LOCUS       NM_001166501            8206 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DENN domain containing 1B (Dennd1b), transcript
            variant 1, mRNA.
ACCESSION   NM_001166501
VERSION     NM_001166501.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8206)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8206)
  AUTHORS   Park,E.W., Kawai,K., Egami,Y. and Araki,N.
  TITLE     A novel DENND1B-localized structure found at the basal side of
            adherent cells
  JOURNAL   Histochem Cell Biol 155 (1), 9-18 (2021)
   PUBMED   33135087
  REMARK    GeneRIF: A novel DENND1B-localized structure found at the basal
            side of adherent cells.
REFERENCE   3  (bases 1 to 8206)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8206)
  AUTHORS   Yang,C.W., Hojer,C.D., Zhou,M., Wu,X., Wuster,A., Lee,W.P.,
            Yaspan,B.L. and Chan,A.C.
  TITLE     Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and
            Allergic Disease
  JOURNAL   Cell 164 (1-2), 141-155 (2016)
   PUBMED   26774822
  REMARK    GeneRIF: Dennd1b(-/-) mice were generated and exhibit
            hyper-allergic responses following antigen challenge. Dennd1b(-/-)
            TH2, but not other TH cells, exhibit delayed receptor-induced T
            cell receptor (TCR) downmodulation, enhanced TCR signaling, and
            increased production of effector cytokines.
REFERENCE   5  (bases 1 to 8206)
  AUTHORS   Akagi,K., Li,J., Stephens,R.M., Volfovsky,N. and Symer,D.E.
  TITLE     Extensive variation between inbred mouse strains due to endogenous
            L1 retrotransposition
  JOURNAL   Genome Res 18 (6), 869-880 (2008)
   PUBMED   18381897
REFERENCE   6  (bases 1 to 8206)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117623.7 and AC138741.7.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.1018.1,
                                           SRR1660819.27976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC117623.7         150932-151108       c
            178-242             AC117623.7         148587-148651       c
            243-286             AC117623.7         91669-91712         c
            287-336             AC117623.7         74768-74817         c
            337-456             AC117623.7         72774-72893         c
            457-526             AC117623.7         61402-61471         c
            527-607             AC117623.7         60196-60276         c
            608-661             AC117623.7         54489-54542         c
            662-772             AC117623.7         51846-51956         c
            773-873             AC117623.7         33544-33644         c
            874-919             AC117623.7         28889-28934         c
            920-1021            AC117623.7         24262-24363         c
            1022-1147           AC117623.7         12724-12849         c
            1148-1249           AC117623.7         4332-4433           c
            1250-1340           AC138741.7         80429-80519
            1341-1381           AC138741.7         86139-86179
            1382-1450           AC138741.7         87210-87278
            1451-1507           AC138741.7         89592-89648
            1508-1615           AC138741.7         90651-90758
            1616-1701           AC138741.7         114429-114514
            1702-1918           AC138741.7         115590-115806
            1919-8206           AC138741.7         116514-122801
FEATURES             Location/Qualifiers
     source          1..8206
