LOCUS       NM_010030                326 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus defensin beta 2 (Defb2), mRNA.
ACCESSION   NM_010030
VERSION     NM_010030.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 326)
  AUTHORS   Ruckert,T., Andrieux,G., Boerries,M., Hanke-Muller,K.,
            Woessner,N.M., Doetsch,S., Schell,C., Aumann,K., Kolter,J.,
            Schmitt-Graeff,A., Schiff,M., Braun,L.M., Haring,E., Kissel,S.,
            Siranosian,B.A., Bhatt,A.S., Nordkild,P., Wehkamp,J.,
            Jensen,B.A.H., Minguet,S., Duyster,J., Zeiser,R. and Kohler,N.
  TITLE     Human beta-defensin 2 ameliorates acute GVHD by limiting ileal
            neutrophil infiltration and restraining T cell receptor signaling
  JOURNAL   Sci Transl Med 14 (676), eabp9675 (2022)
   PUBMED   36542690
  REMARK    GeneRIF: Human beta-defensin 2 ameliorates acute GVHD by limiting
            ileal neutrophil infiltration and restraining T cell receptor
            signaling.
REFERENCE   2  (bases 1 to 326)
  AUTHORS   Agarwal,S., Chauhan,A., Singh,K., Kumar,K., Kaur,R., Masih,M. and
            Gautam,P.K.
  TITLE     Immunomodulatory effects of beta-defensin 2 on macrophages induced
            immuno-upregulation and their antitumor function in breast cancer
  JOURNAL   BMC Immunol 23 (1), 53 (2022)
   PUBMED   36324077
  REMARK    GeneRIF: Immunomodulatory effects of beta-defensin 2 on macrophages
            induced immuno-upregulation and their antitumor function in breast
            cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 326)
  AUTHORS   Manko,A., Motta,J.P., Cotton,J.A., Feener,T., Oyeyemi,A.,
            Vallance,B.A., Wallace,J.L. and Buret,A.G.
  TITLE     Giardia co-infection promotes the secretion of antimicrobial
            peptides beta-defensin 2 and trefoil factor 3 and attenuates
            attaching and effacing bacteria-induced intestinal disease
  JOURNAL   PLoS One 12 (6), e0178647 (2017)
   PUBMED   28622393
  REMARK    GeneRIF: Giardia co-infection promotes the secretion of
            antimicrobial peptides beta-defensin 2 and trefoil factor 3 and
            attenuates attaching and effacing bacteria-induced intestinal
            disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 326)
  AUTHORS   Kwon,J.K., Chi,B.H., Choi,S.Y., Kim,S.J., Lee,T.J., Kim,K. and
            Chang,I.H.
  TITLE     Murine beta-defensin-2 may regulate the effect of bacillus
            Calmette-Guerin (BCG) in normal mouse bladder
  JOURNAL   Urol Oncol 33 (3), 111 (2015)
   PUBMED   25573055
  REMARK    GeneRIF: mouse urothelium produces mBD2 in response to
            intravesicular BCG as a defense mechanism against BCG
REFERENCE   5  (bases 1 to 326)
  AUTHORS   Woo,J.I., Oh,S., Webster,P., Lee,Y.J., Lim,D.J. and Moon,S.K.
  TITLE     NOD2/RICK-dependent beta-defensin 2 regulation is protective for
            nontypeable Haemophilus influenzae-induced middle ear infection
  JOURNAL   PLoS One 9 (3), e90933 (2014)
   PUBMED   24625812
  REMARK    GeneRIF: NOD2-mediated beta-defensin 2 regulation contributes to
            the protection against NTHi-induced otitis media
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 326)
  AUTHORS   Biragyn,A., Ruffini,P.A., Leifer,C.A., Klyushnenkova,E.,
            Shakhov,A., Chertov,O., Shirakawa,A.K., Farber,J.M., Segal,D.M.,
            Oppenheim,J.J. and Kwak,L.W.
