LOCUS       NM_001270555             427 bp    mRNA    linear   ROD 09-OCT-2020
DEFINITION  Mus musculus defensin, alpha, 33 (Defa33), mRNA.
ACCESSION   NM_001270555 XM_003688849
VERSION     NM_001270555.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 427)
  AUTHORS   Shanahan MT, Tanabe H and Ouellette AJ.
  TITLE     Strain-specific polymorphisms in Paneth cell alpha-defensins of
            C57BL/6 mice and evidence of vestigial myeloid alpha-defensin
            pseudogenes
  JOURNAL   Infect Immun 79 (1), 459-473 (2011)
   PUBMED   21041494
REFERENCE   2  (bases 1 to 427)
  AUTHORS   Amid C, Rehaume LM, Brown KL, Gilbert JG, Dougan G, Hancock RE and
            Harrow JL.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 427)
  AUTHORS   Figueredo SM, Weeks CS, Young SK and Ouellette AJ.
  TITLE     Anionic amino acids near the pro-alpha-defensin N terminus mediate
            inhibition of bactericidal activity in mouse pro-cryptdin-4
  JOURNAL   J Biol Chem 284 (11), 6826-6831 (2009)
   PUBMED   19106102
REFERENCE   4  (bases 1 to 427)
  AUTHORS   Patil A, Hughes AL and Zhang G.
  TITLE     Rapid evolution and diversification of mammalian alpha-defensins as
            revealed by comparative analysis of rodent and primate genes
  JOURNAL   Physiol Genomics 20 (1), 1-11 (2004)
   PUBMED   15494476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC240396.3.
            
            On Jul 18, 2012 this sequence version replaced XM_003688849.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV070363.1, AV065409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC240396.3         202557-202773
            218-427             AC240396.3         203329-203538
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8"
     gene            1..427
                     /gene="Defa33"
                     /gene_synonym="Gm21002"
                     /note="defensin, alpha, 33"
                     /db_xref="GeneID:100505096"
                     /db_xref="MGI:MGI:5434357"
     exon            1..217
                     /gene="Defa33"
                     /gene_synonym="Gm21002"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..333
                     /gene="Defa33"
                     /gene_synonym="Gm21002"
                     /codon_start=1
                     /product="alpha-defensin 20-like precursor"
                     /protein_id="NP_001257484.1"
                     /db_xref="CCDS:CCDS57611.1"
                     /db_xref="GeneID:100505096"
                     /db_xref="MGI:MGI:5434357"
                     /translation="MKTLVLLSALVLLAFQVQADPIQNTDEETNTEEQAGEEDQAVSV
                     SFGDPEGSALHEKSSRDLICYCRKGGCNRGEQVYGTCSGRLLFCCRRRHRH"
     exon            218..427
                     /gene="Defa33"
                     /gene_synonym="Gm21002"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacattggg ctcctgctca ccaattctcc aggtgactca cagccatgaa gacacttgtc
       61 ctcctctctg ccctcgtcct gctggccttc caggtccagg ctgatcctat ccaaaacaca
      121 gatgaggaga ctaatactga ggagcaggca ggggaggagg accaggctgt gtctgtctcc
      181 tttggagacc cagaaggatc tgctcttcat gaaaaatcgt cgagagatct gatatgctat
      241 tgtagaaaag gaggctgcaa tagaggagaa caagtttatg ggacctgctc aggacgactt
      301 ttgttctgct gccgccgccg ccaccgccac tgaacatgca gatggcagag atatgacaac
      361 catcagctct gaggctactg atgctggggc ctgataacca cttctcaata aattgtttgc
      421 aatatgc
//
