LOCUS       NM_007843                932 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus defensin beta 1 (Defb1), mRNA.
ACCESSION   NM_007843
VERSION     NM_007843.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 932)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 932)
  AUTHORS   Wei,C., Tang,X., Wang,F., Li,Y., Sun,L. and Luo,F.
  TITLE     Molecular characterization of pulmonary defenses against bacterial
            invasion in allergic asthma: The role of Foxa2 in regulation of
            beta-defensin 1
  JOURNAL   PLoS One 14 (12), e0226517 (2019)
   PUBMED   31881038
  REMARK    GeneRIF: Results found that Foxa2 is involved in the
            transcriptional regulation of DEFB1, and downregulation of DEFB1
            due to suppression of Foxa2 expression is likely to contribute to
            increased infection risk in the Th2-dominated airway inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 932)
  AUTHORS   Williams,H., Crompton,R.A., Thomason,H.A., Campbell,L., Singh,G.,
            McBain,A.J., Cruickshank,S.M. and Hardman,M.J.
  TITLE     Cutaneous Nod2 Expression Regulates the Skin Microbiome and Wound
            Healing in a Murine Model
  JOURNAL   J Invest Dermatol 137 (11), 2427-2436 (2017)
   PUBMED   28647345
REFERENCE   4  (bases 1 to 932)
  AUTHORS   Madon-Simon,M., Grad,I., Bayo,P., Perez,P. and Picard,D.
  TITLE     Defective glucocorticoid receptor signaling and
            keratinocyte-autonomous defects contribute to skin phenotype of
            mouse embryos lacking the Hsp90 co-chaperone p23
  JOURNAL   PLoS One 12 (6), e0180035 (2017)
   PUBMED   28650975
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 932)
  AUTHORS   Maxwell,J.R., Zhang,Y., Brown,W.A., Smith,C.L., Byrne,F.R.,
            Fiorino,M., Stevens,E., Bigler,J., Davis,J.A., Rottman,J.B.,
            Budelsky,A.L., Symons,A. and Towne,J.E.
  TITLE     Differential Roles for Interleukin-23 and Interleukin-17 in
            Intestinal Immunoregulation
  JOURNAL   Immunity 43 (4), 739-750 (2015)
   PUBMED   26431947
REFERENCE   6  (bases 1 to 932)
  AUTHORS   Yamaguchi,Y., Fukuhara,S., Nagase,T., Tomita,T., Hitomi,S.,
            Kimura,S., Kurihara,H. and Ouchi,Y.
  TITLE     A novel mouse beta-defensin, mBD-6, predominantly expressed in
            skeletal muscle
  JOURNAL   J Biol Chem 276 (34), 31510-31514 (2001)
   PUBMED   11408484
REFERENCE   7  (bases 1 to 932)
  AUTHORS   Jia,H.P., Wowk,S.A., Schutte,B.C., Lee,S.K., Vivado,A., Tack,B.F.,
            Bevins,C.L. and McCray,P.B. Jr.
  TITLE     A novel murine beta -defensin expressed in tongue, esophagus, and
            trachea
  JOURNAL   J Biol Chem 275 (43), 33314-33320 (2000)
   PUBMED   10922379
REFERENCE   8  (bases 1 to 932)
  AUTHORS   Morrison,G.M., Davidson,D.J., Kilanowski,F.M., Borthwick,D.W.,
            Crook,K., Maxwell,A.I., Govan,J.R. and Dorin,J.R.
  TITLE     Mouse beta defensin-1 is a functional homolog of human beta
            defensin-1
  JOURNAL   Mamm Genome 9 (6), 453-457 (1998)
   PUBMED   9585433
REFERENCE   9  (bases 1 to 932)
  AUTHORS   Bals,R., Goldman,M.J. and Wilson,J.M.
  TITLE     Mouse beta-defensin 1 is a salt-sensitive antimicrobial peptide
            present in epithelia of the lung and urogenital tract
  JOURNAL   Infect Immun 66 (3), 1225-1232 (1998)
   PUBMED   9488417
REFERENCE   10 (bases 1 to 932)
  AUTHORS   Huttner,K.M., Kozak,C.A. and Bevins,C.L.
  TITLE     The mouse genome encodes a single homolog of the antimicrobial
            peptide human beta-defensin 1
  JOURNAL   FEBS Lett 413 (1), 45-49 (1997)
   PUBMED   9287114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI956736.1, AK142544.1 and DV551556.1.
            
            On Jan 10, 2008 this sequence version replaced NM_007843.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024380.1, DV055613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AI956736.1         67-85
            20-915              AK142544.1         1-896
            916-932             DV551556.1         220-236
FEATURES             Location/Qualifiers
     source          1..932
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..932
                     /gene="Defb1"
                     /gene_synonym="BD-1"
                     /note="defensin beta 1"
                     /db_xref="GeneID:13214"
                     /db_xref="MGI:MGI:1096878"
     exon            1..158
                     /gene="Defb1"
                     /gene_synonym="BD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            159..916
                     /gene="Defb1"
                     /gene_synonym="BD-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      894..899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Defb1"
                     /gene_synonym="BD-1"
                     /note="hexamer: AATAAA"
     polyA_site      916
                     /gene="Defb1"
                     /gene_synonym="BD-1"
                     /note="major polyA site"
ORIGIN      
        1 cctataaaaa aacaagctca ttcaagcctc atctgtcagc ccaactacct gggagtttca
       61 catcctctct gcactctgga ccctggctgc caccactatg aaaactcatt actttctcct
      121 ggtgatgata tgttttcttt tctcccagat ggagccaggt gttggcattc tcacaagtct
      181 tggacgaaga acagatcaat acaaatgcct tcaacatgga ggattctgtc tccgctccag
      241 ctgcccatct aataccaaac tacagggaac ctgtaaacca gataagccca actgttgtaa
      301 gagctgacag tagtttgaag aatgagcata aaggacgagc gatggattgt aaaattagtg
      361 ttttaataaa tgaaatgttt ttgaagttta tttacatcat atcaaaataa attttatttc
      421 tctgtttaga agagcaattt ttttttaaaa agtattgggc ttagaacaag aggtgagaaa
      481 atccagaaca tctgcctggt cctgagtaat gatggtcaca atttgagtga tatcacttct
      541 atgtaatttt atcaccatgc aagatgcatc cagcacaaga aggtcacacg gaatggaaca
      601 gagaacacgg tacacaggct tcctgggata taaaagagaa tgactcttcc acagtcttag
      661 cagtcagttc tatgacaccc catctgcaac cttagcaata gaaactcctt tataactgta
      721 agttgtccaa ccagagcgca tcctccatgg gtaatgtctg gatttcctgg tacttttaaa
      781 aaagattcag ccacaacttt caaatataat tgtgtatcac aaatctgtgt tgggacttgg
      841 acatctgtgt ttcaggtctt ttttgctgtt gtgtctgtag acatgcatga atgaataaaa
      901 gcaatcatga catccaaaaa aaaaaaaaaa aa
//
