LOCUS       NM_001418005            4705 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus DENN domain containing 2A (Dennd2a), transcript
            variant 2, mRNA.
ACCESSION   NM_001418005 XM_030255297
VERSION     NM_001418005.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4705)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4705)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   3  (bases 1 to 4705)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   4  (bases 1 to 4705)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122345.4 and AC153624.20.
            
            On Mar 14, 2023 this sequence version replaced XM_030255297.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.4482629.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-526               AC122345.4         147047-147572       c
            527-1630            AC122345.4         112386-113489       c
            1631-1758           AC122345.4         97972-98099         c
            1759-1880           AC122345.4         96431-96552         c
            1881-2081           AC122345.4         86704-86904         c
            2082-2175           AC122345.4         84907-85000         c
            2176-2226           AC122345.4         84384-84434         c
            2227-2414           AC122345.4         82729-82916         c
            2415-2524           AC122345.4         78497-78606         c
            2525-2594           AC122345.4         77550-77619         c
            2595-2672           AC122345.4         75289-75366         c
            2673-2813           AC122345.4         72743-72883         c
            2814-2962           AC122345.4         69931-70079         c
            2963-3140           AC153624.20        215435-215612       c
            3141-3182           AC153624.20        214009-214050       c
            3183-3300           AC153624.20        210820-210937       c
            3301-3540           AC153624.20        210287-210526       c
            3541-3627           AC153624.20        209448-209534       c
            3628-4705           AC153624.20        207610-208687       c
FEATURES             Location/Qualifiers
     source          1..4705
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 18.26 cM"
     gene            1..4705
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /note="DENN domain containing 2A"
                     /db_xref="GeneID:209773"
                     /db_xref="MGI:MGI:2444961"
     exon            1..526
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            527..1630
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     CDS             657..3659
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /note="isoform a is encoded by transcript variant 2; DENN
                     domain-containing protein 2A; DENN/MADD domain containing
                     2A"
                     /codon_start=1
                     /product="DENN domain-containing protein 2A isoform a"
                     /protein_id="NP_001404934.1"
                     /db_xref="GeneID:209773"
                     /db_xref="MGI:MGI:2444961"
                     /translation="MLEARVDMLSSNMIISGPAADLGAKEASRPWKKQLNSVPNSGPS
                     ARARAQPQPLSIKDKISKWEGKKEPPASDPARQTDGQEDHLPSCKVERRGSELTRTKN
                     GMRLETERLQNDSRARTVCQDTEQLPGPRPIDGQPELSQHRGRELKPSDLRFQSDHLS
                     VLRQVKRLEKALKDGSAGLDPQMPGTCYSPHCLPDKTEEDLPSLESHEKGGVLAAGRR
                     AHHLEVREPGPEISEDWKGQESVYRGSRWYPPKPFINPVPKPRRTFKHAGEGDKDVSP
                     GISFKKEKRNLPPLPSLPPPPPPLPSSPPPTSVNRRLWTGRQRPSADHRKSYEFEDLL
                     QSSSENSRVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDVELHGRCLGKKCVL
                     TFPASPTSSIPDTSTKQSLSKSAFFRQNSERRNLKLLDTRKLSRDGAGSPLRTSPPST
                     PSSPDDTFFNLGDLQNGRKKKKIPRLVLRINAIYEARRGKKRVKRLSQSTESNSGKVT
                     DENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYSSLDRDLIEYQERQLFEYFVVVSL
