LOCUS       NM_013756                347 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus defensin beta 3 (Defb3), mRNA.
ACCESSION   NM_013756
VERSION     NM_013756.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 347)
  AUTHORS   Taylor,T.C., Coleman,B.M., Arunkumar,S.P., Dey,I., Dillon,J.T.,
            Ponde,N.O., Poholek,A.C., Schwartz,D.M., McGeachy,M.J., Conti,H.R.
            and Gaffen,S.L.
  TITLE     IkappaBzeta is an essential mediator of immunity to oropharyngeal
            candidiasis
  JOURNAL   Cell Host Microbe 31 (10), 1700-1713 (2023)
   PUBMED   37725983
REFERENCE   2  (bases 1 to 347)
  AUTHORS   Saqib,Z., De Palma,G., Lu,J., Surette,M., Bercik,P. and
            Collins,S.M.
  TITLE     Alterations in fecal beta-defensin-3 secretion as a marker of
            instability of the gut microbiota
  JOURNAL   Gut Microbes 15 (1), 2233679 (2023)
   PUBMED   37464450
  REMARK    GeneRIF: Alterations in fecal beta-defensin-3 secretion as a marker
            of instability of the gut microbiota.
REFERENCE   3  (bases 1 to 347)
  AUTHORS   Yu,Y., Zhang,B., Ji,P., Zuo,Z., Huang,Y., Wang,N., Liu,C., Liu,S.J.
            and Zhao,F.
  TITLE     Changes to gut amino acid transporters and microbiome associated
            with increased E/I ratio in Chd8+/- mouse model of ASD-like
            behavior
  JOURNAL   Nat Commun 13 (1), 1151 (2022)
   PUBMED   35241668
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 347)
  AUTHORS   Zhang,Y., Zhao,Y., Liu,H., Yu,W., Yang,F., Li,W., Cao,Z. and Wu,Y.
  TITLE     Mouse beta-Defensin 3, A Defensin Inhibitor of Both Its Endogenous
            and Exogenous Potassium Channels
  JOURNAL   Molecules 23 (6), 1489 (2018)
   PUBMED   29925780
  REMARK    GeneRIF: mBD3 Is a novel inhibitor of both endogenous and exogenous
            potassium channels
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 347)
  AUTHORS   Williams,H., Crompton,R.A., Thomason,H.A., Campbell,L., Singh,G.,
            McBain,A.J., Cruickshank,S.M. and Hardman,M.J.
  TITLE     Cutaneous Nod2 Expression Regulates the Skin Microbiome and Wound
            Healing in a Murine Model
  JOURNAL   J Invest Dermatol 137 (11), 2427-2436 (2017)
   PUBMED   28647345
REFERENCE   6  (bases 1 to 347)
  AUTHORS   Morrison,G.M., Semple,C.A., Kilanowski,F.M., Hill,R.E. and
            Dorin,J.R.
  TITLE     Signal sequence conservation and mature peptide divergence within
            subgroups of the murine beta-defensin gene family
  JOURNAL   Mol Biol Evol 20 (3), 460-470 (2003)
   PUBMED   12644567
REFERENCE   7  (bases 1 to 347)
  AUTHORS   Morrison,G.M., Rolfe,M., Kilanowski,F.M., Cross,S.H. and Dorin,J.R.
  TITLE     Identification and characterization of a novel murine
            beta-defensin-related gene
  JOURNAL   Mamm Genome 13 (8), 445-451 (2002)
   PUBMED   12226710
  REMARK    Erratum:[Mamm Genome. 2002 Oct;13(10):603]
REFERENCE   8  (bases 1 to 347)
  AUTHORS   Yamaguchi,Y., Fukuhara,S., Nagase,T., Tomita,T., Hitomi,S.,
            Kimura,S., Kurihara,H. and Ouchi,Y.
  TITLE     A novel mouse beta-defensin, mBD-6, predominantly expressed in
            skeletal muscle
  JOURNAL   J Biol Chem 276 (34), 31510-31514 (2001)
   PUBMED   11408484
REFERENCE   9  (bases 1 to 347)
  AUTHORS   Jia,H.P., Wowk,S.A., Schutte,B.C., Lee,S.K., Vivado,A., Tack,B.F.,
            Bevins,C.L. and McCray,P.B. Jr.
  TITLE     A novel murine beta -defensin expressed in tongue, esophagus, and
            trachea
  JOURNAL   J Biol Chem 275 (43), 33314-33320 (2000)
   PUBMED   10922379
REFERENCE   10 (bases 1 to 347)
  AUTHORS   Bals,R., Wang,X., Meegalla,R.L., Wattler,S., Weiner,D.J.,
            Nehls,M.C. and Wilson,J.M.
  TITLE     Mouse beta-defensin 3 is an inducible antimicrobial peptide
            expressed in the epithelia of multiple organs
  JOURNAL   Infect Immun 67 (7), 3542-3547 (1999)
   PUBMED   10377137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113099.12 and AF092929.1.
            
            On Sep 19, 2006 this sequence version replaced NM_013756.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF092929.1, BC114344.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC113099.12        146868-146900       c
            34-347              AF092929.1         31-344
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..347
                     /gene="Defb3"
                     /gene_synonym="BD-3"
                     /note="defensin beta 3"
                     /db_xref="GeneID:27358"
                     /db_xref="MGI:MGI:1351612"
     exon            1..70
                     /gene="Defb3"
                     /gene_synonym="BD-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..204
                     /gene="Defb3"
                     /gene_synonym="BD-3"
                     /note="beta-defensin 3"
                     /codon_start=1
                     /product="beta-defensin 3 precursor"
                     /protein_id="NP_038784.1"
                     /db_xref="CCDS:CCDS40258.1"
                     /db_xref="GeneID:27358"
                     /db_xref="MGI:MGI:1351612"
                     /translation="MRIHYLLFAFLLVLLSPPAAFSKKINNPVSCLRKGGRCWNRCIG
                     NTRQIGSCGVPFLKCCKRK"
     exon            71..322
                     /gene="Defb3"
                     /gene_synonym="BD-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      295..300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Defb3"
                     /gene_synonym="BD-3"
                     /note="hexamer: ATTAAA"
     polyA_site      317
                     /gene="Defb3"
                     /gene_synonym="BD-3"
                     /note="major polyA site"
ORIGIN      
        1 caggcttcag tcatgaggat ccattacctt ctgtttgcat ttctcctggt gctgctgtct
       61 ccacctgcag cttttagcaa aaaaatcaac aatccagtaa gttgtttgag gaaaggaggc
      121 agatgctgga atcggtgcat tggcaacact cgtcagattg gcagttgtgg agttcctttc
      181 ctcaaatgct gcaagagaaa atagagaaga ccaagatccc gttaaacaaa gaaaacacca
      241 gaatttgctc ctccatgaag atggacaaat cttaaaccaa attaatattc cttgattaaa
      301 tgcaaacaag tgctccctag caaaaaaaaa aaaaaaaaaa aaaaaaa
//
