LOCUS       NM_007851                421 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus defensin, alpha, 5 (Defa5), mRNA.
ACCESSION   NM_007851 XM_001005054
VERSION     NM_007851.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 421)
  AUTHORS   Fernandez Vallone,V., Leprovots,M., Ribatallada-Soriano,D.,
            Gerbier,R., Lefort,A., Libert,F., Vassart,G. and Garcia,M.I.
  TITLE     LGR5 controls extracellular matrix production by stem cells in the
            developing intestine
  JOURNAL   EMBO Rep 21 (7), e49224 (2020)
   PUBMED   32468660
REFERENCE   2  (bases 1 to 421)
  AUTHORS   Sugi,Y., Takahashi,K., Kurihara,K., Nakano,K., Kobayakawa,T.,
            Nakata,K., Tsuda,M., Hanazawa,S., Hosono,A. and Kaminogawa,S.
  TITLE     alpha-Defensin 5 gene expression is regulated by gut microbial
            metabolites
  JOURNAL   Biosci Biotechnol Biochem 81 (2), 242-248 (2017)
   PUBMED   27760493
  REMARK    GeneRIF: alpha-defensin 5 expression can also be regulated by
            microbial metabolites
REFERENCE   3  (bases 1 to 421)
  AUTHORS   Das,S., Yu,S., Sakamori,R., Vedula,P., Feng,Q., Flores,J.,
            Hoffman,A., Fu,J., Stypulkowski,E., Rodriguez,A., Dobrowolski,R.,
            Harada,A., Hsu,W., Bonder,E.M., Verzi,M.P. and Gao,N.
  TITLE     Rab8a vesicles regulate Wnt ligand delivery and Paneth cell
            maturation at the intestinal stem cell niche
  JOURNAL   Development 142 (12), 2147-2162 (2015)
   PUBMED   26015543
REFERENCE   4  (bases 1 to 421)
  AUTHORS   Salzman,N.H., Hung,K., Haribhai,D., Chu,H., Karlsson-Sjoberg,J.,
            Amir,E., Teggatz,P., Barman,M., Hayward,M., Eastwood,D., Stoel,M.,
            Zhou,Y., Sodergren,E., Weinstock,G.M., Bevins,C.L., Williams,C.B.
            and Bos,N.A.
  TITLE     Enteric defensins are essential regulators of intestinal microbial
            ecology
  JOURNAL   Nat Immunol 11 (1), 76-83 (2010)
   PUBMED   19855381
  REMARK    GeneRIF: Data show that DEFA5-expressing mice had striking losses
            of segmented filamentous bacteria and fewer interleukin 17
            (IL-17)-producing lamina propria T cells.
REFERENCE   5  (bases 1 to 421)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 421)
  AUTHORS   Ouellette,A.J., Darmoul,D., Tran,D., Huttner,K.M., Yuan,J. and
            Selsted,M.E.
  TITLE     Peptide localization and gene structure of cryptdin 4, a
            differentially expressed mouse paneth cell alpha-defensin
  JOURNAL   Infect Immun 67 (12), 6643-6651 (1999)
   PUBMED   10569786
REFERENCE   7  (bases 1 to 421)
  AUTHORS   Darmoul,D. and Ouellette,A.J.
  TITLE     Positional specificity of defensin gene expression reveals Paneth
            cell heterogeneity in mouse small intestine
  JOURNAL   Am J Physiol 271 (1 Pt 1), G68-G74 (1996)
   PUBMED   8760109
REFERENCE   8  (bases 1 to 421)
  AUTHORS   Ouellette,A.J., Hsieh,M.M., Nosek,M.T., Cano-Gauci,D.F.,
            Huttner,K.M., Buick,R.N. and Selsted,M.E.
  TITLE     Mouse Paneth cell defensins: primary structures and antibacterial
            activities of numerous cryptdin isoforms
  JOURNAL   Infect Immun 62 (11), 5040-5047 (1994)
   PUBMED   7927786
REFERENCE   9  (bases 1 to 421)
  AUTHORS   Huttner,K.M., Selsted,M.E. and Ouellette,A.J.
  TITLE     Structure and diversity of the murine cryptdin gene family
  JOURNAL   Genomics 19 (3), 448-453 (1994)
   PUBMED   8188287
  REMARK    Erratum:[Genomics 1995 Feb 10;25(3):762]
REFERENCE   10 (bases 1 to 421)
  AUTHORS   Selsted,M.E., Miller,S.I., Henschen,A.H. and Ouellette,A.J.
  TITLE     Enteric defensins: antibiotic peptide components of intestinal host
            defense
  JOURNAL   J Cell Biol 118 (4), 929-936 (1992)
   PUBMED   1500431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129174.3, AV070515.1 and AV067547.1.
            
            On Aug 31, 2006 this sequence version replaced NM_007851.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV049261.1, AV070515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC129174.3         58533-58749         c
            218-327             AC129174.3         57862-57971         c
            328-417             AV070515.1         218-307
            418-421             AV067547.1         247-250
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..421
                     /gene="Defa5"
                     /gene_synonym="Defa29; Defcr29; Defcr5"
                     /note="defensin, alpha, 5"
                     /db_xref="GeneID:13239"
                     /db_xref="MGI:MGI:99583"
     exon            1..217
                     /gene="Defa5"
                     /gene_synonym="Defa29; Defcr29; Defcr5"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..327
                     /gene="Defa5"
                     /gene_synonym="Defa29; Defcr29; Defcr5"
                     /note="defensin-related cryptdin-5; alpha-defensin 5;
                     defensin, alpha, 29"
                     /codon_start=1
                     /product="alpha-defensin 5 precursor"
                     /protein_id="NP_031877.2"
                     /db_xref="CCDS:CCDS22152.1"
                     /db_xref="GeneID:13239"
                     /db_xref="MGI:MGI:99583"
                     /translation="MKTFVLLSALVLLAFQAQADPIHKTDEETNTEEQPGEEDQAVSI
                     SFGGQEGSALHEELSKKLICYCRIRGCKRRERVFGTCRNLFLTFVFCCS"
     exon            218..421
                     /gene="Defa5"
                     /gene_synonym="Defa29; Defcr29; Defcr5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacattggg ctcctgctca acaattctcc aggtgacccc cagccatgaa gacatttgtc
       61 ctcctctctg cccttgtcct gctggccttc caggcccagg ctgatcctat ccacaaaaca
      121 gatgaagaga ctaatactga ggagcagcca ggggaagagg accaggctgt gtctatctcc
      181 tttggaggcc aagaagggtc tgctcttcat gaagaattgt caaaaaagct gatatgctat
      241 tgtagaataa gaggctgcaa aagaagagaa cgcgtttttg ggacctgcag aaatcttttt
      301 ttaactttcg tattctgctg cagctgaata tgcagatgac aaagatatga caaccatcgg
      361 ctctgaggcc actgatgctg gggcctgatg atcacttctc aataaattgt ttgcaatatg
      421 c
//