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 60.84 cM"
     gene            1..8206
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /note="DENN domain containing 1B"
                     /db_xref="GeneID:329260"
                     /db_xref="MGI:MGI:2447812"
     exon            1..177
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..2461
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /note="isoform 1 is encoded by transcript variant 1; DENN
                     domain-containing protein 1B; ASL1/9AS1-1 fusion;
                     connecdenn 2; DENN/MADD domain containing 1B"
                     /codon_start=1
                     /product="DENN domain-containing protein 1B isoform 1"
                     /protein_id="NP_001159973.1"
                     /db_xref="CCDS:CCDS48384.1"
                     /db_xref="GeneID:329260"
                     /db_xref="MGI:MGI:2447812"
                     /translation="MDRRTRENPERTFDLVLKVKCHASENEDPEVLWKFPEDFGDQEV
                     LQSVPKFCFPFDVERVSQNQVGQHFTFVLTDMESKQRFGFCRLTSGGRICLCILSYLP
                     WFEVYYKLLNTLADYLAKELEEDLNETLKSLYNHPVPKANTPVNLSVHSCFITPDITG
                     LPTIPESRNLTEYFVAVDVNNMLRLYASMLHERRIIITSSKLSTLTACLHGSAALLYP
                     MYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVVLNVDTNTLESP
                     FNDLSSLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPIT
                     FCEESFVKHRSSVMKQFLETAVNLQLFKQFIDGRLAKLNAGRGFSDIFEEEITSGGFC
                     GGSPRSYQQWVYTVKKGGALFNTAVTKATPAVRTAYKFAKSHARLGLKEVKSRLKHKD
                     NEEEYGTCSGLVQYTPVYTLHNEKGENREKHKLSQTHLKRPHKSLDGTLYDDDDDDDD
                     IERASKISSEDGEETRAYFYESDDSVEAQVKAPYSGEMDLLGEILDTLSTHSSDQGKL
                     APAKSLDFFRSMDDIDYKPTNKSNAPSENNLALLCASGDQGEWNLGQDDSALHGRQLP
                     PSPRKRVSSGGLTESLFILKEESREKPLCADSVSGPTVVGKPAPTSGLRSQPAAPEAS
                     QTERGRAEVKQTPGQAPLQSEDLSVPGPGSRQSTFVPWEKAGKEDTKPSKDVGLLQEV
                     VSLCHMSCDFQQDLNISEESRSGNQT"
     exon            178..242
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            243..286
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            287..336
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            337..456
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            457..526
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            527..607
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            608..661
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            662..772
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            773..873
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            874..919
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1021
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1147
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1249
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1340
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1381
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1450
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1507
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1615
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1701
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1918
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..8206
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8185..8190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      8206
                     /gene="Dennd1b"
