LOCUS       NM_001001326            4255 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DENN domain containing 2B (Dennd2b), transcript
            variant 1, mRNA.
ACCESSION   NM_001001326
VERSION     NM_001001326.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4255)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4255)
  AUTHORS   Ou,K., Zhang,J., Jiao,Y., Wang,Z.V., Scherer,P. and Kaestner,K.H.
  TITLE     Overexpression of ST5, an activator of Ras, has no effect on
            beta-cell proliferation in adult mice
  JOURNAL   Mol Metab 11, 212-217 (2018)
   PUBMED   29650351
  REMARK    GeneRIF: ST5 overexpression has no mitogenic effect on the adult
            beta-cell under basal and metabolically challenged states.
REFERENCE   3  (bases 1 to 4255)
  AUTHORS   Gohring,I., Tagariello,A., Endele,S., Stolt,C.C., Ghassibe,M.,
            Fisher,M., Thiel,C.T., Trautmann,U., Vikkula,M., Winterpacht,A.,
            FitzPatrick,D.R. and Rauch,A.
  TITLE     Disruption of ST5 is associated with mental retardation and
            multiple congenital anomalies
  JOURNAL   J Med Genet 47 (2), 91-98 (2010)
   PUBMED   19843505
REFERENCE   4  (bases 1 to 4255)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 4255)
  AUTHORS   Amid,C., Bahr,A., Mujica,A., Sampson,N., Bikar,S.E.,
            Winterpacht,A., Zabel,B., Hankeln,T. and Schmidt,E.R.
  TITLE     Comparative genomic sequencing reveals a strikingly similar
            architecture of a conserved syntenic region on human chromosome
            11p15.3 (including gene ST5) and mouse chromosome 7
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 284-290 (2001)
   PUBMED   11528127
REFERENCE   6  (bases 1 to 4255)
  AUTHORS   Cichutek,A., Brueckmann,T., Seipel,B., Hauser,H., Schlaubitz,S.,
            Prawitt,D., Hankeln,T., Schmidt,E.R., Winterpacht,A. and Zabel,B.U.
  TITLE     Comparative architectural aspects of regions of conserved synteny
            on human chromosome 11p15.3 and mouse chromosome 7 (including genes
            WEE1 and LMO1)
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 277-283 (2001)
   PUBMED   11528126
REFERENCE   7  (bases 1 to 4255)
  AUTHORS   Kleyn,P.W., Fan,W., Kovats,S.G., Lee,J.J., Pulido,J.C., Wu,Y.,
            Berkemeier,L.R., Misumi,D.J., Holmgren,L., Charlat,O., Woolf,E.A.,
            Tayber,O., Brody,T., Shu,P., Hawkins,F., Kennedy,B., Baldini,L.,
            Ebeling,C., Alperin,G.D., Deeds,J., Lakey,N.D., Culpepper,J.,
            Chen,H., Glucksmann-Kuis,M.A., Carlson,G.A., Duyk,G.M. and
            Moore,K.J.
