LOCUS       NM_001002791             625 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus defensin beta 22 (Defb22), mRNA.
ACCESSION   NM_001002791
VERSION     NM_001002791.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 625)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 625)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 625)
  AUTHORS   Zhang,J., Yuan,Y., Liu,Q., Yang,D., Liu,M., Shen,L., Zhou,Y. and
            Wang,Z.
  TITLE     Differentially expressed genes in the testicular tissues of
            adenylyl cyclase 3 knockout mice
  JOURNAL   Gene 602, 33-42 (2017)
   PUBMED   27864010
REFERENCE   4  (bases 1 to 625)
  AUTHORS   Yudin,A.I., Tollner,T.L., Treece,C.A., Kays,R., Cherr,G.N.,
            Overstreet,J.W. and Bevins,C.L.
  TITLE     Beta-defensin 22 is a major component of the mouse sperm glycocalyx
  JOURNAL   Reproduction 136 (6), 753-765 (2008)
   PUBMED   18787081
REFERENCE   5  (bases 1 to 625)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ012033.1.
            
            On Mar 28, 2007 this sequence version replaced NM_001002791.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ012033.1, BC139230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..625
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.13 cM"
     gene            1..625
                     /gene="Defb22"
                     /gene_synonym="9230002F21Rik"
                     /note="defensin beta 22"
                     /db_xref="GeneID:442835"
                     /db_xref="MGI:MGI:3045368"
     exon            1..85
                     /gene="Defb22"
                     /gene_synonym="9230002F21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..567
                     /gene="Defb22"
                     /gene_synonym="9230002F21Rik"
                     /note="beta-defensin 22; beta-defensin 126"
                     /codon_start=1
                     /product="beta-defensin 22 precursor"
                     /protein_id="NP_001002791.1"
                     /db_xref="CCDS:CCDS16887.1"
                     /db_xref="GeneID:442835"
                     /db_xref="MGI:MGI:3045368"
                     /translation="MKSLLSTLVIIMFLAHLVTGGWYVKKCANTLGNCRKMCRDGEKQ
                     TEPATSKCPIGKLCCVLDFKISGHCGGGGQNSDNLVTAGGDEGSSAKASTAAMVGAAA
                     MAGTPTKTSAPAKTSAPAKTSTTTKASNAAKASTTTKASNAAKASAATMAGNTTKVST
                     AAIASTPAQASTPTKANST"
     exon            86..625
                     /gene="Defb22"
                     /gene_synonym="9230002F21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacctact gcctactgac aggagccatg aagtccctac tgtctactct tgtgatcatt
       61 atgttcctgg cccatttggt cacaggtggc tggtatgtga aaaagtgtgc aaacacattg
      121 ggcaactgca ggaagatgtg cagagacggg gagaagcaga cggaacctgc aacgagcaaa
      181 tgtcccatag gaaaactgtg ctgtgttctg gacttcaaaa ttagtggtca ctgtgggggc
      241 ggtggacaga attcagataa tcttgtcaca gcaggtgggg acgaagggag cagcgcaaag
      301 gccagcactg ctgcaatggt tggtgctgct gcaatggctg gcactcccac aaagaccagc
      361 gctcccgcaa agaccagcgc tcccgcaaag accagcacta ccacaaaggc cagcaatgcc
      421 gcaaaggcca gcactaccac aaaggccagc aatgccgcaa aggccagcgc tgccacaatg
      481 gctggcaata ccacaaaggt cagcactgct gcaattgcca gcactcccgc acaggccagc
      541 actcccacaa aggccaactc tacctgaaca ctactgcctc ttttctcctg acctaatatc
      601 cctggttgat taaagccaag aggcc
//