                     /gene_synonym="4632404N19Rik; 4930467M19Rik;
                     6820401H01Rik; F730008N07Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgggggcag gggcaggggc gggggcggcg tcgccgcggt gctgtccccg cgaggccgcg
       61 gagggcgccg tgggccagcc gccgctcgga gcagcgcgtc ccggacggcg tgcgggcgtg
      121 cgggcgcggg gcgacggcag ccccgcagcg acatgtgacc atggaccgca ggaccaggga
      181 aaatccagaa agaacttttg acttggtatt gaaagtgaag tgtcatgcct ctgaaaatga
      241 agatcctgag gtattgtgga aattcccaga ggactttgga gaccaggaag ttctgcagag
      301 cgtgcccaag ttctgttttc ccttcgatgt ggaaagggtg tctcagaatc aagttggaca
      361 gcactttacc ttcgtcctga cagacatgga aagtaagcag cgatttgggt tctgcaggct
      421 cacatctgga ggcagaattt gtttatgtat tcttagttac ttgccatggt ttgaagtata
      481 ttataaactt ctaaatactc tggcagatta cttggccaag gaactggaag aggatttgaa
      541 tgaaactctt aaatcactct ataaccaccc agtaccaaag gcaaacactc ctgtcaactt
      601 gagtgtgcac tcctgtttca tcacacctga cataactgga ctcccaacga taccggagag
      661 tagaaacctg accgagtact ttgttgccgt ggatgtcaac aacatgctgc gactgtacgc
      721 cagcatgctg catgagaggc gcatcattat tacctcgagc aaattaagca ctttaactgc
      781 ctgtctccat ggatcggctg cgctactcta cccgatgtac tggcaacaca tatatatccc
      841 cgtgcttcct ccacacctgc tggactactg ctgtgcccca atgccatacc tgattggaat
      901 acactccagt ctcatagaga gagtgaaaaa taaatcattg gaagatgtgg ttgtgttaaa
      961 tgttgacaca aacacgttag aatcaccatt taatgacttg agcagcctgc ccagtgatgt
     1021 ggtctcggcc ttgaaaaata agctgaagaa gcagtccaca gctacgggag atggagtggc
     1081 tcgggccttt ctgagggctc aggcggcttt gtttggctcc taccgagatg ctctgagata
     1141 caagcctggc gagcccatca ccttctgtga ggagagcttt gtaaagcacc gctcaagcgt
     1201 gatgaaacag ttcctggaga ctgcagttaa ccttcagctc tttaagcagt ttattgatgg
     1261 tcgactggca aagcttaacg caggaagagg tttctctgat atcttcgaag aagagatcac
     1321 ttcgggtggc ttctgtggag ggagcccgag gtcatatcag cagtgggtgt atacagtcaa
     1381 gaaaggaggt gcattgttca acacagcagt gaccaaagca actcccgctg tgcggactgc
     1441 atacaaattt gcaaagagtc acgccagact gggactaaag gaggtgaaga gcaggctgaa
     1501 acacaaggac aatgaggaag agtatgggac ctgttctggt ttggtgcagt atacaccagt
     1561 gtacacttta cacaatgaaa agggagagaa cagagagaag cacaagcttt cccagacaca
     1621 cttgaaaagg cctcataaga gcctagatgg taccctgtat gatgatgatg atgatgacga
     1681 tgacattgaa cgggcaagca agatatcttc tgaagacggg gaagaaaccc gtgcttattt
     1741 ctacgaaagc gatgactccg ttgaagccca ggtgaaggct ccttactcag gggagatgga
     1801 cttactgggt gagatcctgg acacgctgag cacgcacagc tctgatcaag gaaagctggc
     1861 gcctgccaag agcctggatt tcttcagatc catggatgac attgattaca agcctacgaa
     1921 caagtccaac gctcccagtg agaataacct ggccctgctg tgtgcttctg gagaccaggg
     1981 agagtggaat ctcgggcagg acgacagcgc cctccatggc aggcaactcc ctccatcccc
     2041 aaggaaacgc gtttcctctg gtgggctgac agagtctctg tttatcctga aagaggagag
     2101 cagggagaag cccctctgtg ctgacagcgt aagtggccct actgtggtgg gaaagccagc
     2161 tccgacttca ggactgcgtt cccagcctgc tgctcctgaa gcttcccaaa cagagagagg
     2221 aagagcagaa gtgaagcaaa caccaggtca ggctccactt cagtcagagg atctgtcggt
     2281 gcccggcccc gggagccgcc agtcgacttt tgttccctgg gagaaggctg gcaaagagga
     2341 cacgaagcct tcaaaggatg tcggacttct ccaagaagta gtgtcattgt gtcacatgtc
     2401 atgtgacttc caacaagatt taaacatttc agaagaaagc agaagtggaa accaaactta
     2461 ggtaccagta gtgggtcagt tgcttgcctc ttggcttctc cggaggcatg tggaattcct
     2521 tccctgagat gggaacagta gagtcactga taggaatggc gacccctact gcagtctagt
     2581 tggtttccct gtctgttcat ctcatggatc tgtattacct gttggtttcc cagcgtaaaa
