LOCUS       NM_001362973            4481 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus DENN domain containing 1A (Dennd1a), transcript
            variant 1, mRNA.
ACCESSION   NM_001362973 XM_006497999
VERSION     NM_001362973.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4481)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4481)
  AUTHORS   Shi,J., Gao,Q., Cao,Y. and Fu,J.
  TITLE     Dennd1a, a susceptibility gene for polycystic ovary syndrome, is
            essential for mouse embryogenesis
  JOURNAL   Dev Dyn 248 (5), 351-362 (2019)
   PUBMED   30884041
  REMARK    GeneRIF: Dennd1a is essential for embryogenesis, probably through
            the mediation of endocytic recycling of selective cargos that are
            involved in cell signaling crucial for the development of multiple
            embryonic organ systems.
REFERENCE   3  (bases 1 to 4481)
  AUTHORS   Allaire,P.D., Marat,A.L., Dall'Armi,C., Di Paolo,G., McPherson,P.S.
            and Ritter,B.
  TITLE     The Connecdenn DENN domain: a GEF for Rab35 mediating
            cargo-specific exit from early endosomes
  JOURNAL   Mol Cell 37 (3), 370-382 (2010)
   PUBMED   20159556
REFERENCE   4  (bases 1 to 4481)
  AUTHORS   Allaire,P.D., Ritter,B., Thomas,S., Burman,J.L., Denisov,A.Y.,
            Legendre-Guillemin,V., Harper,S.Q., Davidson,B.L., Gehring,K. and
            McPherson,P.S.
  TITLE     Connecdenn, a novel DENN domain-containing protein of neuronal
            clathrin-coated vesicles functioning in synaptic vesicle
            endocytosis
  JOURNAL   J Neurosci 26 (51), 13202-13212 (2006)
   PUBMED   17182770
  REMARK    GeneRIF: Connecdenn is a component of the endocytic machinery
            functioning in synaptic vesicle endocytosis, providing the first
            evidence of a role for a DENN domain-containing protein in
            endocytosis.
REFERENCE   5  (bases 1 to 4481)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929186.7, AL929238.22, AL928810.7 and AL805959.11.
            
            On May 5, 2018 this sequence version replaced XM_006497999.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.27443.1,
                                           SRR9219381.257254.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               AL929186.7         116487-116758       c
            273-343             AL929186.7         72776-72846         c
            344-387             AL929238.22        161407-161450       c
            388-437             AL929238.22        138526-138575       c
            438-557             AL929238.22        128129-128248       c
            558-627             AL929238.22        50325-50394         c
            628-708             AL929238.22        44939-45019         c
            709-762             AL929238.22        40752-40805         c
            763-873             AL929238.22        22956-23066         c
            874-974             AL929238.22        4974-5074           c
            975-1020            AL928810.7         70503-70548         c
            1021-1122           AL928810.7         49084-49185         c
            1123-1248           AL928810.7         24062-24187         c
            1249-1353           AL805959.11        161406-161510       c
            1354-1441           AL805959.11        161056-161143       c
            1442-1482           AL805959.11        159154-159194       c
            1483-1554           AL805959.11        157031-157102       c
            1555-1611           AL805959.11        155434-155490       c
            1612-1743           AL805959.11        147815-147946       c
            1744-1832           AL805959.11        119954-120042       c
            1833-1961           AL805959.11        108110-108238       c
            1962-2220           AL805959.11        105053-105311       c
            2221-4481           AL805959.11        102028-104288       c
FEATURES             Location/Qualifiers
     source          1..4481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.19 cM"
     gene            1..4481
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /note="DENN domain containing 1A"
                     /db_xref="GeneID:227801"
                     /db_xref="MGI:MGI:2442794"
     exon            1..272
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..3435
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /note="isoform 1 is encoded by transcript variant 1; DENN
                     domain-containing protein 1A; connecdenn 1; DENN/MADD
                     domain containing 1A"
