LOCUS       NM_001384113            4964 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus DENN domain containing 2C (Dennd2c), transcript
            variant 3, mRNA.
ACCESSION   NM_001384113 XM_006501600
VERSION     NM_001384113.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4964)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4964)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 4964)
  AUTHORS   Marat,A.L., Dokainish,H. and McPherson,P.S.
  TITLE     DENN domain proteins: regulators of Rab GTPases
  JOURNAL   J Biol Chem 286 (16), 13791-13800 (2011)
   PUBMED   21330364
  REMARK    Review article
REFERENCE   4  (bases 1 to 4964)
  AUTHORS   Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
            Barr,F.A.
  TITLE     Family-wide characterization of the DENN domain Rab GDP-GTP
            exchange factors
  JOURNAL   J Cell Biol 191 (2), 367-381 (2010)
   PUBMED   20937701
REFERENCE   5  (bases 1 to 4964)
  AUTHORS   Del Villar,K. and Miller,C.A.
  TITLE     Down-regulation of DENN/MADD, a TNF receptor binding protein,
            correlates with neuronal cell death in Alzheimer's disease brain
            and hippocampal neurons
  JOURNAL   Proc Natl Acad Sci U S A 101 (12), 4210-4215 (2004)
   PUBMED   15007167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150894.4.
            
            On May 30, 2020 this sequence version replaced XM_006501600.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861889.140925.1,
                                           SRR17784647.805320.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AC150894.4         109798-109877       c
            81-1059             AC150894.4         80205-81183         c
            1060-1190           AC150894.4         79191-79321         c
            1191-1303           AC150894.4         78685-78797         c
            1304-1474           AC150894.4         75223-75393         c
            1475-1571           AC150894.4         71381-71477         c
            1572-1616           AC150894.4         65980-66024         c
            1617-1798           AC150894.4         63314-63495         c
            1799-1908           AC150894.4         60134-60243         c
            1909-1978           AC150894.4         58830-58899         c
            1979-2056           AC150894.4         57971-58048         c
            2057-2197           AC150894.4         56356-56496         c
            2198-2346           AC150894.4         55586-55734         c
            2347-2524           AC150894.4         54715-54892         c
            2525-2566           AC150894.4         50947-50988         c
            2567-2672           AC150894.4         49440-49545         c
            2673-2909           AC150894.4         47292-47528         c
            2910-2996           AC150894.4         46037-46123         c
            2997-4964           AC150894.4         42798-44765         c
FEATURES             Location/Qualifiers
     source          1..4964
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.25 cM"
     gene            1..4964
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /note="DENN domain containing 2C"
                     /db_xref="GeneID:329727"
                     /db_xref="MGI:MGI:3036254"
     exon            1..80
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            81..1059
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..3028
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /note="isoform 1 is encoded by transcript variant 3; DENN
                     domain-containing protein 2C; DENN/MADD domain containing
                     2C"
                     /codon_start=1
                     /product="DENN domain-containing protein 2C isoform 1"
                     /protein_id="NP_001371042.1"
                     /db_xref="GeneID:329727"
                     /db_xref="MGI:MGI:3036254"
                     /translation="MHPTGNMDVGFTRSAVQTLSRSHCKNIKQKISQWEGRANGVTKT
                     AKFHPKDFGVRYNCHQESPPHKRPTGEERNGALPRNTDVKSRDQSEDEGEGGECRGSH
                     PSEAGLDSSLVCARVKQIEGCQAVAVGPEASLPPGNFYTSQIPWRSIDGLSPDKPLNL
                     ALAPCNSTGREPDLSVLDSSYGITKSLENIYYEPEGQECGPSINPLPKPRRTFRYLSE