  TITLE     Identification and characterization of the mouse obesity gene
            tubby: a member of a novel gene family
  JOURNAL   Cell 85 (2), 281-290 (1996)
   PUBMED   8612280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126441.5 and AC124457.4.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2245654.1,
                                           SRR17253012.9234774.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC126441.5         153134-153223       c
            91-195              AC126441.5         106083-106187       c
            196-1446            AC124457.4         162795-164045       c
            1447-1583           AC124457.4         159559-159695       c
            1584-1735           AC124457.4         151661-151812       c
            1736-1951           AC124457.4         148904-149119       c
            1952-2048           AC124457.4         147920-148016       c
            2049-2093           AC124457.4         146976-147020       c
            2094-2278           AC124457.4         146246-146430       c
            2279-2388           AC124457.4         145518-145627       c
            2389-2458           AC124457.4         144860-144929       c
            2459-2536           AC124457.4         141878-141955       c
            2537-2677           AC124457.4         141218-141358       c
            2678-2826           AC124457.4         137666-137814       c
            2827-3004           AC124457.4         134198-134375       c
            3005-3046           AC124457.4         133928-133969       c
            3047-3158           AC124457.4         132810-132921       c
            3159-3398           AC124457.4         132123-132362       c
            3399-3485           AC124457.4         131847-131933       c
            3486-4255           AC124457.4         130495-131264       c
FEATURES             Location/Qualifiers
     source          1..4255
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.27 cM"
     gene            1..4255
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /note="DENN domain containing 2B"
                     /db_xref="GeneID:76954"
                     /db_xref="MGI:MGI:108517"
     exon            1..90
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            91..195
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..3520
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     suppression of tumorigenicity 5 protein; DENN
                     domain-containing protein 2B; heLa tumor suppression 1"
                     /codon_start=1
                     /product="DENN domain-containing protein 2B isoform 1"
                     /protein_id="NP_001001326.1"
                     /db_xref="CCDS:CCDS21734.1"
                     /db_xref="GeneID:76954"
                     /db_xref="MGI:MGI:108517"
                     /translation="MTMTANKNSSITHGTGGTKAPRETLSRSQSVSPPPVLYPPRSPI
                     YPLSDSETSACRYPSHSKSQVLLKDRHSRNPSLLGQDPSPETSPPICTLKATSFSYLD
                     RTPSLRKREDQKETVQGAVQDVEGVAACLPLAQSTPFLGAGSRSVLLSCTGTRAHSLG
                     IREKISAWEGRREASPRMSLCGEKREGPGSEWSVSEGCPSVGCPSVVPSPCSSEKTFD
                     FKGLRRMSRTFSECSYPETEEEAEALPGRDSLYRLEKRPGRTEPSALLRGHGIRKESS
                     AVLSRIQKIEQALKEQPGRGLPQLPSSCYSVDQGRRKTGTLGTLEEPTGTASVSPSSR
                     AGGVAGVAGEAGPPLDREGSASMKSETPGNSSSPQLLPPKSSPDPAVNPVPKPKRTFE
                     YEADKNPKTKPSNGLPPSPTPAAPPPLPSTPAPPVTRRPKKDMRGHRKSQNRKSFEFE
                     DASSLQSLYPSSPTENGTESQPKFGSKSTLEENAYEDIVGGLPKENPYEDVDLKNRRA
                     GRKSQQLSENSLDSLHRMWSPQDRKYNHPPMQLSLKSNSQSLRSGNWSERKSHRLPRL
                     PKRHSHDDMMLLAQLSLPSSPSSLNEDSLSTTSELLSSRRSRRIPKLVQRINSIYNAK
                     RGKKRLKKLSMSSLETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSYRTLE
                     LELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKAIP
                     QFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISR
                     LGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVL
                     ELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVV
                     ALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSD
                     RFIRQMDDEDTLLPRKLQAALEQALERKSELISQDSDSDSDDECNTLNGLVSEVFIRF
                     FVETVGHYSLFLTHSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDREL
                     RKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN"
     exon            196..1446
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1583
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1735
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1951
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2048
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2093
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2278
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2388
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2458
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2536
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2677
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2826
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..3004
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3046
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3158
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3398
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3485
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..4255
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4225..4230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /note="hexamer: AATAAA"
     polyA_site      4246
                     /gene="Dennd2b"
                     /gene_synonym="2010004M01Rik; 2610305K15Rik; Denn2b; St5"
                     /note="major polyA site"
ORIGIN      
        1 gaagacaaga gactgcttgg gctctggcac tagtaccatg ggaccctgta ctggctaaaa
       61 gctgtctcca ggacctgaac agtcaacaag ggctctgggt ttgcagagag ccgaaatgac
      121 catgactgcc aacaagaact ccagcatcac tcatggaacc ggaggcacta aggcccctcg
      181 ggagacgctg agcaggtctc agtcagtctc tccacctcca gttttatacc caccaagaag
      241 tcccatctac ccactcagtg acagtgaaac ctcagcctgc aggtacccca gccactctaa
      301 atcccaggtg ctcctcaagg accggcattc tcgaaatcct tcactcctag gtcaagatcc
      361 gtccccagaa acctcaccac ccatttgtac cctcaaggct accagcttca gctatttgga
      421 cagaacccct tcattacgca aaagagagga ccagaaggag actgtccagg gtgcagtcca
      481 ggatgtagaa ggtgtggctg cttgcctccc ccttgcccag agcaccccat tcctaggggc
      541 cgggtctcgg agtgtcttgc tgagttgcac tggtacccga gcccatagcc tgggtatccg
      601 agagaagatc tcagcatggg aaggtcgccg agaggcttca cccaggatga gtctgtgtgg
      661 agagaagcgg gagggccctg ggagcgagtg gtcggtcagt gagggctgcc ccagtgtggg
      721 ctgccccagt gtggtgccat ccccctgcag ctcagaaaag acctttgatt tcaaaggcct
      781 ccggaggatg agcaggacct tctctgagtg ttcctacccc gagacagagg aggaggcaga
      841 ggcacttcct ggacgggact ctttataccg gctggagaag cgtccaggcc ggactgagcc
      901 cagtgccttg ctcagggggc atggcatcag gaaagagagc tcagcagtgc tgagccggat
      961 ccagaagatc gaacaagccc taaaggagca gcctggccgg ggtctccccc agctccctag
     1021 cagctgctac agtgtagacc aagggaggag gaagactgga actttgggca ccttggagga
     1081 gccaacagga actgcaagtg taagccccag cagcagggca ggaggagtgg ccggagttgc
     1141 tggggaggca ggcccacccc tggacaggga aggcagtgct tccatgaagt cagagacccc
     1201 tggaaatagc tccagtcccc agctgctgcc tccgaagagc tcccctgatc cagctgtgaa
     1261 ccctgttccc aaacccaagc gtacctttga gtacgaggct gacaagaatc ctaagactaa
