LOCUS       NM_183026                347 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus defensin beta 14 (Defb14), mRNA.
ACCESSION   NM_183026
VERSION     NM_183026.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 347)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 347)
  AUTHORS   Koren,N., Zubeidat,K., Saba,Y., Horev,Y., Barel,O., Wilharm,A.,
            Heyman,O., Wald,S., Eli-Berchoer,L., Shapiro,H., Nadler,C.,
            Elinav,E., Wilensky,A., Prinz,I., Bercovier,H. and Hovav,A.H.
  TITLE     Maturation of the neonatal oral mucosa involves unique
            epithelium-microbiota interactions
  JOURNAL   Cell Host Microbe 29 (2), 197-209 (2021)
   PUBMED   33412104
REFERENCE   3  (bases 1 to 347)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 347)
  AUTHORS   Williams,H., Campbell,L., Crompton,R.A., Singh,G., McHugh,B.J.,
            Davidson,D.J., McBain,A.J., Cruickshank,S.M. and Hardman,M.J.
  TITLE     Microbial Host Interactions and Impaired Wound Healing in Mice and
            Humans: Defining a Role for BD14 and NOD2
  JOURNAL   J Invest Dermatol 138 (10), 2264-2274 (2018)
   PUBMED   29723492
  REMARK    GeneRIF: although murine beta-defensin 14 might affect local skin
            microbial communities, it may further affect other healing
            parameters. Indeed, exogenously administered murine beta-defensin
            14 directly delayed mouse primary keratinocyte scratch wound
            closure in vitro.
REFERENCE   5  (bases 1 to 347)
  AUTHORS   Yuan,X., Wang,J., Cheng,M. and Zhang,X.
  TITLE     Mouse beta-defensin-14 for inducing the maturation of dendritic
            cells
  JOURNAL   Int Immunopharmacol 55, 133-141 (2018)
   PUBMED   29253819
  REMARK    GeneRIF: this work demonstrates that mouse beta-defensin-14 can
            promote the maturation of dendritic cells in which TLR-4 is
            possibly involved
REFERENCE   6  (bases 1 to 347)
  AUTHORS   Augustin,D.K., Heimer,S.R., Tam,C., Li,W.Y., Le Due,J.M.,
            Evans,D.J. and Fleiszig,S.M.
  TITLE     Role of defensins in corneal epithelial barrier function against
            Pseudomonas aeruginosa traversal
  JOURNAL   Infect Immun 79 (2), 595-605 (2011)
   PUBMED   21115716
REFERENCE   7  (bases 1 to 347)
  AUTHORS   Rohrl,J., Yang,D., Oppenheim,J.J. and Hehlgans,T.
  TITLE     Human beta-defensin 2 and 3 and their mouse orthologs induce
            chemotaxis through interaction with CCR2
  JOURNAL   J Immunol 184 (12), 6688-6694 (2010)
   PUBMED   20483750
  REMARK    GeneRIF: beta-defensin 4 and 14 contribute to the innate and
            adaptive immune response in their role as chemoattractants
REFERENCE   8  (bases 1 to 347)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 347)
  AUTHORS   Taylor,K., Clarke,D.J., McCullough,B., Chin,W., Seo,E., Yang,D.,
            Oppenheim,J., Uhrin,D., Govan,J.R., Campopiano,D.J., MacMillan,D.,
            Barran,P. and Dorin,J.R.
  TITLE     Analysis and separation of residues important for the
            chemoattractant and antimicrobial activities of beta-defensin 3
  JOURNAL   J Biol Chem 283 (11), 6631-6639 (2008)
   PUBMED   18180295
  REMARK    GeneRIF: chemoattractant and antimicrobial activities of
            beta-defensins can be separated, and both of these functions are
            independent of intramolecular disulfide bonds
REFERENCE   10 (bases 1 to 347)
  AUTHORS   Rohrl,J., Yang,D., Oppenheim,J.J. and Hehlgans,T.
  TITLE     Identification and Biological Characterization of Mouse
            beta-defensin 14, the orthologue of human beta-defensin 3
  JOURNAL   J Biol Chem 283 (9), 5414-5419 (2008)
   PUBMED   18167348
  REMARK    GeneRIF: both hBD3 and mBD14 were chemotactic for freshly isolated
            mouse resident peritoneal cells. Thus, mBD14, based on structural
            and functional similarities, appears to be an orthologue of hBD3.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116394.22.
            
            On Sep 2, 2022 this sequence version replaced NM_183026.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EH100644.1, BC116199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC116394.22        146560-146646
            88-347              AC116394.22        147299-147558
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..347
                     /gene="Defb14"
                     /gene_synonym="BD-14"
                     /note="defensin beta 14"
                     /db_xref="GeneID:244332"
                     /db_xref="MGI:MGI:2675345"
     exon            1..87
                     /gene="Defb14"
                     /gene_synonym="BD-14"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..233
                     /gene="Defb14"
                     /gene_synonym="BD-14"
                     /note="beta-defensin 14"
                     /codon_start=1
                     /product="beta-defensin 14 precursor"
                     /protein_id="NP_898847.1"
                     /db_xref="CCDS:CCDS40253.1"
                     /db_xref="GeneID:244332"
                     /db_xref="MGI:MGI:2675345"
                     /translation="MRLHYLLFVFLILFLVPAPGDAFLPKTLRKFFCRIRGGRCAVLN
                     CLGKEEQIGRCSNSGRKCCRKKK"
     exon            88..347
                     /gene="Defb14"
                     /gene_synonym="BD-14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctcagct tgttgggaag cagtcaacta tgaggcttca ttatctgcta tttgtattcc
       61 tcatcttgtt cttggtgcct gctccagggg acgcattcct accaaaaacc ctccgaaaat
      121 ttttctgcag aataagaggt ggccggtgtg ctgtacttaa ctgccttgga aaggaagaac
      181 aaataggtcg atgttctaat agcggtcgaa aatgctgccg aaagaagaag tagaagaccc
      241 tgactcaaac ttagaatatg cagggtgagg gtgggggagg tccttctggg aatgtataaa
      301 aggaaaatca agttattata tatatatatt ttaaaaaact agtagct
//
