LOCUS       NM_025900               2606 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus DEK proto-oncogene (Dek), mRNA.
ACCESSION   NM_025900
VERSION     NM_025900.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2606)
  AUTHORS   Bai,Q., Liu,R., Quan,C., Han,X., Wang,D., Wang,C., Wang,Z., Li,L.,
            Li,L., Piao,H., Song,Y. and Yan,G.
  TITLE     DEK deficiency suppresses mitophagy to protect against house dust
            mite-induced asthma
  JOURNAL   Front Immunol 14, 1289774 (2024)
   PUBMED   38274803
  REMARK    GeneRIF: DEK deficiency suppresses mitophagy to protect against
            house dust mite-induced asthma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2606)
  AUTHORS   Song,Y., Wang,Z., Jiang,J., Piao,Y., Bai,Q., Piao,Q., Li,L., Xu,C.,
            Liu,H., Piao,H., Li,L. and Yan,G.
  TITLE     miR-181-5p attenuates neutrophilic inflammation in asthma by
            targeting DEK
  JOURNAL   Int Immunopharmacol 112, 109243 (2022)
   PUBMED   36115279
  REMARK    GeneRIF: miR-181-5p attenuates neutrophilic inflammation in asthma
            by targeting DEK.
REFERENCE   3  (bases 1 to 2606)
  AUTHORS   Chen,Z., Huo,D., Li,L., Liu,Z., Li,Z., Xu,S., Huang,Y., Wu,W.,
            Zhou,C., Liu,Y., Kuang,M., Wu,F., Li,H., Qian,P., Song,G., Wu,X.,
            Chen,J. and Hou,Y.
  TITLE     Nuclear DEK preserves hematopoietic stem cells potential via
            NCoR1/HDAC3-Akt1/2-mTOR axis
  JOURNAL   J Exp Med 218 (5) (2021)
   PUBMED   33755722
  REMARK    GeneRIF: Nuclear DEK preserves hematopoietic stem cells potential
            via NCoR1/HDAC3-Akt1/2-mTOR axis.
REFERENCE   4  (bases 1 to 2606)
  AUTHORS   Cao,J., Su,J., An,M., Yang,Y., Zhang,Y., Zuo,J., Zhang,N. and
            Zhao,Y.
  TITLE     Novel DEK-Targeting Aptamer Delivered by a Hydrogel Microneedle
            Attenuates Collagen-Induced Arthritis
  JOURNAL   Mol Pharm 18 (1), 305-316 (2021)
   PUBMED   33253580
  REMARK    GeneRIF: Novel DEK-Targeting Aptamer Delivered by a Hydrogel
            Microneedle Attenuates Collagen-Induced Arthritis.
            Erratum:[Mol Pharm. 2021 Nov 1;18(11):4231. doi:
            10.1021/acs.molpharmaceut.1c00732. PMID: 34582206]
REFERENCE   5  (bases 1 to 2606)
  AUTHORS   Pease,N.A., Shephard,M.S., Sertorio,M., Waltz,S.E. and
            Vinnedge,L.M.P.
  TITLE     DEK Expression in Breast Cancer Cells Leads to the Alternative
            Activation of Tumor Associated Macrophages
  JOURNAL   Cancers (Basel) 12 (7), 1936 (2020)
   PUBMED   32708944
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2606)
  AUTHORS   Misawa,K., Nosaka,T., Morita,S., Kaneko,A., Nakahata,T., Asano,S.
            and Kitamura,T.
  TITLE     A method to identify cDNAs based on localization of green
            fluorescent protein fusion products
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3062-3066 (2000)
   PUBMED   10716735
REFERENCE   7  (bases 1 to 2606)
  AUTHORS   Hollnagel,A., Oehlmann,V., Heymer,J., Ruther,U. and Nordheim,A.
  TITLE     Id genes are direct targets of bone morphogenetic protein induction
            in embryonic stem cells
  JOURNAL   J Biol Chem 274 (28), 19838-19845 (1999)
   PUBMED   10391928
REFERENCE   8  (bases 1 to 2606)
  AUTHORS   Kobayashi,T., Inoue,I., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.
            and Watanabe,T.
  TITLE     Cloning, RNA expression, and chromosomal location of a mouse
            histamine H2 receptor gene
  JOURNAL   Genomics 37 (3), 390-394 (1996)
   PUBMED   8938453
REFERENCE   9  (bases 1 to 2606)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 14 (22), 5646-5659 (1995)
   PUBMED   8521822
  REMARK    Erratum:[EMBO J. 1996 Apr 15;15(8):2030.. PMID: 8617250]
REFERENCE   10 (bases 1 to 2606)
  AUTHORS   Avraham,K.B., Givol,D., Avivi,A., Yayon,A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of murine fibroblast growth factor receptors refines
            regions of homology between mouse and human chromosomes
  JOURNAL   Genomics 21 (3), 656-658 (1994)
   PUBMED   7959747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV449751.1, BU920290.1, AK033451.1, AK141790.1 and BY429959.1.
