LOCUS       NM_026437               2335 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus DENN domain containing 10 (Dennd10), transcript
            variant 1, mRNA.
ACCESSION   NM_026437
VERSION     NM_026437.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2335)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163019.5.
            
            On Dec 23, 2021 this sequence version replaced NM_026437.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007867.1, AK145769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC163019.5         119680-119762
            84-280              AC163019.5         122701-122897
            281-360             AC163019.5         125620-125699
            361-509             AC163019.5         129296-129444
            510-621             AC163019.5         130384-130495
            622-722             AC163019.5         133920-134020
            723-830             AC163019.5         138876-138983
            831-925             AC163019.5         140673-140767
            926-2335            AC163019.5         142915-144324
FEATURES             Location/Qualifiers
     source          1..2335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 56.52 cM"
     gene            1..2335
                     /gene="Dennd10"
                     /gene_synonym="1810055E12Rik; Fam45a"
                     /note="DENN domain containing 10"
                     /db_xref="GeneID:67894"
                     /db_xref="MGI:MGI:1915144"
     exon            1..83
                     /gene="Dennd10"
                     /gene_synonym="1810055E12Rik; Fam45a"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1102
                     /gene="Dennd10"
                     /gene_synonym="1810055E12Rik; Fam45a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM45A; family with sequence similarity 45, member
                     A; DENN domain-containing protein 10"
                     /codon_start=1
                     /product="DENN domain-containing protein 10 isoform 1"
                     /protein_id="NP_080713.2"
                     /db_xref="CCDS:CCDS29942.1"
                     /db_xref="GeneID:67894"
                     /db_xref="MGI:MGI:1915144"
                     /translation="MAAVVAMDTQLMLGVGLIEKDSNGEALWVWCYPSTTASLRNLLL
                     RKCCLTDENKLLHPFVFGQYRRTWFYVTTVEVPDSSVLKKVTHFSIVLTAKDFNPEKY
                     AAFTRILCRIYLKYGSPVKMMESYIAVLTKGICQSEENGSFLSRDFDGRKAYLAGSIK
                     DIVSQFGMETVILHTALMLKKRIVVYHPKIEAVQEFTRTLPALVWHRQDWTILHSYMH
                     LHAEELEGLQMCTGYIAGFVELEVSNRPDLYDVFVNLADSEITIAPLAKEAMTMGKLH
                     KEIGQLIVQSAEDPEKSDSQVIQDIALKTKEIFTHLAPFSEVSDDGGKVILNVEALKQ
                     QRFPPATENFLYHLAAAEQMLKV"
     exon            84..280
                     /gene="Dennd10"
                     /gene_synonym="1810055E12Rik; Fam45a"
                     /inference="alignment:Splign:2.1.0"
     exon            281..360
                     /gene="Dennd10"
                     /gene_synonym="1810055E12Rik; Fam45a"
                     /inference="alignment:Splign:2.1.0"
     exon            361..509
                     /gene="Dennd10"
                     /gene_synonym="1810055E12Rik; Fam45a"
                     /inference="alignment:Splign:2.1.0"
     exon            510..621
                     /gene="Dennd10"
                     /gene_synonym="1810055E12Rik; Fam45a"
                     /inference="alignment:Splign:2.1.0"
     exon            622..722
                     /gene="Dennd10"
                     /gene_synonym="1810055E12Rik; Fam45a"
                     /inference="alignment:Splign:2.1.0"
     exon            723..830
                     /gene="Dennd10"
