LOCUS       NM_153108                287 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus defensin beta 8 (Defb8), mRNA.
ACCESSION   NM_153108
VERSION     NM_153108.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 287)
  AUTHORS   Foronda,M., Martinez,P., Schoeftner,S., Gomez-Lopez,G.,
            Schneider,R., Flores,J.M., Pisano,D.G. and Blasco,M.A.
  TITLE     Sox4 links tumor suppression to accelerated aging in mice by
            modulating stem cell activation
  JOURNAL   Cell Rep 8 (2), 487-500 (2014)
   PUBMED   25043184
REFERENCE   2  (bases 1 to 287)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 287)
  AUTHORS   Taylor,K., Rolfe,M., Reynolds,N., Kilanowski,F., Pathania,U.,
            Clarke,D., Yang,D., Oppenheim,J., Samuel,K., Howie,S., Barran,P.,
            Macmillan,D., Campopiano,D. and Dorin,J.
  TITLE     Defensin-related peptide 1 (Defr1) is allelic to Defb8 and
            chemoattracts immature DC and CD4+ T cells independently of CCR6
  JOURNAL   Eur J Immunol 39 (5), 1353-1360 (2009)
   PUBMED   19404978
REFERENCE   4  (bases 1 to 287)
  AUTHORS   Morrison,G.M., Semple,C.A., Kilanowski,F.M., Hill,R.E. and
            Dorin,J.R.
  TITLE     Signal sequence conservation and mature peptide divergence within
            subgroups of the murine beta-defensin gene family
  JOURNAL   Mol Biol Evol 20 (3), 460-470 (2003)
   PUBMED   12644567
REFERENCE   5  (bases 1 to 287)
  AUTHORS   Morrison,G.M., Rolfe,M., Kilanowski,F.M., Cross,S.H. and Dorin,J.R.
  TITLE     Identification and characterization of a novel murine
            beta-defensin-related gene
  JOURNAL   Mamm Genome 13 (8), 445-451 (2002)
   PUBMED   12226710
  REMARK    Erratum:[Mamm Genome. 2002 Oct;13(10):603]
REFERENCE   6  (bases 1 to 287)
  AUTHORS   Bauer,F., Schweimer,K., Kluver,E., Conejo-Garcia,J.R.,
            Forssmann,W.G., Rosch,P., Adermann,K. and Sticht,H.
  TITLE     Structure determination of human and murine beta-defensins reveals
            structural conservation in the absence of significant sequence
            similarity
  JOURNAL   Protein Sci 10 (12), 2470-2479 (2001)
   PUBMED   11714914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ300674.1 and AC121131.14.
            
            On May 22, 2007 this sequence version replaced NM_153108.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ300674.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AJ300674.1         1-93
            94-211              AC121131.14        29574-29691         c
            212-287             AJ300674.1         209-284
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..287
                     /gene="Defb8"
                     /gene_synonym="BD-8; Defr1"
                     /note="defensin beta 8"
                     /db_xref="GeneID:244334"
                     /db_xref="MGI:MGI:2654206"
     exon            1..71
                     /gene="Defb8"
                     /gene_synonym="BD-8; Defr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..196
                     /gene="Defb8"
                     /gene_synonym="BD-8; Defr1"
                     /note="defensin related 1; beta-defensin 8;
                     defensin-related peptide"
                     /codon_start=1
                     /product="beta-defensin 8 precursor"
                     /protein_id="NP_694748.3"
                     /db_xref="CCDS:CCDS40259.1"
                     /db_xref="GeneID:244334"
                     /db_xref="MGI:MGI:2654206"
                     /translation="MRIHYLLFTFLLVLLSPLAAFSQKINDPVTYIRNGGICQYRCIG
                     LRHKIGTCGSPFKCCK"
     exon            72..287
                     /gene="Defb8"
                     /gene_synonym="BD-8; Defr1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      282
                     /gene="Defb8"
                     /gene_synonym="BD-8; Defr1"
ORIGIN      
        1 ccaggcttca gtcatgagga tccattacct tctcttcaca tttctcctgg tgctgctgtc
       61 tccacttgca gcttttagcc aaaaaatcaa tgatccagta acttacattc gaaacggagg
      121 catatgccag tatcggtgca ttggccttag gcataagatt ggaacttgtg gatctccttt
      181 caaatgctgc aagtgataat agagaagaag acaaagatcc tgcaaaccaa agaaaacacc
      241 agaatttttt cctccatgaa gatggacaaa acttaaacca aattaaa
//