                     /codon_start=1
                     /product="DENN domain-containing protein 1A isoform 1"
                     /protein_id="NP_001349902.1"
                     /db_xref="GeneID:227801"
                     /db_xref="MGI:MGI:2442794"
                     /translation="MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQ
                     EVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSY
                     LPWFEVFYKLLNILADYTTKRQESQWNELLETLHRLPIPDPGVSVHLSVHSYFTVPDS
                     RELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAML
                     YPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLE
                     TPFDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEP
                     ITFSEEAFVSHYRSGAMKQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMG
                     EYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLK
                     QKDITENGCVSSAEDPLPKTMPSPQAETQDPRLREDRRPITVHFGQVRPPRPHVVRRP
                     KSNITVEGRRTSVSSPEHLVKPLRHYAVFLSEDSSDEECRREEAPSTGFTESLLFSAP
                     FEWPQPYRTLKESDSAEGDETESPEQLVREPWGPTPAPPDRAASIDLLEDVFSSLDVE
                     APLQPLGQAKSLEDLRAPKDLREQPGSFDYQRLDLCRSERGLSMAAALKLAHPYTKLW
                     SLGQDDMAIPSKPSITSPEKPSALLGTSPALPLRPQNQEGILSPSIKEETPIPTPGSI
                     TIPRPQGRKTPELGIVPPPPTARPAKLQAAGGPLGDFSSEPLQMDRERQAALSPALLS
                     GLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTIPSHPATPSAA
                     TPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAY
                     APSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSRIRTL
                     PLARSSARAAEAKQGLALRPGESPLLPPRPPQSLQPTPQPSVPTQARDPFEDLLRKTK
                     QDVSPSPAPALAPASTSVEQLRRQWETFE"
     exon            273..343
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            344..387
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            388..437
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            438..557
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            558..627
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            628..708
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            709..762
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            763..873
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            874..974
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1020
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1122
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1248
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1353
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1441
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1482
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1554
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1611
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1743
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1832
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1961
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2220
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..4481
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4458..4463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /note="hexamer: AATAAA"
     polyA_site      4478
                     /gene="Dennd1a"
                     /gene_synonym="6030446I19Rik; connecdenn"
                     /note="major polyA site"
ORIGIN      
        1 gggcggcgcg cgccgggtac gcgcgcgggc gaccatggcg ctcgcccggc tggagcgagt
       61 actttaaccc cgggaggcga cagcagctgc ggcggccggg gagcgagcct cgagcgggcg
      121 ggcccctgcc tgagggaagg gaggaagggg cggggagagc tcctgaggga ggcctgtcgg
      181 ccgcgggcgg gcgggcagtg cagtgcagcg cagcaccgag cggggcccgc gggtccatga
      241 ggaggccccg ggaccatggg ctccaggatc aagcaaaacc cagagactac atttgaagtg
      301 tatgtggaag tggcttatcc taggacaggt ggcactcttt cagatcctga ggtgcagagg
      361 caattcccag aggactacag tgaccaggaa gttctacaga ctttgaccaa gttttgtttt
      421 cccttctatg tggacagcct cacagttagc caagttggcc agaacttcac atttgtgctc
      481 actgacattg acagcaaaca gagattcggg ttctgccgct tatcttcagg agccaagagc
      541 tgcttctgta tcttaagcta cctcccctgg ttcgaggtat tctataagct ccttaacatc
      601 ttggcagatt acacgacgaa acgacaggaa agtcagtgga atgaacttct tgaaactctg
      661 cacagacttc ccatccctga tcctggagtg tctgttcacc tcagtgtgca ttcttacttc
      721 actgtgcctg atagcagaga gcttcccagc atacctgaga atagaaatct gacagaatat
      781 tttgtggctg tggatgtgaa caacatgttg catctgtacg ccagcatgct gtatgaacgc