     2641 cgaattctgc tgtgctgtta aatcaggtac taacttgtac ataggctgaa agtgtgtttt
     2701 gaatttaagc tttcccagta tttggtgctt aatgctgttt gttttattta aactaagtgt
     2761 gcgtatataa ccccacatat cgccagtagt tactgtacta acctggctga gcatgaactg
     2821 atcaagatgt caaaactgat ggaaaatagc ctgacactga tgaaactgtt aacccactaa
     2881 ttgccttaat cttccagtta tgctaaacat acagatgacg cgtgatgcaa agcttgaaag
     2941 aggagttatc ttgtcctgca gagcagtgat gcctttttct accatgaact aagctcacca
     3001 ttcttttcca gtttcaatgc actctagcag aaataatttg ctttttatga agacatgtag
     3061 ccatgttttc caagcaacgt gaatgtgtat atttaccttt cagtgaacta tattaagtgc
     3121 tgacttacaa tgtgaagtta aaagcttctg cttacaaaga agcccctcaa tggtcgatct
     3181 catgtatgtg ttaaccatgg ttcaccgccc gaaagccaaa tgccctgcag agtccagata
     3241 ggctgttgtc ctcttctctt aactgacgtg ctgtgaagat gctcatagcc ttaccttgtg
     3301 tttgcttttt taaagaatta actttgtatt ttaaatgttc ttctagattt gtagaaaaaa
     3361 tgcaaagatg gtactgagtt gctctctgcc ctggaccctg tctctgctgt tgttagcatc
     3421 ctatgttagt gtgctgcatt tgccctatca ttgactcgct gtgtggtagt cagagctctg
     3481 actgttccct gctgtcccct ttctgttccc ttatcgcctc agcgttctag agtatgttct
     3541 acgatcatgt cttctgaggt tcctcctcac cctgggactt cactttctta gtttgatggc
     3601 tttgaagtta tcaggaatat tgttcagatg tccagctcct gtactgtata tagtattttt
     3661 ctccttatta caccgaggtt atccagcttt gagggaggag atcacagaag aaaagtgccg
     3721 ttttcagcat ctgaaggggt gtgctgcaag catatgccat gttgtgttga ctttgaacac
     3781 ctgctggggt tctctattct gagtgtgtcc cctgcaggca agcaggaggg gtgcaggcaa
     3841 agaagagagg aagggcaggc acaatagaat tatttagggc agagaagtat caaaatgcat
     3901 cctttgtgat tctccgtgga tcctgcctcc ctcatgatta ctctagcttt ggagcacacc
     3961 tgagagcaca tgcagatccc tagatgtgca ggtagtgtgt ttgaacacgc catggttcta
     4021 gtctatacat cctcaagtgt gatgattact tttcaaaaat tgtctttttt tagtgaaaaa
     4081 aaaaagtttg caaaaccatt gaagaattcc agtaaggcca tactctaaag tatttactta
     4141 aagaatataa ttttagctag aattttagga ggtttattta acatagtcct taaaatattt
     4201 acacaggtct tttttttttt tttttttggt attaagtgct ttattcagtc agctatgtca
     4261 ctagaccatg aatacacttt cttaaaactg aaaaattaaa agttaaacag tataagctag
     4321 tacagttgtt cctggttgcc ttccagaagt taaaggtaac tgcattgctg aagatatcat
     4381 ggacttcaaa cccaggactg tgttctggcc taaaagcctc ttccctgggg actagctttc
     4441 ataatactgt aagaaactat aaaaacttct cagagatgga agcatccact actacactgt
     4501 ttgacacaca caggtcattt tttaaaactg cattccaaaa tataactagg tagttttact
     4561 tgaggtaatg gttccctctt ttgtagtgga tggtggagcc tgtccttctg aggatgggct
     4621 cactatagaa gggaagattt aatccttgtc ttcacacaat aataatatgc aaggttgtga
     4681 gattgtgcct gtatgtgttg ttcattagtc ccagtttact gaaacaacag gagagtacac
     4741 atggaagagc tgatttcagc gggaagtgga aaagttattg tggtagtcac actgctgggc
     4801 aggggttccc accagattcc tcaacagaat ggagcgcttt taatgccatt tttcaagtga
     4861 ggtctctttt tcacatcaga actcattgtc taaaaaaatg agagcatcct gactgcagct
     4921 taaaacactg gcttccagtc tacttccatg gtaatcccat ggccacaggt ttgtggctct
     4981 ctaccttgag tcagcttgtg agatgttcta ctgtaacact agactatttg gaaacattta
     5041 tccactcaca aataatgtcc taagccacga aagtgatctg tgccttatgt aacaagcaaa
     5101 aacagctact ttatgttaaa aagaaaaact gtacacatta tttttaaatg tccagaaaac
     5161 tggaagcaag taggtgcttc gcaccattaa aaccttgagt atttgaagtc agcttttaaa
     5221 tgacacttcc cagtattatg atggaaacag ttgtaaaaat aagagaccat caggtgagct
     5281 ctgaaatttt aaaaaaggga atataaatgg agtatttttt tgttttgttt tgctttgccc
     5341 aaaccaaatc aaatataagt tccctgctat tgaaaatatg tgtttctgtt tgcactgtca
     5401 ttctatatac tgagcaccaa caactggagc tcccaaaata aatctttcag acaagctgct
