LOCUS       NM_145157                414 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus defensin beta 19 (Defb19), mRNA.
ACCESSION   NM_145157
VERSION     NM_145157.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 414)
  AUTHORS   Li,X., Yuan,C., Shi,J., Kang,H., Chen,Y., Duan,Y., Jin,J.,
            Cheung,L.P., Li,T.C., Liu,Y., Cui,Y., Ruan,Y.C., Jiang,X., Cai,Z.,
            Chan,H.C., Ji,L., Zeng,X., Liu,J., Chen,H. and Fok,K.L.
  TITLE     beta-Defensin 19/119 mediates sperm chemotaxis and is associated
            with idiopathic infertility
  JOURNAL   Cell Rep Med 3 (12), 100825 (2022)
   PUBMED   36513070
  REMARK    GeneRIF: beta-Defensin 19/119 mediates sperm chemotaxis and is
            associated with idiopathic infertility.
REFERENCE   2  (bases 1 to 414)
  AUTHORS   Correa,S.M., Washburn,L.L., Kahlon,R.S., Musson,M.C., Bouma,G.J.,
            Eicher,E.M. and Albrecht,K.H.
  TITLE     Sex reversal in C57BL/6J XY mice caused by increased expression of
            ovarian genes and insufficient activation of the testis determining
            pathway
  JOURNAL   PLoS Genet 8 (4), e1002569 (2012)
   PUBMED   22496664
REFERENCE   3  (bases 1 to 414)
  AUTHORS   Munger,S.C., Aylor,D.L., Syed,H.A., Magwene,P.M., Threadgill,D.W.
            and Capel,B.
  TITLE     Elucidation of the transcription network governing mammalian sex
            determination by exploiting strain-specific susceptibility to sex
            reversal
  JOURNAL   Genes Dev 23 (21), 2521-2536 (2009)
   PUBMED   19884258
REFERENCE   4  (bases 1 to 414)
  AUTHORS   Patil,A.A., Cai,Y., Sang,Y., Blecha,F. and Zhang,G.
  TITLE     Cross-species analysis of the mammalian beta-defensin gene family:
            presence of syntenic gene clusters and preferential expression in
            the male reproductive tract
  JOURNAL   Physiol Genomics 23 (1), 5-17 (2005)
   PUBMED   16033865
REFERENCE   5  (bases 1 to 414)
  AUTHORS   Bouma,G.J., Albrecht,K.H., Washburn,L.L., Recknagel,A.K.,
            Churchill,G.A. and Eicher,E.M.
  TITLE     Gonadal sex reversal in mutant Dax1 XY mice: a failure to
            upregulate Sox9 in pre-Sertoli cells
  JOURNAL   Development 132 (13), 3045-3054 (2005)
   PUBMED   15944188
REFERENCE   6  (bases 1 to 414)
  AUTHORS   Bouma,G.J., Hart,G.T., Washburn,L.L., Recknagel,A.K. and
            Eicher,E.M.
  TITLE     Using real time RT-PCR analysis to determine multiple gene
            expression patterns during XX and XY mouse fetal gonad development
  JOURNAL   Gene Expr Patterns 5 (1), 141-149 (2004)
   PUBMED   15533830
REFERENCE   7  (bases 1 to 414)
  AUTHORS   Menke,D.B. and Page,D.C.
  TITLE     Sexually dimorphic gene expression in the developing mouse gonad
  JOURNAL   Gene Expr Patterns 2 (3-4), 359-367 (2002)
   PUBMED   12617826
REFERENCE   8  (bases 1 to 414)
  AUTHORS   Yamamoto,M. and Matsui,Y.
  TITLE     Testis-specific expression of a novel mouse defensin-like gene, Tdl
  JOURNAL   Mech Dev 116 (1-2), 217-221 (2002)
   PUBMED   12128228
  REMARK    GeneRIF: Tdl is specifically expressed in Sertoli cell-lineage in
            seminiferous cords in embryonic testes, but not in embryonic
            ovaries after 12.5dpc when the sexual differentiation of gonads is
            initiated.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ012035.1 and AF532614.1.
            
            On Nov 22, 2008 this sequence version replaced NM_145157.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049701.1, AY098993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               DQ012035.1         1-393
            394-414             AF532614.1         390-410
FEATURES             Location/Qualifiers
     source          1..414
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.31 cM"
     gene            1..414
                     /gene="Defb19"
                     /gene_synonym="BD-19; Defb24; mBD-19; Tdl"
                     /note="defensin beta 19"
                     /db_xref="GeneID:246700"
                     /db_xref="MGI:MGI:2385955"
     exon            1..123
                     /gene="Defb19"
                     /gene_synonym="BD-19; Defb24; mBD-19; Tdl"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..317
                     /gene="Defb19"
                     /gene_synonym="BD-19; Defb24; mBD-19; Tdl"
                     /note="beta-defensin 19; beta-defensin 24; testis-specific
                     beta-defensin-like protein"
                     /codon_start=1
                     /product="beta-defensin 19 precursor"
                     /protein_id="NP_660139.1"
                     /db_xref="CCDS:CCDS38277.1"
                     /db_xref="GeneID:246700"
                     /db_xref="MGI:MGI:2385955"
                     /translation="MRLALLLLAILVATELVVSGKNPILQCMGNRGFCRSSCKKSEQA
                     YFYCRTFQMCCLQSYVRISLTGVDDNTNWSYEKHWPRIP"
     exon            124..394
                     /gene="Defb19"
                     /gene_synonym="BD-19; Defb24; mBD-19; Tdl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      375..380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Defb19"
                     /gene_synonym="BD-19; Defb24; mBD-19; Tdl"
                     /note="hexamer: ATTAAA"
     polyA_site      394
                     /gene="Defb19"
                     /gene_synonym="BD-19; Defb24; mBD-19; Tdl"
                     /note="major polyA site"
ORIGIN      
        1 agtgaaggaa ctctgctgcc gtcccctgca ggccacttac cacctccacc ctgggtggtg
       61 ccaccatgag gctggctctc ctgcttcttg ccatacttgt ggcaacggaa ctggtcgtgt
      121 ctggcaaaaa tcctatcctt caatgcatgg gtaacagagg attctgtagg tcttcctgca
      181 aaaagagtga acaggcctac ttctactgca gaactttcca gatgtgctgc ctccagtcct
      241 acgtgaggat cagcctcaca ggagtagatg acaacactaa ctggtcttac gagaagcact
      301 ggccaagaat accgtgacag cctgcacacc gtgtacagac ttccagggaa gccgtccctg
      361 ctgtctgccc ccttattaaa atgtatgcat ctgaaaaaaa aaaaaaaaaa aaaa
//
