LOCUS       NM_001039121             418 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus defensin beta 43 (Defb43), mRNA.
ACCESSION   NM_001039121
VERSION     NM_001039121.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 418)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 418)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 418)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ012045.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ012045.1, BC132224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.23 cM"
     gene            1..418
                     /gene="Defb43"
                     /gene_synonym="BD-43; EG654458; mBD-43"
                     /note="defensin beta 43"
                     /db_xref="GeneID:654458"
                     /db_xref="MGI:MGI:3647180"
     exon            1..97
                     /gene="Defb43"
                     /gene_synonym="BD-43; EG654458; mBD-43"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..249
                     /gene="Defb43"
                     /gene_synonym="BD-43; EG654458; mBD-43"
                     /note="beta-defensin 43"
                     /codon_start=1
                     /product="beta-defensin 43 precursor"
                     /protein_id="NP_001034210.1"
                     /db_xref="CCDS:CCDS36946.1"
                     /db_xref="GeneID:654458"
                     /db_xref="MGI:MGI:3647180"
                     /translation="MRVLFSILGVLTLLSIVPLARSFLENQDCSKHRHCRMKCKANEY
                     AVRYCEDWTICCRVKKKESKKKKMW"
     exon            98..408
                     /gene="Defb43"
                     /gene_synonym="BD-43; EG654458; mBD-43"
                     /inference="alignment:Splign:2.1.0"
     regulatory      323..328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Defb43"
                     /gene_synonym="BD-43; EG654458; mBD-43"
                     /note="hexamer: AATAAA"
     polyA_site      349
                     /gene="Defb43"
                     /gene_synonym="BD-43; EG654458; mBD-43"
                     /note="major polyA site"
     regulatory      390..395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Defb43"
                     /gene_synonym="BD-43; EG654458; mBD-43"
                     /note="hexamer: AATACA"
     polyA_site      408
                     /gene="Defb43"
                     /gene_synonym="BD-43; EG654458; mBD-43"
                     /note="major polyA site"
ORIGIN      
        1 attccagcct ctggttctca ttggcctccc tcctctgcta tgagggtcct gttctccatc
       61 ctgggggtcc tcaccttgtt atccatagtt cctctggcca ggagcttcct tgagaatcag
      121 gactgttcaa agcaccgcca ctgcaggatg aagtgcaaag ctaacgaata cgccgtcaga
      181 tactgcgagg actggaccat ctgctgtcgg gtgaagaaga aggaatccaa gaagaagaag
      241 atgtggtgac atgttgagct ctgtcttctt agattccagg agaaggcacc gaaagcagat
      301 acaagttcct tgtctactta cgaataaatg gtatgatgag taacaggaac ttcacgacaa
      361 tttcatgctt aggtggtcat gttcacataa atacacgtct tatcatgcaa aaaaaaaa
//
