LOCUS       NM_139221                346 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus defensin beta 11 (Defb11), mRNA.
ACCESSION   NM_139221
VERSION     NM_139221.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 346)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 346)
  AUTHORS   Morrison,G.M., Semple,C.A., Kilanowski,F.M., Hill,R.E. and
            Dorin,J.R.
  TITLE     Signal sequence conservation and mature peptide divergence within
            subgroups of the murine beta-defensin gene family
  JOURNAL   Mol Biol Evol 20 (3), 460-470 (2003)
   PUBMED   12644567
REFERENCE   3  (bases 1 to 346)
  AUTHORS   Yamaguchi,Y., Nagase,T., Makita,R., Fukuhara,S., Tomita,T.,
            Tominaga,T., Kurihara,H. and Ouchi,Y.
  TITLE     Identification of multiple novel epididymis-specific beta-defensin
            isoforms in humans and mice
  JOURNAL   J Immunol 169 (5), 2516-2523 (2002)
   PUBMED   12193721
  REMARK    GeneRIF: The epididymis-specific expression pattern of the
            beta-defensin isoform mBD-11 has been characterized.
REFERENCE   4  (bases 1 to 346)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590619.9.
            
            On Sep 4, 2022 this sequence version replaced NM_139221.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ044726.1, AJ437646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AL590619.9         126210-126323
            115-346             AL590619.9         127044-127275
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.59 cM"
     gene            1..346
                     /gene="Defb11"
                     /gene_synonym="BD-11; Defb8"
                     /note="defensin beta 11"
                     /db_xref="GeneID:246081"
                     /db_xref="MGI:MGI:2179197"
     exon            1..114
                     /gene="Defb11"
                     /gene_synonym="BD-11; Defb8"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..287
                     /gene="Defb11"
                     /gene_synonym="BD-11; Defb8"
                     /note="beta-defensin 11"
                     /codon_start=1
                     /product="beta-defensin 11 precursor"
                     /protein_id="NP_631967.1"
                     /db_xref="CCDS:CCDS52515.1"
                     /db_xref="GeneID:246081"
                     /db_xref="MGI:MGI:2179197"
                     /translation="MRTLCSLLLICCLLFSYTTPAVGDLKHLILKAQLARCYKFGGFC
                     YNSMCPPHTKFIGNCHPDHLHCCINMKELEGST"
     exon            115..346
                     /gene="Defb11"
                     /gene_synonym="BD-11; Defb8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      320..325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Defb11"
                     /gene_synonym="BD-11; Defb8"
                     /note="hexamer: AATAAA"
     polyA_site      346
                     /gene="Defb11"
                     /gene_synonym="BD-11; Defb8"
                     /note="major polyA site"
ORIGIN      
        1 agtcctgctg tagtcactga ctctctggag tctgagtgcc ctttctacca gccatgagga
       61 ctctctgctc tctgctgctg atatgctgcc tccttttctc atataccact ccagctgttg
      121 gagatctaaa acatcttata ctcaaagcac aacttgcacg gtgctacaag ttcggagggt
      181 tctgttacaa ttccatgtgt cctcctcata ccaagtttat aggtaactgt cacccagacc
      241 acctccactg ttgcataaac atgaaagaat tggaaggaag cacatagaag ccaaatgaca
      301 gatgtgtaac tgatgtttta ataaaggaaa catttcttta agctta
//
