LOCUS       NM_019728                458 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus defensin beta 4 (Defb4), mRNA.
ACCESSION   NM_019728
VERSION     NM_019728.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Koren,N., Zubeidat,K., Saba,Y., Horev,Y., Barel,O., Wilharm,A.,
            Heyman,O., Wald,S., Eli-Berchoer,L., Shapiro,H., Nadler,C.,
            Elinav,E., Wilensky,A., Prinz,I., Bercovier,H. and Hovav,A.H.
  TITLE     Maturation of the neonatal oral mucosa involves unique
            epithelium-microbiota interactions
  JOURNAL   Cell Host Microbe 29 (2), 197-209 (2021)
   PUBMED   33412104
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Zieman,A.G., Poll,B.G., Ma,J. and Coulombe,P.A.
  TITLE     Altered keratinocyte differentiation is an early driver of keratin
            mutation-based palmoplantar keratoderma
  JOURNAL   Hum Mol Genet 28 (13), 2255-2270 (2019)
   PUBMED   31220272
REFERENCE   3  (bases 1 to 458)
  AUTHORS   Fitschen-Oestern,S., Weuster,M., Lippross,S., Behrendt,P.,
            Fuchs,S., Pufe,T., Tohidnezhad,M., Bayer,A., Seekamp,A., Varoga,D.
            and Kluter,T.
  TITLE     Hepatocytes express the antimicrobial peptide HBD-2 after multiple
            trauma: an experimental study in human and mice
  JOURNAL   BMC Musculoskelet Disord 18 (1), 100 (2017)
   PUBMED   28270138
  REMARK    GeneRIF: The time course of MBD-4 levels in plasma of trauma mice
            has a similar trend to the HBD-2 levels in plasma of multiple
            injured patients. MBD-4 expression is induced in liver tissue after
            multiple trauma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 458)
  AUTHORS   Kolar,S.S., Baidouri,H., Hanlon,S. and McDermott,A.M.
  TITLE     Protective role of murine beta-defensins 3 and 4 and
            cathelin-related antimicrobial peptide in Fusarium solani keratitis
  JOURNAL   Infect Immun 81 (8), 2669-2677 (2013)
   PUBMED   23670560
  REMARK    GeneRIF: this investigation revealed an indispensable role for BD3,
            BD4, and CRAMP in defense against F. solani-induced keratitis
REFERENCE   5  (bases 1 to 458)
  AUTHORS   Augustin,D.K., Heimer,S.R., Tam,C., Li,W.Y., Le Due,J.M.,
            Evans,D.J. and Fleiszig,S.M.
  TITLE     Role of defensins in corneal epithelial barrier function against
            Pseudomonas aeruginosa traversal
  JOURNAL   Infect Immun 79 (2), 595-605 (2011)
   PUBMED   21115716
REFERENCE   6  (bases 1 to 458)
  AUTHORS   Rivas-Santiago,B., Sada,E., Tsutsumi,V., Aguilar-Leon,D.,
            Contreras,J.L. and Hernandez-Pando,R.
  TITLE     beta-Defensin gene expression during the course of experimental
            tuberculosis infection
  JOURNAL   J Infect Dis 194 (5), 697-701 (2006)
   PUBMED   16897670
  REMARK    GeneRIF: Mycobacterial infection induces the expression of mBD3 and
            mBD4, and both might participate in the control of mycobacterial
            growth.
REFERENCE   7  (bases 1 to 458)
  AUTHORS   Dorschner,R.A., Lin,K.H., Murakami,M. and Gallo,R.L.
  TITLE     Neonatal skin in mice and humans expresses increased levels of
            antimicrobial peptides: innate immunity during development of the
            adaptive response
  JOURNAL   Pediatr Res 53 (4), 566-572 (2003)
   PUBMED   12612195
  REMARK    GeneRIF: Murine beta-defensins-1 and -4 were present in newborn
            skin
REFERENCE   8  (bases 1 to 458)
  AUTHORS   Morrison,G.M., Semple,C.A., Kilanowski,F.M., Hill,R.E. and
            Dorin,J.R.
  TITLE     Signal sequence conservation and mature peptide divergence within
            subgroups of the murine beta-defensin gene family
  JOURNAL   Mol Biol Evol 20 (3), 460-470 (2003)
   PUBMED   12644567
REFERENCE   9  (bases 1 to 458)
  AUTHORS   Morrison,G.M., Rolfe,M., Kilanowski,F.M., Cross,S.H. and Dorin,J.R.
  TITLE     Identification and characterization of a novel murine
            beta-defensin-related gene
  JOURNAL   Mamm Genome 13 (8), 445-451 (2002)
   PUBMED   12226710
  REMARK    Erratum:[Mamm Genome. 2002 Oct;13(10):603]
REFERENCE   10 (bases 1 to 458)
  AUTHORS   Jia,H.P., Wowk,S.A., Schutte,B.C., Lee,S.K., Vivado,A., Tack,B.F.,
            Bevins,C.L. and McCray,P.B. Jr.
  TITLE     A novel murine beta -defensin expressed in tongue, esophagus, and
            trachea
  JOURNAL   J Biol Chem 275 (43), 33314-33320 (2000)
   PUBMED   10922379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EH111306.1, AK009061.1 and AV083507.1.
            
            On Apr 9, 2010 this sequence version replaced NM_019728.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EH110671.1, AK009061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 EH111306.1         1-2
            3-456               AK009061.1         2-455
            457-458             AV083507.1         293-294
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..458
                     /gene="Defb4"
                     /gene_synonym="2310001F05Rik; BD-4"
                     /note="defensin beta 4"
                     /db_xref="GeneID:56519"
                     /db_xref="MGI:MGI:1927667"
     exon            1..87
                     /gene="Defb4"
                     /gene_synonym="2310001F05Rik; BD-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..221
                     /gene="Defb4"
                     /gene_synonym="2310001F05Rik; BD-4"
                     /note="beta-defensin 4"
                     /codon_start=1
                     /product="beta-defensin 4 precursor"
                     /protein_id="NP_062702.1"
                     /db_xref="CCDS:CCDS40254.1"
                     /db_xref="GeneID:56519"
                     /db_xref="MGI:MGI:1927667"
                     /translation="MRIHYLLFTFLLVLLSPLAAFTQIINNPITCMTNGAICWGPCPT
                     AFRQIGNCGHFKVRCCKIR"
     exon            88..458
                     /gene="Defb4"
                     /gene_synonym="2310001F05Rik; BD-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      299..304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Defb4"
                     /gene_synonym="2310001F05Rik; BD-4"
                     /note="hexamer: ATTAAA"
     polyA_site      331
                     /gene="Defb4"
                     /gene_synonym="2310001F05Rik; BD-4"
                     /note="major polyA site"
ORIGIN      
        1 gcatctctgc atctcaccag gcttcagtca tgaggatcca ttaccttctc ttcacatttc
       61 tcctggtgct gctgtctcca cttgcagcct ttacccaaat tatcaacaat ccaataacat
      121 gcatgaccaa tggagccata tgctggggtc cgtgccctac cgcttttcga cagattggca
      181 attgtggcca ttttaaagtc agatgctgta agataagata gataaaaaga cgaagaacca
      241 gcaagatgaa taaattgcca gaatttgctc ctccatgaag attcacaaat caaacccaat
      301 taaagttctt tgattacctt ctctaactcc agttctaggg gatgcacacc ttcttttgac
      361 ctttataaca accatttgca gagtacatac agaaaaaata ccatacaaat aaaattataa
      421 taatagtaat aattataatt ttaaaaataa agtcactg
//