      841 cggatcctca tcatctgcag caagctcagt acattgacgg cctgcatcca cggctcagct
      901 gccatgctct accctatgta ctggcagcat gtgtacatcc ctgtgctgcc cccacatctg
      961 ctggactact gctgtgctcc catgccctac ctcataggaa tccatttaag tttaatggag
     1021 aaggtcagga acatggccct cgatgatgtt gtgatcttga acgtggacac caacaccctg
     1081 gaaacccctt ttgatgacct ccagagcctc ccaaatgatg tgatctcctc cctgaagaac
     1141 aggctgaaga aggtctctac aaccacaggt gatggggtgg ccagagcctt cctcaaggcc
     1201 caggctgctt tctttggcag ctaccggaat gcactgaaaa ttgagccaga agaacccatc
     1261 actttcagtg aggaagcctt tgtatcccac taccgctctg gagccatgaa acagttccta
     1321 cagaatgcca cacagttgca gctcttcaag cagtttatcg atggccgact agaccttctc
     1381 aattccggtg aaggtttcag cgatgtcttt gaggaggaaa tcaacatggg agagtatgcc
     1441 ggcagtgata aactgtacca tcagtggctg tccacagtca ggaaaggaag tggtgcgatt
     1501 ctgaatactg taaaaacaaa agctaaccca gccatgaaga ctgtctacaa gtttgcaaaa
     1561 gatcatgcaa aaatgggaat aaaggaggtg aaaaaccgct tgaagcaaaa ggacatcacg
     1621 gagaacggct gtgtgtcctc tgcagaagat ccactgccaa agaccatgcc atccccacag
     1681 gcagagaccc aggaccccag acttcgagaa gaccggagac caatcacagt ccactttggg
     1741 caggtacggc ctcctcgtcc acatgtcgtc aggagaccca agagcaacat cactgtggaa
     1801 ggcaggagga catctgtctc aagccctgag cacctggtaa agcccttgcg acactatgct
     1861 gtcttcctct ctgaagactc ctctgatgag gaatgccgac gggaagaggc ccccagcact
     1921 ggcttcactg aaagccttct cttctctgct ccctttgaat ggccacagcc ataccggaca
     1981 ttgaaagaat cagacagcgc agaaggtgat gagaccgaga gtccagagca gctagttcga
     2041 gaaccctggg gacctacccc tgctccacct gaccgagctg ccagcattga ccttctagaa
     2101 gatgtcttca gcagcctaga cgtggaggca ccactgcagc cgctgggcca agccaagagc
     2161 ctggaggatc tccgggcccc caaagacttg cgggaacagc cagggagctt tgattaccag
     2221 agactggacc tgtgcagaag tgagaggggc cttagcatgg ctgcagcctt gaagcttgct
     2281 catccatata ctaagctctg gagtctgggt caggacgaca tggccatccc cagcaagccc
     2341 tccataacct cccctgagaa gccctcagct ctgcttggta cttccccagc cctgcctctc
     2401 agaccccaga accaggaggg catcctgagc cccagcatca aggaggagac tcccatccca
     2461 actccgggca gcatcaccat tcccaggcca caaggcagaa agacccctga gctgggcatc
     2521 gtgcctccac cacccactgc ccggccagcc aagctccagg ctgctggcgg cccacttggt
     2581 gacttctctt cagagccact gcagatggac cgggaaagac aagccgctct gagtccagcc
     2641 ctcctgtcag ggctgctccc cagagctgtc ccccaaggtc ccacagaact tctgcagcca
     2701 cccagcccag ccccaggagc tgcaggcaca ggcagcgatg ccctgctcgc tctcctggat
     2761 ccacttaaca cagcctggtc aggcagcacc atcccatcac atcctgctac ccccagtgca
     2821 gccaccccat tcatccctca gctcagcttc cccccaacag tgacacccac cccttttgta
     2881 cagacaccac tcaatccctt tgtcccatct gtgccagtag taccaccctc catgcccctg
     2941 agctctacac cagccaggcc ttttgggacc cctccagcat ccctagggcc agcatatgca
     3001 cctagcattc tattgtctag ttctggcttc tatgcccctc acaggtctca gcccaacctc
     3061 tctgctctct ccatgcccaa cctctttggc cagatcccaa tgggtgccca cactagtccc
     3121 ctgcagccac ttggcccccc agccgttgcc ccctccagga tccgaacatt gcctctggcc
     3181 cgctcaagtg ccagggctgc tgaggccaag caggggttgg ccctgaggcc tggtgaatcc
     3241 ccactgttgc ctcccagacc gccccagagc ctacagccaa ccccgcagcc ctctgttcct
     3301 acacaggcca gagacccctt tgaggatttg ctgcgaaaaa ccaagcaaga tgtgagccca
     3361 agcccagccc cggccctggc cccagcctcc acctccgtgg agcagctccg cagacagtgg
     3421 gagacctttg agtgagcagg cctgtgccac tgtctaatac tgtgcctccc caacgtccca
     3481 tttctagcca ggcttcatgg ggcaaaggga ctctgccccc tcctccacag cccatctctg
     3541 aggcctggcc ctgggaatgg ccatcccaga agagctgcct gccgccaccc ttggcaccct
     3601 gtgtgggttt tgcactatat gtcaactgga ccagctgtat cctatcctcc catagcccaa
     3661 gaggagtcaa gaagctcaag gctgctttca agcccagctc tcctcctttg ctgggcccca
     3721 ccccacaggg cagatgtcag taacaacctg tgtaagcaca gctttggggg acatgggtgt
     3781 ttggggggct gaaatgaggc ccactcctag gctggcattt ctccctggtg gtcatctcca
     3841 aacctctcta gcaatatact ctttcctgag tcttcaccta accaccaact ggagttgttc
     3901 ctgaagggtc aggggtctgg agacctaatg gtcagcaaac ccagccccag ccagctcttc
     3961 caggggttgg gaacaccagc aactctaact tataagagaa gctccaaacc tgagtcttag
     4021 gagccgccct cagctctctg ccaccctcat acctctgggc tctcgtgtca gtcaaagctc
     4081 aggcccagcc tcctgccact tggagcttta tgggcagagc tgggcagcag tgacccagat
     4141 tccaactcaa aggacaagct tcctgccaca gacaaaggga gggaggcaca gctgttagag
     4201 ctcctgggtc aggaccaggt ggggccccag ggctccccag gttcccccat ggagtgaaga
     4261 tacacgtggc ctctgagcgt gcggcaagtg ggggcctgga agccagccct ccccactctc
     4321 tccagcttct cgacagcgca gaaattcctg agcccaagtc accaaagtta taatgaaatg
     4381 ttttgttatt ttttctttga tcttgctttt cctttttacc ttattgattt gatgaatctt
     4441 gaaaattgat tcctttcaat aaaccaaggt aaaacacaga c
//