     5461 tctgagcgat gagagacttg actaactcac agctctggct cccgaatctt gtgctttata
     5521 cgcctctaaa ggaaccctga tctgtgactc atcgagtctc cctcaggctt tgcatccagg
     5581 ccaggtcagg ggctaaagat agaaggacaa atgtcggtct gcagttgtgt taaagtgaag
     5641 acgttgccga gtaaaatgca tgggtgatta cctagtcttg ccaatcttac tatcagctta
     5701 tggcatactg acttttccaa ttcagagtta gtaactcctt cactgagaaa atatttattg
     5761 acttttcagg agcaaggtat aaaaattaag gatgtaaggg tacgggagga aacaattacc
     5821 cagctctggg gaatcaatta aaagggaaag gaactgtagg tgttaaaata ataactaata
     5881 ataataataa taataataat ataataaaaa tacaataagg atgtatttgc ttagatggta
     5941 ctcgctcaag aatcaacacc gagagatgct ttttaaaaat agctgcttta tttaaagtat
     6001 gttcaaacta caaaatcgtt aactctttta gtaattatat gagccactca ctagaatgct
     6061 gctaagatcc caccctaaag gacagattca gaggcactgc ttggctgagt ccttgctctg
     6121 accatccaca cgacctgaca ttgtcccttt gcagtactga tggccgtttc ccccagttca
     6181 ggagtaactt agagtatata aaggaagaac ctagtcatgt tgctgggagt cccgatttta
     6241 catttaaaaa aaaaaaatct tggtaacaac attttctagg gagccttttt tttcttagct
     6301 aatggtgtga ctgttattaa gatgctatgc tgatatctaa tggtgtgacc caggaatgcc
     6361 catgaaatac ttgttggtta aacaaaggga agattcctgg tcaacagcaa atggctgtgg
     6421 acattcttgc agtcaacagc tgtcccttct ctgctcagat ctccagttca agttcatcac
     6481 tttcatgagt aaattgtctc ctgagaactt caggttctgg gttggtgtca gtgagtctcc
     6541 aatctgagaa gatatttgaa aatcagaatg aaagttcaaa atggaaactg aaccccctaa
     6601 atgtaggctc tccccaggca tctcttaatg ttggtagtca gttttttagc agtctgattc
     6661 tctgagcatt ttccccacgt tgaggccaga ggcctattag tgtctgtttt ttaaagcttc
     6721 caggaataga aacgctttgc aacagccagt tgatgttagg atttgtttat aaaataggga
     6781 attatgtata ttgagacaga aatattttat tttgaaacat aggattttgt gcaatatttt
     6841 tcttgcattg tttagtttat ataaatatgc acatctgctt ttctggcaga taccttaagg
     6901 tcatgtcttt cagtatttgc ctaaaactgt atgtagcaat gttctatgtg atttcagaaa
     6961 aaaaaattac tctttctatt attagtagaa gtgttcttgt ttatttaaaa taataatgtg
     7021 gagattgcat tattgtatca taacgaactg cctcagccac aataaatatg caataagaaa
     7081 ttcctgttcc tttgattagt attgacaata ctgttacttt aacagaaatg tttgtggtac
     7141 agagtgctgg ttctatctgt gttcatttaa cagctactct gcagcacaag aatctaaacg
     7201 gtatatttat gtgataacca tgtgtatgta gattatgaca tcctttgtga tgagtctttg
     7261 ttgaggcttg taaagggcat tgccaatact ttttgattgt aaattaattt ttttgtatga
     7321 tgtatagttt gtttagcctt agagcttctt tagatttcta cttttattat acttgaatga
     7381 ggcagaaagc actgtgggca gtttgtaact ctggatgcaa tatgcagata taccaaaaat
     7441 aaaacaaggt actgaacagc agcgctaatg gaatgcgtta taatccagga gttgtgtttt
     7501 tcaagccaca ttttagtgaa atgaagtaat tgaagatata cagtctttta tctagacagt
     7561 atagtctcaa atgattacct cttcaatgtg tcaaaggtgt gtgtcctttt taacttctgt
     7621 atcagtcctt agctgagcct agaggaccat ccatcctccc tcctcggacc acatgatgtc
     7681 taggacagaa caaatcaact acattgtgca tattaggtgc actgtctgtg tgaagtcact
     7741 gtgttttaga tagagtagct ttcataggta attttgagaa ctctttaata atcatatacc
     7801 aaaaactaaa aactaaattt tttaaatgag ttattactta gctgtgccta aaatctctta
     7861 gacataaagg ccacatgagg gactcaggat tgaatgtttc caaagtttat gttcattcct
     7921 ttagctaaag agttgtttgc tcaacatata accagtagct taaaaaacaa aactaagcaa
     7981 aacaaaacag aaaaccatga gcagcaagac actgagatgt gcttcgtggt gcttgccctc
     8041 gagactacag tttatcatct ctggacttaa ttacgattgg gaagatgttc tgtataaaat
     8101 tattgtttgg aagtttttta atatgcaaaa taaaatgttg aatgaactct gctttgccat
     8161 aaagtaccca ataatgtcgc tgaaaataaa attggtcacg atcaaa
//