                     HKKQAGAAYVPELTQQFPLKLEKSFKFMREAEDQLKAIPQFCFPDAKDWAPVQEFTSE
                     TFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSKILDEVEKRRG
                     ISPALVQPLMRSVMEAPFPALGKTIIVKNFLPGSGTEVIELCRPLDSRLEHVDFESLF
                     SSLSVRHLVSVFASLLLERRVIFIADKLSTLSKCCHAMVALIYPFSWQHTYIPVLPPA
                     MIDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLINDRFLRQMEDEDSILPRKLQV
                     ALEHILEQRNDLACDQDGGPLDCVHGPESSSLSEVVSEAFVRFFVEIVGHYPLFLTSG
                     EERSLQREAFRKAVSSKSLRRFLEVFMETQTFRGFIQERELRRQDAKGLFEVRAQEYL
                     ETLPSGEHSGVNKFLKGLGNKMKFLHKK"
     exon            1631..1758
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1880
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2081
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2175
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2226
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2414
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2524
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2594
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2672
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2813
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2962
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3140
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3182
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3300
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3540
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3627
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..4705
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4151..4156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /note="hexamer: AATAAA"
     polyA_site      4170
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
     regulatory      4684..4689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /note="hexamer: AATAAG"
     polyA_site      4705
                     /gene="Dennd2a"
                     /gene_synonym="B930096L08Rik; C130031G22; mKIAA1277"
                     /note="major polyA site"
ORIGIN      
        1 agacggtcgc ggcgcagccc agggcagagg aaggggccgc gcgcgcggga ggccagagga
       61 gacgcagcac gcctccgagg ccggaggcgg cggggaccgg acgggagcgc gcgcggcggg
      121 gacccgaggg gctcgcggcg gccgggggag gccgcgcgga caaaggcgcg gagggcagcg
      181 ggccatggcg ccccaggccc ccgccgcccc tgccccgggc gaccgcgagt tgcgccccag
      241 aacccgcgga gccgacgccc gtagagaggt agggctgggc gccggagtgc gggcgacctc
      301 gggggagacc cgggagggta cgcgcggggg cgacgaggag actgcaggcg caagccgggg
      361 ctcctcgcag gcggcgctgg ggacgcttca gcggggccct ggggacccgc gcaggaagcg
      421 atccacagct ctttcccggg tcgggctaac ttcagggccg aagaaacttg cagaaactgg
      481 gcagagcccg gccctgcgct gtgccggagc tcccgggcgg ctgtgaggtc aaggcagaag
      541 ttgcaaagac tagggaagta cctggaaggc aaccacttgg gaggcccatt cctttgccga
      601 agactcatcc agcagtgccc ttgggaagga gtccctccgg gagcccccac accctcatgc
      661 tggaggccag agtggacatg ctcagctcca acatgatcat cagtggcccg gctgcagacc
      721 ttggcgctaa agaagccagc agaccctgga agaagcagct taacagtgtc ccgaactctg
      781 gaccatccgc ccgagccaga gcccagcccc agcccctcag cataaaggac aagatatcca
      841 agtgggaagg caagaaggag ccacccgcct ccgatcccgc caggcaaaca gatggccaag
      901 aggaccacct gccatcctgc aaggtagaga gaagaggcag tgagctcacc agaactaaga
      961 atggaatgag gcttgaaaca gagagattgc aaaatgacag ccgggcaaga actgtgtgtc
     1021 aggacacaga acagttgcca ggcccgaggc ctatcgatgg acagccagag ctcagccagc
     1081 accgaggtcg tgagctgaaa cccagcgatc tacgctttca aagtgaccat ctctctgtgc
     1141 tgagacaggt caagagacta gagaaggcct tgaaggatgg ctccgctggc ttggaccctc
     1201 agatgccggg gacttgttat tcacctcact gtctgcctga caaaacagag gaagacctgc
     1261 ccagtcttga aagccacgag aaggggggtg tcttagcagc tggccggaga gctcaccacc
     1321 tggaggtcag ggagccgggc cctgagattt cagaggattg gaaaggccag gagagtgtct
     1381 ataggggctc caggtggtac cccccaaagc cttttatcaa ccctgtcccc aagccccgca
     1441 gaacattcaa acatgctgga gaaggggaca aggatgtcag cccaggcatc agcttcaaga