            
            On Jul 14, 2009 this sequence version replaced NM_025900.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.105591.1,
                                           SRR1660811.44060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AV449751.1         3-18
            17-110              BU920290.1         1-94
            111-1220            AK033451.1         1-1110
            1221-2594           AK141790.1         573-1946
            2595-2606           BY429959.1         408-419
FEATURES             Location/Qualifiers
     source          1..2606
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 24.5 cM"
     gene            1..2606
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /note="DEK proto-oncogene"
                     /db_xref="GeneID:110052"
                     /db_xref="MGI:MGI:1926209"
     exon            1..149
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            150..315
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            316..417
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            418..527
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            528..622
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            623..743
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            744..932
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1071
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1220
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1289
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..2602
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2570..2575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /note="hexamer: AATAAA"
     polyA_site      2587
                     /gene="Dek"
                     /gene_synonym="1810019E15Rik; D13H6S231E"
                     /note="major polyA site"
ORIGIN      
        1 cgctctgctt cccgaaccgc cattttgaaa atcttgttga ttctgaggag cggggagaga
       61 gagagcgcga gagagagcga gcgcgcggcg cgaggacctc ggccccgcgc gacttctaca
      121 cagcggcggc cttctcgtgc gcacccgcgg cccccagcat gtcggcggcg gcggcccccg
      181 ctgcggaggg agaggacgcc cccgtgccgc cctcatccga gaaggaaccc gagatgccgg
      241 gtcccaggga agagagtgag gaggaggagg aggatgacga agacgatgat gaagaggacg
      301 aggaggaaga aaaagaaaag agtcttatcg tggaaggcaa gagagagaag aagaaagtag
      361 agagactgac gatgcaagtg tcttccttac agagagagcc atttacagtg acacaaggga
      421 agggtcagaa actttgtgaa attgaaagga tacatttctt tctgagtaag aaaaaaccag
      481 atgaacttag aaatctacac aaactgcttt acaacaggcc gggcacagtg tcctcgttga
      541 agaagaacgt gggtcagttc agtggctttc cattcgaaaa aggcagtacc cagtataaaa
      601 agaaggaaga aatgttgaaa aagtttcgaa atgccatgtt aaagagcatc tgtgaggttc
      661 ttgatttaga gaggtcaggc gtgaacagcg aactcgtgaa gaggatcttg aacttcttaa
      721 tgcatccaaa gccttctggc aaaccattac caaaatccaa aaaatcttcc agcaaaggta
      781 gtaaaaagga acggaacagt tctggaacaa caaggaagtc aaagcaaact aaatgccctg
      841 aaattctgtc agatgagtct agtagtgatg aagatgagaa gaaaaataag gaagagtctt
      901 cggaagatga agagaaagaa agtgaagagg agcaaccacc aaaaaagaca tctaaaaaag
      961 aaaaagcaaa acagaaagct actgctaaaa gtaaaaaatc tgtgaagagt gctaatgtta
     1021 agaaggcaga cagcagtacc accaagaaga atcaaaaaag ttccaaaaaa gagtctgaat
     1081 ctgaagacag ttctgatgat gaacccttaa ttaaaaaatt gaaaaagcca cctacagatg
     1141 aagagctaaa ggaaacagtg aagaaattac tggctgatgc taacttggaa gaagtcacaa
     1201 tgaagcagat ttgcaaagag gtatatgaaa attatcctgc ttatgatttg actgagagga
     1261 aagatttcat taaaacaact gtaaaagagc taatttcttg agaagcggac agatggcttg
     1321 ttctcagatt tgaagatctg attttatacc agcaaagaga atgtattctt ttttaaggct
     1381 attgttggta gaacttgctg ctgactcttt tgcgtgttaa catatttgag cttgttttaa
     1441 attgtatttt cttgtagttt tcagtttaaa tcttgcatgg cagtaatcgt tccttgcttt
     1501 ttatagttgt acattttggg tttctttatt gtaaggtcac agattcctga actattgtga
     1561 attttagtga acttaatgtt agcttgctta agacattact tttaatcaaa gcaaaaacta
     1621 ttataaccag catttatatg tgcaaagact attgcagtat ttagtataca aaatattttg
     1681 aatacgcctt ctgtcagtgt gaaaacatag cggcagtctg ttcatcatag ggcacagctg
     1741 ttcagatgac cgagtcggaa ccttttctgc atgtgtatat acgtcaagtt gttggcatga
     1801 cagaagtgac agatgttatt tttgtatttt taaaaaccaa tttgttgtat ataatttttt
     1861 tatttctttt gtgcaaatca attttttaaa ctcttgtgtc tttaaacttg taactaaatg
     1921 tcagtgttca tccaggcagc agtgacagcg cagagttcag tggtgatggc actgaggact
     1981 gtccagttct gctttgccct caaagtgtca tcaatgtggt tgtgttaact ctaagtgtca
     2041 tagaaatttt ataatgagga taaacacatc acagcttcaa aaactgggaa ggcgtgagca
     2101 cacatggatt tatatataag tgaactgaca gtagtaaact gttgaccata taaatatatt
     2161 agatacagga aacctggtta ccttcataat tatgattaaa agcatcaagt gtaaccagag
     2221 ttggtgtgga caacataggt atctctgaaa gtatttatca aaaaccatac attaatattg
     2281 aagtattaca gaatcaaggc tgtttgattt ttaaagtgat gaaacatgga ctgcccctta
     2341 aattttgact gtcctaaaaa cctatttctg atttataata tgctgcctga taaagtgaca
     2401 ctagatgtac cagctgagtg tttaatcttc ccatcacaga tcagatttga gcattaacag
     2461 gtattttcac atacttgact tcaatatgct taaagtgagg aacaagcaat taagtgggga
     2521 ctaaaaatgt tggcctttaa gcaatttgtc ataaatcttc acaataaaga ataaatcaat
     2581 gttttaagtg tcttgtattt aaaaaa
//
