LOCUS       NM_001412580             710 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus defensin beta 42 (Defb42), transcript variant 2, mRNA.
ACCESSION   NM_001412580 XM_030247907
VERSION     NM_001412580.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 710)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 710)
  AUTHORS   Tachibana,M., Nozaki,M., Takeda,N. and Shinkai,Y.
  TITLE     Functional dynamics of H3K9 methylation during meiotic prophase
            progression
  JOURNAL   EMBO J 26 (14), 3346-3359 (2007)
   PUBMED   17599069
REFERENCE   3  (bases 1 to 710)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
REFERENCE   4  (bases 1 to 710)
  AUTHORS   Jalkanen,J., Huhtaniemi,I. and Poutanen,M.
  TITLE     Discovery and characterization of new epididymis-specific
            beta-defensins in mice
  JOURNAL   Biochim Biophys Acta 1730 (1), 22-30 (2005)
   PUBMED   16023745
  REMARK    GeneRIF: Defb41 and Defb42 are suggested to have a role in the
            antimicrobial protection of sperm and urogenital tract epithelia.
            [Defb42]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090659.19.
            
            On Oct 7, 2022 this sequence version replaced XM_030247907.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA274113.1, SRR14995043.1035474.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AC090659.19        162506-162664
            160-334             AC090659.19        162954-163128
            335-710             AC090659.19        163738-164113
FEATURES             Location/Qualifiers
     source          1..710
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.24 cM"
     gene            1..710
                     /gene="Defb42"
                     /gene_synonym="BD-42; Defb44; mBD-42"
                     /note="defensin beta 42"
                     /db_xref="GeneID:619548"
                     /db_xref="MGI:MGI:3033850"
     exon            1..159
                     /gene="Defb42"
                     /gene_synonym="BD-42; Defb44; mBD-42"
                     /inference="alignment:Splign:2.1.0"
     exon            160..334
                     /gene="Defb42"
                     /gene_synonym="BD-42; Defb44; mBD-42"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..507
                     /gene="Defb42"
                     /gene_synonym="BD-42; Defb44; mBD-42"
                     /note="beta-defensin 44; beta-defensin 42; beta-defensin
                     136"
                     /codon_start=1
                     /product="beta-defensin 42 precursor"
                     /protein_id="NP_001399509.1"
                     /db_xref="GeneID:619548"
                     /db_xref="MGI:MGI:3033850"
                     /translation="MNLRLSCLLFILVTSLPAGRCSIGNKGISFETCTAIEGLCFFGC
                     KLGWVWIAYCNNIMSCCRKDTDFVLPQTKGI"
     exon            335..710
                     /gene="Defb42"
                     /gene_synonym="BD-42; Defb44; mBD-42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      676..681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Defb42"
                     /gene_synonym="BD-42; Defb44; mBD-42"
                     /note="hexamer: AATAAA"
     polyA_site      710
                     /gene="Defb42"
                     /gene_synonym="BD-42; Defb44; mBD-42"
                     /note="major polyA site"
ORIGIN      
        1 atttggaaaa ggaagctctc tggggacttt tccacagcag aatctggcca aacgagtaag
       61 taaaactgaa agaggagact tctccactcg ctgagcaaac cctctactct tagtcaaacc
      121 ctgttgacat gctaagagcc ttttgcttct tggaacccta agctgggctc tccctggaag
      181 agtgagcttg aatccagcgc cacctaaccc agatcatctc tataaacaag gcttccagac
      241 agctgtctcg gcagttccag ctccagaccc tccacagcta tgaacctgcg tctttcatgc
      301 ttactgttca tcctggtgac atcattgcct gcaggtcgct gttcgatcgg gaataagggc
      361 atatcctttg agacgtgcac cgcaatcgaa ggcttgtgtt tctttggttg taagttaggg
      421 tgggtatgga ttgcctactg taacaacata atgtcctgtt gtagaaagga taccgatttt
      481 gtacttcctc aaaccaaagg tatatgacct agcctcacag ctccagttaa aaggccatgt
      541 gaatgattaa acactcccaa tctgtctgtg aggcccaaga gctcaagaaa aagtggacgt
      601 gacgcataag ggtgacgctg gccacgtgtc tgtttactgg caaaagccca gatggcattt
      661 tgtaagaagc tttgcaataa atggcacccc gtggtcttcc ttgtcttaaa
//