                     /gene_synonym="1810055E12Rik; Fam45a"
                     /inference="alignment:Splign:2.1.0"
     exon            831..925
                     /gene="Dennd10"
                     /gene_synonym="1810055E12Rik; Fam45a"
                     /inference="alignment:Splign:2.1.0"
     exon            926..2335
                     /gene="Dennd10"
                     /gene_synonym="1810055E12Rik; Fam45a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2310..2315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dennd10"
                     /gene_synonym="1810055E12Rik; Fam45a"
                     /note="hexamer: ATTAAA"
     polyA_site      2335
                     /gene="Dennd10"
                     /gene_synonym="1810055E12Rik; Fam45a"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggagc ccagggtagc ggcggaagat ggctgcggtt gtggcaatgg acacccagct
       61 gatgctcgga gtcgggctga tcgaaaagga ctctaatgga gaagccctgt gggtgtggtg
      121 ttatccttcc acgacagcct cactaaggaa tctgctgctc cgaaaatgct gcctaactga
      181 tgaaaacaaa cttctccacc ctttcgtctt tggtcagtac agaagaacat ggttttatgt
      241 cacgacagtt gaagttccag attcttcagt tttgaaaaag gtgactcatt tttctattgt
      301 tctgaccgcc aaagatttta acccagagaa atatgccgcc ttcactagga tattgtgtag
      361 aatatatttg aaatatggaa gtccggttaa aatgatggag agttacattg cagttctcac
      421 caaggggatc tgccagagtg aagaaaatgg ctctttcctt agtagagact ttgatggtcg
      481 aaaggcatac cttgctggct ccatcaaaga cattgtatct caatttggaa tggaaactgt
      541 tattttacac acagcattga tgctgaaaaa acgaattgtt gtctatcacc ccaaaataga
      601 agctgtccag gagttcacca ggactctgcc tgccctggtg tggcatcgac aggattggac
      661 catcctgcat tcttacatgc accttcatgc tgaagagcta gaaggcctac agatgtgcac
      721 aggctacatt gctggctttg tagaattgga ggtgagcaac agaccagacc tctatgacgt
      781 gtttgtgaat ctggcagata gtgagatcac catcgctcca cttgcaaaag aggccatgac
      841 gatgggcaaa ctgcataaag agattggtca actaattgtg caatctgcag aagacccaga
      901 gaaatcagac agccaggtta tacaggacat tgccctaaaa acaaaagaaa tcttcactca
      961 cctggcacca ttctcagaag tgtctgatga tgggggaaaa gtcatcctca atgttgaggc
     1021 actgaagcag cagcgatttc cacccgcaac agaaaacttc ctgtatcatc tagcagcagc
     1081 tgaacaaatg ctgaaggtct gactgttctc aacatcttgc tgcgacccct acagaacttc
     1141 ccttttattc ctagtaccca ttgacattat acactattgg aattatagga atgttctatt
     1201 tttaatgact tatttccaaa tagtgagatc ttaggtgaga gcacataaaa acaattgtga
     1261 tttttctccc tgccaatttg atccagtgct ggacagtgtt ttaattttaa ttactgtcct
     1321 aatggtagga gccacacaga tcgcacatgc tagccttcat tgttcattcc tatttagtct
     1381 tactgtagcc ataaacttaa tggtttattt tcagaaagct gcctcaaagt ttgcttttta
     1441 ttcttctaga aaaaaacttg aattcctcat gagagagtat actttttgag cctaactgct
     1501 atgttttctg cagaattgtc tagaaggtca ttcaagagat actacagttg cactttcttg
     1561 tggaaaaaaa aaatgttttg ggcctttgaa acttttgcct atattatgtg ggttattcat
     1621 agacttttat acttgagtag acaaatccaa caacccttat actgccctag atataagcat
     1681 ttaataaaca tccaccatta gaactcttgg actaattgct gctagcagtg tctttggaaa
     1741 agaggccagt ccccaacaag gaaacccctt ttaaatgtaa acatgtataa gaaaaaaata
     1801 cctttactgt ttttatttgc agtgttggag ctagaacctg gggccttgca tatgcaaggc
     1861 attgctttcc cactaaacta aacccccagc ccataatgct ttcatatatt ggtaaaggaa
     1921 catgagaatc aaattgccaa ggccaaaact agacagtgtc ttccagtgac tgcagtaaag
     1981 gaatttggcc acatcatcag gacactgtta ttagcctctc ttaatttgag atcttaaaat
     2041 taccaaataa gcacaaatgt ctcaattatg cattccttat gtctactcac attaactatg
     2101 aaaggccacc tttcttcagt atagttgcag agcattcaaa ccttaccagg aaacatattt
     2161 gcaaaaatgt tatctaagtt gggtattttt tttttaaatc ttattgttag acatttaagt
     2221 aaaaataaaa aaatagcctt tccctcttgt ccttgggtaa aaacagggag gacttgacat
     2281 actttgttta ctggagctaa caactaatga ttaaatttgc actttataaa aagaa
//
