LOCUS       NM_153551               2509 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus DENN domain containing 1C (Dennd1c), transcript
            variant 1, mRNA.
ACCESSION   NM_153551
VERSION     NM_153551.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2509)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2509)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2509)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT571247.13.
            
            On May 30, 2020 this sequence version replaced NM_153551.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035208.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               CT571247.13        96756-96864         c
            110-174             CT571247.13        95307-95371         c
            175-218             CT571247.13        95184-95227         c
            219-268             CT571247.13        95013-95062         c
            269-388             CT571247.13        93735-93854         c
            389-458             CT571247.13        92859-92928         c
            459-539             CT571247.13        92640-92720         c
            540-605             CT571247.13        92480-92545         c
            606-659             CT571247.13        92340-92393         c
            660-770             CT571247.13        92139-92249         c
            771-871             CT571247.13        90702-90802         c
            872-917             CT571247.13        90375-90420         c
            918-1019            CT571247.13        90154-90255         c
            1020-1145           CT571247.13        89938-90063         c
            1146-1250           CT571247.13        89285-89389         c
            1251-1344           CT571247.13        88896-88989         c
            1345-1385           CT571247.13        88774-88814         c
            1386-1457           CT571247.13        88479-88550         c
            1458-1490           CT571247.13        86283-86315         c
            1491-1535           CT571247.13        86155-86199         c
            1536-1643           CT571247.13        85959-86066         c
            1644-1711           CT571247.13        85415-85482         c
            1712-1922           CT571247.13        85098-85308         c
            1923-2509           CT571247.13        84421-85007         c
FEATURES             Location/Qualifiers
     source          1..2509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.65 cM"
     gene            1..2509
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /note="DENN domain containing 1C"
                     /db_xref="GeneID:70785"
                     /db_xref="MGI:MGI:1918035"
     exon            1..109
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2453
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /note="isoform 1 is encoded by transcript variant 1; DENN
                     domain-containing protein 1C; connecdenn 3; DENN/MADD
                     domain containing 1C"
                     /codon_start=1
                     /product="DENN domain-containing protein 1C isoform 1"
                     /protein_id="NP_705779.1"
                     /db_xref="CCDS:CCDS37669.1"
                     /db_xref="GeneID:70785"
                     /db_xref="MGI:MGI:1918035"
                     /translation="MGSTETRHPPAMFDWFFEAGCPNSLEEDPPILRQFPPDFQEQEA
                     MQMVPRFCFPFDIEREPPSPAVQHFTFALTDLVGNRRFGFCRLRAGARSCLCILSHFP
                     WFEVFYKILNNVGDLLAQNQVAEAEELLQNLQQHPLLGPRFSGRSEMDSSITVRSECG
                     ILPPALGNSKLLSCFVAPDAASLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVL
                     LTASKLSTLTACVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHGSLAER
                     VREKALEDVVVLNADSNTLETPFDDVQALPPDVVSLLRLRLRKVALSPGEGVSRLFLK
                     VQALLFGGYRDALVCIPGQPVTFSEEAFLAQKPGAPLQAFHKKAVHLQLFKQFIESRL
                     EKLNAGEGFSDQFEQEIIACRGASSGTLRSYQLWVDSLKKGSDALLHSMKTKTQPAVR
                     NMYRSGDSLQEYCASKAKSGLKGMQNLLTIKDGDSGLQRGGSLRTPSLTSRSDRLQQR
                     LPISQHFGQNRPLRPSRRLKTEEGPSEPLRERSPTLSPGDTQNPWAEDTLDGSFLGSG
                     EELDLLSEILDSLNVETKSGDLQRASQSLDCCQRGAASESCSSLPDIPVGLPWQLEED
                     KRSQDPQPWSLPGDLSLLQDTPFSEVVSYSKNSCSQPFQQSPPSQGDPGPSLSKLDPR
                     PSQSPCPKLLRVPTRHSPPESPQLLVSTEPNSDAVQRLQSISSPSCSHSAENPRNQPP
                     QVLLGQACVQPLEELGAPTYVSHVSTQQRPQDKQPRVADLKKCFEN"
     exon            110..174
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            175..218
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            219..268
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            269..388
