LOCUS       NM_054074                323 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus defensin beta 6 (Defb6), mRNA.
ACCESSION   NM_054074
VERSION     NM_054074.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 323)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 323)
  AUTHORS   Taylor,K., Rolfe,M., Reynolds,N., Kilanowski,F., Pathania,U.,
            Clarke,D., Yang,D., Oppenheim,J., Samuel,K., Howie,S., Barran,P.,
            Macmillan,D., Campopiano,D. and Dorin,J.
  TITLE     Defensin-related peptide 1 (Defr1) is allelic to Defb8 and
            chemoattracts immature DC and CD4+ T cells independently of CCR6
  JOURNAL   Eur J Immunol 39 (5), 1353-1360 (2009)
   PUBMED   19404978
REFERENCE   3  (bases 1 to 323)
  AUTHORS   Yamaguchi,Y., Nagase,T., Tomita,T., Nakamura,K., Fukuhara,S.,
            Amano,T., Yamamoto,H., Ide,Y., Suzuki,M., Teramoto,S., Asano,T.,
            Kangawa,K., Nakagata,N., Ouchi,Y. and Kurihara,H.
  TITLE     Beta-defensin overexpression induces progressive muscle
            degeneration in mice
  JOURNAL   Am J Physiol Cell Physiol 292 (6), C2141-C2149 (2007)
   PUBMED   17215327
  REMARK    GeneRIF: The present findings may unravel a concealed linkage
            between the innate immune system and the pathophysiology of
            degenerative diseases.
REFERENCE   4  (bases 1 to 323)
  AUTHORS   de Guzman Strong,C., Wertz,P.W., Wang,C., Yang,F., Meltzer,P.S.,
            Andl,T., Millar,S.E., Ho,I.C., Pai,S.Y. and Segre,J.A.
  TITLE     Lipid defect underlies selective skin barrier impairment of an
            epidermal-specific deletion of Gata-3
  JOURNAL   J Cell Biol 175 (4), 661-670 (2006)
   PUBMED   17116754
REFERENCE   5  (bases 1 to 323)
  AUTHORS   Morrison,G.M., Semple,C.A., Kilanowski,F.M., Hill,R.E. and
            Dorin,J.R.
  TITLE     Signal sequence conservation and mature peptide divergence within
            subgroups of the murine beta-defensin gene family
  JOURNAL   Mol Biol Evol 20 (3), 460-470 (2003)
   PUBMED   12644567
REFERENCE   6  (bases 1 to 323)
  AUTHORS   Yamaguchi,Y., Nagase,T., Makita,R., Fukuhara,S., Tomita,T.,
            Tominaga,T., Kurihara,H. and Ouchi,Y.
  TITLE     Identification of multiple novel epididymis-specific beta-defensin
            isoforms in humans and mice
  JOURNAL   J Immunol 169 (5), 2516-2523 (2002)
   PUBMED   12193721
  REMARK    GeneRIF: The epididymis-specific expression pattern of the
            beta-defensin isoform mBD-6 has been characterized.
REFERENCE   7  (bases 1 to 323)
  AUTHORS   Morrison,G.M., Rolfe,M., Kilanowski,F.M., Cross,S.H. and Dorin,J.R.
  TITLE     Identification and characterization of a novel murine
            beta-defensin-related gene
  JOURNAL   Mamm Genome 13 (8), 445-451 (2002)
   PUBMED   12226710
  REMARK    Erratum:[Mamm Genome. 2002 Oct;13(10):603]
REFERENCE   8  (bases 1 to 323)
  AUTHORS   Yamaguchi,Y., Fukuhara,S., Nagase,T., Tomita,T., Hitomi,S.,
            Kimura,S., Kurihara,H. and Ouchi,Y.
  TITLE     A novel mouse beta-defensin, mBD-6, predominantly expressed in
            skeletal muscle
  JOURNAL   J Biol Chem 276 (34), 31510-31514 (2001)
   PUBMED   11408484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB063109.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB063109.1, BX637585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..323
                     /gene="Defb6"
                     /gene_synonym="BD-6"
                     /note="defensin beta 6"
                     /db_xref="GeneID:116746"
                     /db_xref="MGI:MGI:2151044"
     exon            1..85
                     /gene="Defb6"
                     /gene_synonym="BD-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..219
                     /gene="Defb6"
                     /gene_synonym="BD-6"
                     /note="beta-defensin 6"
                     /codon_start=1
                     /product="beta-defensin 6 precursor"
                     /protein_id="NP_473415.1"
                     /db_xref="CCDS:CCDS40255.1"
                     /db_xref="GeneID:116746"
                     /db_xref="MGI:MGI:2151044"
                     /translation="MKIHYLLFAFILVMLSPLAAFSQLINSPVTCMSYGGSCQRSCNG
                     GFRLGGHCGHPKIRCCRRK"
     exon            86..323
                     /gene="Defb6"
                     /gene_synonym="BD-6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctctgcac ctcaccaggc atcagtcatg aagatccatt acctgctctt tgcctttatc
       61 ctggtgatgc tgtctccact tgcagccttt tcccaattaa tcaacagtcc agtaacatgc
      121 atgagctatg gaggctcatg ccagcgttca tgcaatggag gttttcgact gggtggccat
      181 tgtggccatc ctaaaatcag atgctgccgc agaaaataga taaaaggacc aagaaccagc
      241 aatgtgaata agtgccagaa tttgcttctt cgtgaatatg cacaaaacaa acccaattaa
      301 agttctttga ttatcttctg taa
//
