LOCUS       NM_001040027             389 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus defensin beta 41 (Defb41), transcript variant 2, mRNA.
ACCESSION   NM_001040027
VERSION     NM_001040027.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 389)
  AUTHORS   Trigg,N.A. and Conine,C.C.
  TITLE     Epididymal acquired sperm microRNAs modify post-fertilization
            embryonic gene expression
  JOURNAL   Cell Rep 43 (9), 114698 (2024)
   PUBMED   39226174
REFERENCE   2  (bases 1 to 389)
  AUTHORS   Sharma,U., Sun,F., Conine,C.C., Reichholf,B., Kukreja,S.,
            Herzog,V.A., Ameres,S.L. and Rando,O.J.
  TITLE     Small RNAs Are Trafficked from the Epididymis to Developing
            Mammalian Sperm
  JOURNAL   Dev Cell 46 (4), 481-494 (2018)
   PUBMED   30057273
REFERENCE   3  (bases 1 to 389)
  AUTHORS   Jerczynski,O., Lacroix-Pepin,N., Boilard,E., Calvo,E., Bernet,A.,
            Fortier,M.A., Bjorkgren,I., Sipila,P. and Belleannee,C.
  TITLE     Role of Dicer1-Dependent Factors in the Paracrine Regulation of
            Epididymal Gene Expression
  JOURNAL   PLoS One 11 (10), e0163876 (2016)
   PUBMED   27695046
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 389)
  AUTHORS   Bjorkgren,I., Alvarez,L., Blank,N., Balbach,M., Turunen,H.,
            Laajala,T.D., Toivanen,J., Krutskikh,A., Wahlberg,N.,
            Huhtaniemi,I., Poutanen,M., Wachten,D. and Sipila,P.
  TITLE     Targeted inactivation of the mouse epididymal beta-defensin 41
            alters sperm flagellar beat pattern and zona pellucida binding
  JOURNAL   Mol Cell Endocrinol 427, 143-154 (2016)
   PUBMED   26987518
  REMARK    GeneRIF: function in sperm maturation
REFERENCE   5  (bases 1 to 389)
  AUTHORS   Bjorkgren,I., Gylling,H., Turunen,H., Huhtaniemi,I., Strauss,L.,
            Poutanen,M. and Sipila,P.
  TITLE     Imbalanced lipid homeostasis in the conditional Dicer1 knockout
            mouse epididymis causes instability of the sperm membrane
  JOURNAL   FASEB J 29 (2), 433-442 (2015)
   PUBMED   25366345
REFERENCE   6  (bases 1 to 389)
  AUTHORS   Bjorkgren,I., Saastamoinen,L., Krutskikh,A., Huhtaniemi,I.,
            Poutanen,M. and Sipila,P.
  TITLE     Dicer1 ablation in the mouse epididymis causes dedifferentiation of
            the epithelium and imbalance in sex steroid signaling
  JOURNAL   PLoS One 7 (6), e38457 (2012)
   PUBMED   22701646
REFERENCE   7  (bases 1 to 389)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   8  (bases 1 to 389)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
REFERENCE   9  (bases 1 to 389)
  AUTHORS   Jalkanen,J., Huhtaniemi,I. and Poutanen,M.
  TITLE     Discovery and characterization of new epididymis-specific
            beta-defensins in mice
  JOURNAL   Biochim Biophys Acta 1730 (1), 22-30 (2005)
   PUBMED   16023745
  REMARK    GeneRIF: Defb41 and Defb42 are suggested to have a role in the
            antimicrobial protection of sperm and urogenital tract epithelia.
REFERENCE   10 (bases 1 to 389)
  AUTHORS   Jalkanen,J., Huhtaniemi,I. and Poutanen,M.
  TITLE     Mouse cysteine-rich secretory protein 4 (CRISP4): a member of the
            Crisp family exclusively expressed in the epididymis in an
            androgen-dependent manner
  JOURNAL   Biol Reprod 72 (5), 1268-1274 (2005)
   PUBMED   15673606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC168116.3.
            
            On Jun 20, 2019 this sequence version replaced NM_001040027.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ012028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC168116.3         77851-77963
            114-389             AC168116.3         82323-82598
FEATURES             Location/Qualifiers
     source          1..389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 5.7 cM"
     gene            1..389
                     /gene="Defb41"
                     /gene_synonym="9230102D03Rik; BD-17; Bd-41; Defb16;
                     Defb17; Gm15386"
                     /note="defensin beta 41"
                     /db_xref="GeneID:77673"
                     /db_xref="MGI:MGI:1924923"
     exon            1..113
                     /gene="Defb41"
                     /gene_synonym="9230102D03Rik; BD-17; Bd-41; Defb16;
                     Defb17; Gm15386"
                     /inference="alignment:Splign:2.1.0"
     exon            114..389
                     /gene="Defb41"
                     /gene_synonym="9230102D03Rik; BD-17; Bd-41; Defb16;
                     Defb17; Gm15386"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaaaaccta ctgactttca aaagatccat tgccttttct tgtccaagaa actgtaccat
       61 gaagtttcat ctatttttct ttattctgct ctttggggcc acaatattaa cagctaaaaa
      121 gagttatcct gagtatggta gcttggattt gaggaaagaa tgcaaaatgc gtagaggtca
      181 ctgtaaactt cagtgctctg aaaaggaact taggatttct ttctgcataa gacctggaac
      241 tcactgttgc atgtagaatt aaagatggag gatgaaaagg acacattacc caagaagaag
      301 aacaagtctc attaagtctt cccagcagga cttccaagat acgtgtgtct ccataaagca
      361 aaaatgatta aatacaattt aattctgaa
//