                     SDGIPYKERNCDQKYCESISCVDPSLASSQDPEPKKYGGKIRGRSKRKSFEFEDIQHF
                     RNSRKIHEELGRNAGSALYYTQSEDNIYEDIIYPAKENPYEDIPVQSFPVWRSPSAWR
                     LPPAKSAFRTPKLPPKPQFFQRKTMELKNSQAYFRSKITKDTTLPVTLTEWKLFRAGE
                     VANKKKRNLPPLVLKINDTFESKRGKKRVKLQPYTGKEAPSSKGETSGNESDAEYLPK
                     NRHKRLAQLQPSSKRNPHYQTLERDLIELQEQQLFELFVVVSLQKKPAGYTPQVIQQF
                     PSKGDHGYKQSKDTEERLKVIPRFCFPDSEDSAPTLELKSETFSFVLTGEDGSRWFGY
                     CKKLLPEGRGKRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSVMEAP
                     FPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFECLFKCLSVRHLIRVCASLLL
                     ERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPVSMIDIVCSPTPFFIGILS
                     CSLPHLQDLPIEEVLIVDLCADRFLQEVSDEDEILPPKLQAALVQILEDRDEVLAQEQ
                     QFSQEVTLSSLVSEAFVRFFVELVGHYSLNMTVTERGERVFQREPFRKSHTSRSVRHF
                     LDLFMETQMFAGFVQDRELRQSGVKGLFEVRALQYLETIPESEPSGVNRILRSLGSKM
                     KFLHKK"
     exon            1060..1190
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1303
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1474
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1571
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1616
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1798
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1908
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1978
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2056
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2197
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2346
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2524
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2566
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2672
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2909
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..2996
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..4964
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4944..4949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /note="hexamer: GATAAA"
     polyA_site      4964
                     /gene="Dennd2c"
                     /gene_synonym="A930010I20Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaagatgtgg gcgctggatc ccagaggcca ccgacgcgag tctgggatcc ctgcgcgagg
       61 cggcgtcgcg gcccaggcag gatcattcat gatacagttg tagctgtttt caacaaagct
      121 cggtgatgaa aactgttatt tttaacaaga tacctccaag ttaaacatga aacgaaaaca
      181 cttggatcgt ttccgttctg gcaaggcaaa gaatacagcg ttttccagct aactggtcat
      241 ggcacctctc taagagtgac tcgtcatgca ccccaccggg aacatggatg ttggctttac
      301 acggtctgct gttcagacct tgtccaggag ccactgcaaa aacatcaaac agaagatttc
      361 ccagtgggaa ggaagagcta acggtgtaac caagacagct aagtttcacc caaaggactt
      421 tggagtgagg tataactgcc accaagagag tccccctcat aagcgtccca ctggtgagga
      481 aaggaatggg gctttaccca gaaacacgga tgtcaaaagc cgagatcaaa gtgaggatga
      541 aggcgagggt ggagagtgta gaggctccca cccctcggaa gctggactgg actccagcct
      601 ggtgtgtgct cgggtcaaac aaatcgaagg ctgccaagct gttgctgtgg gtccagaggc
      661 ttccttaccg ccaggaaact tctacacctc ccagataccg tggagaagca tagacgggct
      721 ctccccagat aaacccttaa atttggcctt agcaccttgt aactctacag ggagagaacc
      781 ggatctcagt gttctggata gttcttacgg aataaccaag agcttggaaa atatttatta
      841 tgaacctgag gggcaggaat gtggcccctc tataaatcct ttacccaaac cccgtaggac
      901 attcaggtat ttatctgaat ctgatggtat accatataaa gaaaggaact gtgatcaaaa
      961 gtactgtgaa agtatttcct gtgtggaccc ttctttggcc tcttctcagg atcccgaacc
     1021 aaagaaatat ggcgggaaga tcagagggcg gtccaaaagg aaatcctttg aatttgaaga
     1081 tatccagcac tttcggaact cacgaaagat ccatgaagaa cttggaagaa atgctggctc
     1141 agcactttac tacacacagt ccgaggataa tatctatgag gatattatat atccagccaa
     1201 ggaaaatcca tacgaagata tcccagtgca gtcgttccct gtttggagat ccccttcagc
     1261 gtggaggctg ccacctgcta agagcgcctt ccgaacaccc aagcttcctc ccaaacccca
     1321 gttctttcag cggaagacta tggaactgaa gaattctcaa gcatattttc gatcaaaaat
     1381 cacaaaggat actactttgc ctgtcaccct aacggaatgg aaactgttcc gagctggaga
     1441 ggtggctaac aagaagaaga gaaatctccc accgcttgtt ttgaaaataa atgatacatt
     1501 tgaatctaag agagggaaga agagggtaaa gttacagcct tacactggaa aggaagcccc
     1561 ctcctcaaaa ggtgaaacca gtgggaacga gagcgatgcc gagtacctgc caaagaatcg
