaa ggaaacatac
     3241 acagtgtttt tcagattcct ctgtgatgaa aacaaatcta gaacacatgt atttatttca
     3301 gttagtctct agtacctcag tttaaagctt tggagtgata caaaaaatag ctagaatgac
     3361 agcctaaatt ccattctcaa atgtagcaat actgtgtgac aactggtagc caattgaggt
     3421 ctcaatttcc actaggtata aacacctgtt aggtctgctg aactaatcaa ataaaacaat
     3481 agatataact gtactaatgg aggattacct cttctttctc ctgccttgtc agagattatc
     3541 tttatatcct gacccctccg attttctgtg tcttatatag cccagactag cctacaactc
     3601 cagtcaagga taaccttgaa cttctgctcc tcttcctgct tctacctctg agtgctggga
     3661 ttcactatcc tttatactaa agaaacagaa aatatgtata caatgaaagc aaatgtgatt
     3721 cacagagaaa cctggctcct atggtaaagc gcagtctaaa taccaaaatg gagagtacaa
     3781 agtgacaacc cacctccacc ccatctgaac aattactgaa ataatggggt aataactgca
     3841 aaataaagac ccataggttg aaaaaaatga acacaccatg atgacacggc tgaccatatt
     3901 tccttaattg ttaaagaaga gaaataaaat ttgtttaact tttaaaaaac attgaaactt
     3961 agtttacagt tcccctgaat aaaattgaga aaaaagctgg ttctgagatc atatatttat
     4021 ttaaaaaaat aaaatggatt gacaaagt
//