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            389..458
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            459..539
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            540..605
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            606..659
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            660..770
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            771..871
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            872..917
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1019
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1145
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1250
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1344
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1385
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1457
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1490
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1535
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1643
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1711
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1922
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2509
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2484..2489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2509
                     /gene="Dennd1c"
                     /gene_synonym="4432409M07Rik"
                     /note="major polyA site"
ORIGIN      
        1 agatcagggg cccagcccca agcaaacaca ggctccccca gccccagaag cactagggga
       61 aagggcccag ctgggccagc cctgcagaga ccatgggatc cacagagaca aggcatcccc
      121 ctgccatgtt tgactggttc tttgaagctg gctgccccaa ctccctggaa gaggatcccc
      181 ccatcctgcg gcagttccct ccagacttcc aggagcagga agccatgcag atggtgccca
      241 ggttctgttt ccccttcgac atagaaaggg agccacccag ccctgctgtt cagcatttca
      301 cctttgccct cactgacctg gtgggcaacc gtagatttgg cttctgccgc ctgcgagctg
      361 gtgcacggag ttgtctctgt atcctcagcc actttccctg gtttgaagtg ttctacaaga
      421 ttctcaataa cgtgggggac cttctagccc agaaccaagt cgccgaggct gaagaactcc
      481 tacaaaacct acagcaacac ccacttcttg gaccccggtt ttcaggaaga tcagagatgg
      541 acagcagcat cactgtccgg agtgaatgtg gaatcttgcc tcctgccctg gggaatagca
      601 agctgctttc ttgttttgtg gctccggatg ccgccagcct gccatctatt cctgagaata
      661 ggaacctcac tgagctggtg gtcgctgtga cagatgagaa catcgtgggg ctcttcgcag
      721 cgctgctagc tgagaggagg gtcttgctca ctgccagcaa gctcagcact ctgacagcct
      781 gtgttcacgc atcctgtgcc ctgctctacc ccatgcgctg ggagcacgtt ctgatcccca
      841 ctctaccccc acacctactg gactactgct gtgcgcccat gccctacctc ataggagtcc
      901 atggcagtct cgcagagaga gtccgagaaa aagcgctgga agatgttgtg gtgttgaatg
      961 cagactctaa caccctggag acaccctttg acgatgtgca agctctgccg ccggatgtgg
     1021 tatccctgct gaggcttcgg ctaaggaagg ttgccctgag ccctggggaa ggggtgtccc
     1081 gtctcttcct caaagtgcag gccctgctct ttggagggta ccgtgatgcc cttgtctgca
     1141 tcccgggtca gccagtgacc ttcagtgagg aagctttttt ggctcagaag cccggggcac
     1201 ccctgcaggc attccacaaa aaggcggtac acttgcagct gttcaagcag ttcatcgaat
     1261 cccgactgga aaaactcaat gctggggaag gcttctcaga ccaatttgag caagagatca
     1321 ttgcctgccg cggagcttcc tcaggcaccc ttcggtctta ccagctctgg gtagatagtc
     1381 ttaagaaagg tagcgatgcc cttctgcatt caatgaagac aaaaacccaa ccagctgtca
     1441 ggaacatgta ccgatcgggt gactccctcc aggaatattg tgcatcaaag gcaaagagtg
     1501 gcttgaaggg tatgcagaac ctgctcacga ttaaggatgg agactctggc ctgcagaggg
     1561 ggggctccct gagaacccca agcctcacca gccgctctga tcgtctgcaa cagcgcctgc
     1621 ctattagcca gcactttgga cagaacaggc ccctccgccc cagcaggaga ctcaagactg
     1681 aagagggacc ttccgaaccc ctgcgggaga ggagccccac cttgagccct ggggacactc
     1741 agaacccctg ggcagaagat actctagatg gcagctttct ggggtctgga gaagagctgg
     1801 atctactgag tgagattcta gacagcctga acgtggaaac caagagtggc gacctgcaga
     1861 gggccagcca gagcttagac tgctgtcagc gaggggcggc gtcagagagc tgctccagcc
     1921 tgcctgacat cccagtgggg ttaccatggc aactggaaga agacaagaga tcccaggatc
     1981 ctcagccttg gtccctacct ggtgacctgt cacttctgca agacacccca ttttcagagg
     2041 ttgtaagcta ctcaaagaac tcctgttctc agccatttca gcagagcccc ccaagccaag
     2101 gggaccccgg gccctctctc agcaagctgg atcctagacc ctcacaaagc ccctgcccca
     2161 agctcctcag agtccccact aggcacagtc ctccagaaag cccccagctt cttgtctcca
     2221 cagagcccaa ctctgatgct gtccaaagat tacaatccat ttcgtctccc tcatgctctc
     2281 attctgcaga gaaccccaga aaccagcctc cccaggtcct cctgggccag gcttgtgtac
     2341 aacccctcga ggagctggga gcccccactt atgtctctca tgtaagcacg cagcaaaggc
     2401 cacaggacaa gcaacctcga gttgctgatc tgaagaagtg tttcgaaaac taagataagg
     2461 agtgtgaggg gttcccaact ctcaataaag ctgaatttct tttccttga
//