  TITLE     Toll-like receptor 4-dependent activation of dendritic cells by
            beta-defensin 2
  JOURNAL   Science 298 (5595), 1025-1029 (2002)
   PUBMED   12411706
  REMARK    GeneRIF: acts directly on immature dendritic cells as an endogenous
            ligand for Toll-like receptor 4, inducing up-regulation of
            costimulatory molecules and dendritic cell maturation
REFERENCE   7  (bases 1 to 326)
  AUTHORS   Morrison,G.M., Rolfe,M., Kilanowski,F.M., Cross,S.H. and Dorin,J.R.
  TITLE     Identification and characterization of a novel murine
            beta-defensin-related gene
  JOURNAL   Mamm Genome 13 (8), 445-451 (2002)
   PUBMED   12226710
  REMARK    Erratum:[Mamm Genome. 2002 Oct;13(10):603]
REFERENCE   8  (bases 1 to 326)
  AUTHORS   Yamaguchi,Y., Fukuhara,S., Nagase,T., Tomita,T., Hitomi,S.,
            Kimura,S., Kurihara,H. and Ouchi,Y.
  TITLE     A novel mouse beta-defensin, mBD-6, predominantly expressed in
            skeletal muscle
  JOURNAL   J Biol Chem 276 (34), 31510-31514 (2001)
   PUBMED   11408484
REFERENCE   9  (bases 1 to 326)
  AUTHORS   Jia,H.P., Wowk,S.A., Schutte,B.C., Lee,S.K., Vivado,A., Tack,B.F.,
            Bevins,C.L. and McCray,P.B. Jr.
  TITLE     A novel murine beta -defensin expressed in tongue, esophagus, and
            trachea
  JOURNAL   J Biol Chem 275 (43), 33314-33320 (2000)
   PUBMED   10922379
REFERENCE   10 (bases 1 to 326)
  AUTHORS   Morrison,G.M., Davidson,D.J. and Dorin,J.R.
  TITLE     A novel mouse beta defensin, Defb2, which is upregulated in the
            airways by lipopolysaccharide
  JOURNAL   FEBS Lett 442 (1), 112-116 (1999)
   PUBMED   9923615
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590619.9.
            
            On Sep 2, 2022 this sequence version replaced NM_010030.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ011800.1, BC109129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AL590619.9         192623-192716       c
            95-326              AL590619.9         189139-189370       c
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.45 cM"
     gene            1..326
                     /gene="Defb2"
                     /gene_synonym="BD-2"
                     /note="defensin beta 2"
                     /db_xref="GeneID:13215"
                     /db_xref="MGI:MGI:1338754"
     exon            1..94
                     /gene="Defb2"
                     /gene_synonym="BD-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..249
                     /gene="Defb2"
                     /gene_synonym="BD-2"
                     /note="beta-defensin 2"
                     /codon_start=1
                     /product="beta-defensin 2 precursor"
                     /protein_id="NP_034160.1"
                     /db_xref="CCDS:CCDS40284.1"
                     /db_xref="GeneID:13215"
                     /db_xref="MGI:MGI:1338754"
                     /translation="MRTLCSLLLICCLLFSYTTPAVGSLKSIGYEAELDHCHTNGGYC
                     VRAICPPSARRPGSCFPEKNPCCKYMK"
     exon            95..326
                     /gene="Defb2"
                     /gene_synonym="BD-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      300..305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Defb2"
                     /gene_synonym="BD-2"
                     /note="hexamer: AATAAA"
     polyA_site      326
                     /gene="Defb2"
                     /gene_synonym="BD-2"
                     /note="major polyA site"
ORIGIN      
        1 ctctctggag tctgagtgcc ctttctacca gccatgagga ctctctgctc tctgctgctg
       61 atatgctgcc tccttttctc atataccact ccagctgttg gaagtttaaa aagtattgga
      121 tacgaagcag aacttgacca ctgccacacc aatggagggt actgtgtcag agccatttgt
      181 cctccttctg ccaggcgtcc tgggagctgt ttcccagaga agaacccctg ttgcaagtac
      241 atgaaatgat tagaaggaag cacatggaag tcaagtgaca gatgtgtaat tgatgtttca
      301 ataaaggaaa cattttttta agctta
//