     1501 aagagaagag aaacctgcct cccctgccct ctctgcctcc ccctccccca ccgctgcctt
     1561 cctcccctcc tcccacttcc gtgaatagaa gactgtggac cgggaggcag agacccagtg
     1621 ctgaccacag aaagtcctat gagttcgagg acttactaca gtcttcctca gagaacagca
     1681 gggtggactg gtatgcacag accaaattgg gactcacacg cactttatcg gaggagaacg
     1741 tctatgaaga cattctagat ccgccaatga aggaaaatcc ttatgaagat gtggagctgc
     1801 atggccgctg cctgggcaag aagtgtgtct tgactttccc cgcatctccc acctcttcca
     1861 tcccggacac gtccaccaag cagtccttgt ccaagtctgc atttttccgg cagaactcag
     1921 aaagaagaaa cttgaagctg ttggacacta ggaagcttag tcgggatgga gctgggtccc
     1981 cgctgaggac cagtcctccc tctacaccta gcagcccgga cgacacgttc tttaaccttg
     2041 gagacctaca gaatggcagg aagaagaaaa agatccccag gctggtattg aggatcaatg
     2101 ccatttatga ggcccggaga ggaaagaaac gggtgaagag gctatcccag tccacggaga
     2161 gcaactcagg aaaagtgaca gatgagaaca gtgagtctga cagcgacaca gaggagaagc
     2221 tgaaagctca cagccagcgc ctggtcaatg tgaagtctcg cctgaagcag gcccctcgat
     2281 actcatcgct tgaccgggat ctcattgagt accaagagag gcaactcttc gagtacttcg
     2341 tggttgtgtc tctgcacaag aagcaggcag gggccgccta cgtgccagag ctcacccagc
     2401 aatttcctct gaagttagaa aagtcattca agttcatgag agaggctgag gaccagctga
     2461 aggctatccc ccagttctgc ttccccgatg ctaaggactg ggctcctgtc caggagttta
     2521 ccagtgaaac attctcgttt gtcttaactg gagaagacgg gagcagaagg ttcggttact
     2581 gccgaagact gctgcctggg ggcaaaggga agcggcttcc tgaggtttat tgcattgtga
     2641 gccgcctggg atgcttcagc ctcttttcaa agatcttgga tgaggtggaa aagaggagag
     2701 gaatctcccc tgccctcgtg cagcccctca tgaggagcgt catggaagcc cctttcccag
     2761 ccctgggcaa aaccatcatt gtcaagaact tcctgccagg ctcggggact gaggtgattg
     2821 agctgtgccg accgctggac tcccggctag agcacgtgga ctttgagtct ctgttctcct
     2881 ccctcagtgt ccgacacttg gtcagtgtct ttgcctccct ccttctggaa aggagagtca
     2941 tcttcatcgc agacaaactc agcactctgt ccaaatgctg ccacgcaatg gtggcgctca
     3001 tctacccctt cagctggcag cacacctaca tcccggtgct accgcccgcc atgatcgaca
     3061 tagtgtgctc gcccacgccc ttcctcatcg ggctgctctc cagctcgctg cctctgctca
     3121 gggagctgcc actggaagag gttctcgtgg tcgatctcat caatgatcgg ttcctcaggc
     3181 agatggagga cgaggattcc attctgcccc ggaagcttca ggttgccctg gaacacattc
     3241 tggagcagag gaatgacctg gcctgtgacc aggatggagg cccgctggac tgtgtgcacg
     3301 gccctgaatc cagttccttg agtgaggtgg tgtccgaagc ctttgtccgc ttttttgtgg
     3361 agattgtggg ccactacccc ctgttcctga catcgggtga ggagagaagc ctgcaacgag
     3421 aggccttcag aaaagctgtc tcctctaaga gcctgcggcg cttcctggag gtcttcatgg
     3481 agacccagac gttccgtggc ttcatccagg agcgggaact acgcaggcaa gatgccaaag
     3541 gtctgtttga agtccgagcc caggagtacc tggaaaccct gcccagcgga gagcacagcg
     3601 gagtcaataa attcctcaag ggactgggca ataaaatgaa gtttctccac aagaaataac
     3661 cctcatcttg gcccaaggga aaacctcctc cctacgcccc agtcctccca ggatggaccc
     3721 cttagctggg caggtggcac gcgctcacaa cagctccgga agggaccagc cagcatgcag
     3781 aatgttgtta ctgtggttag ttgcttctgg gacctttaaa tcttagatat taaaagagaa
     3841 gaagaaggaa agtgtttggc tcttccttca ttcagctctc ctgccccatc tcatcgcctc
     3901 tgggccagct cattgactct gtggagccag gagttaggaa gcgcggcagc cacagaaaca
     3961 cttctgccca cgccactgct tcttccgcac tggtctatga cgccacctgg tggcagagac
     4021 tggactttac tgttcttgac tacattttct ttttttttct cctagaagcc gtatagctcc
     4081 attcatgccc caaaagtctg tggcttttag agggacacat ttaaaaaaac aggaaatctt
     4141 gttaactggt aataaaatgt tctaagggtc ctgaagtttc tatttcctgt ggcccaacca
     4201 tgacacttag gccactgctg tgagcctgtt cctcttgacc aacaaagcta ggagaggttt
     4261 ctgtagttgc ttctctttta tgagagagag gacccgaatc agctgacctg tggggacagt
     4321 aagagtctgc aggagccctg tgtgcagcaa aggaaggttc tcgggctggc ctcggggctg
     4381 ccaccccgat actgtgaatg ccaccaaaaa ctgactacat ctggatcgcc tctgacctgg
     4441 gcaggattaa taggagtgcg tggctgggat gttggaggta gccagagaaa gcaggtgagc
     4501 acagcacggg ggctcaggga ccgattccac aagctcctag gcttaggtaa ctttctgata
     4561 gcaatattct gtgtattttt atattgcccc caagtgatca cagttagtat tttggaatat
     4621 acgttctttt ctaacttatt ttatattata ctgttttact taagaacttc aggtgaataa
     4681 ataaataagt atatctttat caaca
//