     1321 gccaagcaat ggtctacctc cttcacccac acctgctgct ccacccccct tgccttccac
     1381 cccagcccca ccagtcaccc ggagacccaa gaaggacatg cgtggtcacc ggaagtcaca
     1441 gaacagaaaa tccttcgagt ttgaggatgc atccagtctc caatccctgt atccctcttc
     1501 tcctactgag aatggtactg agagtcaacc caagtttgga tccaaaagca ctttagaaga
     1561 gaatgcctat gaagatattg tgggagggct tcccaaggag aatccctacg aggatgtgga
     1621 cttaaagaac cggagagctg gacgaaaatc ccagcaactg tctgagaact ccttggactc
     1681 tttgcacagg atgtggagtc cccaagacag gaagtacaac cacccaccca tgcagctgtc
     1741 cctgaagtcc aacagccagt ccctgcgcag tgggaactgg tcagaaagga agagccatcg
     1801 tttgccacga ttacccaaga ggcatagcca tgatgacatg atgctgttgg ctcagctgag
     1861 cctgccatct tcaccctcca gcctcaatga ggacagcctc agcaccacaa gtgagctgct
     1921 gtccagccgc aggtcccgcc gcattcccaa gcttgtccaa agaattaact ctatctataa
     1981 tgccaagaga ggaaagaaga ggttgaaaaa gctgtctatg tccagccttg agacagcatc
     2041 attgagagat gagaacagtg aaagcgagag tgactctgat gacaggttca aagcccacac
     2101 ccagcgcttg gtccacatcc agtcgatgct gaagcgagcg cccagctatc ggacgctgga
     2161 gctggagctg ctcgagtggc aggagcggga gctttttgag tactttgtgg ttgtgtccct
     2221 caagaagaag ccatctcgga acacctacct ccctgaagtc tcctatcagt ttcccaagct
     2281 ggaccgtccc accaaacaga tgcgggaggc agaagaaagg ctcaaagcta tcccccagtt
     2341 ttgctttccg gatgccaagg actggctccc tgtgtcagaa tacagcagtg aaaccttttc
     2401 tttcatgctg actggggaag atggcagcag gcgctttggc tattgtaggc gcttactgcc
     2461 aagtgggaaa gggcctcggt tgccagaggt gtactgtgtc atcagccgcc taggctgctt
     2521 cggtttgttt tccaaggtcc tagatgaggt ggagcgccgg cgtgggatct cagctgcact
     2581 ggtctacccc ttcatgagaa gtctcatgga atcgcccttt ccagccccag ggaaaaccat
     2641 caaagtgaag acatttcttc ccggcgctgg caatgaggtg ttagagctgc gtcggcctat
     2701 ggactcccgc ctggagcacg tggactttga gtgcctcttc acctgcctca gtgtgcgtca
     2761 gcttatccga atctttgcct cattgctgtt ggaacgcaga gtcatttttg tagcagataa
     2821 gctcagtacc ctgtccagct gctctcacgc ggtggtggcc ttgctctacc ccttctcctg
     2881 gcagcacaca ttcattcctg tcctcccagc ctccatgatt gacattgtct gctgtcccac
     2941 ccctttcctg gttggcctgc tctccagctc ccttcccaaa ctgaaggagc tgcctgtgga
     3001 agaggcactg atggtgaatc tgggatctga ccgattcatc cgacagatgg acgacgagga
     3061 cacactgtta cctagaaagt tgcaagctgc tctggagcag gctctggaga ggaagagtga
     3121 gctcatctcc caggactctg acagtgactc tgatgatgaa tgtaataccc tcaatggact
     3181 tgtgtcagag gtgtttatcc ggttctttgt ggagactgtg ggtcactact ccctcttcct
     3241 gacacacagt gagaaggggg aaagggcttt tcagcgagag gccttccgca agtctgtggc
     3301 ctccaaaagt atccgccgtt ttcttgaagt ttttatggaa tctcagatgt ttgctggctt
     3361 catccaagac agggagctaa ggaagtgtcg agccaagggc ctctttgagc agagagtgga
     3421 acagtatcta gaagagctcc ctgacactga gcagagcggg atgaacaagt ttctccgggg
     3481 cctgggcaac aagatgaagt tcctccacaa gaagaattaa atgcctttcc tggtagcaga
     3541 gtttagtgct ttgcagagcc cagggagagg gcccagcctg ggaccctgtg ggctgctgtg
     3601 gctactttgc ttctacaggc cccactccaa gccagcccac ttctgccttc accatattcc
     3661 aggatactgt ttgtaaataa tctgctgtaa gctttcctgt ttttgtaaca agcaaagaaa
     3721 atctggtaaa tatttgtata ttcccaaagg gccaggtgct ttcttgcctt gtctgagctt
     3781 ggatggagtc ttgctgggtg ctggtgactg gccaattatg tgcagctgac tgtctcagcc
     3841 aaaccactca tgtttcctca agacttctgg cctgtctgcc tgaggccctg ctgccagtct
     3901 tgggccctgg agagcaggtg ctgtcttaat tatgtataag aggactggtt ttttttttgt
     3961 ttttgttttt ttggttgttt ttaaatctag agtttctaat tttttcttct tagtagttcc
     4021 cctatctgcc aagcctcttg tttctgaaag gcaaggatca cttcgccctt ttttgcaatg
     4081 tagagccagg cacttgggcc tggtccttgt tccttccatc ctctgacatg gtcagtgagt
     4141 catgggaagc ggagctcccg tcagtcagtg gtggccatga tgcggtacag ggcatttctc
     4201 cttccaccat ccacagatgt tctcaataaa ctgtacattc attttggctg aagag
//
