LOCUS       NM_007844                505 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus defensin, alpha, 29 (Defa29), mRNA.
ACCESSION   NM_007844
VERSION     NM_007844.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   McMahan,R.H., Hulsebus,H.J., Najarro,K.M., Giesy,L.E., Frank,D.N.
            and Kovacs,E.J.
  TITLE     Changes in gut microbiome correlate with intestinal barrier
            dysfunction and inflammation following a 3-day ethanol exposure in
            aged mice
  JOURNAL   Alcohol 107, 136-143 (2023)
   PUBMED   36150609
  REMARK    GeneRIF: Changes in gut microbiome correlate with intestinal
            barrier dysfunction and inflammation following a 3-day ethanol
            exposure in aged mice.
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Kinzel,B., Pikiolek,M., Orsini,V., Sprunger,J., Isken,A.,
            Zietzling,S., Desplanches,M., Dubost,V., Breustedt,D., Valdez,R.,
            Liu,D., Theil,D., Muller,M., Dietrich,B., Bouwmeester,T.,
            Ruffner,H. and Tchorz,J.S.
  TITLE     Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin
            development in mice
  JOURNAL   Dev Biol 390 (2), 181-190 (2014)
   PUBMED   24680895
REFERENCE   3  (bases 1 to 505)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   4  (bases 1 to 505)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 505)
  AUTHORS   Patil,A., Hughes,A.L. and Zhang,G.
  TITLE     Rapid evolution and diversification of mammalian alpha-defensins as
            revealed by comparative analysis of rodent and primate genes
  JOURNAL   Physiol Genomics 20 (1), 1-11 (2004)
   PUBMED   15494476
REFERENCE   6  (bases 1 to 505)
  AUTHORS   Grandjean,V., Vincent,S., Martin,L., Rassoulzadegan,M. and Cuzin,F.
  TITLE     Antimicrobial protection of the mouse testis: synthesis of
            defensins of the cryptdin family
  JOURNAL   Biol Reprod 57 (5), 1115-1122 (1997)
   PUBMED   9369178
REFERENCE   7  (bases 1 to 505)
  AUTHORS   Bry,L., Falk,P., Huttner,K., Ouellette,A., Midtvedt,T. and
            Gordon,J.I.
  TITLE     Paneth cell differentiation in the developing intestine of normal
            and transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 91 (22), 10335-10339 (1994)
   PUBMED   7937951
REFERENCE   8  (bases 1 to 505)
  AUTHORS   Ouellette,A.J. and Lauldi,J.C.
  TITLE     A novel gene family coding for cationic, cysteine-rich peptides.
            Regulation in mouse small intestine and cells of myeloid origin
  JOURNAL   J Biol Chem 269 (28), 18702 (1994)
   PUBMED   8034619
  REMARK    Correction to:[J Biol Chem. 1990 Jun 15;265(17):9831-7.. PMID:
            2351676]
REFERENCE   9  (bases 1 to 505)
  AUTHORS   Lin,M.Y., Munshi,I.A. and Ouellette,A.J.
  TITLE     The defensin-related murine CRS1C gene: expression in Paneth cells
            and linkage to Defcr, the cryptdin locus
  JOURNAL   Genomics 14 (2), 363-368 (1992)
   PUBMED   1427853
REFERENCE   10 (bases 1 to 505)
  AUTHORS   Ouellette,A.J. and Lualdi,J.C.
  TITLE     A novel mouse gene family coding for cationic, cysteine-rich
            peptides. Regulation in small intestine and cells of myeloid origin
  JOURNAL   J Biol Chem 265 (17), 9831-9837 (1990)
   PUBMED   2351676
  REMARK    Erratum:[J Biol Chem. 1994 Jul 15;269(28):18702.. PMID: 8034619]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129174.3.
            
            On Oct 7, 2022 this sequence version replaced NM_007844.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008584.1, BC145556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC129174.3         29125-29339
            216-505             AC129174.3         29966-30255
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..505
                     /gene="Defa29"
                     /gene_synonym="2010300L12Rik; 2010319H24Rik; CRS1C;
                     CRS1C-2; CRS1C-4; CRS1C-5; Defa-rs1; Defcr-rs1"
                     /note="defensin, alpha, 29"
                     /db_xref="GeneID:13218"
                     /db_xref="MGI:MGI:94881"
     exon            1..215
                     /gene="Defa29"
                     /gene_synonym="2010300L12Rik; 2010319H24Rik; CRS1C;
                     CRS1C-2; CRS1C-4; CRS1C-5; Defa-rs1; Defcr-rs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..394
                     /gene="Defa29"
                     /gene_synonym="2010300L12Rik; 2010319H24Rik; CRS1C;
                     CRS1C-2; CRS1C-4; CRS1C-5; Defa-rs1; Defcr-rs1"
                     /note="defensin related sequence cryptdin peptide (paneth
                     cells) (MGD|MGI:94881 GB|NM_007844, evidence: BLASTN, 98%,
                     match=468); putative; defensin-related cryptdin-related
                     sequence 1; alpha-defensin-related sequence 1;
                     cryptdin-related protein 1C; testis defensin; defensin,
                     alpha, related sequence 1; alpha-defensin 29"
                     /codon_start=1
                     /product="alpha-defensin 29 precursor"
                     /protein_id="NP_031870.2"
                     /db_xref="CCDS:CCDS40271.1"
                     /db_xref="GeneID:13218"
                     /db_xref="MGI:MGI:94881"
                     /translation="MKTLVLLSALVLLAFQVQADPIQNTDEETKTEEQPEEEDQAVSV
                     SFGGTEGSALQDVAQRRFPWCRKCRVCQKCQVCQKCPVCPTCPQCPKQPLCEERQNKT
                     AITTQAPNTQHKGC"
     exon            216..505
                     /gene="Defa29"
                     /gene_synonym="2010300L12Rik; 2010319H24Rik; CRS1C;
                     CRS1C-2; CRS1C-4; CRS1C-5; Defa-rs1; Defcr-rs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acattgagct cctgctcact aatcttccag gtgactccca gccatgaaga cactagtcct
       61 cctctctgcc ctcgttctgc tggccttcca ggtccaggct gatcctatcc aaaacacaga
      121 tgaagagact aaaactgagg agcagccaga ggaagaggac caggctgttt ctgtctcctt
      181 tggaggcaca gaaggctctg ctcttcaaga tgtagcccaa agaaggtttc cgtggtgccg
      241 gaagtgccga gtgtgccaga agtgccaagt gtgccagaag tgccctgtgt gcccgacatg
      301 cccccagtgc ccaaagcagc cattgtgcga agaaaggcaa aataaaactg caatcaccac
      361 ccaagctcca aatacacagc ataaaggctg ttgagctgaa tgtggaatct gggttgagat
      421 gaccatttgc ttttggtcct cacgatccca ttgtgcttag cctcaattgc aattccttct
      481 ctcataaact ccttgctgaa aaatc
//