     1621 ccacaagcgc ttggcacagc tgcagccgtc ctccaagagg aacccccact accagacctt
     1681 ggagcgcgac ctcattgagc tacaggagca gcagctcttt gaactcttcg tggtggtttc
     1741 tctgcagaag aagccggcag ggtacactcc ccaggtcata cagcagttcc ctagcaaggg
     1801 tgaccatggc tacaagcagt ccaaagacac tgaggaaagg ctcaaagtca tccccaggtt
     1861 ttgttttcct gattcagagg acagcgcacc aaccttagaa ctcaagagtg aaaccttctc
     1921 cttcgtgctg actggagaag atggaagccg gtggtttggc tactgtaaga agcttttgcc
     1981 agaaggcagg ggaaagcggc tccctgaggt gtactgcatg gttagtcgct tgggctgctt
     2041 caatcttttc tcaaagatcc tggatgaagt agagaagagg agagagatgt ctccagccct
     2101 tgtgtaccca ttcatgcgaa gtgtcatgga agcccctttc ccagctcctg gccgcaccat
     2161 cacagttaag agctacctcc ctggggctgg agatgagtca attgaactct gccgaccact
     2221 cgattcacgc ctggaacatg tggactttga atgccttttc aaatgcttga gtgtgcgtca
     2281 tctcatccgg gtctgtgcct ctctccttct cgagcggagg gtaatctttg ttgctaacag
     2341 cttaagcacc ctttcaaaat gcggccatgc tgtggtagct acactgtatc cgttcacctg
     2401 gcagcacacc tacatcccag tgctgccagt gtccatgatt gacatagtgt gctcacctac
     2461 tccgttcttt atcgggatct tgtcttgttc cttaccccac ctccaggacc ttccgattga
     2521 ggaggtgctg atagttgatc tctgtgcaga caggttccta caggaggtgt ctgatgagga
     2581 tgaaattctg ccacctaaac ttcaagcagc cttggtgcag attttagaag atcgagatga
     2641 agtcttggct caggaacagc agttttcaca agaggtgaca ctcagttctc tggtgtcgga
     2701 agcgttcgtc aggttttttg tggagctcgt ggggcattat tctctgaaca tgactgtcac
     2761 agagcgtggg gagcgtgtgt tccaaaggga gccattccgg aagtcccaca cttcccgaag
     2821 tgtccgccac ttcctagatc tcttcatgga gacacagatg tttgcaggat ttgtccagga
     2881 ccgggagctt cggcaaagcg gagttaaagg tttgtttgaa gtccgggctc ttcaatattt
     2941 ggaaacaatt cctgagtcgg aacccagcgg ggtgaataga attttacgta gtcttggaag
     3001 taaaatgaaa tttcttcaca agaagtgaaa tcttttcttc attctaaaca tagctggaag
     3061 tgccaacgac agtgttttcc caaggatctg gatgctcggg agagtcctgt aacatctgtg
     3121 actgtaaaag gagaaagact gttggaaaac tctcctgttg ctgcagacca actgggagca
     3181 gtctagaacc agtgcgctct cttctccttc tgatttgggg actgttttgt ttgtttgttg
     3241 tttttgagac agggtctctc gctatagccc tgactgtgat ggaactcgtt ctgtagatcg
     3301 ggctggcctc aaatcctgat gtcacaaatc tcaaagatct cacagaggtc ctcctgcctc
     3361 tgcctcccaa gtgctgagat caaaggcgtg caccgccatg cctgggctcg ttattttaca
     3421 gtggtgtttt atctttggtt actgatgggt gcaagagcct ctgctttgtg cttgtggttg
     3481 tcctttacaa ggagaagact cagaaatact tggtgttgag ttcctaaaaa caatgcaaag
     3541 atgagattga cagagaaata aggagaataa tgagagtttc aggtactagg gagacagaca
     3601 tggaggacac catggtcaca cgattctcat cactgaagca tcatattgct ttaaatacgt
     3661 ggacggtttg tgctttctaa ttccagtact gtcaccattg attaaacccc ccttttgtcc
     3721 catgtcctat cttggagaat ttcactcatg ttagaacttt aaaaaaaaag cagacaccag
     3781 gcatggcctc ctcagaacac gtgtcctgct gggatagctt gcttctcata tgtcagcatt
     3841 atgctttatg gaatggagcc aacattaaaa tgtcctttta aggacatagc tatctgagtt
     3901 ttggtgttta caatttgcag cactgtgata atctacatgt catcttattc aagctttaga
     3961 tcagcttcat gatattctac aagaaactgg agttcagaga agctaaggaa tttggccagt
     4021 tatatacaag aaagaactaa gccaaacact tgacttatga acacatacaa agctggttag
     4081 tcctacagct gtaaatgaac tctttatagt gatgtttaaa gttctctgtg gagcacacca
     4141 gagcttcctt tttggctctg atgagacgtt aagctatggg ggtctagaca aggtttgttc
     4201 ctttgtttct tcttctgctg ctggggatag gacccagggc cttttgtgtg ctctgccaca
     4261 ctggttattt ttacatcggt gtgagttttt agtgtttcct aagcctcttc atcaaccaga
     4321 tgctgaaaat ctaaagtagg agtagcacct gggaaaggga gtttgtcagt gagggtacag
     4381 ttttcattga taagtgagaa atgttgtggt aaatgtcagt tgttttctgt aacctttgcc
     4441 cactgcttta cctggcatgg aaaatactca ttcagacttg gaaagtgttg tttgttgtac
     4501 tgggatacaa ctcactgact tgtatagtat tgtcattgtc actcatacta gggtgtctga
     4561 atgaatccat ttaagactgg tgctgtgcaa tatagttccc acacatgggt ccagggaaga
     4621 gaactgagtc tgtcctttca aatgttagtg cagctcaccc aggggagctc ctcccagaca
     4681 gctctctcct ttccttcttc ctacactcca atcccgatgg aacaattcat gactggttgt
     4741 ttataagatg gggaaggagg gtttactgtg gtcaatcatg actgtccctc tgcagggaga
     4801 ctgcttttgg gagagtctta accttcttaa gatctaaagc tgcttccttt ccttgagttt
     4861 gttgtaattt gtttttgtaa atgttgtgaa ttctaaatac gtttgtaaaa agaattgttc
     4921 aatatttcta tcaaatgttt acagataaag gcattttaaa aaaa
//
