LOCUS       NM_139220                306 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus defensin beta 7 (Defb7), mRNA.
ACCESSION   NM_139220
VERSION     NM_139220.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 306)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 306)
  AUTHORS   Munger,S.C., Aylor,D.L., Syed,H.A., Magwene,P.M., Threadgill,D.W.
            and Capel,B.
  TITLE     Elucidation of the transcription network governing mammalian sex
            determination by exploiting strain-specific susceptibility to sex
            reversal
  JOURNAL   Genes Dev 23 (21), 2521-2536 (2009)
   PUBMED   19884258
REFERENCE   3  (bases 1 to 306)
  AUTHORS   Morrison,G.M., Semple,C.A., Kilanowski,F.M., Hill,R.E. and
            Dorin,J.R.
  TITLE     Signal sequence conservation and mature peptide divergence within
            subgroups of the murine beta-defensin gene family
  JOURNAL   Mol Biol Evol 20 (3), 460-470 (2003)
   PUBMED   12644567
REFERENCE   4  (bases 1 to 306)
  AUTHORS   Morrison,G.M., Rolfe,M., Kilanowski,F.M., Cross,S.H. and Dorin,J.R.
  TITLE     Identification and characterization of a novel murine
            beta-defensin-related gene
  JOURNAL   Mamm Genome 13 (8), 445-451 (2002)
   PUBMED   12226710
  REMARK    Erratum:[Mamm Genome. 2002 Oct;13(10):603]
REFERENCE   5  (bases 1 to 306)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
REFERENCE   6  (bases 1 to 306)
  AUTHORS   Bauer,F., Schweimer,K., Kluver,E., Conejo-Garcia,J.R.,
            Forssmann,W.G., Rosch,P., Adermann,K. and Sticht,H.
  TITLE     Structure determination of human and murine beta-defensins reveals
            structural conservation in the absence of significant sequence
            similarity
  JOURNAL   Protein Sci 10 (12), 2470-2479 (2001)
   PUBMED   11714914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ298147.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ298147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..306
                     /gene="Defb7"
                     /gene_synonym="BD-7"
                     /note="defensin beta 7"
                     /db_xref="GeneID:246080"
                     /db_xref="MGI:MGI:2179200"
     exon            1..69
                     /gene="Defb7"
                     /gene_synonym="BD-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..227
                     /gene="Defb7"
                     /gene_synonym="BD-7"
                     /function="antimicrobial peptide"
                     /note="beta-defensin 7"
                     /codon_start=1
                     /product="beta-defensin 7 precursor"
                     /protein_id="NP_631966.1"
                     /db_xref="CCDS:CCDS40261.1"
                     /db_xref="GeneID:246080"
                     /db_xref="MGI:MGI:2179200"
                     /translation="MRIHYVLFAFLLVLLSPFAAFSQDINSKRACYREGGECLQRCIG
                     LFHKIGTCNFRFKCCKFQIPEKKTKIL"
     exon            70..306
                     /gene="Defb7"
                     /gene_synonym="BD-7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      299..304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Defb7"
                     /gene_synonym="BD-7"
ORIGIN      
        1 aggcttcagt catgaggatc cattatgttc tgttcgcatt tctcctggtg ttgctgtctc
       61 catttgcagc ttttagccaa gacatcaaca gtaaacgagc ttgctatcgg gaaggaggcg
      121 aatgcctgca acggtgcatt ggcctttttc ataagattgg aacttgtaat tttcgtttca
      181 aatgctgcaa gtttcaaatc ccagagaaga agacaaagat cctgtgaaac caaagaaaac
      241 accagaattt gttcctccat gaagatggac aaaacttaaa ccaaattaaa gttccttgat
      301 taaatg
//
