LOCUS       NP_631966                 71 aa            linear   ROD 03-APR-2024
DEFINITION  beta-defensin 7 precursor [Mus musculus].
ACCESSION   NP_631966
VERSION     NP_631966.1
DBSOURCE    REFSEQ: accession NM_139220.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 71)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 71)
  AUTHORS   Munger,S.C., Aylor,D.L., Syed,H.A., Magwene,P.M., Threadgill,D.W.
            and Capel,B.
  TITLE     Elucidation of the transcription network governing mammalian sex
            determination by exploiting strain-specific susceptibility to sex
            reversal
  JOURNAL   Genes Dev 23 (21), 2521-2536 (2009)
   PUBMED   19884258
REFERENCE   3  (residues 1 to 71)
  AUTHORS   Morrison,G.M., Semple,C.A., Kilanowski,F.M., Hill,R.E. and
            Dorin,J.R.
  TITLE     Signal sequence conservation and mature peptide divergence within
            subgroups of the murine beta-defensin gene family
  JOURNAL   Mol Biol Evol 20 (3), 460-470 (2003)
   PUBMED   12644567
REFERENCE   4  (residues 1 to 71)
  AUTHORS   Morrison,G.M., Rolfe,M., Kilanowski,F.M., Cross,S.H. and Dorin,J.R.
  TITLE     Identification and characterization of a novel murine
            beta-defensin-related gene
  JOURNAL   Mamm Genome 13 (8), 445-451 (2002)
   PUBMED   12226710
  REMARK    Erratum:[Mamm Genome. 2002 Oct;13(10):603]
REFERENCE   5  (residues 1 to 71)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
REFERENCE   6  (residues 1 to 71)
  AUTHORS   Bauer,F., Schweimer,K., Kluver,E., Conejo-Garcia,J.R.,
            Forssmann,W.G., Rosch,P., Adermann,K. and Sticht,H.
  TITLE     Structure determination of human and murine beta-defensins reveals
            structural conservation in the absence of significant sequence
            similarity
  JOURNAL   Protein Sci 10 (12), 2470-2479 (2001)
   PUBMED   11714914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ298147.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ298147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..71
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     Protein         1..71
                     /product="beta-defensin 7 precursor"
                     /function="antimicrobial peptide"
                     /note="beta-defensin 7"
                     /calculated_mol_wt=5754
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2556
     Site            23
                     /site_type="pyrrolidone-carboxylic-acid"
                     /note="Pyrrolidone carboxylic acid.
                     /evidence=ECO:0000250|UniProtKB:P46165; propagated from
                     UniProtKB/Swiss-Prot (Q91V70.1)"
     mat_peptide     26..71
                     /product="Beta-defensin 7. /id=PRO_0000006934"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91V70.1)"
                     /calculated_mol_wt=5398
     Region          30..60
                     /region_name="Defensin_beta"
                     /note="Beta defensin; pfam00711"
                     /db_xref="CDD:459914"
     CDS             1..71
                     /gene="Defb7"
                     /gene_synonym="BD-7"
                     /coded_by="NM_139220.1:12..227"
                     /db_xref="CCDS:CCDS40261.1"
                     /db_xref="GeneID:246080"
                     /db_xref="MGI:MGI:2179200"
ORIGIN      
        1 mrihyvlfaf llvllspfaa fsqdinskra cyreggeclq rciglfhkig tcnfrfkcck
       61 fqipekktki l
//
