LOCUS       NM_007849                420 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus defensin, alpha, 25 (Defa25), mRNA.
ACCESSION   NM_007849 XM_891205 XM_909581
VERSION     NM_007849.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 420)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 420)
  AUTHORS   Kim,B.M., Buchner,G., Miletich,I., Sharpe,P.T. and Shivdasani,R.A.
  TITLE     The stomach mesenchymal transcription factor Barx1 specifies
            gastric epithelial identity through inhibition of transient Wnt
            signaling
  JOURNAL   Dev Cell 8 (4), 611-622 (2005)
   PUBMED   15809042
REFERENCE   3  (bases 1 to 420)
  AUTHORS   Patil,A., Hughes,A.L. and Zhang,G.
  TITLE     Rapid evolution and diversification of mammalian alpha-defensins as
            revealed by comparative analysis of rodent and primate genes
  JOURNAL   Physiol Genomics 20 (1), 1-11 (2004)
   PUBMED   15494476
REFERENCE   4  (bases 1 to 420)
  AUTHORS   Garabedian,E.M., Humphrey,P.A. and Gordon,J.I.
  TITLE     A transgenic mouse model of metastatic prostate cancer originating
            from neuroendocrine cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15382-15387 (1998)
   PUBMED   9860977
REFERENCE   5  (bases 1 to 420)
  AUTHORS   O'Brien,E.P., Novak,E.K., Keller,S.A., Poirier,C., Guenet,J.L. and
            Swank,R.T.
  TITLE     Molecular map of chromosome 19 including three genes affecting
            bleeding time: ep, ru, and bm
  JOURNAL   Mamm Genome 5 (6), 356-360 (1994)
   PUBMED   8043950
REFERENCE   6  (bases 1 to 420)
  AUTHORS   Ko,M.S., Wang,X., Horton,J.H., Hagen,M.D., Takahashi,N., Maezaki,Y.
            and Nadeau,J.H.
  TITLE     Genetic mapping of 40 cDNA clones on the mouse genome by PCR
  JOURNAL   Mamm Genome 5 (6), 349-355 (1994)
   PUBMED   8043949
REFERENCE   7  (bases 1 to 420)
  AUTHORS   Huttner,K.M., Selsted,M.E. and Ouellette,A.J.
  TITLE     Structure and diversity of the murine cryptdin gene family
  JOURNAL   Genomics 19 (3), 448-453 (1994)
   PUBMED   8188287
  REMARK    Erratum:[Genomics 1995 Feb 10;25(3):762]
REFERENCE   8  (bases 1 to 420)
  AUTHORS   Eisenhauer,P.B., Harwig,S.S. and Lehrer,R.I.
  TITLE     Cryptdins: antimicrobial defensins of the murine small intestine
  JOURNAL   Infect Immun 60 (9), 3556-3565 (1992)
   PUBMED   1500163
REFERENCE   9  (bases 1 to 420)
  AUTHORS   Selsted,M.E., Miller,S.I., Henschen,A.H. and Ouellette,A.J.
  TITLE     Enteric defensins: antibiotic peptide components of intestinal host
            defense
  JOURNAL   J Cell Biol 118 (4), 929-936 (1992)
   PUBMED   1500431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129197.4.
            
            On Oct 6, 2022 this sequence version replaced NM_007849.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY746430.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AC129197.4         121630-121851
            223-420             AC129197.4         122417-122614
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.35 cM"
     gene            1..420
                     /gene="Defa25"
                     /gene_synonym="Defcr-2; Defcr2; Defcr25"
                     /note="defensin, alpha, 25"
                     /db_xref="GeneID:13236"
                     /db_xref="MGI:MGI:3630385"
     exon            1..222
                     /gene="Defa25"
                     /gene_synonym="Defcr-2; Defcr2; Defcr25"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..325
                     /gene="Defa25"
                     /gene_synonym="Defcr-2; Defcr2; Defcr25"
                     /note="alpha-defensin 25; defensin-related cryptdin-25;
                     defensin related cryptdin 2"
                     /codon_start=1
                     /product="alpha-defensin 25 precursor"
                     /protein_id="NP_031875.1"
                     /db_xref="CCDS:CCDS52502.1"
                     /db_xref="GeneID:13236"
                     /db_xref="MGI:MGI:3630385"
                     /translation="MKTLVLLSALALLAFQVQADPIQNRDEESKIDEQPGKEDQAVSV
                     SFGDPEGSSLQEECEDLICYCRTRGCKRRERLNGTCRKGHLMYMLWCC"
     exon            223..420
                     /gene="Defa25"
                     /gene_synonym="Defcr-2; Defcr2; Defcr25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacatattga gctcctgctc accaatcctc caggtgactc ccagccatga agacactagt
       61 cctcctctct gcccttgccc tgctggcctt ccaagtccag gctgatccta tccaaaacag
      121 agatgaagag agtaaaattg atgagcagcc agggaaagaa gaccaagctg tttctgtctc
      181 ctttggagac ccagaaggct cttctcttca agaggaatgt gaagatctga tatgctattg
      241 tagaacaaga ggctgcaaaa gaagagaacg cctgaatggg acctgcagaa agggtcattt
      301 aatgtacatg ctctggtgct gctgaacatg gagaccacag aggacaagac agccatgagt
      361 actgaggcca catgctgggg cctgatgaac atttctcaat aaattgttgc ccagatggtc
//
